November 2009 - Medical Microbiology _ Immunology
Microbiology is the branch of biology. It is to study the various types of micro-organisms (bacteria, actinomycetes, fungi, viruses, rickettsia, mycoplasma, chlamydia, spirochetes, and single-cell algae, protozoa) and morphology, physiology, biochemistry, classification and ecology Science.
November 30, 2009 Volume 1, Issue 1 Medical Microbiology & Immunology Department Faculty: University of Wisconsin-Madison Room 1334 Microbial Sciences Building David Andes, MD 1550 Linden Drive James Bangs, PhD Madison WI 53706 Curtis Brandt, PhD Phone: 608-262-3351 Email: firstname.lastname@example.org Joseph Dillard, PhD Website: medmicro.wisc.edu Jenny Gumperz, PhD Christina Hull, PhD Greetings! Anna Huttenlocher, MD Nancy Keller, PhD Welcome from the Department of Medical Microbiology & Immunology, Bruce Klein, MD University of Wisconsin School of Laura Knoll, PhD Medicine and Public Health! On å behalf of our current faculty, Miroslav Malkovsky, MD, postdocs, staff and students, let me PhD say hello. Personally, I’d like to say John Mansfield, PhD how much we miss you. For most of Margaret McFall-Ngai, us, this department is a second with, to reach our teaching and PhD home; reconnecting with you via this research goals. Since this is our first newsletter is our attempt at a family newsletter in some time, we also Donna Paulnock, PhD reunion. You’ve received this include updates from a sampling of Edward Ruby, PhD newsletter because you are formerly our labs and courses. associated with our department (a Ronald Schell, PhD past student or postdoc, a retired We’d love to hear from you. Please Robert Striker, MD, PhD faculty or staff member, a friend, etc). write or email, letting us know where William Weidanz, PhD you are and what you’re up to… Our plan is to devote a substantial we’ll include your “hello” in our next Rodney Welch, PhD, portion of each newsletter to a newsletter. See page 7 for more Dept. Chair specific topic. This issue is largely information on alums and how to Jon Woods, MD, PhD devoted to the ‘partners’ we work reach us. Dept Administrator: Tracy Wiklund Upcoming Events Newsletter Editors: Alicia Cramer The year 2010 marks the 75th Additionally, in early spring 2010 Tracy Wiklund "Birthday" of the Department of Medical Microbiology & Immunology Medical Microbiology & Immunology. will host the first annual Perlman To celebrate, the Department plans Symposium on Antibacterial to hold a birthday bash in late spring Discovery and Development. The or early summer (we're leaning symposium will include a morning towards the first week of June 2010 session of local speakers and an at the moment). Part of the program early afternoon poster session. will be devoted to alumni Again, more information will be updates/talks. Stay tuned for more made available after the holidays. information. Medical Microbiology & Immunology Page 2 of 8 Congratulations to the following Our Partners in Teaching and Research MMI faculty for Teaching and research are activities postdocs and students to accomplish their recent promotions! common to nearly all departments at our teaching and research goals. UW-Madison and are critical We also established the Wisconsin components of the Wisconsin Idea*. Center for Infectious Disease However, many “hands” help us (WisCID) with funding provided by accomplish our teaching and the conversion of Blue Cross & Blue research goals. Shield United of Wisconsin to a for- profit corporation. Over time, funding available to the Department for its teaching and In the last few years, we’ve received research missions has grown and gifts and donations from alumni and changed. Ten years ago, our community members for activities not Dr. Jenny department was funded largely by traditionally funded from other Gumperz, PhD Will be promoted to federal grants from NIH (National sources. For example, a gift from the Associate Professor Institutes of Health) and the State of Paul F. Clark family allows us to with tenure effective Wisconsin (our University of bring nationally renowned July 1, 2010. Her Wisconsin budget). Today, as you immunologists to campus, sharing tenure/promotion dossier was see in the chart, a number of other knowledge through research reviewed and entities assist the State of Wisconsin seminars. We plan to use funds from approved by the UW and NIH in providing support for our a gift from the Bonnie Anne DeMaio Biological Sciences work. estate to create/mail this newsletter Division Tenure and provide food at our annual committee in October 2008. department research retreat. We are organizing a Spring 2010 “Perlman Symposium on Antibiotic Discovery and Development” with funds generously provided by Kato Perlman in honor of her husband, Dave Perlman. With future gifts, we hope to establish funding mechanisms for: MMI graduate and postdoctoral student travel awards, Dr. Robert