Alterations in Hemorheological Determinants and Glycated Hemoglobin in Black Diabetic Patients With Retinopathy by ProQuest

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Alterations	in	Hemorheological	Determinants	
and	Glycated	Hemoglobin	in	Black	Diabetic	
Patients	With	Retinopathy
Dagogo	J.	Pepple,	PhD;	Harvey	L.	Reid,	PhD



  Alterations	of	hemorheological	determinants	and	glycated	                    of plasma viscosity, is increased in diabetic retinopathy
  hemoglobin	levels	are	prominent	features	of	diabetic	reti-                   patients.4-6 The concentration of plasma fibrinogen has
  nopathy,	resulting	in	the	increased	whole-blood	and	plasma	                  been reported to be lower in blacks than in whites.7 The
  viscosities	observed	in	this	condition.	These	variables	have	                packed cell volume is another important determinant of
  been	reported	to	show	ethnic	variations.	The	present	study	                  whole-blood viscosity, which has been reported to be
  was	designed	to	investigate	the	pattern	of	alterations	in	                   increased in diabetic retinopathy patients.4,5,8 This vari-
  these	variables	and	the	possible	influence	of	plasma	viscos-                 able also shows some racial variations, being lower in
  ity	in	black	diabetic	retinopathy	patients.	Forty-two	patients,	             blacks compared with whites.9
  who	included	14	males	and	28	females	(mean	age,	62.81	                          The alterations in these determinants are responsible
  ±	11.38	years)	were	studied.	The	control	group	consisted	of	                 for the increase in whole-blood and plasma viscosities
  30	black,	nondiabetic,	age-matched	subjects,	including	                      seen in patients with diabetic retinopathy. We therefore
  10	males	and	20	females.	Relative	plasma	viscosity,	plasma	                  decided to investigate the pattern of alterations of these
  fibrinogen	concentration,	packed	cell	volume,	and	mean	                      hemorheological determinants in our black patients with
  glycated	hemoglobin	were	significantly	higher	in	the	dia-                    diabetic retinopathy.
  betic	subjects	compared	with	the	controls.	We	observed	an	
  increase	in	plasma	viscosity	in	our	study	population,	similar	               MATERIALS AND METHODS
  to	those	reported	in	previous	studies	for	Caucasians.
                                                                               Patients
  Keywords:	ophthalmic	■	diabetes	mellitus                                         Forty-two diabetic retinopathy patients attending the
                                                                               ophthalmology clinic of the University of the West
  J Natl Med Assoc.	2009;101:258-260
                                                                               Indies, Mona, were selected for this study. There were
                                                                               14 males and 28 females with a mean age of 62.81 ±
Author Affiliations:	Department	of	Basic	Medical	Sciences	(Physiology	Sec-
tion),	Faculty	of	Medical	Sciences,	The	University	of	the	West	Indies,	Mona	   11.38 years. The duration of diabetes was between 2
Campus,	Kingston,	Jamaica,	West	Indies.                                        months and 30 years (13.61 ± 9.50 years). Thirty of
Corresponding Author:	Harvey	L.	Reid,	PhD,	Department	of	Basic	Medical	        these patients had background retinopathy and 12 had
Sciences	(Physiology	Section),	Faculty	of	Medical	Sciences,	The	University	    proliferative retinopathy. Insulin was used to treat 15 of
of	the	West	Indies,	Mona	Campus,	Kingston,	Jamaica,	West	Indies	(harvey.
                                                                               these patients, while 27 were noninsulin treated. Twenty-
reid@uwimona.edu.jm).
                                                                               three of these were hypertensive while the other 19 were
                                                                               normotensive. The study was approved by the ethics
INTRODUCTION                                                                   committee of the Faculty of Medical Sciences, Univer-


D
         iabetic retinopathy is a common complication                          sity of the West Indies, Mona, and an informed/writ
								
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