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The St George Hospital and Community Health Service (SGH) 2003/04 research activities Title of research project Dept or institution on Researcher Brief description of research whose behalf the research is being undertaken Acute Care Nursing Professorial Unit (ACNPU), SEH and SGH Evaluation of after hours clinical nursing ACNPU, Division of Blay N, Donoghue J, Evaluation of the roles of the after hours clinical support service. Critical Care and Surgery, Jones S, Kingston S. support nurses, division of critical care and SGH. surgery. Education and support needs of Arabic- ACNPU, Division of Bothe J, Mitten-Lewis S, Pre and post-discharge interviews with 28 speaking patients. Critical Care and Surgery, Chalitta V. Arabic-speaking patients. Qualitative data on Clinical Practice their experiences, participation and adequacy Improvement Unit, SGH. of information provision. Prevention of inpatient falls on Aged ACNPU, Clinical Practice Donoghue J, Murphy M, Use of volunteer companion-observers to Care ward. Improvement Unit, Graham J, Lamey M. prevent falls of at-risk patients assigned to Aged Care, SGH. special 4-bedded rooms on the ward. Managing medications misadventure. ACNPU, Division of Donoghue J, Cahill P, Aim to develop a sustainable process of risk Nursing and Community Mant A, Stelter K, Tierney J, identification and discharge planning for older, Care, Wards 3 East and 3 Melbourne G. community-dwelling patients at risk of South and Pharmacy medicines misadventure. SGH, St George Division of General Practice, Quick Response Program and Heart Failure Program. . Improving elderly patients’ use of patient ACNPU, Pain Donoghue J, Melbourne G. Investigating if a post operative coaching control analgesia. Management Team, intervention will improve elderly patients’ use of SGH. patient control analgesia. Pilonidal sinus wound healing. ACNPU, SGH, Stewart A, Donoghue J, Descriptive study describing the course of Sutherland Hospital, Melbourne G, Rogan F, wound healing in patients who have a pilonidal Southcare, UTS Faculty Wyllie A, Doolan K. sinus surgically managed. of Nursing Midwifery and Health. Identification and nursing response to ACNPU, Haemodialysis Tranter S, Donoghue J. Ethnographic study of the haemodialysis unit at patients with ESRF treated with Unit SGH. SGH. haemodialysis. SGH Patient Evaluation of Care Survey. ACNPU, Clinical Practice Mitten-Lewis S, Challita V, Develop an instrument to collect patient Improvement Unit, SGH. Donoghue J, Warner A. feedback, based on validated tool. Survey one month’s discharges from each ward on a rolling basis. Morbidity serving tool for surgical ACNPU, Division of Eather B, Donoghue J, Development of objective post operative patients related to “failure to rescue” Critical Care and Surgery Kam P. scoring parameters to assess patient risk and patients. 5 West, SGH. instigate medical response. Outcomes for patients following insertion ACNPU, Division of Patton V, Donoghue J, The study aims to identify patients’ outcomes in of Chait trapdoor caecostomy catheter Critical Care and Surgery Lubowski D. bowel management and quality of life following for antegrade colonic enemas. SGH, St George Private the surgical procedure. Hospital Development of a feedback system for ACNPU SGH, Donoghue J, Watterson P. Development of a feedback device/system to elderly patients using patient control Engineering UTS. provide patients with auditory and visual analgesia. (PCA) post operatively. feedback to improve the use of patient control analgesia. A model of nursing care for day surgery ACNPU, Division of Bothe J, Donoghue J. Development of a nursing care model for day patients. Critical Care and Surgery, surgery patients based on patient centredness, SGH. effectiveness and patient safety. Department of Cardiothoracic Surgery Novel Gene Targeting agents for the Cardiothoracic Surgery Giradi. This research has a great potential for local treatment of Intimal Hyperplasia in SGH, Centre for Vascular discovering novel therapy agents for