awards to MMI faculty and/or staff for Striker, MD, PhD creation of new, novel means of Was promoted to transmitting knowledge (Twitter, Associate Professor anyone?), establishment of an with tenure July 1, In terms of federal funding, NIH is no undergraduate MMI laboratory 2009. Dr. Striker’s tenure home is the longer the only “game in town”. We course on probiotics or vaccines, and Department of now have awards from NSF the creation of staffed, shared Medicine, Infectious (National Science Foundation), DOD research facilities (such as mass Diseases Section; (Department of Defense) and USDA spectrometry) within our Microbial he holds a joint Sciences building for scientists and appointment in (United States Department of Medical Agriculture). Similarly, non-federal students across campus. Microbiology & groups like American Cancer Immunology. Society, American Heart Association, * for more information on the Howard Hughes Institute, Hartwell Wisconsin Idea, see Foundation, Pew Charitable Trusts http://www.wisconsinidea.wisc.edu/ and the Burroughs Wellcome Fund are now partnering with MMI faculty, Medical Microbiology & Immunology Page 3 of 8 Notes from the Weidanz Lab Promotions Continued… During this past year, we have been Also, in collaboration with Dr. William working on several projects. Our Burlingham, UW Dept. of Surgery, we interest in the role of !" T cells in are studying malaria in immunodeficient malaria continues. These cells, which mice engrafted with human fetal liver, collaborate with CD4+ T cells, are liver stem cells and embryonic thymic responsible for cell-mediated immunity tissue. The resulting “humanized mice” against experimental blood-stage have varying numbers of human immune malaria induced with Plasmodium cells including B cells and T cells. As chabaudi. Merle Elloso (Ph.D., 1995) might be expected, these mice are very Dr. Laura Knoll, and Henri van der Heyde (Ph.D., 1993) fragile, often dying of infection or graft PhD had observed that human !" T cells versus host disease. When infected with Was promoted to inhibited the growth of P. falciparum in P. chabaudi, which we use as a Associate Professor vitro, a finding confirmed by Swedish surrogate for P. falciparum, humanized with tenure July 1, mice produce human cytokines and 2008. colleagues. Now 15 years later, we can report that the depletion of !" T cells make human antibodies reactive with P. from B cell deficient mice chronically chabaudi antigens. However, these infected with P. chabaudi causes the immune responses fail to protect the immediate exacerbation of parasitemia mice from lethal disease. I sometimes to high levels. These findings indicate feel it may be easier to teach them to !" T cells are capable of killing malaria talk rather than protect them against parasites in vivo as well as in vitro, malaria. suggesting an important role for !" in the immune response to malaria. ~ Bill Weidanz Dr. Jon Woods, Understanding Vaccines MD, PhD Was promoted to full Professor effective In Spring 2009, MMI offered a new and pathogenesis components of our July 1, 2008. course entitled, “Vaccines: Practical curriculum by providing students with Issues for a Global Society.” The new information and views not presented goal of this 600-level course is to in other courses. By presenting topics introduce the student to vaccinology. which are relevant, contemporary and of Course topics include: immunology of public health importance, we believe vaccination, vaccine development and students and others will gain an licensing, vaccine safety, the application understanding of the many issues of new technologies, role of related to vaccinology, enabling them to immunization in public health programs participate in finding solutions to the for infectious disease prevention, problems related to the development and economics, political, legal and ethical use of vaccines. Dr. Anna issues relating to human immunization, Huttenlocher, MD and the impact of immunization in The course, for advanced undergraduate Was promoted to full and graduate students, was developed Professor on July 1, animal populations. 2008. and taught by Drs. Stacey Schultz- Dr. Huttenlocher Vaccines represent the most cost- Cherry, Peter Shult, and William holds joint effective medical intervention known to Weidanz. Funding for the course was appointments in the prevent death and disease. The public provided by a grant from the Robert Departments of Pediatrics and is exposed to “vaccine” issues almost Wood Johnson Foundation Health & Medical daily, ranging from availability and cost Society Scholars Program and the Microbiology & of vaccines to vaccine safety and the University of Wisconsin School of Immunology. ethics of vaccination. Accordingly, this Medicine and Public Health. new course strengthens the immunology ~ William Weidanz Medical Microbiology & Immunology Page 4 of 8 Our New Home: The Microbial