Cells relevant to the cardiovascular system, including bovine aortic endothelial cells (BAEC), the monocytic cell line THP-I, and RAT-I fibroblasts, were treated for various time periods (0-72 h) with different concentrations of lycopene (1, 5, and 10 ?), solubilized either in tetrahydrofuran (THF) or micelles as solvents.
inform August 2009, Vol. 20 (8) 535 Publications Extracts & α-ESA, PA, and CLA feeding. The contents of 22:6n-3 and total n-3 PUFA were signif- icantly increased in the liver, kidney, and day but were not different when consumed once per day (3.43 ± 0.62, 3.22 ± 0.58, and 3.30 ± 0.65 mmol/L: control, three times Distillates heart by PA feeding, but not by α-ESA. In per day, and single-BF, respectively). Rel- contrast to PA, supplementation with CLA ative to the control, end-point LDL level significantly decreased 22:6n-3 in the liver, was 0.21 ± 0.27 mmol/L (6%) lower (P < kidney and heart. The content of 20:4n-6 0.05) at the end of the three-times-per-day was significantly decreased in the liver and phase. Cholesterol fractional synthesis rate kidney by CLA feeding, but not by α-ESA was highest (P < 0.05) after the three-times- Effect of unsaturated acyl and PA. The present results indicate that per-day-phase (0.0827 ± 0.0278, 0.0834 chains on structural α-ESA, PA, and CLA have differential ± 0.0245, and 0.0913 ± 0.0221 pool/day, transformations in effects on 22:6n-3 and 20:4n-6 contents in control, single-BF and three times per day, mouse tissues. Conjugated linolenic acid respectively). Cholesterol-absorption effi- triacylglycerols (CLnA), a group of octadecatrienoic acid ciency decreased (P < 0.05) by 36 and 39% Mykhaylyk, O.O., and C.M. Martin, Eur. J. isomers with a conjugated triene system, after the three times-per-day and single- Lipid Sci. Technol. 111:227–235, 2009. has been reported to exhibit favorable phys- BF phase, respectively, relative to control. Simultaneous time-resolved small- iological effects, including anticancer prop- Present data indicate that to obtain optimal angle and wide-angle X-ray scattering has erties and regulation of lipid metabolism. cholesterol-lowering impact, plant sterols been used in the study of the isothermal Punicic acid and α-ESA, two isomers of should be consumed as smaller doses given crystallization behavior, after quenching, of CLnA, have been shown to convert into more often, rather than one large dose. triacylglycerols (TAG) with 18 carbons in cis9,trans11-18:2 in vivo. The effect of the hydrocarbon chains. Saturated, unsatu- rated TAG, their blends, and mixed satu- CLnA on fatty acid composition in mouse Delivery of lycopene to tissues was investigated in comparison with rated/unsaturated TAG were studied. The CLA mixtures in the present study. The data physiologically relevant mixed saturated/unsaturated TAG and their obtained here could provide information for vascular cells blends form an α2-phase with a longitudinal the potential application of CLnA-contain- packing different from two-chain and three- Lorenz, M., V. Stangl, C. Jacob, K. Daemen, ing seeds as functional food ingredients, a V. Böhm, K. Fröhlich, G. Baumann, K. chain packings, which distinguishes them natural source of endogenously formed from the other fats. The unstable α2-phase, Stangl, R. Simone, and P. Palozza, J. Food cis9,trans11-18:2, and a dietary feeding Lipids 16:259–272, 2009. observed at the initial stage of crystalliza- strategy to beneficially modify the fatty tion of mixed saturated/unsaturated TAG, Lycopene most likely contributes to acid composition of animal tissues. the positive health effects of tomatoes on is classified as a transient mesophase. Two dimeric units proposed for a structural the cardiovascular system. However, eluci- model of the α2-phase have been used to Plant sterol consumption dation of underlying cellular mechanisms describe the structural organization of TAG frequency affects plasma lipid is hampered
Pages to are hidden for
"Delivery of lycopene to physiologically relevant vascular cells"Please download to view full document