SYSTEMATIC REVIEWS META-ANALYSES OF DIAGNOSTIC TEST ACCURACY by vev19514

VIEWS: 25 PAGES: 2

									                  Respiratory Epidemiology and Clinical Research Unit (RECRU)
                                Montreal Chest Institute, Montreal

                               & Cochrane Infectious Diseases Group (CIDG)

                        SYSTEMATIC REVIEWS & META-ANALYSES OF
                              DIAGNOSTIC TEST ACCURACY
                                           Dates: May 25 & 26, 2009
        Venue: Meakins-Christie Seminar Room, Meakins-Christie Laboratories, 3626, St Urbain St, Montreal

                                                 Co-instructors:
                                          Dr. Mariska M Leeflang, PhD
               Dept. of Clinical Epidemiology & Biostatistics, Academic Medical Center, Amsterdam
                Joint Coordinator, Cochrane Diagnostic Test Accuracy Working Group (DTAWG)

                                           Dr. Madhukar Pai, MD, PhD
                         Dept. of Epidemiology & Biostatistics, McGill University, Montreal
                                    Editor, Cochrane Infectious Diseases Group


                                               Monday May 25, 2009

8.00     Registration                                                     Ms. Danielle Bastien/Esther Tomkee
8.15     Welcome                                                          Dr. Jean Bourbeau,
                                                                          Director, RECRU
8.20     Introductions                                                    Dr Pai
8.30     Diagnostic test accuracy: a quick review                         Dr. Pai
10.30    COFFEE BREAK
10.45    Overview of diagnostic accuracy systematic reviews               Dr. Leeflang
                 - Why systematic reviews?
                 - Outline of a review; basic steps
11.15    Formulating a review question and inclusion criteria             Dr. Leeflang
                 - PICOs
                 - Objectives of a DTA review
                 - Comparative questions
                 - Which study designs to include?
                 - Participants, tests, etc.
12.00    Identification of DTA studies                                    Dr. Leeflang
                 - Search terms
                 - Databases
                 - Tips and tricks for searching




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12.30 – 13.30            LUNCH


13.30   Quality Assessment                                        Dr. Leeflang
                - Introduction to methodological quality
                - Assignment
15.00   Example of a diagnostic meta-analysis                     Dr. Leeflang
        - Galactomannan detection for invasive aspergillosis
15.45   COFFEE AND CLOSE OF SESSION


                                           Tuesday May 26, 2009

8.30    Introduction to diagnostic meta-analysis                  Dr. Leeflang
                - Principles of meta-analysis
                - sROC curve
                - Heterogeneity
9.30    Introduction to meta-analytic modelling                   Dr. Leeflang
                - Why not pool sens and spec separately?
                - Moses-Littenberg
                - Bivariate model
                - Hierarchical sROC model
                - When a curve and when an ellipse?
10.30   COFFEE BREAK
10.45   Other issues in diagnostic meta-analysis                  Dr. Leeflang
                - More about heterogeneity
                - More about comparative analyses
                - More about hypothesis testing
                - More about publication bias
12.00   Example of a diagnostic meta-analysis                     Dr Karen Steingart
        - Serological tests for tuberculosis
12.30 – 13.30   LUNCH
13.30   Demonstration: MetaDiSc                                   Ms Daphne Ling
14.30   Demonstration: SAS / STATA                                Dr. Leeflang
15.30   COFFEE BREAK
15.45   Interpretation of the results                             Dr. Leeflang
                (includes assignment)
17.00   Summary, evaluation and wrap-up                           Dr. Pai
17.15   CLOSURE




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