Reducing Hot Flushes with Lifenol by ProQuest


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									32            women’s health

Reducing Hot Flushes with Lifenol
The total number of people suffering from menopausal discomfort accounts for more than 51 million in
the US and more than 121 million in Europe. They are women between the ages of 45 and 55 with good
incomes and purchasing power.1 Menopause is defined as when a woman stops having menstrual periods
for 12 consecutive months. This leads to a decrease in the production of estrogen, which is associated
with symptoms such as hot flushes, insomnia and mood changes, as well as post-menopausal osteoporosis
and vaginal atrophy. More than 70% of menopausal women are affected by hot flushes.

          ollowing the initial debate on              preparations based on hops are relatively new.     Lifenol, a female hop cone extract that
          hormone replacement therapy (HTR),          The principle estrogen — 8-prenylnaringenin        is	standardized	in	prenylflavonoids.	The	
          menopausal women are now looking            (8-PN) — was only identified in 1999.3 The US      patented process guarantees a unique
          for natural, efficient and safe solutions   daily intake of beer is estimated to be 225 mL.4   prenylflavonoid	profile.	Lifenol	contains	8-PN	
to balance their lack of estrogen. Interest in the    Considering that the 8-PN content of American      at a concentration of 0.12–0.2% and more
use of phytoestrogens for the management              beers is between 1 µg/L in lager beer and          than 1% of isoxanthohumol, a molecule that
of menopausal complaints has increased                240 µg/L in American porter beer, the daily        can be transformed into 8-PN by the intestinal
considerably. Phytoestrogens are mostly               consumption of 8-PN per capita in the US           microflora.	This	specific	profile	has	been	
non-steroidal polyphenolic plant-derivative           can be estimated to be between 3.3 µg and          associated, for the first time, with efficacy
compounds that functionally mimic the activity        54 µg of 8-PN per day.5 8-PN has a greater         studies on menopausal disorders. Lifenol
of human estrogen; typical sources include soy        affinity for estrogenic receptors compared         has been demonstrated to be effective at
and	red	clover	(isoflavones),	flaxseeds	(lignans)	    with coumestrol from red clover (Trifolium         reducing	hot	flushes	in	post-menopausal	and	
and	hops	(prenylflavonoids).2 Hops (Humulus           pretense L.) or genistein and daidzein from soy    menopausal women in two clinical studies.
lupulus L.) have been used since the middle           (Glycine max L.). 8-PN and genistein both have     Moreover, several scientifically validated
ages	to	flavour	beers,	and	their	estrogenic	          estrogen-like structures, but 8-PN has a lateral   participant questionnaires were used in both
effects have been reported in bodies of               chain that increases its estrogenic receptor       clinical studies as a self-evaluating instrument
literature since the 18th century. Although hops      binding strength compared with genistein.6         to measure the menopause-related quality of
have been known to be estrogenic from both               Based on these observations, the NAT’Life       life. The first double-blind, placebo-controlled
medical and anecdotal reports, phytoestrogen          Division of Naturex developed and patented         clinical study involved 67 post-menopausal

  Lifenol has been
  demonstrated to be
  effective at reducing
  hot flushes in post-
  menopausal and
  menopausal women in
  two clinical studies. March/April 2009
                                                                                                                    women’s health                          33
                                                                study. The results
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