Regenerative Medicine Roadmap Poster by AmirMedovoi


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									                                                                                                                       regenerative medicine rOadmap 1.1
Regenerative medicine development
roadmap is an essential tool for increasing
the scope of research and attracting
potential investors.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     tissuE EnginEERing MEthOds dEVELOPMEnt
Mikhail Batin (Science for Life Extension
Elena Kokurina (Science for Life Extension                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Bionics tissue Engineering (BitE)                                                                               Bioprinting
Maria Konovalenko (Science for Life Extension
                                                                                         Real-time cellular interrogation technology:
                                                                                                                                                                                Monitoring of SC implants
                                                                                                                                                                                 in the recipient organ
                                                                                                                                                                                                                            Diagnostic devices for targeting biomarkers
                                                                                                                                                                                                                                  indicative of cellular disorders                                                                                                                         OrganizatiOnal aSpect                                                                                                                                                                                                                                                   3D bioprinters development
Alexander sprygin (PhD, Federal Centre for Animal                                                                                                                   Real-time tracking of migration, proliferation                                                                                                                                                                                                                                                                                                                               Intrabody rapid SC activation for formating tissue or organ
                                                                                       fluorescent microscopy               Microfluidic platforms                                                                         Targeting of cancer-specific cellswith Tetrahymena
Health, Vladimir);                                                                                                                                                     and fate of stem cells implanted in the                           group I intron ribozyme
                                                                                     for detection of amiloidoo-            for real-time imaging                                    myocardium
Maria thomas (PhD, Institute of clinical                                                 genic protein states
                                                                                                                                                                       Magnetic resonance                Optic             Replacement of the cancer-         Selective delivery of                                                             Scale up                                       technology                                               legal issues                                                 reimburcements                                                                                                            Быстрая активация СК для формирования ткани или органа
pharmacology Robert Bosch Stiftung, Stuttgart);
Maria tutukina (PhD, Dep. of Functional genomics                                     Alternating current scanning
                                                                                                                           Single-cell analysis of
                                                                                                                         intracellular compounds
                                                                                                                                                                         imaging scan                  microscopy           specific transcript with a       a cytotoxin gene into                                                                                                          commercialization                                                                                                                                       Increase the number of available SC both in situ and
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        in peripheral circulation (recruitmet factors)
                                                                                                                                                                                                                           new (non-cancer) transcript            a cancer cell                                                                                                                                                                                                                                                                                                                                                                                                         Formation of 3D-heterocellular
and cellular stress, Institute of Cell Biophysics RAS,                               electrochemical microscopy          and changes in intracel-                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Generation of 2D- and 3D-homocel-
                                                                                       (AC-SECM) for real-time               lular compounds                          Through the expression of а labelled reporter                                                                                                                                                                                                                                                                                                                                                                                                                             lular cell aggregates:                         cell aggregates:
Moscow);                                                                              observation of living cells                                                        gene (Na/I symporter, D-luciferin, etc.)                                                                                                                                                                                                                                                                                                                                                                                                                                                                        •	 simple models of artificial skin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             •	 sheets and tubes
Alexei ulasov (Department of Molecular Genetics                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Granulocyte colony-stimulating factor (G-CSF)                                         •	 Cubes and rings,                            and neural tubes
                                                                                                                             Monitoring of host-                                                                                        Nanoparticles for detection                                                                                                                                                                                                                                                                                                                                                                                                                      •	 simplified bone marrow
of Intracellular Transport, Institute of Gene Biology                                 Tissue microarrays: real-                                                          Positron emission tomography and/or                           of a target and drug delivery                                                                                                                                                                                                                                                                                                                                                                         •	 Rods and branching rods
                                                                                     time monitoring of expres-             pathogen interactions                         single photon emission tomography                                                                                                                                                                                                                                                                                                                                                                                                                                  •	 Embryoid bodies                          •	 tissue-engineered vascular
RAS, Moscow);

                                                                                                                                                                                                                                                                                                                                                                                                        Scientific aSpect
                                                                                       sion of tumor supressor              and cellular signaling                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          grafts
dmitry Chistyakov (PhD, D.Sci., State Research                                           genes (p16, p53, RB)                                                            Non-radioactive labeling for detection
                                                                                                                                                                                                                            Superparamagnetic               Gold and silver
Institute of Genetics and Selection of Industrial                                                                                                                                                                           iron oxide nanopar-        nanoparticles in detection
                                                                                                                                                                                                                           ticles for detection of         of a specific DNA                                                                                                                                                                                                                                                                       Activation of a permissive situation of wound healing                                                                                  Formation of intermediate
Microorganisms, Moscow);                                                                                                                                                                                                    cancer cells, viruses,                                                                                                                                                                                                                                                                                                                  (Permissive factors)                                                   Generation of three-dimentional              diameter branching tubes and
                                                                                                                                                                                                                                                       sequence, bacterium, virus,
