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drug1109.qxp 10/22/2009 5:40 PM Page 16 DrugUpdate New drug information from the publishers of MPR Long-acting opioid for continuous pain relief Product: Embeda to-severe pain.The patients Company: King were initially titrated to pain Pharmacologic class: control in an open-label Opioid + opioid antagonist phase using Embeda,then Active ingredients: Mor- randomized to either contin- phine sulfate 20 mg,naltrex- uation with Embeda or Embeda is designed to reduce the drug’s appeal in the event of tampering. one HCl 0.8 mg;extended- placebo.The mean change in release caps. the weekly pain assessment equipment).Paralytic ileus. tated.Pregnancy (Cat.C).La- Indication: Moderate-to- score from randomization to During or within 14 days of bor and delivery,nursing severe pain management the end of the study was sta- monoamine oxidase in- mothers:not recommended. when continuous,around- tistically significantly superi- hibitors. Interactions: See Con- the-clock opioid is needed or for patients using Embeda Precautions: Ingestion of traindications.CNS depres- for an extended time period. compared to those given tampered product may pre- sion with CNS depressants Not for as-needed use. placebo. cipitate withdrawal symp- (e.g.,antiemetics,pheno- Pharmacology: Embeda Adults: Swallow whole,or toms in opioid-tolerant; thiazines,sedatives,hypnotics, contains pellets of an sprinkle pellets on apple- overdose in opioid-naïve. muscle relaxants;reduce dose extended-release formulation sauce;do not chew pellets. 100/4 strength for opioid- of either by half ).Paralytic of the opioid analgesic See literature.Do not give via tolerant only.Head injury.In- ileus with anticholinergics. morphine surrounding a nasogastric or gastric tubes. creased intracranial pressure. Ma
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