Following the initial debate on hormone replacement therapy (HTR), menopausal women are now looking for natural, efficient and safe solutions to balance their lack of estrogen. Interest in the use of phytoestrogens for the management of menopausal complaints has increased considerably.
32 women’s health Reducing Hot Flushes with Lifenol The total number of people suffering from menopausal discomfort accounts for more than 51 million in the US and more than 121 million in Europe. They are women between the ages of 45 and 55 with good incomes and purchasing power.1 Menopause is defined as when a woman stops having menstrual periods for 12 consecutive months. This leads to a decrease in the production of estrogen, which is associated with symptoms such as hot flushes, insomnia and mood changes, as well as post-menopausal osteoporosis and vaginal atrophy. More than 70% of menopausal women are affected by hot flushes. F ollowing the initial debate on preparations based on hops are relatively new. Lifenol, a female hop cone extract that hormone replacement therapy (HTR), The principle estrogen — 8-prenylnaringenin is standardized in prenylflavonoids. The menopausal women are now looking (8-PN) — was only identified in 1999.3 The US patented process guarantees a unique for natural, efficient and safe solutions daily intake of beer is estimated to be 225 mL.4 prenylflavonoid profile. Lifenol contains 8-PN to balance their lack of estrogen. Interest in the Considering that the 8-PN content of American at a concentration of 0.12–0.2% and more use of phytoestrogens for the management beers is between 1 µg/L in lager beer and than 1% of isoxanthohumol, a molecule that of menopausal complaints has increased 240 µg/L in American porter beer, the daily can be transformed into 8-PN by the intestinal considerably. Phytoestrogens are mostly consumption of 8-PN per capita in the US microflora. This specific profile has been non-steroidal polyphenolic plant-derivative can be estimated to be between 3.3 µg and associated, for the first time, with efficacy compounds that functionally mimic the activity 54 µg of 8-PN per day.5 8-PN has a greater studies on menopausal disorders. Lifenol of human estrogen; typical sources include soy affinity for estrogenic receptors compared has been demonstrated to be effective at and red clover (isoflavones), flaxseeds (lignans) with coumestrol from red clover (Trifolium reducing hot flushes in post-menopausal and and hops (prenylflavonoids).2 Hops (Humulus pretense L.) or genistein and daidzein from soy menopausal women in two clinical studies. lupulus L.) have been used since the middle (Glycine max L.). 8-PN and genistein both have Moreover, several scientifically validated ages to flavour beers, and their estrogenic estrogen-like structures, but 8-PN has a lateral participant questionnaires were used in both effects have been reported in bodies of chain that increases its estrogenic receptor clinical studies as a self-evaluating instrument literature since the 18th century. Although hops binding strength compared with genistein.6 to measure the menopause-related quality of have been known to be estrogenic from both Based on these observations, the NAT’Life life. The first double-blind, placebo-controlled medical and anecdotal reports, phytoestrogen Division of Naturex developed and patented clinical study involved 67 post-menopausal Lifenol has been demonstrated to be effective at reducing hot flushes in post- menopausal and menopausal women in two clinical studies. www.nutraceuticalmag.com March/April 2009 women’s health 33 study. The results
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