Maria shkrob (PhD, Institute of Bioorganic                                               Micro-electromechanical system (Bio-MEMS)                                                                                          pathogenic bacteria,             antibody, etc.                                                                                                                                                                                                                                                                                                                                                               vascularized microtissue and tissue             large tubes (macrovessels)
                                                                                         devices for studying cultivated microtubules                                                                                                etc.                                                                                                                                                                                                                                                                                                                                                                                                      (microvascular networks):
Chemistry RAS, Moscow);                                                                                                                                                Development of biomarkers of aging,
                                                                                              in bioartificial muscle engineering                                                                                                                                                                                                            diagnostic                                     mathematical                                                                                         culturing in bioreactors                                Trauma cytokines release control, such as
Paolo Macchiarini (MD, PhD, professor, department                                                                                                                        viability, health and pathologies
                                                                                                                                                                                                                                                                                                                                                                                             modeling                                      data bases                                                                                                             IL-6, IL-1β and TNF-α
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             •	 3D-vascularized cardiac
of regenerative surgery and biotransplantation,                                                                                                                                                                                                                                                                                              platforms                                                                                                                                            and synthetic media                                                                                                                           muscle                                  Development of three-dimen-
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         tional vascularized organ
University of Florence, Hospital Clinic University of
Mikhail Paltsev (academician RAS and RAMS, I.M.
Sechenov Moscow Medical Academy)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Control of SC shifting towards a commitment
                                                                                                                                                                                                                                                                                                                                             Supporting                                                                                                                                                            tiSSue                                          (Commitment factors)
                                                                                                                                                           Preservation of regional SC of a young organism
                                                                                                                                                                                                                                                                                                                                                                                        cell tHerapy                                             Healing therapies
          Initiator: Welfare Foundation for
                                                                                                                Stem cell preservation methods
                                                                                                                                                                                                                                                                                                                                            technologies                                                                                                                                                         engineering                           TGF-β and other factors to control in vivo dif-                                                therapeutic cloning                                        nerve development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   in the artificial
                                                                                         •	 SC from umbilical blood               •	 Hair follicle SC                                       Methods of collection,    Cryopreservation               Culturing in bioreactors and                                                                                                                                                                                                                                                                          ferentiation towards cartilage rings
          Scientific Research Support                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   organ
                                                                                         •	 SC from the placental complex         •	 Endometrium mesenchymal cells                         processing, and testing      and thawing                        synthetic media
                                                                                         •	 Dental pulp SC                        •	 Other types of SC (more invasive collec-                                                                                                                                                                                                                                                                                                                                                                                                                                                                Oocyte nuclear and citoplasm Transfer
          “science for Life Extension”                                                                                               tion procedures)

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Remodelling enhancement, inflammation reduction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   and SC activation to propagate and to protect against                                         Development of cell resourses
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                ischemia (Boosting factors)                                                                                                                        Vascularization
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    for therapeutic cloning

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Erythropoietin (Epo) as an “enhancing”
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               factor in regeneration process                                              Oocyte cryopreser-             Human amniotic
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          vation (oocyte bank,               fluid SC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           immature oocytes)

                                                          CELL REMOVAL                                                                                                                                                                                       Adding CELLs                                                                                                                                                                         CELL REPROgRAMMing                                                                                                                                                                                                                                                  Cell sheets

                                                                                                                                                                                                                                                                                                                                                                                                                       Study of iPSC as a unique subtype of pluripotent cell                                     Reprogramming methods
                                                                                                                                                                                                                                          In vitro culturing                                             Growth factors control
                                                                                                                                                                                      Stem cell biomarkers                                                                                                                                         hESC differentiation potential
                       Identification of cancer stem cells                       Reduction of the number of anergic killer T-cells
                       markers in various types of tumors                                                                                                                                                                  Optimal growth-supporting microenvironment                                                                                                                                                           Morphological criteria of iPSC isolation
                                                                                                                                                                                                                                        for satellite cells                                                                                                                                                                                                                                                   Using hESC (somatic cell nuclear
                                                                                                                                                                                                                                                                                                     Organo-specific growth factors                                                                                                                                                                              transfer, fusion with hESC)
                                                                                                                                                                                   Specific markers of cellular                                                                                      (LGF, EGF, FGF, HGF, IGF, VEGF,                       Into hemopoetic
                                                                             Reduction of the amount                                                                                         surface                                                                                                   BNDF, Epo, GCSF, GMCSF)                       or differentiated blood cells
                             Population homogenity                                                                       Markers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CELLs fOR usE in tissuE EnginEERing
                                                                            of macrophages in visceral                                                                                                                                                                                                                                                                                                            Gene expression signature and epigenetic remodeling of iPSC
