Need to clinically investigate BHUx for atherosclerosis and osteoporosis
Yamini B. Tripathi and Deepshikha Tripathi
Cardiovascular diseases have been asso- Although soy consumption has been it may remain confined to research papers
ciated with reduced bone mineral density associated with decreased incidence of and project reports, as happens with most
and fracture risk1. A major atherogenic atherosclerosis and osteoporosis, acting of the patents.
molecule is believed to be oxidized phos- through receptors for estrogens, proges- If BHUx is developed as functional
pholipid, which has also been found to terone, androgen, vitamin D, retinoic acid food or as food supplement, on the above
inhibit the spontaneous osteogenic dif- and also thyroid hormones, it may adver- suggested line of further research, it can
ferentiation of marrow stromal cells, sug- sely influence these endocrine functions9. be safely recommended by doctors of
gesting a link between atherosclerosis Therefore, new herbal formulations are both the systems of medicine and can
and osteoporosis. These oxidized phos- the demand of time. benefit the suffering humanity. It will also
pholipids have also been shown to alter In this series of searches, we have capture the big international herbal ex-
the net effects of bone anabolic agents, developed BHUx (a polyherbal formula- port market, where India has only 2%
such as bone morphogenetic protein and tion patented by DBT and BHU in EU, share.
parathyroid hormone, as seen in MC3T3- USA, China and India), which has shown
E1 cells2. Secondly, a negative association significant antiatherosclerotic property10. 1. Hofbauer, L. C., Brueck, C. C.,
Shanahan, C. M., Schoppet, M. and
between plasma lipid concentrations and It enhances the HDL level and also in-
Dobnig, H., Osteoporosis Int., 2007, 18,
bone mineral density supports the hypo- hibits lipoxygenase 15, which are direc-
thesis of harmful effect of hyperlipidae- tly associated with the oxidation of LDL 2. Huang, M. S. et al., J. Biol. Chem., 2007,
mia on bone metabolism3. phospholipids, turning it to atherogenic 282, 21237–21243.
Further, osteoporosis and osteoarthritis molecule and cyclooxygenase-2, respon- 3. Stulc, T., Ceska, R., Horínek. A and
are major concerns for aging societies sible for the release of inflammatory Stĕpán, J., Cas. Lek. Cesk., 2000, 139,
worldwide. Epidemiological and genetic molecules11. Recently, we have reported 267–271.
studies have shown that it is a polygenic that its precursor formulation, (Sandhika, 4. Miyamoto, Y. et al., Nature Genet., 2007,
disease and involves both genetic and an ayurvedic medicine already in clinical 39, 529–533.
environmental factors. Interestingly, pa- use for arthritis)12, enhances Ca nodule 5. Mitchell, R. N. and Libby, P., Circ. Res.,
2007, 100, 967–978.
tients with osteoporosis frequently suffer formation in osteoblast-like cells, both in
6. Taylor, B. C., Schreiner, P. J., Doherty,
from vascular calcification, which predicts the presence and absence of LPS13.
T. M., Fornage, M., Carr, J. J. and Sidney,
both cardiovascular morbidity/mortality Thus BHUx has shown therapeutic re- S., Hum. Genet., 2005, 116, 525–528.
and osteoporotic fractures. Both athero- sponse for both pathologies in the ex- 7. Hommels, M. J. et al., Neth. J. Med.,
sclerosis and osteoporosis often appear perimental set-up and this formulation 2007, 65, 203–207.
together, especially in the elderly and may be worth international patenting. 8. Ahn, K. S. and Aggarwal, B. B., Ann.
post-menopausal women4. However, it would be futile if BHUx can- N. Y. Acad. Sci., 2005, 1056, 218–233.
In the near past, inflammation has been not be delivered to the society for its clini- 9. Xiao, C. W, Wood, C. and Gilani, G. S.,
associated with the pathogenesis of athero- cal use and for this, collaborative research J. AOAC Int., 2006, 89, 1207–1214.
sclerosis5 and inflammatory genes are in project mode with leading laboratories 10. Tripathi, Y. B., Singh, B. K., Pandey,
R. S. and Kumar, M., Evidence-based
good candidates for the risk of developing and hospitals is needed. The Ministry of
Complementary Alternative Medicine,
atherosclerosis. Further, vascular miner- Health and the Ministry of Science and
2005, 2, 217–221.
alization and loss in bone density have Technology, Government of India, must 11. Tripathi, Y. B., Reddy, M. M., Pandey,
been significantly correlated by clinical take up this project for further studies, by R. S., Subhashini, J., Tiwari, O. P., Singh,
and experimental investigations (genetic, breaking the boundaries of ayurvedic and B. K. and Reddanna, P., Inflammophar-
hormonal and biochemical)6, and indi- allopathic drugs. macology, 2004, 12, 131–152.
cate common signalling pathways, tran- Studies in terms of multi-centric clini- 12. Chaurasia, S., Tripathi, P. and Tripathi,
scription factors and extracellular matrix cal trials, toxicity and side effects, accu- Y. B., Indian J. Exp. Biol., 1995, 33, 428–
interactions for both skeletal and vascu- mulative consequences when given with 432.
lar abnormalities. Various common risk conventional drugs of these diseases and 13. Tripathi, Y. B., Tripathi, P., Korlagunta,
K., Chai, S. C., Smith, B. J. and Arjmandi,
factors have been suggested, such as aging, also pharmaco-genomics are needed.
B. H., Inflammation, Pubmed (ahead of
estrogen deficiency, vitamin D and K These studies will help doctors in mak-
print) 9 August 2007.
abnormalities, chronic inflammation and ing specific recommendations of BHUx
oxidative stress1. Pro-inflammatory cyto- to various patients with these age-related
kines, like interleukin-6 and tumour necro- diseases, such as type-2 diabetes, athero- Yamini B. Tripathi* is in the Department
sis factor-alpha, C-reactive protein, sclerosis, cancer and osteoporosis ac- of Medicinal Chemistry, Institute of
resistin, an adipokine, and polymorphism cording to the individual’s susceptibility Medical Sciences, Banaras Hindu Uni-
of the Toll-like receptor 4 are also impli- for better response. versity, Varanasi 221 005, India; Deep-
cated in the development of atherosclero- Without coordinated efforts of scien- shikha Tripathi is in R&D Centre, Prof.
sis and osteoporosis7. Recent evidence tists and doctors, from leading laborato- S.N. Tripathi Memorial Foundation, 1,
indicates that LOX genes are associated ries of our country, BHUx can never be Gandhi Nagar, Naria, Varanasi 221 005,
with osteoporosis and atherosclerosis8. delivered to the international society and India. *e-mail: email@example.com
1658 CURRENT SCIENCE, VOL. 93, NO. 12, 25 DECEMBER 2007