treatment rabbit models of vein bypass grafting. Research, UNSW. of vein graft athero sclerosis. The project aims to demonstrate an inhibitor of neointima formation in the vein graft of the rabbit model by the use of DNA enzymes in vivo. Emergency Department Management of acute bacterial meningitis in Emergency Department Grant P. Formulation of Greater Eastern Sydney Child Health children. SGH. Network guidelines (GESCHN). One year review of the Emergency Medicine Emergency Department Chan T, Chan A, Lee J. Retrospective review of patient profiles for Unit at St George Hospital. SGH. Emergency Medicine Unit admissions and the impact on emergency department and hospital length of stays, occupied bed days and representation rates for the top 10 diagnostic reference groups. Review of patients admitted to the ward from Emergency Department Chan T, Donnelly D. Determining patient profiles leading to ongoing the Emergency Medicine Unit . SGH. hospital management from Emergency Medicine Unit. Fractured neck of femur collaboration. Emergency Department Chan T. Streamlining management of patients with fractured SGH. neck of femur through a multi disciplinary approach. Evaluation of an outpatient early pregnancy Emergency Department Brownlea S, Holdgate A. A retrospective review of the success of an early problem service. SGH. pregnancy problem service initiative. Emergency management of the morbidly Emergency Department Newcombe M, Grant P. Literature review of Emergency Department issues obese. SGH. relevant to the morbidly obese. CATCH Study - Comparison of blood Emergency Department Somerville A, Dwyer D, A study comparing haemolysis rates for different collection through intravenous devices. SGH. Fry M. methods of venous blood collection. Retrospective review of narcotic usage in the Emergency Department Fry M, Arendts G. A study into the factors which result in delayed emergency department. SGH. narcotic analgesia for patients. Characteristics and profiles of mental health Emergency Department Fry M, Brunero S. A retrospective review of mental health patients patients presenting to the emergency SGH. presenting to the Emergency Department. department.. Review of clinical initiative nurse role in the Emergency Department Fry M, Jones K. A retrospective study to evaluate the efficacy of the emergency department. SGH. clinical initiative nurse. A systematic review of adenosine versus Emergency Department Holdgate A, Foo A. A review of the usage and efficacy of adenosine verapamil for SVT. SGH. versus verapamil for terminating supraventricular tachycardia. A review of the diagnosis and management Emergency Department Dunlop S, Holdgate A, Literature review of blunt aortic branch injuries with of aortic branch injuries in blunt trauma. SGH. Dwyer D. reference to a case report. A retrospective review of adult mortality Emergency Department Fry M, Rhodes-Sutton A. A retrospective review of patients who died in the characteristics of patients presenting to a SGH. Emergency Department or after admission to ward. metropolitan tertiary emergency department. Patients regularly leave emergency Emergency Department Fry M, Thompson J, Chan A. A study into why patients leave the Emergency departments before medical assessment. A SGH. Department before being seen by a medical officer study of did not wait patients, medical profile and the outcome to the patient. and outcome characteristics. A prospective study of nurse initiated Emergency Department Fry M, Ryan J, Alexander N. A study aimed to improve the efficiency and panadeine forte: expanding pain SGH. effectiveness of timely analgesia for patients in management in the emergency department. moderate pain and who had a significant delay prior to medical assessment. Bringing relevant information to diverse Emergency Department Fry M, Ajami A, Borg A. An education project to inform the local non-english groups about emergency department SGH. speaking community about health care choices. services. The “BRIDGE” project. Enteral versus intravenous rehydration Emergency Department, Fonseca