                                                                                 adipose tissues                    of senescent cells                                                                                        Differentiation and proliferation control

                                                                                                                                                                                                                                                                                                                                                                                                                       Optimal combination               Increasing reprogramming                                   Without using hESC
                         Molecular mechanisms of cancer                                                                                                                          Gene expression profiles in SC               Via signalling pathways          SC prolifera-                                                                       Into insulin-producing beta cells                                    of genetic factors              efficiency (e.g. using kerati-
                          stem cell population stability                                                                                                                                                                   (JAK/STAT, MT-MMP, P19 ARF)         tion control                               Expression regulation                                                                                                                                                                                                                                                                                                                                           use of stem cells
                                                                                       Possible markers of cells to remove                                                                                                                                                                             of growth factors receptors                                                                                       for generation of              nocytes for iPSC generation,                                                                            study the sC properties of different origin
                                                                                                                                                                                                                                                                                                                                                                                                                     therapeuticaly safe iPSC                    vitamin C)                                                                                                                                                                                          of various stage specificity
                                                                             •	 Telomerase reactivation,                                                                                                                                                                                                                                                                                                                                                                                                          Necessary and sufficient
                           Signaling mechanisms of self                      •	 Decreased levels of repair,                                                                                                                                                                                                                                                                                                                                                                                                       factors to generate iPSC                                      •	 Xenogenic
                                                                             •	 increase in oxidative DNA damage and inactivation of tumor                                                                                   Usage of targeted                                                                                                    Creation of well-characterized ESC                                                                                                                                                                                                                                                                                           •	 ESC
                            renewal and tumorigenesis                                                                                                                              Epigenetic pattern features                                           Epigenetic control                             NfкB transcription factor                                                                                                                                                                                                                                               •	 Allogeneiс
                                                                                supression.                                                                                                                                       siRNA                                                                                                                   lines in cell banks                                                                                                                                                                                                                                                                                                  •	 adult SC
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                •	 Autologous
                                                                                                                                                                                                                                                                                                                                                                                                                                   Therapeutic applications of iPSC                                                      Using small
                                                                                                                                                                                                                                                                                                                                                        Therapy applications:
                                                                Methods of cell removal                                                                                                                                                                                                                                                                                                                           Generation of patient-specific           Obtaining a range of differ-
                                                                                                                                                                                  In vivo cell growth features                                                                                                                                                                                                      (disease-corrected) iPSC               nent cell types from iPSC:
                                                                                                                                                                                                                                             Use of SC in repair of organ-tissue functions lost during aging                                                                                                                                               •	 motoneurons,
                                                                                   Apoptosis activation                                                                                                                                                                                                                                            Differentiated hESC – for repair                                                                        •	 cardiomyocytes, s
                        Suicide gene therapy                                                                                                                                                                                                                                                                                                             of the CNS integrity                                                                              •	 mooth muscle cells,
                                                                                                                                                                                                                                                                                        Therapy of diseases caused by locomotor                    (multiocular sclerosis, trauma)                                                                         •	 endothelial cells,                                    Using genes or gene
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     sCAffOLd CREAtiOn fOR tissuE EnginEERing
                                                                                                                                                                                                                        Therapy of age-related neurodegenerative diseases                                                                                                                                            iPSC-based vaccination                                                                              products
                                                                                           Direct activation of proapoptotic                                                    New strategies in cell acquisition                                                                                    system aging                                                                                                                                         •	 hematopoietic cells,
                                                               Activation of               proteins, “death receptors” and                                                                                                                                                                                                                                                                                                                                 •	 primordial germ cells
                                                             apoptosis though                suppression of the apoptosis
                        Elimination of cells                signaling pathways                                                                                                                                                                                  Studies
                        based on activation                                                        inhibitors activity                                                                                                    •	 Parkinson’s desease            of integration                 Bone tissue and                                         Cells of vascular endothelium or                                   Infertility treatment
                                                                                                                                                                                                                          •	 Alzheimer’s desease                                                                          MSC isolation                                                                                                                                                                               Reprogramming
                          of angiogenesis                                                                                                                                           Enhancing the efficiency                                               features for all               articular cartilage                                      their precursors – for treatment
