"[...] that we have a very good idea about how much DHA is just right, the next step is to try it out in an expanded clinical trial that involves many more people," said Gerald Weissmann, editor-in-chief of The FASEB Journal. [...] I'll stick with tasty foods that contain DHA, like fish, rather man getting a quick fatty-acid fix at the local vitamin store.
700 inform November 2009, Vol. 20 (11) 12% less and had 70% lower blood sugar levels. They also exhibited a significant decrease in low-density lipoprotein choles- terol of approximately 35%, and a lesser decrease in high-density lipoprotein cho- lesterol of approximately 22%. The con- centration of fatty acids in their blood was actually higher, a sign of the greater demand for fat to burn. Whereas the livers of the obese mice were heavy and pale with fat, treated animals’ livers were more than 30% lighter and were a healthy-looking red. Although less obvious, the SREBP-blocking ability might also explain the molecule’s earlier reported effects against prostate cancer cells in culture since cells require fatty acids and cholesterol to build their cell membranes and continue growing. Fatostatin is not the first molecule to act on SREBP, according to the researchers, but it appears to do so in a somewhat dif- scientists show that a 200 mg dose of DHA per day is enough to affect biochemical Soy and fish oil and ferent way than those described previously. Many steps remain, but Wakil and Uesugi markers that reliably predict cardiovascu- lar problems, such as those related to aging, cell proliferation atherosclerosis, and diabetes. The study is “Isoflavonoids and fish oil may be protec- are optimistic that fatostatin could prove to the first to identify how much DHA is nec- tive against colorectal cancer, but the evi- be useful clinically in the context of obesity, essary to promote optimal heart health, dence in relation to breast cancer risk is and perhaps in cardiovascular disease and according to a news release from FASEB. ambiguous,” the authors of a new study diabetes as well. “[We hope that] down the “This study shows that regularly con- write. road, fatostatin or a derivative of fatostatin suming small amounts of DHA is likely to “In the present study, we have inves- may be helpful,” said Wakil, who has been improve the health status of people, espe- tigated the impact of soya-derived isofla- studying the enzymes involved in fat syn- cially in regard to cardiovascular function,” vonoids and omega-3 fatty acids from fish thesis ever since he discovered them in the said Michel Lagarde of the Université de oil, both individually and in combination, late 1950s. “It could have a broad impact Lyon, who co-authored the study. on apoptosis (programmed cell death), cell on the key diseases [from which] we all To determine the optimal dose of proliferation, and estrogen receptor (ER) suffer.” DHA, Lagarde and colleagues examined the expression in the colon and mammary gland Fatostatin or its analogs may also serve effects of increasing doses of DHA on 12 of the rat. Female rats were fed diets high in as tools for gaining further insights into the healthy male volunteers
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