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Little effect of soy isoflavones on bone loss by ProQuest


The multicenter clinical trial of 224 postmenopausal women - led by D. Lee Alekel, professor of nutrition and interim associate director of the Nutrition and Wellness Research Center (NWRC) at ISU and supported by the National Institute of Arthritis, Musculoskeletal and Skin Diseases, one of the research institutes of the National Institutes of Health (NIH) - was the longest ever conducted on the effects of soy isoflavones on bone mineral density (BMD).

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									                                                                                               inform April 2010, Vol. 21 (4) 225

  Comprehensive metabolomic analy-
                                              Health & Nutrition
  ses led by Shawn Ritchie of Phenom-
  enome Discoveries Inc. in Saskatoon,
  Saskatchewan, Canada, revealed sig-
  nificantly reduced levels of C28 –C36
  carbon-containing hydroxylated poly-
  unsaturated ultra-long-chain fatty acids
  in all three independent cohorts of
  colorectal cancer (CRC) patient
  samples relative to controls. “These
  metabolites are easily measurable in
  serum and a decrease in their con-
  centration appears to be highly sen-
  sitive and specific for the presence
  of CRC, regardless of ethnic or geo-
  graphic background,” the authors write
  in BMC Medicine (doi: 10.1186/1741-
  7015-8-13). “The measurement of
  these metabolites may represent an
  additional tool for the early detec-
  tion and screening of CRC,” they con-
  clude. The complete article is available
  Another recent study suggests a daily
  dose of 1.8 grams of docosahexaenoic
  acid (DHA) “has potential to substan-
  tially increase survival in metastatic
                                               Little effect of soy                           of soy isoflavones on bone mineral density
                                                                                              (BMD). It compared the effects of ingest-
  breast cancer patients treated with          isoflavones on                                 ing daily either 80-mg or 120-mg soy iso-
                                                                                              flavone tablets, compared to placebo tablets,
                                               bone loss
  chemotherapy,” according to research-
                                                                                              on BMD and other health outcomes.
  ers led by Philippe Bougnoux of the
                                                                                                   ISU NWRC researchers collaborated
  French Institut National de la Santé et      A previous six-month study by Iowa             with research physiologist Marta D. Van
  de la Recherche Médicale (INSERM)            State University (ISU; Ames, Iowa, USA)        Loan and her colleagues at the US Depart-
  in Tours. The new study, if supported        researchers had indicated that consuming       ment of Agriculture Agricultural Research
  by additional research, suggests that        modest amounts of soy protein, rich in iso-    Service’s Western Human Nutrition
  DHA may help improve survival by             flavones, lessened lumbar spine bone loss      Research Cent
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