                                                                                                                                                                                                                                                                                                                          from adipose                                                                                                                                                                                factors-delivery
                                                                                                                                                                                          of induced                      •	 Multiocular sclerosis       types of specialized
                                                                                                                                                                                                                                                          cells using animal
                                                                                                                                                                                                                                                                                            recovery using
                                                                                                                                                                                                                                                                                           autologous MSC                    tissue                of vascular network pathologies
                                                                                                                                                                                                                                                                                                                                                                                                                                                               iPSC-based cellular                                        systems:                                                                                       Decellularization
                                                                                                                                                                                       pluripotent cells                  •	 ALSсклероз)                                                                                                                                                                           Treatment of degenerative                  and animal models of
                                                                                                                                                                                                                                                                tissues                                                                                                                                                                                                                                               •	 non-integrating
                                                                                                                                                                                                                                                                                                                                                                                                                          diseases:                                 diseases:                                            virus vectors,
                                                                                                                                                                                                                                                                                                                                                                                                                   •	 Parkinson disease,                                                                                                                    Morphological evaluation
                                                             Immune response stimulation                                                                                                                                                                                                                                                                                                                                                                   •	 sickle cell aneamia,                                    •	 polycistronic                                                                       Vessel decellularization with minimal damage                  Rapid diagnostic technique of obtained grafts
                                                                                                                                                                                                                                                                                                                                                      Dopaminergic neurons –                                       •	 ALS etc.                                                                                                                    of cytoarchitectonic organization of grafts
                                                                                                                                                                                                                                                                                                                                                                                                                                                           •	 familial dysautonomia,                                     nonviral vectors,                                                                           to the extracellular matrices                                     using laser radiation
                                                                                                                                                                                                                                                                                                                                                   for transplantation to patients                                                                                                                                                                    utilizing laser-induced fluorescense
                                                                                                                                                                                   SC isolation without viral                  Therapy of diseases associated with loss of myocardial function and tissue blood supply                                with Parkinson’s disease                                                                             •	 spinal muscular atrophy,                                •	 adding recombi-
                               Therapeutic humanized monoclonal                      Study of the mechanisms of tumor cell                                                        vectors and protooncogenes                                                                                                                                                                                                                                                                                                             nant reprogram-
                                                                                                                                                                                                                                                                                                                                                                                                                                                           •	 Down’s syndrome
                                           antibodies                                             sustainability                                                                                                                                                                                                                                                                                                                                                                                                         ming proteins
                                                                                                                                                                                                                                                                                       Cell and gene therapies (CD133, VEGF,                                                                                          Treatment of genetic                 •	 Gaucher disease
                                                                                                                                                                                                                                                           Cardiomyocyte                    FGF) for ischemia treatment:                                                                                                   disorders:
                                                                                                                                                                                                                             Reactivation of                 precursors                                                                                                                                                                                    •	 muscular dystrophies,
                                                                                                                                                                                                                                                                                                                                                      hESC differentiation into                                   •	 isickle cell anaemia,
                                                                                                                                                                                                                             myocardial SC                 isolation from             •	 lower limb atherosclerosis,                                neuroepithelium – for therapy                                                                          •	 Parkinson’s disease,
                            Identification of unwanted cells antigens                        Adaptive T-cell therapy                                                                    Isolation of viable                                                                           •	 diabetic foot,                                                                                                           •	 Fanconi anaemia,
                                                                                                                                                                                  pluripotent cells with nucleus                                            hESC or iPSC                                                                                   of eye diseases                                                                                 •	 Huntington’s disease,
                                                                                                                                                                                       from human donors                                                                              •	 myocardial ischemia and others                                                                                           •	 hemophilia type A,
                                                                                                                                                                                                                                                                                                                                                                                                                  •	 Duchenne muscular dystrophy           •	 diabetes mellitus type I etc.                                                                                                                                Biomaterials

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         natural biomaterials

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Use of urinary bladder matrix as a                                                                                                        Marine sponges as precursors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Fish scale in collagen scaffolds          Biomaterials from silk protein and                in the production of ceramic