Sciences Building Since 2007, the Department of Medical Microbiology & Immunology, Medical Microbiology and the Food Research Institute, the Immunology has had a new home Great Lakes Bioenergy Research within the beautiful, state-of-the-art Center, and the Wisconsin Center for Microbial Sciences Building (1550 Infectious Disease. Linden Drive on the UW-Madison campus). “We!ve already found some new synergies,” says Rod Welch, The 330,000-square-foot facility – the professor and chair of the campus! largest academic building – Department of Medical Microbiology combines facilities for innovative and Immunology. “Rather than instruction, “neighborhoods” of world- segregate the two departments on class research laboratories to separate floors, we!ve mixed people stimulate collaboration, and up and broken down artificial barriers architectural features that recognize between us.” the lifestyles and shared needs of researchers. Scientists in the In addition to research laboratory building study infectious diseases, space, the building features state-of- emerging pathogens, food-borne the-art classrooms for undergraduate diseases, food toxicants, parasites, and graduate instruction, a 6th floor fungal and viral pathogens, and bio- meeting room with an outstanding defense strategies. Other view of Lake Mendota and the Allen researchers study the amazing Centennial Gardens, as well as the abilities of microbes to produce sophisticated 450-seat Ebling alternative energy sources and Symposium Center, which has microbial fuel cells, mitigate global already hosted many national and climate change, improve water international conferences and quality, clean up environmental workshops. pollutants and serve as biological control agents in agriculture. Still Department staff members have others study genetic systems, given numerous tours of the building metabolic pathways, communication to diverse groups, and the networks, relationships with microbial overwhelming response is one of communities and between microbes amazement at the great space. and other organisms, regulatory Friends and alumni are urged to visit mechanisms, molecular structure the Microbial Sciences Building and and function, and systems biology. behold the opportunities that lie within! “The environment created by this building encourages the cross- For more information about the building disciplinary work and discussion that (including events that occur within the can help solve problems and space), see: advance research,” says Glenn http://www.microbialsciences.wisc.edu/ Chambliss, professor emeritus and former chair of the Department of Bacteriology, which occupies the building with the Department of Medical Microbiology & Immunology Page 5 of 8 Notes from the Gumperz Lab The immune system protects the host understanding of how NKT cells against pathogens and also manages function has been learning the beneficial microbial colonies. This molecular identities of compounds that involves making complex decisions activate them. The Gumperz lab has about whether to tolerate or fight recently shown that human NKT cells particular microbes, and about the recognize a molecule generated by the kind of defensive responses to mount. body during inflammation, suggesting The Gumperz lab studies a subset of they recognize internal stress or T lymphocytes, called Natural Killer T disease signals. Other lines of cells (“NKT cells”), which can research involve determining how NKT contribute to a wide variety of immune cells generate qualitatively distinct responses and are thought to play an responses in different situations, how important role in immunological they interact with other cells to “decision-making.” influence subsequent immune Drs. Jayati NKT cells are “innate” lymphocytes, responses, and how they contribute to Mookerjee Basu and which means they are present in the Epstein-Barr virus infection control. Subramanya Hegde separating body from birth and they recognize These studies are providing leukocytes from evolutionarily conserved molecules. fundamental information on the biology samples of human (In contrast, most T cells are of innate T cells that can be used to blood to use in “adaptive” lymphoctyes, generated in develop new strategies to promote analses of Natural Killer T cell function response to infections we encounter.) human health. A central problem hindering our ~ Jenny Gumperz Update from MMI 301 Course Director With the retirement of Dr. Harry Hinze review bacterial cell structure, cell in 1995, Dr. Gerry Byrne and I took physiology, and immunology and then over MMI’s 301 undergrad cover identification, epidemiology and “Pathogenic Microbiology” course, pathogenic mechanisms of important Rod Welch with PhD human bacterial pathogens. students, Gary Baisa taught by Dr. Hinze for years. Dr. and Erica Raterman Hinze had historically presented Course enrollment has increased material