Document Sample
					                                           Dr Julianne Bayliss
                                        was awarded a PhD in
                                     October 2008 for work on
                                    mechanisms of rejection in
                                       cardiac transplantation.

Head: Professor Catriona McLean BSc, MBBS, FRCPA, MD

RESEARCH ACTIVITIES                                                               the potential for misclassification of cases of dystrophy identified as juvenile
HIV neuropathogenesis                                                             polymyositis.
Dr Katherine Thompson
                                                                                  Pulmonary veno-occlusive disease
This research examines the timing and type of brain cells infected by HIV and
                                                                                  Susan Haarchand
the events that lead to the establishment of the virus in the brain.
                                                                                  Collaborating partner: Department of Allergy, Immunology and Respiratory
                                                                                  Medicine. This study was part of a BMedSc project highlighting that failure of
Progressive multifocal leucoencephalopathy neuropathogenesis
                                                                                  Bosentan treatment in pulmonary hypertension may be related to pulmonary
Dr Tanja Jankovic-Karasoulos
                                                                                  venooclusive disease as a missed diagnosis.
The frequency and genotype of PML infection in disease and in latent states in
the brain and the kidney are examined.
                                                                                  Neuroimaging (using novel binders) of neurodegenerative diseases
                                                                                  Professor Catriona McLean
Humoral rejection in cardiac transplantation
                                                                                  Collaborating partner: National Neuroscience Foundation. This research
Julianne Bayliss, PhD student
                                                                                  highlights novel binders and their utility in the neuroimaging diagnosis of
This research supports the involvement of vascular endothelial growth factor
                                                                                  Alzheimer’s disease.
(VEGF) as an important mediator of lymphocyte recruitment and extravasation
during ACR. The involvement of VEGF in acute humoral rejection as a marker
                                                                                  TDP-43 in motor neurone disease
of endothelial activation is also demonstrated. Julianne’s study extrapolates
                                                                                  Professor Catriona McLean
the mechanisms through which VEGF may contribute to the development of
                                                                                  Collaborating partner: University of Melbourne. The study highlights a possible
cardiac vasculopathy through perpetuation of the immune response and the
                                                                                  novel cerebrospinal fluid marker of disease.
promotion of collagen and fibrin deposition by cardiac myofibroblasts.

Breast cancer sub-typing and epidemiology                                         MAJOR ACHIEVEMENTS
Professor Catriona McLean                                                         Professor Catriona McLean
Collaborating partner: Cancer Council Victoria. This multinational study (with    • Australian Medical Association Victoria Crawford Mollison Prize for
Cambridge University) highlights the relationship of various subtypes of breast     ‘outstanding contribution to Pathology including service pathology, research
cancers with diet, environmental factors and a new prognostic marker in             and registrar training’
breast cancer.                                                                    • Noel Callahan Award, Cork, Ireland
                                                                                  • Alfred Week Research Poster Display 2008: two WTMS clinical poster prizes
Neurotrauma brain bank                                                            • Two NHMRC Project Grants commencing in 2008
Dr Tony Frugier (NTRI), Professor Catriona McLean                                 Dr Katherine Thompson
Collaborating partner: NTRI. This study investigates the acute inflammatory       • Travel grant to present at the conference ‘Infectious diseases of the nervous
response in the two weeks following human brain trauma, including cytokine          system: pathogenesis and worldwide impact’ at the Pasteur Institute, Paris
RNA expression and morphologic change.                                            Dr Julianne Bayliss
                                                                                  • Finalist 2008 Cardiac Society of Australia and New Zealand Ralph Reader
Psychosis in frontal lobe dementia                                                  Prize (Clinical Science)
Professor Catriona McLean                                                         • Finalist 2008 Transplantation Society of Australia and New Zealand (TSANZ)
Collaborating partners: Australian Brain Bank Network and Dr Dennis                 President’s Prize
Velakoulis, Neuropsychiatry Department, Royal Melbourne Hospital. This study      • Finalist 2008 Alfred Postgraduate Research Symposium
highlighted the frequent presentation of young frontal lobe dementia patients     • 2008 TSANZ/AMGEN Young Investigator Award
with an initial schizophreniform illness.

Muscular dystrophy in children
Colleen D’Arcy
                                                                                                                                           12 Journal Articles
Collaborating partners: Murdoch Childrens Research Institute and State
Neuropathology Service. This study was part of a BMedSc project highlighting