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   potential treatment for tympanic                  for corneal regeneration               chitosan or gelatin for 3D scaffolds             based tissue engineered bone
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       membrane regeneration

                                                                                                                                                                                                                                  REstORAtiOn Of REgEnERAtiVE POtEntiAL                                                                                                                                                                                                                                                                                       Chitosan                                                                                Fibrin

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Microparticles from                                                    Effects of fibrino-     Addressing the                                  Hybrid stable
                                                            STUDy of ExoGENoUS fACToRS oN REGENERATIvE PoTENTIAl of CEllS                                                                                                EPIGENETIC AlTERATIoNS DURING                                                                                                                                   CHANGES IN ExTRACEllUlAR MATRIx                                                                                                                              chitosan with inorganic
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Fibrin scaffolds          gen- and thrombin        issue of using            of photo-           porous network
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                with sustained release                                                         crosslinking
                                                                                                                                                                                                                                 REGENERATIoN                                                                                                                                                                                                                                                                                                          components and MSC                                                    based fibrin gels for       xenogenic                                   from fibrinogen,
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 of endothelial groth                                                          of fibrin gels
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       to serve as bone-void                                                  neural tissue engi-       stem cell in                                  fibronectin and
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         factor                                                                 for greater
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               fillers                                                       neering applications        fibrin gels                                      laminine
                                                                                                             Impact on cellular                                                                                                                                                                             Uv-induced connective                                                                                                                                Beta-amyloid depositions                                                                                                                                                                                        stiffness
                             Effects of P-selectin                                                                                                                                                                                                                                                                                                                  Non-enzymatically glycated
                                                                         Investigation                       microenvironment of                      •	 Protection of cells from oxidative stress                      Regulation of transcription in tissue regeneration,                                      tissue aging                                               products
                           and other adhesion mol-                    of dedifferentiation                   SC niche to increase                     •	 Attraction of stem cells to the site of reparation             also covalent modification of DNA and topological
                           ecules on the aging rate                   mechanisms in vivo                     the repair potential                     •	 Stimulation of differentiation                                      chromosome reorganisation for selective
                                     of SC                                                                                                                                                                                      manipulation of gene exprerssion                                                                                                                                                                                         Mechanisms of beta-amyloid deposits formation
                                                                                                             of SC                                                                                                                                                                                                                                                    Detection and quantification
                                                                                                                                                                                                                                                                                                                                                          of non-enzymatically glycated proteins (AGE-products)
                                                                                                                                                                                                                                                                                                              Strategies for prevention                                of the extracellular matrix                                                                                             Mechanisms of the increase in levels
                                                                                                                                                                                                                                                                                                            and prophylaxis of photoaging                                                                                         Molecular mechanisms of the induction                       of metal ions in brain and other tissues                                                                                   synthetic biomaterials
                                                                                                                                                                                                                                                                                                                                                                                                                                  and progression of sporadic Alzheimer’s
                                                                                                                                                                                                                            Activation of Notch signaling for vascular                                                                                                                                                                                                                              and their role information
                                                          Mechanisms of maintaining the regenerative potential of SC populations through:                                                                                                                                                                                                                                                                                                        disease
                                                                                                                                                                                                                                regeneration with progenitor cells                                                                                                                                                                                                                                   of beta-amyloid deposits
                                                                                                                                                                                                                                                                                                                                                            Study of mechanisms of formation and regulation
                                                                                                                                                                                                                                                                                                                                                                           of AGE-products                                                                                                                                                           Reduction of toxicity of polyure-              Biodegradable microspheres with                        Porous biocompatible cross-linked hydrogels
                                                                                                                                                                                                                                                                                                               Use of anti-inflammatory                                                                                                                                                                                                                      thane scaffolds                        linking components from organic
                                           Trophic factors                                     Changes in basal membrane and                                  Interaction with capillary endothelium                                                                                                                  compounds                                                                                                                                                                                                                                                                     acid motifs and gelatin with poly-
                                                                                               extracellular matrix parameters                                                                                                        Genes governing                                                         (cyclooxygenase inhibitors,                                                                                                                                                                                                                                                          trimethylene carbonate in order to                Modifying the polymeric sugar hyaluronic acid with varying
                                                                                                                                                                                                                                     regeneration of SC:                                                         inhibitors of cytokine                         Expression levels of a soluble form of the                                                    Prevention of beta-amyloid deposition                                                                                                     construct porous scaffolds                    numbers of photocrosslinkable methacrylate groups in
