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Pharmacology: Inro
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mruby
Pharmacology Introduction Key Topics • How are drugs described and referenced? • What are the relevant drug laws and regulations? • What are the factors affecting how drugs are given? • What are some of the key terms? Drug Descriptions • • • • • Names Sources Forms Reference Materials Components of Drug Profiles Drug Names • Chemical Name: 2-(diethylamino)-2’,6’acetooxylid monohydrochloride monohydrate. Not Particularly Useful! Drug Names • Generic Name: lidocaine hydrochloride • Official Name: Lidocaine Hydrochloride, USP • Brand (Trade) Name: Xylocaine® Much More Useful Drug References • • • • • • USP PDR Drug Inserts Nursing Drug References Pocket Field Guides Digital Guides – Jeff’s Pharmacology Review http://www.templejc.edu/ems/drugs/PharmIndex.html Components of a Drug Profile • Names • Classification (including prototype) • Mechanism of Action • Kinetics • Indications • Contraindications • Side Effects • Interactions • Routes of Administration • Dosage • How Supplied • Special Considerations Drug Laws • Pure Food and Drug Act of 1906 • Harrison Narcotic Act of 1914 • Federal Food, Drug and Cosmetic Act of 1938 – Durham-Humphrey Amendments • Comprehensive Drug Abuse Prevention and Control Act of 1970 Controlled Substances Schedule I Schedule II Schedule III High abuse potential with risk of severe dependence; no medical use. High abuse potential with risk of severe dependence. Some medical indications Moderate abuse potential with risk of moderate to low physical dependence and/or high psychological dependence. Low abuse potential with limited risk of dependence. Lowest abuse potential with limited dependence risks. Schedule IV Schedule V State and Local Laws • ‘Scope of Practice’ Laws • Responsibility vs Authority of Medical Direction Drug Standardization • • • • Assays Bioequivalence Bioassay USP is the official standard Research and Development • Key points from FDA handout – – – – – Purpose? What are controls? What are the phases? What is an IND? An NDA? Why is skepticism important? Handout Source: http://www.fda.gov/fdac/special/newdrug/testing.html Six Rights of Medication Administration • • • • • • Right Medication Right Dose Right Time Right Route Right Patient Right Documentation Pregnancy Considerations • Increased maternal HR, CO and blood volume – May affect absorption, distribution, effectiveness • Drugs may cross placenta • Drugs may cross into breast milk • Tertatogens Pregnancy Categories • A: controlled studies in pregnancy (<1 %). • B: animal studies show no risk; Inadequate human data. • C: animal studies show risk, inadequate human data. • D: human data show risk, benefit may outweigh risk. • X: animal or human data positive for risk. Use unwarranted. Pediatric Considerations • Oral absorption • Thinner skin ( topical absorption) • Plasma protein concentration – Free protein-bound drug availability • • • • Extracellular fluid in neonate Altered metabolic rates Elimination/metabolism BSA/weight based dosing important! Geriatric Considerations • • • • • • Oral absorption Plasma protein concentration Muscle mass, body fat Liver/renal function Multiple drugs Multiple diseases Some Terminology • • • • Receptor affinity Efficacy 1° vs. 2nd messengers Up vs. down receptor regulation • Agonist vs. antagonist • -lytic vs. -mimetic • Inhibition (antagonism) – Competitive vs. noncompetitive vs. irreversible • Allergic reaction • Idiosyncrasy • Tolerance More Terminology • • • • • • Cross tolerance Tachyphylaxis Cumulative effect Dependence Drug interactions Summation (1+1=2) – Additive effect • Synergism (1+1=3) • Potentiation • Interference Basics of Drug Classification • Knowledge grouping • Prototype drug • Predictive value Drug Classification • By chemistry – electrolytes • By mechanism – Beta blockers – benzodiazepines • By disease – antihypertensives – Antiemetics Resources • Clinical Pharmacology 2000 – http://cp.gsm.com/default.asp • University of Kansas Medical Center – http://www.kumc.edu/AMAMSS/study/pharmacology.htm • Infomed Online! – http://www.infomed.org/index-e.html • Mosby’s GenRX – http://www.genrx.com/genrxfree/Top_200_2000/Top_200_2000.html Resources • Hardin MD (Meta-Directory) – http://www.lib.uiowa.edu/hardin/md/pharm.html • Top 200 Prescription Drugs – http://www.rxlist.com/top200.htm • Medline Plus: Consumer Information on Prescription Drugs – http://www.nlm.nih.gov/medlineplus/druginformation.html • FDA Online (Testing Drugs in People) – http://www.fda.gov/fdac/special/newdrug/testing.html
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