ED Signals Higher Mortality And Cardiovascular Risk by ProQuest


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									                                                                                                                 www.renalandurologynews.com       MAY 2010      Renal & Urology News 9

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                                                   Short Takes                                            ED Signals Higher Mortality
Diabetes Increases
Post-op Death Risk
                                                               of mice were genetically programmed
                                                               to develop prostate cancer. The tumors
                                                                                                          And Cardiovascular Risk
Patients with diabetes who undergo                             that developed in the walnut-fed mice
cancer surgery are approximately
50% more likely to die shortly after
                                                               were about half the size of those in the
                                                               other mice, and grew 30% more slowly.
                                                                                                          E   rectile dysfunction (ED) is a strong predictor of all-cause mortality and the
                                                                                                              composite of cardiovascular death, heart attack, stroke, and heart failure in
                                                                                                          men with cardiovascular disease (CVD), according to the results of a worldwide
the operation than non-diabetics. This                                                                    study of 1,519 men with ED and CVD. Compared with men who had CVD only,
additional risk was present across a                           Donor Gene Variants Predict                men with both CVD and ED were twice as likely to die from all causes and 1.6
range of cancers and surgical treat-                           Kidney Graft Success                       times more likely to suffer the composite of cardiovascular death, heart attack,
ments for the disease, according to a                          Particular variations of the CAV1 gene
                                                                                                          stroke, and heart-failure hospitalization. Specifically, men with the dual diagnoses
                                                                                                          were twice as likely to die from CVD or to have a heart attack. They also were
meta-analysis of 15 published studies.                         in a kidney donor may determine the
                                                                                                          20% more likely to be hospitalized for heart failure and 10% more likely to
The heightened mortality risk may be                           success of a kidney transplant. A new
                                                                                                          have a stroke. The findings, published in Circulation (2010;121:1439-1446), also
at least partially attributable to the                         analysis uncovered significant differ-      revealed that ACE inhibitors, angiotensin receptor blockers, or a combination of
higher infection and cardiovascular                            ences in graft survival according to       the two had no influence on the development or course of ED, but could reduce
disease rates associated with diabe-                           donor genotypes of CAV1, which has         cardiovascular events in high-risk patients, according to researchers.
tes. Findings appear in Diabetes Care                          a role in tissue fibrosis and vascular
(2010;33:931-939)                                              proliferation. In 785 kidney donors

Walnuts Slow Prostate
                                                               and their recipients in Birmingham,
                                                               England, allograft failure rates were
                                                                                                          HCV-Infected Kidneys May
Tumor Growth
Mice that consumed approximately 14
                                                               38.6% for donor genotype AA, 22.3%
                                                               for donor genotype CC, and 22.2%
                                                                                                          Help HCV-Infected Recipients
shelled walnuts per day for two months                         for donor genotype AC over a median
exhibited significantly smaller, slower-
growing prostate tumors after 18
                                                               follow-up of 81 months, according to
                                                               a report in the Journal of the American
                                                                                                          A    lthough kidneys infected with hepatitis C virus (HCV) were 2.
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