                                                                                                                                                                                                                                                                                                                      generation)                           AGE- products receptor as a biomarker of chronic                                                                                                                                          Prosthetic vascular vessels for                                                                   hydrogels for neural progenitor cell differentiation
                                                                                                     Biomaterials to direct                                        Platelet-derived adhesin SDF-1                                                                                                                                                                                                                                                                                                                                                      in situ arterial regeneration
                                     Mechanistic impact on SC                                         stem-cell functions                                         in differentiation of CD34+ into                                                                                                                                                          inflammatory diseases (vascular atherosclerosis,
                                                                                                                                                                     progenitor endothelial cells                                directing proliferation (e.g.,Plzf)                                                                                                     diabetes, renal injury)
                                                                                                                                                                                                                                                                                                                                                                                                                                                         Metal-chelators                                                                                                                           Porous ε-caprolactone membranes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    New agents to                                                                    for nutrient supply and waste                      Self-assembled rosette                Multilayered hydrogels
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                destabilize and remove              Porous polycaprolactone scaffolds               product removal from the tissue                    nanotube/hydrogel com-                      with channels
                                                                                                                                                                                                                                                                                                                                                                                                                                        D-penicilamine-                 Lipophilic chelating                     preexisting amyloid                and their construction using laser                    engineered construct                        posites for cartilage tissue             for better distribution
                              Secretion of cytokines and chemokines                                                                                                                                                                                                                                              Anti-oxidant treatment                         Prevention of deposition of AGE-proteins                                                                                                               deposits                                 sintering
                                                                                         Changes in intercellular contact parameters                                                                                                                                                                                                                                                                                                containing nanoparticles          agent DP-109 for pre-                                                                                                                                                                   engineering                     of oxygen and nutrients
                                                                                                                                                               Secretion of non-protein substances                              IGF gene family encoding insulin-                                                                                             and removal of intermolecular protein-protein
                                                                                                                                                                                                                                       like growth factors                                                                                                                      crosslinks                                              in treatment of               vention of new amyloid
                                    Temporal patterns of neural                                                                                                                                                                                                                                                                                                                                                                       Alzheimer’s disease,             aggregates formation
                                                                                               Microvesicule-vectored transfer                                     Effects of nitric oxide (NO) on                                                                                                                                                                                                                                  Parkinson’s disease, and           and for solubilization                                                                                                        Diopside (CaMgSi2O6) powders
                                     growth factor stimulation                                 of genetic material between SC                                                                                                                                                                                                                                                                                                                                                                                          Protollin                   Electrospun nanofibrous scaffolds
                                                                                                                                                                intracellular regeneration processes                                                                                                                                                                                                                                 other central nervous            of preexisting amyloid                                                       with biomimetic nanostructure and                and dense ceramics as bioactive                              Porous fibrillar hyaluronic acid scaffolds
                                                                                                                                                                                                                                                                                                                  Inhibition of matrix                          Generation of new glucose-lowering agents                              system disorders                       depots                                                                growth factors for control of SC                  biomaterials for bone repair                                      using crystal templating
                                                                                                                                                                                                                                    Hox gene family encoding                                                    metalloproteases (MMP)                                                                                                                                                                                                                     behavior and fate
                                                                                                                                                                                                                                      transcription factors                                                          activity with:
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     «Beta-sheet                                                                                                                                                              Adipose-derived hydro-
                                                                                                                                                                                                                                                                                                                •	 neutrophil elastase                                                                                                     Clioquinol in treatment of Alzheimer’s disease                             breakers»
                                                                                        Secretion of growth-stimulating factors (e.g. BMPs)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Enzymatic crosslinking of                 gels for stimulation
                                                                                                                                                                                                                                                                                                                   inhibitors,                                                                                                                                                                                                                     Hydroxyapatite particles/poly(ester-                                                              dextran-tyromine hydrogels               of vascularized adipose
                                                                                                                                                                                                                                                                                                                                                                      Search for efficient inhibitors                                                                                                                                                                                              Multifunctional bioactive chemically
                                                                                                                                                                                                                                                                                                                •	 retinoids,                                                                                                                                                                                                                      urethane) with the advantage of an               cross-linked elastin-like polymers                                                           formation in vivo
                                                                                                                                                                                                                                      encoding MAP kinases                                                                                                     (pyridoxine, pyridoxamine, aminoguanidine,                                                                                                                                               osteoconductive surface
                                   Regeneration processes in muscle tissue:                                                                                                                                                                                                                                     •	 natural and synthetic                               2,3-diamino phenazon, etc.)
