A global leader in serving libraries of all types, ProQuest LLC (“ProQuest”) supports the breadth of the information community with innovative discovery solutions that power the business of books and the best in research experience. More than a content provider or aggregator, ProQuest is an information partner, creating indispensable research solutions that connect people and information. Through innovative, user-centered discovery technology, ProQuest offers billions of pages of global content that includes historical newspapers, dissertations, and uniquely relevant resources for researchers of any age and sophistication—including content not likely to be digitized by others.
p1-8-9 cover_jumps 10/27/09 1:16 PM Page 1 NOVEMBER 2009 • VOLUME 8, NUMBER 11 MIRP vs. Open Prostatectomy Ascorbic Acid May Boost Minimally-invasive surgery more likely to result in incontinence and ED BY JODY A. CHARNOW Hemoglobin MEN WHO undergo minimally in- ASCORBIC ACID may be effective vasive radical prostatectomy (MIRP) in helping to manage anemia in for prostate cancer have significantly hemodialysis patients, according to shorter hospital stays and fewer sur- a recent meta-analysis by Canadian gical complications than those who investigators. undergo retropubic radical prostate- Brenda R. Hemmelgarn, MD, PhD, ctomy (RRP), but they experience of Foothills Medical Centre in significantly more genitourinary com- Calgary, Alberta, and collaborators plications and erectile dysfunction conducted a meta-analysis of six (ED), according to a study. randomized clinical trials of ascorb- © COLIN CUTHBERT / PHOTO RESEARCHERS, INC. Researchers found that MIRP pa- ic acid use in addition to standard tients had a median hospital stay of anemia management. These trials in- two days compared with three for cluded a total of 326 patients. The RRP patients. Compared with RRP duration of the studies ranged from patients, MIRP patients had an 89% two to six months. decreased risk of requiring blood Three trials included 125 patients transfusions, a 37% decreased risk of subjects with baseline mean hemoglo- postoperative respiratory complica- bin (Hb) levels below 11 g/dL and tions, and a 25% decreased risk of OPEN SURGERY for prostate cancer is associated with fewer genitourinary complications. three included subjects with baseline miscellaneous surgical complications. mean Hb levels of 11 g/dL or higher. MIRP patients, however, had a and Women’s Hospital in Boston, RRP patients, men who underwent Ascorbic acid dosages ranged from twofold increase risk of genitourinary found that fewer black and Hispanic MIRP tended to have higher socioeco- 500 mg IV once weekly to 500 mg IV complications and a 30% and 40% patients opted for MIRP rather than nomic status: They were more likely three times weekly. All studies used increased risk of incontinence and RRP, whereas Asian men were more to live in areas with at least 90% high recombinant human erythropoietin ED, respectively. likely to choose MIRP over RRP. school graduation rates and to have a (rHuEPO) therapy with baseline Additionally, the researchers, led by White men opted for MIRP and RRP median household income of $60,000. doses ranging from 47-477 U/kg/wk. Jim C. Hu, MD, MPH, of Brigham in similar proportions. Compared with continued on page 9 continued on page 9 Kidney Waitlist Numbers Rise Toxin Eases INSIDE THIS ISSUE The number of patients on the active waiting list for a kidney transplant has been increasing. At the end of 2007, nearly 49,000 patients were on that list, according to the recently released Refractory Warfarin may hike stroke risk Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) 2008 Annual Report. Below are the numbers of patients on the active renal transplant waiting list at the end of selected years. Incontinence in ESRD
Pages to are hidden for
"MIRP vs. Open Prostatectomy"Please download to view full document