English - Nicolas Aznavour

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					                                                                École Polytechnique Fédérale de Lausanne
                                                                Laboratoire de neuroénergétique et dynamique cellulaire
     NICOLAS AZNAVOUR                                           AAB 1 31, Station 15, CH-1015 Lausanne
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                                                                Tel: +41 78 891 84 61 Courriel : nicolas.aznavour@epfl.ch
                                                                Fax:+41 21 693 16 50 Website : www.nicolasaznavour.com




                                                EDUCATION

  Research Assistant :
   Prof. Pierre Magistretti, EPFL-CIBM, University of Lausanne.                                         03/2008 –

  Post-doctoral Fellow in Neuroimaging :
     Prof Chawki Benkelfat, Department of Psychiatry, McGill Health Centre.                             06/2006 – 02/2008
     Prof. Luc Zimmer, Biomedical Cyclotron of Lyon, CERMEP.                                            04/2005 – 06/2006

  Ph.D. in Neuroscience, supervised by Prof. Laurent Descarries :                                      01/2001 – 03/2005
   University of Montreal, Faculty of medicine, Department of physiology.

  M.Sc. in Neuroscience, supervised by Prof. Laurent Descarries :                                      09/1999 - 12/2000
   University of Montreal, Faculty of medicine, Department of physiology.

  B.Sc. in Biological Sciences :                                                                       09/1996 – 08/1999
   University of Montréal, Faculty of arts & sciences, Department of biology.

  French Baccalaureate specialized in Life Sciences:                                                                     07/1996
   Faculty of Grenoble.

  International School of Geneva :                                                                     09/1986 – 06/1996



ADDITIONAL TRAINING :      Swiss Animal Care Training                                                                       05/2008
                           McGill University Animal Care Training                                                           07/2006
                           PET Imaging Course (INSERM, Lyon, France)                                                        04/2005

LANGUAGES :                Bilingual French/English.
                           German basics.

COMPUTER SKILLS :          Programming : Matlab
                           Graphic & Web design (Photoshop, Illustrator, Dreamweaver).
                           Image analysis: PET & MRI (MINC,CAPP,SPM, PMOD), Autoradiography.


                                        GRANTS AND AWARDS
Postdoctoral fellowship, Quebec Health Research Foundation (FRSQ)                                       04/2007 - 04/2009
Postdoctoral fellowship, McGill University Health Centre (offer declined)                               08/2007 - 08/2008
Postdoctoral fellowship, Swiss National Science Foundation.                                             09/2005 - 09/2006
Ph.D. award, Univ. of Montreal.                                                                                                  2005
Excellency award, Faculty of Graduate Studies, Univ. of Montreal.                                                   2001 - 2004
Grant from the Neuroscience Research Center (CRSN), Univ. of Montreal.                                              1999 - 2004
                                             PUBLICATIONS


Aznavour N., Benkelfat C., Gravel P., Aliaga A., Rosa-Neto P., Bedell B., Zimmer L., Descarries L. (2008).
MicroPET imaging of 5-HT1A receptors in rat brain : a test-retest [18F]MPPF study. Eur J Nucl Med Mol
Imaging (DOI 10.1007/s00259-008-0891-1).

Sibon I., Benkelfat C., Gravel P., Aznavour N., Costes N., Mzengeza S., Booij L., Baker G., Soucy J-P.,
Zimmer L., Descarries L. (2008). Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a
single oral dose of fluoxetine: A PET study in healthy volunteers. Biological Psychiatry. 63:1135-1140.

Riad M., Rbah L., Verdurand M., Aznavour N., Zimmer L., Descarries L. (2008). Unchanged density of 5-
HT1A autoreceptors on the plasma membrane of nucleus raphe dorsalis neurons in rats chronically treated with
fluoxetine. Neuroscience 151:692-700.

Aznavour N., Zimmer L. (2007). [18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal
and human brain. Neuropharmacology 52:695-707.

Aznavour N., Rbah L., Riad M., Reilhac A., Costes N., Descarries L., Zimmer L. (2006). A PET imaging
study of 5-HT1A receptors in cat brain after acute and chronic fluoxetine treatment. NeuroImage 33:834-842.

Aznavour N., Rbah L., Leger L., Buda C., Sastre J.P., Imhof A., Charnay Y., Zimmer L. (2006). A
comparison of in vivo and in vitro neuroimaging of 5-HT1A receptor binding sites in the cat brain. J Chem
Neuroanat 31:226-232.

