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The goal of the Oral Microbiology Unit in the

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The goal of the Oral Microbiology Unit in the Powered By Docstoc
					  Strategic Collaborative Units

Director
Dr. Dennis Cvitkovitch
                           MOLECULAR
Coinvestigators/
Collaborators
Dr. Céline M. Lévesque
                           MICROBIOLOGY
                           T
Dr. Paul Santerre
Dr. Lori Burrows                 he goal of the Oral Microbiology Unit in the            study of the genetics, physiology and metabolism
Dr. Joyce deAzavedo              Faculty of Dentistry is to promote under-               of the oral pathogen Streptococcus mutans. Dr.
Dr. Jeannine Brady               standing of the way microbes compromise                 Cvitkovitch is currently appointed as a tenured as-
Dr. Gunnel Svensater       oral health and oral health-care delivery. Active             sociate professor in the Dental Research Institute
Dr. Bernard Guggenheim     research in the Section includes studies on oral bio-         in the Faculty of Dentistry at the University of To-
Dr. Jason Tanzer           films, host/microbe interactions, endodontic micro-           ronto where he has established an active research
Dr. Gary Dunny
Dr. Steven Goodman         biology and infection control. A major research foci          program along with his teaching and academic re-
Dr. Grace Spatafora        is understanding the mechanisms that biofilms use             sponsibilities. He is continuing the study of the acid
Dr. Donald Morrison        to cause disease, with a focus on the oral cavity.            tolerance response of S. mutans (CIHR funded) and
Dr. Wenyuan Shi            The unit is typically well funded and has a research          using DNA microarrays to help unravel the genes
Dr. Fengxia Qi             group encompassing 4 principal Investigators (Dr.             encompassing this system.
Dr. Jusin Merrit           Ellen, Dr. Fillery, Dr. Cvitkovitch, Dr. Lévesque) and
Dr. Scott Peterson         a strong support staff for imaging, flow cytometry            Dr. Cvitkovitch has also been recently awarded
Dr. Robert Burne           and sterilization. There are continuous training op-          an R01 grant by the NIH to study genetic compe-
Dr. Michael Mulvey         portunities and several scholarships offered for              tence in S. mutans biofilms. This project began
Dr. Richard Gregory                                                                      in September of 1999 and has continued to make
                           Graduate Trainees.
Dr. Erin Gaynor                                                                                                    excellent progress at
Dr. Debora Foster                                                                                                  gaining insight into the
Dr. Michael Surette
                                                                                                                   mechanisms that oral
Research Associates/                                                                                               bacteria use to com-
PDFs                                                                                                               municate in biofilms. The
Dr. Dilani Senadheera                                                                                              molecular microbiology
                                                                                                                   group has published nu-
Research Assistants/                                                                                               merous manuscripts and
Technicians                                                                                                        book chapters describing
Kirsten Krastel                                                                                                    these processes.
Elena Voronejskaia
Richard Mair                                                                                                              The laboratory is ac-
                                                                                                                          tively involved in knowl-
Ph.D. Students                                                                                                            edge translation and
Julie Perry
Salim Kowthar                                                                                                             has several interactions
Julianna Kus                                                                                                              and ongoing projects
Prashanth Suntharalingam                                                                                                  with industrial partners
Bryan Korithoski                                                                                                          that are developing
Shelly Bolotin                                                                                                            both diagnostics and
                           ▲Molecular Microbiology members (left to right): K. Singh, R. Mair, R. Matsui, Dr. J. Kus,     treatments for biofilm-
M.Sc. Students             K. Krastel, Dr. D. Cvitkovitch, D. Del Re, Dr. D. Senadheera                                   mediated infections.
Deanna Del Re
Rob Matsui
J.P. Singh                 Research Foci
Jennifer Kim                                                                             Statistics for ‘Molecular Microbiology’
                           Dr. Cvitkovitch’s main research interests focus on
Undergraduates             cell-cell signalling and acid tolerance of Streptococ-                                       2007           To date
Anousheh Persadmehr        cus mutans biofilms. The molecular microbiology
                                                                                          Patents                        0                1
                           group has discovered that S. mutans has at least
                           two cell-cell signalling systems that allow the cell to        Peer Reviewed
                                                                                                                         7               46
                           become genetically competent, acid tolerant and                Publications
                           allow it to form biofilms. They have deduced part              Funding                  $520,000          ~ $3 million
                           of the molecular pathway of one of these quorum
                                                                                          PDFs                           1                4
                           sensing systems and discovered it to be analagous
                           to a peptide-pheromone cell-cell signalling system             Ph.D. Students                 6                8
                           of S. pneumoniae. Research is currently examining              MSc. Students                  4               10
                           other potential systems using a combination of in
                                                                                          Undergradute
                           silico and in vitro techniques.                                                               1               17
                                                                                          students
                           In the course of Dr. Cvitkovitch’s graduate and                High school
                                                                                                                         4               18
                           post-doctoral training, his research focused on the            Students

				
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Description: Microbiology is the branch of biology. It is to study the various types of micro-organisms (bacteria, actinomycetes, fungi, viruses, rickettsia, mycoplasma, chlamydia, spirochetes, and single-cell algae, protozoa) and morphology, physiology, biochemistry, classification and ecology Science.