A simple model for iron oxide biomineralization - synchrotron X by pwb10855


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									          A simple model for iron oxide biomineralization -
               synchrotron X-ray scattering analysis
     of iron oxide precipitated in the presence of amino acids
                        Alexandre MANTION1, Andreas TAUBERT2
                        Department of Chemistry, University of Basel,
                          Klingelbergstrasse 80 CH-4056 BASEL
                          Institut für Chemie, Universität Potsdam,
                         Karl-Liebknecht-Str. 24-25 D-14476 Golm

                                email: a.mantion@unibas.ch


Iron oxides are very common materials that have a large spectrum of applications
both in industry, and in biological systems. In living systems, they can be used as
compass, teeth hardener, and iron sink. Some proteins and peptides are used by
living organisms as tools to template the synthesis of spatially controlled and
polymorph specific iron oxides. We study a peptide sequence, first isolated by Brown
[1], which binds specifically to Fe2O3. Potential applications of this study are as wide
as the design of new storage material, new magnetic imaging resonance material, or
new supported catalyst.

To simplify the system, we have studied each amino acid present in the peptide
isolated by Brown (l-lysine, l-asparagine, l-valine, l-threonine, l-histidine and l-
arginine) and designed experiments to determine the effect of each of them on the
iron oxide precipitation process. Using Rietveld analysis[2], we have determined and
quantified some possible interactions of the various iron hydroxides and oxides with
the amino acids.

Amino acid templates are interesting thanks to their low price, large availability and
safety. Experiments with other amino acids present in iron proteins and other
peptides are in progress.

[1] Brown, S. Proc Natl Acad Sci (1992) 89(18): 8651-5
[2] Rodriguez-Carvajal, J. "FULLPROF: A Program for Rietveld Refinement and Pattern Matching
    Analysis", Abstracts of the Satellite Meeting on Powder Diffraction of the XV Congress of the IUCr,
    p. 127, Toulouse, France (1990).

                                          7th SLS Users’ Meeting, Sep 28-29, 2006, PSI

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