CUSTOMIZED ADHESIVE AND COATING TECHNOLOGIES ENABLE NOVEL DRUG DELIVERY METHODS

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CUSTOMIZED ADHESIVE AND COATING TECHNOLOGIES ENABLE NOVEL DRUG DELIVERY METHODS Powered By Docstoc
					drug delivery
www.pharma-mag.com




Customized Adhesive
And CoAting
teChnologies
enAble novel drug
delivery methods
Pharmaceutical-grade pressure-sensitive adhesives (PSAs) have played a critical role in the function and accurate
delivery of transdermal drug delivery systems (TDDS) ever since the launch of the scopolamine transdermal patch in
the late 1970s. Most drug delivery development projects begin by considering an existing base adhesive technology.
However, the end result is typically a customized adhesive based on application design input and the requirements
of each customer’s manufacturing process. New advances in adhesive technology during the past 10 years have
opened up new windows of opportunity for the development of transdermal delivery products, encompassing many
new and exciting applications that would have been unheard of just a decade ago.
             lthough transdermal patches offer many advantages, passive         a sustained immune response. When considering adhesive and
             systems are restricted to low-dosage lipophilic and low            component materials for this type of delivery system, formulators
             molecular-weight molecules (<500 Daltons).1 Much of the            must ensure the proper chemical compatibility of these materials
             current growth for transdermal drug delivery is focused on         with the device’s proteins and active ingredients. In addition, the
active systems to deliver a wider range of drug molecules, including proteins   materials should not contain any biocides or toxic leachables that
such as vaccines. As transdermal product designs and capabilities continue      could potentially denature proteins or interfere with biological activities
to evolve, adhesive manufacturers are embracing new opportunities to            or targeted immunization response. Skin-contact adhesives should
formulate highly specialized pressure-sensitive adhesives (PSAs), coatings      demonstrate good wear properties and moisture control to prevent
and related polymer technologies to meet the requirements of these              lateral movement of the vaccine, which could alter dosage and
delivery systems (Table I, Figure 1).                                           decrease device efficacy.


Needle-Free Vaccine Delivery                         AS DevelOPerS exPlOre                                Iontophoretic Drug Delivery
The needle-free delivery of therapeutics and                                                              PSAs perform multiple functions in iontophoretic
vaccines can potentially address the growing
                                                     New               MeTHODS                    Of      drug delivery systems, including bonding to the
global issues associated with diseases                                                                    skin, creating a protective seal and forming
that are passed intravenously through the            DeliveriNg                 DrugS,          PSA       conductive bonds for internal electronic
improper use and disposal of needles.                                                                     component assemblies. Iontophoretic devices
Patch-based      needle-free       immunization      MANufAcTurerS                             will       offer a non-invasive alternative for delivering
systems for the safe and convenient delivery                                                              therapeutic substances via the electrotransport
of vaccines are currently in clinical trials.2 The   cONTiNue TO PuSH THe                                 of molecules that would not normally diffuse
construction of the vaccine patch is similar                                                              across the skin. A small electric current passes
to that of a transdermal patch, but contains         cAPAbiliTieS TO MeeT THe                             through the patient’s skin, between positively
an antigen and an immune-boosting adjuvant                                                                and negatively charged electrodes. The drug
to stimulate the body’s immune system. The           uNique cHAlleNgeS Of                                 or active substance is located at one of the
patch works by delivering the vaccine to a                                                                electrode sites, depending upon the drug’s
group of antigen-presenting cells in the skin        New            AND            eMergiNg               polarity. The active electrode repels the charged
called Langerhans cells, which transport the                                                              drug, forcing it into the skin by electrorepulsion,
vaccine to nearby lymph nodes to produce             APPlicATiONS.                                        where it is picked up by the blood or lymph

 Sept/Oct 2009
                                                                                                                                        drug delivery
                                                                                                                                  www.pharma-mag.com




 Adhesive Description                        Chemistry                                    Functional Properties for Drug Delivery
 Skin-friendly PSAs              
				
DOCUMENT INFO
Description: The needle-free delivery of therapeutics and vaccines can potentially address the growing global issues associated with diseases that are passed intravenously through the improper use and disposal of needles.
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