Researchers at the University of Minnesota (Minneapolis, USA) say they have identified a compound that can prevent transmission of the primate version of HIV (human immunodeficiency virus), called SIV (simian immunodeficiency virus).
enzyme in mice, they found that lack of 166 inform March 2009, Vol. 20 (3) DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resulted in the loss of hair. Their Earthjustice made special note of alkyl- Communication Initiative was unveiled in findings were reported in The Journal phenol ethoxylates in its comments: “Inde- November 2008 by SDA, the Consumer of Biological Chemistry (284:4292–4299, pendent research has also documented Specialty Products Association, and the 2009). troubling hormone-disrupting qualities of Canadian Consumer Specialty Products “For some time, we have been alkylphenol ethoxylates (APEs)—com- Association. The initiative provides dif- studying the enzymes that make tri- monly found in detergents, disinfectants, ferent means to inform consumers about glycerides,” said Farese, senior investi- stain removers, and floor cleaners. Some the ingredients in products: on the product gator and senior author on the study. breakdown products of these man-made label; on the manufacturers’, distributors’, “We found that one of these enzymes chemicals can mimic the hormone estro- or importers’ websites; through a toll-free is a major regulator of retinoic acid gen and, when released into the environ- telephone number; or through some other actions in the skin.” ment, are toxic to aquatic wildlife. In nonelectronic means. RA, which comes from vitamin laboratory studies, they cause breast cancer “The cleaning product industry’s A (retinol), has been used to treat cells to proliferate, alter cells in the pla- ingredient communication initiative goes skin disorders, such as acne and pso- centa, and cause reproductive abnormali- beyond any law on the books in providing riasis, and certain cancers, but it is ties. This raises concerns about whether meaningful information to consumers,” fairly toxic and must be carefully con- they may increase the risk of breast cancer, added Radecki. trolled. In mice without DGAT1, the miscarriages, and reproductive damage in SDA stated that responsible manu- humans.” facturers ensure their products go through skin was very sensitive to retinol. The Laura Haight, senior environmental comprehensive, extensive risk assessments, loss of DGAT1 also caused alopecia, or associate with the New York Public Interest and also review scientific developments and hair loss. Both of these effects could Research Group, said, “Manufacturers of monitor product use data that may affect be prevented by depriving the mice household cleaning products have a respon- the safety assessment process. SDA said of a source of retinol in their diet. It sibility to inform consumers and state regu- that “an incredible amount” of research and turns out that DGAT1 can convert lators about chemicals in their products that development goes on before products ever retinol to a relatively inert storage may endanger human health or the environ- hit the shelves, not to mention that the prod- form. Without DGAT1, this ability is ment. This is not only common sense; here ucts must meet federal and state quality and lost, and any excess retinol in the skin in New York, it’s the law.” safety regulations. can be converted to RA. nnn inDUSTRY RESPOnSE Huntsman Corp. (Salt Lake City, Utah, The Soap and Detergent Association (SDA; Researchers identify surfactant USA) and Zavod Sintanolov (Nizhny Washington, DC, USA)) responded by Novgorod, Russia) have announced arguing that the lawsuit was unfounded, that they have signed a cooperation agreement by which both companies lacked legal standing, and was not sup- ported by state law. SDA went on to say that could prevent “will share know-how, expertise, and resources to develop the Russian that the challenge ignores efforts by indus- try to offer more information than ever HiV transmission market for surfactants.” According before about cleaning products and their Researchers at the University of Minnesota to the agreement, the Performance ingredients. The association expressed (Minneapolis, USA) say they have identi- Products
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