Other types of psoriasis include guttate, which appears as small dotlike lesions; pustular, which manifests as weeping lesions and intense scaling; inverse, which is characterized by intense inflammation; and erythrodermic, which causes intense shedding and redness of the skin. * The disease most commonly appears on the scalp, knees, elbows, and torso; however, psoriasis can develop anywhere, including the nails, palms, soles, genitals and, on rare occasions, the face. Psoriasis occurs nearly equally in males and females across all socioeconomic groups, and manifests in all racial groups at varying rates. * Persons with psoriasis often respond well to exposure to natural and/or artificial UV light. Patients should choose a sunscreen that does not contain perfumes, dyes, or other ingredients that may irritate their skin and/or trigger an allergic reaction or psoriatic flare. * Data from National Psoriasis Foundation. www.psoriasis.org.
drug0509.qxp 4/24/09 12:13 PM Page 14 New Drug Information F R O M T H E E D I T O R S O F T H E PA P R PRODUCT: Vectical The safety and effectiveness of ADVERSE REACTIONS: Hypercalcemia, Ointment Vectical Ointment in patients with lab test and urine abnormalities, psoria- COMPANY: Galderma erythrodermic, exfoliative, or pustular sis, hypercalciuria, pruritus. PHARMACOLOGIC CLASS: Vitamin D3 psoriasis have not been evaluated. derivative In controlled clinical trials with HOW SUPPLIED: Oint—5g, 100g ACTIVE INGREDIENTS: Calcitriol Vectical Ointment, among patients 3micrograms/g; ointment. having laboratory monitoring, hyper- calcemia was observed in 24% (18/74) Facts about psoriasis INDICATION: Topical treatment of mild of patients exposed to the drug and in to moderate plaque psoriasis in adults 16% (13/79) of patients exposed to • According to the National Institutes ≥18 years of age. vehicle. However, the increases in cal- of Health, 5.8 to 7.5 million Americans have psoriasis, and 10% to 30% of per- cium and albumin-adjusted calcium sons with psoriasis also develop psori- PHARMACOLOGY: Psoriasis is an auto- levels were less than 10% above the atic arthritis. immune skin disorder that causes accel- upper limit of normal. If aberrations eration of the skin cell growth cycle. It in parameters of calcium metabolism • Plaque psoriasis is the most common type. Other types of psoriasis include affects 2 to 3 percent of the U.S. popula- occur, treatment should be discontin- guttate, which appears as small dotlike tion. Plaque psoriasis presents as dry, ued until these parameters have nor- lesions; pustular, which manifests as red, scaly patches or lesions that are cov- malized. The effects of Vectical Oint- weeping lesions and intense scaling; in- ered with dead skin cells which give off ment on calcium metabolism following verse, which is characterized by intense a silvery-white appearance. treatment duration greater than 52 inflammation; and erythrodermic, which Vectical Ointment contains calcitriol, weeks have not been evaluated. In- causes intense shedding and redness the naturally-occurring, active form of creased absorption may occur with of the skin. vitamin D3. Its mechanism of action in occlusive use. • The disease most commonly appears the treatment of plaque psoriasis has on the scalp, knees, elbows, and torso; not been established. ADULTS: ≥18 years: Apply to affected however, psoriasis can develop any- where, including the nails, palms, soles, areas of the body twice daily (AM
Pages to are hidden for
"New Drug Information"Please download to view full document