Prosiding I Seminar Nasional Tumbuhan Obat Indonesia XXXVI, Bengkulu 11-12 Nov 2009 EFEK EKSTRAK KULIT BUAH JERUK PURUT (Citrus hystrix DC) TERHADAP KOLONISASI Salmonella thypimurium di Ileum Mencit (Upaya untuk mendapatkan kandidat obat demam tifoid) Zulvikar Syam Bani Ulhaq1, Tenta Hartian H1, dan Faizanah Bt. Mohd Shaul Hameed2 1 Progam Studi Pendidikan Dokter (Regular Class), Fak. Kedokteran Brawijaya 2 Progam Studi Pendidikan Dokter (International Class), Fak. Kedokteran Brawijaya ABSTRACT Antimicrobial effect of extract kaffir lime peels (Citrus hystrix DC) observed in mice with typhoid fever model. The peel of kaffir lime is extracted using ethanol and then the extract administered orally with 16 mg dose. To evaluate the antimicrobial effect from extract of kaffir lime peels, the mice is infected with Salmonella typhimurium orally with 108 concentrations and incubated 7 days. In addition, the research was divided into groups (n=5) including negative control (as a confirmation), positive control and 3 groups were treated by extract of kaffir lime peels at 16 mg dose and incubated 24, 48 and 72 hour after adminstration. Then, the result of Salmonella typhimurium colonization which inoculated in Bismuth Sulphite Agar (BSA) is calculeted and analyzed using ANOVA and regression-correlation Pearson (p<0,05). The result showed that a significant decrease of colonization with increasement of incubating time after oral administration of extract. The best decreasement of colonization is observed at 72 hours incubations after oral adminstration of extract compered with 24 and 48 hours incubations. In conclusion, extract of kaffir lime peels is found to be effective in decreasing the Salmonella typhimurium colonization in mice with typhoid fever model. Key words: Kaffir lime peels, Colonization, Salmonella typhimurium.
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