Aznavour N., Watkins K.C., Descarries L. (2005). Postnatal development of the cholinergic innervation in the
dorsal hippocampus of rat: A quantitative light and electron microscopic immunocytochemical study. J Comp
Neurol 486:61-75.

Descarries L.D., Aznavour N., Hamel E. (2005). The acetylcholine innervation of cerebral cortex: New data
on its development and its fate in the hAPPSW,IND mouse model of Alzheimer’s disease. J Neural Transm
112:149-162.

Aucoin J.-S., Jiang P., Aznavour N., Tong X.K., Buttini M., Descarries L., Hamel E. (2005). Selective
cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease.
Neuroscience 132:73-86.

Descarries L, Mechawar N, Aznavour N, Watkins KC. (2004). Structural determinants of the roles of
acetylcholine in cerebral cortex. Prog Brain Res. 145:45-58.

Aznavour N., Mechawar N., K.C. Watkins, Descarries L. (2003). Fine structural features of the acetylcholine
innervation in the developing neostriatum of rat. J Comp Neurol 460:280-291.

Meilleur S., Aznavour N., Descarries L., Carmant L., Orval A., Psarropoulou C. (2003). Pentylenetetrazol-
induced seizures in immature rats provoke long-term changes in adult hippocampal cholinergic excitability.
Epilepsia 44:507-517.

Descarries L., Aznavour N. (2003). Diffuse (volume) transmission. In: The Encyclopedia of Neuroscience.
Adelman G and Smith BH, eds. Amsterdam: Elsevier Science.

Aznavour N., Mechawar N., Descarries L. (2002). Comparative analysis of cholinergic innervation in the
dorsal hippocampus of adult mouse and rat: A quantitative immunocytochemical Study. Hippocampus
12:206-217.
                                               ABSTRACTS