                                                                                                           Proangiogenic effects                                                                                                                                                                                   inhibitors
                                  •	 Muscle-derived SC, mediated by the niche                          of exogenous erythropoietin                                  Influence of various substances
                                     microenviroment                                        Study of erythropoietin receptors on macrophages                           on homing of grafted cells
                                  •	 Non-muscle-derived SC                                           in fibrin-unduced wound healing                                                                                                                                                                                                                                                                                                        Therapeutics preventing interaction between amyloid deposition precursors
                                  •	 stimulatory and inhibitory growth factors                                                                                                                                                     responsible for cytoskeleton
                                                                                                                                                                                                                                      structure (e.g. lamin A)
                                                                                                                                                                                                                                                                                                                                                                Development of synthetic drugs (2-phenyl-
                                                                                                                                                                                                                                                                                                                                                                thiozoline, phenylsetam and its derivatives)                                                                                                                                                                                                        Biomaterials quality protocols development using the criteria:
                                                                                                                                                                                                                                                                                                                                                                    and discovery of natural compounds                                      Inhibitors of serum                 Natural compounds (wine-related polyphenols,                      Biological membranes
                                                                                                                                                                                                                                                                                                                Dissection of mechanisms                                                                                                   amyloid P component                         tannic acid, curcumin, nicotine)
                                                                                                                                                                                                                                    STAT gene family encoding                                                    of photoinduced aging:                                                                                                                                                                                                                                                                                                                                                   Stiffness and stability
                                                                                   Changes in physical parameters of intercellular environment                                                                                                                                                                                                                                                                                                                                                                                                                                                  No toxicity when biodegraded           Biocompatibility with host tissue
                                                                                                                                                                                                                                     transcription activators                                                                                                                                                                                                                                                                                                                                                                                                                           at the site of implantation
                                                                                                                                                                                                                                                                                                          •	 functions and features of MMP,                            N-acetylcarnosine and histidyl                                                                                                                                                 Tissue engineered
                                                                                                                                                                                                                                                                                                          •	 mechanisms of photoinduction and                      hydrazide as promising therapeutics                                      Inhibitors of the interaction between beta-amyloid fibers and beta-amyloid                            scaffolds based on natural
                                    Various oxygen tension values in tissue                     Influence of Са ions on osteoblast                         Influence of external electrical field on                                                                                                         activation of MMP,                                    for treatment of senile cataracts and                                               pathological chaperons (ApoE, glucosaminglycans, etc.)                                        bacterial membanes
                                   for modulation of regeneration processes                    differentiation for bone regeneration                       cytosceleton and membrain mechanics                                                                                                                                                                              diabetic retinopathy                                                                                                                                                                                                                                         Shape and size preservation of                  No rough encapsulation
                                                                                                                                                                                                                                                                                                          •	 specific and efficent MMP                                                                                                                                                                                                                                                              Minimal inflammation                     reconstructed organ
                                                                                                                                                                                                                                         р53/р21 gene axis                                                                                                                                                                                                                                                                                                                                                                                                                            or rejection of endoprosthesis

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