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Anesthesia Induces Hyperphosphorylation of Tau at Sites Related to Alzheimer’s Disease cientists from The New York phosphorylation of tau protein at the S State Office of Mental Retardation and Developmental Disabilities’ (OMRDD) New York State AD-related abnormal hyperphospho- rylation sites suggests that tau hyper- phosphorylation might be the mecha- Institute for Basic Research in nism that links anesthesia and the risk Developmental Disabilities (IBR) of cognitive impairment and/or AD. reported in the March 2009 issue of AD is the most common cause of the Journal of Alzheimer’s Disease that dementia in adults and affects anesthesia induces phosphorylation approximately 27 million individuals of tau. Tau is a key neuronal protein worldwide and over 4 million in the involved in neurodegeneration in United States alone. Most AD cases Alzheimer’s disease (AD) and several are sporadic and are believed to be other neurodegenerative disorders. caused by multiple factors. Anesthesia has previously been Understanding the mechanism by found to be associated with cognitive which anesthesia may increase the impairment and the risk for AD. This risk for cognitive impairment will study helps clarify the molecular mech-
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