on both bacteria and viruses. nearly 40% in the past 2 years, with 74 With the recruitment of Dr. Stacey students currently in the class. Our Schultz-Cherry, who started a new MMI undergrad majors, along with undergrad course on pathogenic students in other biology programs, virology, Gerry and I evolved 301 into take the course. The majority of my a course dedicated to pathogenic students go on to graduate programs bacteriology. or medical school. In 2002, when Dr. Byrne retired, I Teaching undergraduates is very became the course director. I give 23- rewarding. I look forward to each 25 lectures each year and a second- lecture and over the years have filled year doctoral student serves as the out the material with anecdotes about course’s graduate assistant. The famous microbiologists, disease student helps write and grade exams, outbreaks and my own run-ins with Fluorescently-tagged and gives 2 lectures. This year Eric pathogens. I would enjoy hearing from uropathogenic E. coli Battaglioli, a Colgate University my former students. constructed in Welch graduate, is the MMI 301 assistant. In ~ Rod Welch lab terms of material taught, I briefly Medical Microbiology & Immunology Page 6 of 8 On the Death of Professor Emeritus Duard Lee Walker, MD “Duard was a highly collaborative scientist. Duard Lee Walker, MD, Professor member and a chairman on a Being collaborative was a natural extension of Emeritus of Medical Microbiology & number of committees for the Duard’s personality – he Immunology died Monday, Sept. 14, medical school. In addition, he was a warm, interactive, 2009. During his distinguished 36- advised and mentored many calming, friendly, year career at the University of graduate students and fellows, both outgoing, energetic Wisconsin, his contributions as in his own laboratory and within the individual. Duard was always a gentleman, and professor and department chair in the department of Medical Microbiology. to this day I consider research, teaching and service He was a member of numerous myself very lucky to have missions of his department, the editorial boards and medical had him as my mentor.” Medical School and the University of societies. Dr. Walker will be best ~ Dr. Richard Frisque Wisconsin were highly meritorious remembered for his work in virology. and greatly enhanced the institution's He was initially interested in viral reputation as a place of higher interactions with host cells that learning. allowed the establishment of latency of the viral pathogen in the host cells. Professor Walker was born on June In 1971, in collaboration with Billie 2, 1921, in Bishop, California. He Padgett, his lab accomplished the received a bachelor's degree (Phi first isolation of the JC virus. This Beta Kappa) from the University of virus has been demonstrated to be California (Berkeley) in 1943, the causal agent for progressive graduated from the University of multifocal leukoencephalopathy California Medical School, San (PML), a devastating neurological Francisco, in 1945, and received a disease that occurs in master's degree in 1947, also from immunocompromised patients. Dr. the University of California at Walker's group in collaboration with Berkeley. He married Dorothea V. other investigators characterized the McHenry on Aug. 11, 1945. JC virus and its natural history. In collaboration with the group headed In 1952 the family moved to Madison by Gabriele ZuRhein, the oncogenic “Duard was a scholar of when he took a position as an potential of the virus was the highest order. His associated professor at the demonstrated and characterized in outwardly stern University of Wisconsin. He was hamsters. Dr Walker retired from the demeanor overlay a caring individual who did appointed professor of medical University of Wisconsin in 1988; for much to facilitate the microbiology in 1959. He became his body of work, Dr. Walker was training of students in the chairman of the department of elected to the National Academy of Medical Microbiology Medical Microbiology first from 1970 Sciences in 1990. program” to 1976 and again later from 1981 to ~ Dr. Chuck Czuprynski 1988. He was appointed the Paul F. Duard is survived by his wife, Clark professor of medical Dorothea; his children, Douglas, “Duard was an microbiology in 1988. During his Donna Fisher (Bruce), David (Tracy) outstanding mentor, who years at the University, Dr. Walker and Diane Craig (Alan); and three made it his mission to help develop the careers was an active teacher of students. grandchildren, Kate Fisher, Lesley of women in science. He He was first an instructor and then a Fisher and Lorelle Craig. He was was ahead of his time in director of the medical school course preceded in death by his parents and this regard.” on infectious disease. He served as a brother. ~ Dr. June Osborn Medical Microbiology & Immunology Page 7 of 8 What are our MMI grads doing these days? Our department’s