B, Holdgate A, A meta-analysis of randomised controlled trials therapy for children with gastroenteritis: a Paediatrics Department, Craig J. comparing intravenous versus enteral hydration for meta-analysis of randomised controlled trials SGH. acute paediatric gastroenteritis. Nonsteroidal anti-inflammatory drugs Emergency Department Holdgate A, Pollock T, A Cochrane review comparing efficacy of NSAIDS (NSAIDS) versus opioids for acute renal SGH. versus opioids in acute renal colic. colic. Comparison of a verbal numeric rating scale Emergency Department Holdgate A, Asha S, To test the agreement between VAS and VNRS in with the visual analogue scale for the SGH. Craig J, Thompson J. the management of presentations with acute pain. management of acute pain. International EMS Systems: New South Emergency Department Trevithick S, Flabouris A, An analysis of NSW Emergency Medicine Services. Wales, Australia. Retrieval Service. Tall G, Webber CF. The accuracy of external blood loss Emergency Department Tall G, Wise D, Grove P, A study of the accuracy of observed acute blood estimation by ambulance and hospital Retrieval Service. Wilkinson C. loss by Emergency healthcare providers. personnel. Cranial CT interpretation by senior Emergency Department , Arendts G, Manovel A, Review of the accuracy of cranial CT interpretation emergency department staff. Radiology Department, Chai A. by senior emergency clinicians. SGH. Department of Gastroenterology, Motility Research Unit Colonic motility research program. Gastroenterology Motility Cook I, Dinning P, Overall aims to clarify the mechanism Research Unit SGH. Szczesniak M, underpinning propulsive motor patterns and Fuentealba S. how they are affected in disorders of defaecation such as severe constipation as a prelude to examine novel therapeutic techniques. Oesophago-pharyngeal research Gastroenterology Motility Cook I, Dinning P, Overall aims to investigate the mechanisms of program. Research Unit SGH. Szczesniak M, pharyngeal neuromuscular dysfunction in Fuentealba S. swallowing disorders and which underlie oesophago-pharyngeal regurgitation and to examine mechanisms underpinning disordered oesophageal sensory perception. Division of Intensive Care Signs of critical conditions and Division of Intensive Harrison D (PI), Jacques T, Cross sectional case note review for early and emergency responses (SOCCER). Care, SGH. McLaws ML, Kilborn G. late signs of critical conditions in 3160 admissions in general wards across 5 SEH hospitals to establish the prevalence and predictive value of the signs. Intensive Care Medicine A comparison of albumin and saline for Clinical Trials Group, Myburgh JA (PI), A 7,000 patient, multi-centred, double blind fluid resuscitation in the intensive care Australian and New Jovanoversuska A, randomised controlled trial. unit (SAFE). Zealand Intensive Care Hodgetts M, Girling K, Society, the George Skowronski G, Jacques T, Institute for International O’Leary M, McKeag A. Health and the Australian Red Cross Blood Transfusion Service. Quantification of outcomes of patients Clinical Trials Group, Myburgh JA (PI), Post hoc analysis and follow-up of 468 patients with traumatic brain injury in the SAFE Australian and New Jovanoversuska A, Girling with traumatic brain injury enrolled in the SAFE study (above). Zealand Intensive Care K. study. Completion of 24-month functional Society, the George outcome assessments of 27 patients at SGH in Institute for International June 2005. Health and the Australian Red Cross Blood Transfusion Service. A comparison of adrenaline and Intensive Care Medicine Myburgh JA (PI), A 250 patient, double blind, randomised noradrenaline in reversing shock in SGH. Jovanoversuska A, controlled trial. critically ill patients – the CAT study. Hodgetts M, Girling K, Skowronski G, Jacques T, O’Leary M, McKeag A. Normoglycaemia in Intensive care – the Clinical Trials Group, Myburgh JA (PI), A 4000 patient, multi-centred randomised trial NICE study. Australian and New Jovanoversuska A, assessing the effect of an intensive insulin Zealand