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									drug0509.qxp    4/24/09     12:13 PM      Page 14

                                   New Drug Information
                                                    F R O M T H E E D I T O R S O F T H E PA P R

      PRODUCT: Vectical                                 The safety and effectiveness of            ADVERSE REACTIONS: Hypercalcemia,
      Ointment                                        Vectical Ointment in patients with           lab test and urine abnormalities, psoria-
      COMPANY: Galderma                               erythrodermic, exfoliative, or pustular      sis, hypercalciuria, pruritus.
      PHARMACOLOGIC CLASS: Vitamin D3                 psoriasis have not been evaluated.
      derivative                                        In controlled clinical trials with         HOW SUPPLIED: Oint—5g, 100g
      ACTIVE INGREDIENTS: Calcitriol                  Vectical Ointment, among patients
      3micrograms/g; ointment.                        having laboratory monitoring, hyper-
                                                      calcemia was observed in 24% (18/74)
                                                                                                    Facts about psoriasis
      INDICATION: Topical treatment of mild           of patients exposed to the drug and in
      to moderate plaque psoriasis in adults          16% (13/79) of patients exposed to            • According to the National Institutes
      ≥18 years of age.                               vehicle. However, the increases in cal-       of Health, 5.8 to 7.5 million Americans
                                                                                                    have psoriasis, and 10% to 30% of per-
                                                      cium and albumin-adjusted calcium             sons with psoriasis also develop psori-
      PHARMACOLOGY: Psoriasis is an auto-             levels were less than 10% above the           atic arthritis.
      immune skin disorder that causes accel-         upper limit of normal. If aberrations
      eration of the skin cell growth cycle. It       in parameters of calcium metabolism           • Plaque psoriasis is the most common
                                                                                                    type. Other types of psoriasis include
      affects 2 to 3 percent of the U.S. popula-      occur, treatment should be discontin-         guttate, which appears as small dotlike
      tion. Plaque psoriasis presents as dry,         ued until these parameters have nor-          lesions; pustular, which manifests as
      red, scaly patches or lesions that are cov-     malized. The effects of Vectical Oint-        weeping lesions and intense scaling; in-
      ered with dead skin cells which give off        ment on calcium metabolism following          verse, which is characterized by intense
      a silvery-white appearance.                     treatment duration greater than 52            inflammation; and erythrodermic, which
         Vectical Ointment contains calcitriol,       weeks have not been evaluated. In-            causes intense shedding and redness
      the naturally-occurring, active form of         creased absorption may occur with             of the skin.
      vitamin D3. Its mechanism of action in          occlusive use.                                • The disease most commonly appears
      the treatment of plaque psoriasis has                                                         on the scalp, knees, elbows, and torso;
      not been established.                           ADULTS: ≥18 years: Apply to affected          however, psoriasis can develop any-
                                                                                                    where, including the nails, palms, soles,
                                                      areas of the body twice daily (AM
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