MAY 2010 ■ VOLUME 9, NUMBER 5
Weight Gain Raises
PCa Relapse Risk
Likelihood is increased twofold, study shows
BY JOHN SCHIESZER Hopkins Bloomberg School of Public
WASHINGTON, D.C.—Weight gain Health in Baltimore.
in the ﬁve years before and one year Prior research has shown that obesity
after radical prostatectomy (RP) for at or near the time of RP is associated
prostate cancer (PCa) could increase with an increased risk of recurrence.
the risk of disease recurrence, investiga- Whether weight gain in the years prior
tors reported here at the 101st Annual to surgery is associated with recurrence
Meeting of the American Association has been unclear. In addition, no stud-
for Cancer Research. ies have looked at sedentary behavior
Men who are obese one year after and whether it exacerbates the obesity- OBESITY ONE-YEAR after RP is associated with a higher risk of recurrence.
RP, especially sedentary and inac- related risk of recurrence.
tive men, also are at increased risk of Dr. Joshu and her colleagues ret- had hormone or radiation therapy. The physical activity, and sedentary behavior
recurrence. rospectively studied 1,337 men with investigators followed up the men for for the ﬁve years prior to surgery and
“Obesity and weight gain may be fac- clinically-localized PCa. Subjects recurrence, metastasis, or PCa death. one year after.
tors that tip the scale to recurrence,” said had undergone RP at Johns Hopkins They sent patients a survey questionnaire At the time of surgery, the 102 men
study investigator Corinne Joshu, PhD, between January 1993 and March of asking about dietary, lifestyle, and medi- who had recurrence were older than
MPH, a postdoctoral fellow at Johns 2006. None of the patients previously cal factors, including weight, height, continued on page 13
INSIDE THIS ISSUE
Iron Lowers Platelet Counts AKI, ARF
9 Walnuts found to slow prostate
tumor growth ORLANDO, Fla.—Correcting iron DRIVE (The Dialysis Patients’ Response
14 Despite advantages, peritoneal
dialysis is underused
deﬁciency in non-dialysis CKD patients
lowers platelet counts and improves
to IV Iron with Elevated Ferritin) study
revealed a decrease in platelet counts Pandemic Flu
erythropoiesis, researchers reported here following iron administration (1,000 mg
16 Upswing in imaging studies
at the National Kidney Foundation’s over eight dialysis sessions). ORLANDO, Fla.—Acute kidney inju-
has no clear causes
2010 Spring Clinical Meetings. The result In the study by Dr. Besarab and his col- ry (AKI), acute renal failure (ARF),
26 Tips on diagnosing prostatitis is higher hemoglobin (Hb) levels achieved leagues, 132 non-dialysis CKD patients and the need for dialysis are common
with lower doses of an erythropoiesis- received either 500 or 1,000 mg of low complications in critically ill patients
stimulating agent (ESA). molecular weight iron dextran (ID) dur- with pandemic H1N1 Influenza A
ON THE WEB The investigators, led by Anatole ing two to four hour infusion sessions (pH1N1), and are associated with
Besarab, MD, Adjunct Professor of to correct iron deﬁciency (deﬁned as an increased death risk, according to
■ News reports from the Medicine at Wayne State University and a transferrin saturation [TSAT] below Canadian researchers.
American Transplant Congress Director of Clinical Research at Henry 20% and ferritin level below 100). The Manish M. Sood, MD, and col-
in San Diego (May 1-4) Ford Hospital in Detroit, noted that iron subjects were receiving once-monthly leagues at the University of Manitoba
■ Coverage of the American deﬁciency may result in elevated platelet darbepoetin injections and were on oral in Winnepeg, prospectively studied
Urological Association annual counts elevations that could contribute to iron therapy (100 mg or more of elemental 50 patients with pH1N1 (47 conﬁrmed,
meeting, San Francisco thrombotic complications seen in clinical iron per day). The r