Intensive Care Hodgetts M, therapeutic strategy on outcome in critically ill Society. Girling K, Skowronski G, patients. Jacques T, O’Leary M, McKeag A. The effects of dexanabinol on outcome Omnicare, Pharmos Myburgh JA (PI), An international Phase III clinical drug trial of this for isolated traumatic brain injury. corporation. Jovanoversuska A, synthetic cannabinoid looking at the safety and Hodgetts M, efficacy of neuroprotection for head injured Girling K. patients. International recruitment completed in May 2004. Parenteral versus enteral nutrition in Intensive Care Medicine, O’Leary M (PI). Research study in an animal model of sepsis. sepsis: influence on the growth hormone SGH in collaboration with – IGF-1 axis. the Department of Surgery, Royal North Shore Hospital. Supported in part by a grant from ANZCA An analysis of agreement between Intensive Care Medicine, Kulkarni A, Saxena M, Prospective study of blood glucose capillary and arterial blood glucose SGH. Price G, Myburgh JA, measurements in intensive care patients – 500 measurements in critically ill patients. Jacques T, O’Leary M. paired measurements. Correlation of levels of -Atrial Intensive Care Medicine, Price g (PI), Kulkarni A, Descriptive physiological study in five intensive Natriuretic Peptide and ACE inhibition in SGH. Saxena M, Myburgh JA, care patients. mechanical ventilated patients. O’Leary M Prospective survey of microbial antibiotic Intensive Care Medicine, Kulkarni V (PI), Jacques T, Survey of the incidence and prevalence of resistance patterns in the Intensive Care SGH. O’Leary M, Taylor P. antibiotic resistant organisms in patients Unit (ICU). admitted to ICU over three months. Their acquisition and changes in superficial body flora were documented. The influence of different parenteral Intensive Care Medicine, Dan A (PI), O’Leary M, An investigation of the effect of changing from a nutritional solutions on glycaemic control SGH. Jacques T. glucose based to a lipid based nutrition solution in ventilated ICU patients. on glycaemic control in patients treated with an intensive insulin protocol. Medical Physics Department National intercomparison of radiation Sir Charles Gairdner Duggan L (one of five Quantify doses delivered to prostate patients doses delivered in high dose rate Hospital, Perth (Principle principle investigators participating in brachytherapy clinical trials in prostate brachytherapy. Investigator Ms Annette nationally). Australia. Haworth). Verification of doses delivered to the Prostate Cancer Institute, Duggan L, Bucci J. Measurements of the dose distribution in the tumour and critical structures in prostate SGH. tumour during prostate brachytherapy. brachytherapy using thermoluminescence dosimeters. Quality assurance of LDR and HDR University of Wollongong Bucci J, Duggan L, Enari E, Design of new detectors for quality assurance in prostate brachytherapy. Rule G. prostate brachytherapy. Design of quality assurance phantoms Prostate Cancer Institute Rule G. Design and manufacture of tissue-equivalent for prostate brachytherapy. SGH, University of phantoms for verification of dose delivered to Wollongong. prostate and critical structures during brachytherapy. Use of LA48 linear array for daily UNSW, Cancer Care Howie A, Gupta R, Development of new technique for performing constancy checks (photons). Centre SGH. Khanna S. daily constancy checks – increasing speed and accuracy/reproducibility. Use of LA48 linear array for daily Cancer Care Centre Howie A Gupta R, Expansion of new technique for daily constancy constancy checks (electrons). SGH. Khanna S. checks to include electron beams. Department of Nuclear Medicine Vasodilator induced stress in Nuclear Medicine, SGH. Butler P. A new vasodilator, Binodenosine, for cardiac concordance with Adenosine. VISION. stress imaging. Thromboview study. Nuclear Medicine, SGH. Butler P. A protein fragment for deep vein thrombosis imaging. Technegas study. Nuclear Medicine, SGH. Butler P. Assessment of a lung perfusion imaging technique. Y-90 SIRspheres for carcinoid liver Nuclear