undergraduate pathogens from clinical samples. degree program has about 125 She also teaches microbiology to students at any given point in time. pathology residents, medical After graduation, where do our students, and clinical laboratory students go and what do they do? sciences students. Colleen finds the We asked a few: hospital to be a dynamic environment, interacting daily with Jason Paltzer (’99 MMI graduate) colleagues, physicians, and other went on to earn a Master’s in Public medical staff to provide high quality Health degree from University of patient care and to educate future Jason Paltzer Minnesota. From 2003-2009, he health professionals. Colleen worked as a program director for a recently completed a MS degree in health & development program in Bacteriology (UW-Madison) and is Zambia (central Africa). Currently, now applying to doctoral programs. he’s working on a PhD degree in the She hopes to eventually work in University of Wisconsin-Madison public health at the Federal or State Population Health Sciences and level. Development Studies program. While in Zambia, Jason found he Robert (Bob) Zemple (’06 MMI really enjoyed the community-based graduate) is currently working on his Jeniel Nett approach to health and intervention, MD degree at the University of and looks forward to connecting his Wisconsin School of Medicine and field experience with academic Public Health (started in 2008). After research after his PhD studies. getting his BS in MMI, Bob earned a MA in Medical Sciences at Loyola Jeniel Nett (’99 MMI graduate) went University (Chicago), taught for on to earn an MD from University of Kaplan in 2007-08, and became an Wisconsin School of Medicine and EMT in the Waunakee, Wisconsin Public Health. She completed her area. In his free time as a medical residency training in Internal student, Bob also works at MEDiC Medicine at the University of (free healthcare clinics for Madison’s Wisconsin Hospital and Clinics. underserved population), helps Currently, she is working as a conduct medical student admission Colleen Zaccard research assistant in Dr. David interviews, is doing research in the Andes laboratory and will receive a Cardiothoracic Surgery department, PhD in Cellular and Molecular and serves as the Class of 2012 co- Biology (December 2009). She plans president and president of the to continue studying Candida biofilms student body. [Bob is also known for and to pursue subspecialty training playing the role of “Santa” at a past as a fellow in Infectious Diseases. annual MMI holiday party.] Colleen Zaccard (’01 MMI graduate) If you are a past undergrad and works as a Medical Technologist in would like to be featured in this Bob Zemple and his the microbiology laboratory at UW section, please drop us an email! fiancé, Sarah Hospitals and Clinics. At the bench, email@example.com she applies routine and advanced laboratory techniques to identify Keller Lab Statement My research focus lies in uncovering A particular joy in my work is the traits required for fungi, mentoring of undergraduate, particularly Aspergillus species, to be graduate and post-doctoral students. potent human, animal and plant As the Aspergillus diseases (e.g. pathogens. A specific interest is the aspergillosis, aflatoxicosis) occur role that fungal toxins play in the worldwide – coupled with my own disease process. My interest in this international experiences - I strive to topic stems back to a seminal bring diverse backgrounds into my graduate school presentation by the lab for the benefit of all of my lab late Dr. Paul Nelson on what was personnel. Over the years I have then a newly described mycotoxin, been lucky enough to have students fumonisin, implicated as causing not only from the USA but other esophageal cancer in the South countries including South Korea, African population. I had recently Republic of South Africa, Nigeria, completed a stint as a Peace Corps Egypt, Mexico, the Netherlands, Sri volunteer in Lesotho, a South African Lanka, Lesotho, Australia, India, Subset of Keller Lab country, and had direct experiences Sweden, United Kingdom, Spain, From left to right: with molded food supplies, hence this Puerto Rico, Belgium, Greece, Dr. JinWoo Bok, Carrie seminar hit home at both a personal China, Malaysia, the Philippines, Lauer, Dr. Nancy Keller, and intellectual level. Poland, Japan and Germany. It is Ali Soukup, Alex La Reau, Saori Amaike very exciting to watch how my former students develop their careers in venues all over the world. Medical Microbiology & Immunology University of Wisconsin- Madison 1334 MSB 1550 Linden Drive Madison WI 53706 Phone: 608-262-3351 Non-Profit Org. PRESORT U.S. Postage Fax: PAID 608-262-8418 Madison, WI Permit #648 E-Mail: firstname.lastname@example.org Find us on the Web at: www.medmicro.wisc.edu NAME Street Address City, State 00000 This newsletter printed on recycled, post-consumer paper.