Aznavour N., Gravel P., Rosa-Neto P., Benkelfat C., Mzengeza S., Bedell B., Zimmer L., Descarries L.
  (2007). MicroPET measurement of [18F]MPPF binding to 5-HT1A receptors in rat brain. Abstract
  Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2007. Online.
Aznavour N., Riad M., Rbah L., Descarries L., Zimmer L. (2006). PET imaging reveals a reduction of
    [18F]MPPF binding in cat dorsal raphe nucleus after acute but not chronic treatment with the
    antidepressant fluoxetine. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience,
    2006. Online.
Aznavour N., Riad M., Rbah L., Descarries L., Zimmer L. (2006). PET imaging reveals a reduction of
    [18F]MPPF binding in cat dorsal raphe nucleus after acute but not chronic treatment with the
    antidepressant fluoxetine. Rencontres Scientifiques de l'IFNL, 9.
Aznavour N., Rbah L., Descarries L., Sappey-Marinier D., Zimmer L. (2006). Brain Imaging Reveals
    Reduced Binding of the PET Radioligand [18F]MPPF in Cat Dorsal Raphe Nucleus After Acute Treatment
    with the Antidepressant Fluoxetine. 5th Forum of European Neuroscience.
Descarries L., Aznavour N., Riad M., Rbah L., Zimmer L. (2006). Brain Imaging of the Internalization of 5-
    HT1A Serotonin Autoreceptors at the Onset of Antidepressant Treatment. 26th European Winter
    Conference on Brain Research.
Riad M., Rbah L., Verdurand M., Aznavour N., Zimmer L., and Descarries L. (2006). Functional plasma
    membrane 5-HT1A autoreceptors are replaced by desensitized receptors in the nucleus raphe dorsalis of
    rats chronically treated with fluoxetine. Abstract Viewer/Itinerary Planner. Washington, DC: Society for
    Neuroscience, 2006. Online.
Zimmer L., Riad M., Rbah L., Aznavour N., Verdurand M., Sibon I., Descarries L. (2006). Exploration in
    vivo de l’internalisation des récepteurs sérotoninergiques 5-HT1A lors d’un traitement antidépresseur:
    Apport de l’imagerie TEP. 2ème Colloque Méditerranéen de Neurosciences Marrakech, Maroc.
Sibon I., Benkelfat C., Gravel P., Aznavour N., Mzengeza S., Booij L., Baker G., Soucy J.P., Zimmer L.,
    Descarries L. (2006). Decreased Binding of [18F]MPPF in the Dorsal Raphe Nucleus of Healthy
    Volunteers in Response to Single Oral Dose of Fluoxetinee. ACNP.
Sibon I., Benkelfat C., Gravel P., Aznavour N., Mzengeza S., Baker G., Zimmer L., Descarries L. (2006).
    Lowered 5HT1A Binding in the Nucleus Raphe Dorsalis (NRD) of Humans in Response to Acute
    Fluoxetine Measured with [18F]MPPF/PET. ECNP.
Aznavour N., Watkins K.C., Descarries L. (2005). Développement précoce et rapide de l’innervation
    cholinergique dans l’hippocampe dorsal du rat. 7e Colloque de la Société des Neurosciences.
Aznavour N., Watkins KC, Descarries L. (2004). Early and rapid postnatal development of the cholinergic
    innervation in the dorsal hippocampus of rat. Abstract Viewer/Itinerary Planner. Washington, DC: Society
    for Neuroscience, 2004. Online.
Aznavour N., Tong X.K., Aucoin J.-S., Descarries L., Hamel E. (2003). Neurotoxicity of -amyloid and
    selective, age-dependant loss of cholinergic fibers in the hippocampus and cerebral cortex of the PDAPP
    mouse. Program No. 842.7. Abstract Viewer/Itinerary Planner. Washington, DC: Society for
    Neuroscience, 2003. Online.
Aznavour N., Mechawar N., Watkins K.C., Descarries L. (2003). Innervation cholinergique (ACh) du
    néostriatum en développement : caractérisation ultrastructurale. Congrès de l’AEGSFM, Montréal. Méd
    Sci, Suppl 2, 19:4.
Descarries L., Aznavour N., Aucoin J.-S., M. Buttini, L.Mucke, Hamel E. (2003). Loss of cholinergic
    innervation in the cerebral cortex and hippocampus of transgenic mice overexpressing V717F -amyloid
    precursor protein. Journée scientifique 2003, Département de pathologie et biologie cellulaire.
Aznavour N., Mechawar N., Watkins K.C., Descarries L. (2002). Ultrastructural features in the developing
    neostriatum of rat. Program No. 129.7. 2002 Abstract Viewer/Itinerary Planner. Washington, DC : Society
    for Neuroscience, 2002. Online.
Aznavour N., Mechawar N., Watkins K.C., Descarries L. (2002). Caractéristiques ultrastructurales de
    l’innervation cholinergique (ACh) du néostriatum en développement. Journée scientifique 2002,
    Département de pathologie et biologie cellulaire.
Descarries L., Aznavour N., Aucoin J.-S., M. Buttini, L.Mucke, Hamel E. (2002). Loss of cholinergic
    innervation in the cerebral cortex and hippocampus of transgenic mice overexpressing V717F -amyloid
   precursor protein. Program No. 295.17. Abstract Viewer/Itinerary Planner. Washington, DC: Society for
   Neuroscience, 2002. Online.
Aznavour N., Mechawar N., Descarries L. (2001). Cholinergic innervation of the dorsal hippocampus in adult
   mouse and rat: A comparative immunocytochemical study. Soc. Neurosci. Abstr. 27:1566.
Aznavour N., Mechawar N., Descarries L. (2001). Données quantitatives sur l’innervation cholinergique de
   l’hippocampe chez la souris et le rat adultes. Congrès de l’AEGSFM, Montréal.
Aznavour N., Mechawar N., Descarries L. (2001). Description quantitative de l’innervation cholinergique
   (ACh) de l’hippocampe chez la souris adulte. Journée scientifique 2001, Département de pathologie et
   biologie cellulaire.
Aznavour N., Mechawar N., Dubuc, R., Descarries L. (2000). Quantitative data on the cholinergic innervation
   in adult hippocampus. Soc. Neurosci. Abstr. 26:2141.
Aznavour N., Mechawar N., Descarries L. (2000). Données quantitatives sur l’innervation cholinergique de
   l’hippocampe chez la souris. Congrès de l’AEGSFM, Montréal.
Aznavour N., Mechawar N., Descarries L. (2000). Données quantitatives sur l’innervation cholinergique de
   l’hippocampe chez la souris. Journée scientifique 2000, Département de pathologie et biologie cellulaire.
Meilleur S., Aznavour N., Mechawar N., Descarries L., Psarropoulou C. (2000). Pentylenetetrazol-induced
   convulsions in immature and adult rats have different long-term effects on cholinergic transmission in the
   hippocampal CA3 area. Soc. Neurosci. Abstr. 26:1053
Meilleur S., Aznavour N., Mechawar N., Descarries L., Psarropoulou C. (2000). Pentylenetetrazol-induced
   convulsions in immature and adult rats have different long-term effects on cholinergic transmission in the
   hippocampal CA3 area. American Epilepsy Society. Epilepsia 41: S7, p. 52.

				
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