Genetic Markers for Coronary Artery Disease

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         Genetic Markers for Coronary Artery Disease
                                                         LINNEA M BAUDHUIN

INDEX TERMS: association, atherosclerosis,                          Linnea M. Baudhuin, PhD, DABMG is assistant
coronary artery disease, genetics, genome wide                      professor of laboratory medicine, Mayo Clinic,
association, genomics, linkage, myocardial infarction               Jacksonville, FL.

LEARNING OBJECTIVES                                                 Address for correspondence: Linnea M. Baudhuin,
Upon completion of this activity, participants should               PhD, DABMG, Assistant Professor of Laboratory
be able to:                                                         Medicine, Department of Laboratory Medicine and
 1. Compare linkage studies with association studies                Pathology, Mayo Clinic, 200 First St SW, Rochester,
    and recognize aspects regarding the utility and                 MN 55905, (507) 284-2511, (507) 266-4176 (fax),
    limitations of these studies in identifying markers             baudhuin.linnea@ .
    associated with complex disease.
 2. Describe genome wide association studies and                    The hereditary component of coronary artery disease
    their advantages and disadvantages for identifying              (CAD) is widely recognized. However, identifying
    genetic markers.                                                clinically useful genetic markers for a complex disease
 3. Discuss various aspects regarding the 9p21 risk                 like CAD has been challenging. Linkage-based and
    allele, its association to CAD, and its potential as            association-based genetic studies have pointed to
    a clinical marker for CAD.                                      some interesting findings, but many of these studies
 4. Describe microRNAs and their potential utility as               have lacked reproducibility or statistical significance.
    CAD markers.                                                    Recently, genome-wide association (GWA) and
 5. Discuss aspects of genetic markers that would                   microRNA discoveries have uncovered some poten-
    lend to their ability to enter the clinical realm as            tially promising new markers for CAD. The current
    risk markers for complex disease.                               status of genetic markers for CAD and their utility in
                                                                    the clinical arena are summarized here.
Clin Lab Sci 2009;22(4);226
                                                                    Coronary artery disease (CAD) is a multifactorial
                                                                    disease that can be influenced by a multitude of
                                                                    environmental and heritable risk factors. While there
The Focus section seeks to publish relevant and timely              are many traditional and novel analyte risk markers
continuing education for clinical laboratory practitioners.         associated with CAD, a large gap for CAD risk
Section editors, topics, and authors are selected in advance to     prediction remains. Epidemiological evidence points
cover current areas of interest in each discipline. Readers can
                                                                    to an approximate 50% genetic susceptibility to
obtain continuing education credit (CE) through P.A.C.E.® by
                                                                    CAD. Many different genetic associations with CAD
completing the continuing education registration form,
                                                                    have been identified through family and population-
recording answers to the examination, and mailing a
photocopy of it with the appropriate fee to the address             based analyses, and genetic risk markers may be
designated on the form. Suggestions for future Focus topics and     important for better defining individuals at risk for
authors, and manuscripts appropriate for CE credit are              CAD and CV events. Some potentially promising and
encouraged. Direct all inquiries to the Clin Lab Sci Editorial      interesting markers produced from such studies are
Office, Westminster Publishers, 315 Westminster Court,              highlighted here.
Brandon MS 39047. (601) 214-5028, (202) 315-5843

                                     FOCUS: CARDIOVASCULAR RISK ASSESSMENT

Linkage Analysis and CAD  
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