Medicine and Quinn R, Morris D. Yttrium 90 labelled microspheres for carcinoid metastases. Surgery, SGH. liver tumours. Tc99m rt-PA for DVT. Nuclear Medicine and Butler P, Brighton T. For the detection of deep vein thrombosis. Haematology, SGH. Tc 99m HMPAO brain imaging. Nuclear Medicine and the Nour R, Morris A. Cerebral imaging for patients with urinary Pelvic Floor Physiology incontinance. Unit, SGH. SPECT lung perfusion study. Nuclear Medicine, SGH. Nour R. Tomographic imaging of lung perfusion scans. Orthopaedic Research Institute, Department of Orthopaedic Surgery Long-term outcomes after rotator cuff Orthopaedic Research Walton JR, Murrell GAC, The results of this clinical study will furnish as repair. Institute SGH, Cummins CA. knowledgeable basis for advising patients on Lake Cook Orthopaedic how long is required for full recovery of strength, Associates, Chicago. range of motion, and loss of pain after surgery for rotator cuff tear. Diagnostic values of tests for Orthopaedic Research Walton JR, Paxinos A, A comparison of tests to determine the most acromioclavicular joint pain. Institute SGH, Melbourne Murrell GAC. effective non-invasive way to diagnose Orthopaedic Group. acromioclavicular joint pain. An improved diagnostic staining method Orthopaedic Research Walton JR, Diamond T, We have developed a new staining method for for bone diseases. Institute SGH. Clark W, Gupta S, bone that we expect to be useful for Murrell GAC. investigating the cause of osteoporosis and some other bone diseases. Assessment of shoulder problems in Orthopaedic Research Sein ML, Appleyard RC, This study investigates the nature and causes elite swimmers. Institute SGH, NSW Walton JR, Kuah D of shoulder pain in a large proportion of elite Institute of Sport. Murrell GAC. Australian swimmers. The development of shoulder stiffness Orthopaedic Research Trenerry K, Walton JR, This study analyses the causes for shoulder after rotator cuff repair. Institute. Murrell GAC. stiffness. An autologous cell injection-based Melbourne Orthopaedic Paxinos A, McClelland D, This randomised clinical investigates the treatment for tennis elbow. Group Vic, Orthopaedic Walton JR. efficacy of a new non-steroidal treatment for Research Institute SGH. tennis elbow. Long-term follow-up of patients who Orthopaedic Research Bowman N, Khatib Y, This clinical study compares the long-term received “Restore” (biological tissue) Institute SGH. Walton JR, Murrell GAC. results from patients whose large shoulder tears patches for their large rotator cuff tear were repaired using tissue-engineered repair. “Restore” patches with others repaired without “Restore” patches. Hip replacement cup. Orthopaedic Department Sekel R, Wingrove P. Equator plus cup to eliminate backwear of SGH, Portland polythene osteoblast of diphosphonates. Orthopaedics. Bone deposition/osteoblasts. Orthopaedic Department Sekel R, McLeod K. Osteoblast activity in the presence of SGH, Ian Wark Institute, diphosphonates plus variable electrical fields. University of South Australia. Revision knee replacement. Orthopaedic Department Sekel R, Barker D. Development of a tertiary knee replacement SGH, Portland system using five axis taper. Orthopaedics. Margron hip replacement stem. Orthopaedic Department Sekel R. Ongoing prospective 10 year clinical trial – SGH, Portland primary revision and mini-series stems. Orthopaedics. Hydroxy-apatite irradiation. Monash University, Sekel R, Gross K. Effects of irradiation on hydroxy-apatite Orthopaedic Department properties. SGH. DEXA studies on total hip replacements. Orthopaedic Department Sekel R, Eberle R. DEXA results after total hip replacements. SGH. Inhibition of urokinase receptor (uPAR) Orthopaedic Research de Bock CE, Lin Z, UPAR is a key enzyme receptor and plays gene expression by DNAzymes in Institute SGH. Itoh T, Morris D, Murrell important roles in cancer and inflammation. We osteosarcoma cells. GAC, Wang Y. have designed and characterised an anti-uPAR DNAzyme. Novel interacting partners of urokinase Orthopaedic Research de Bock C, Lin Z, Morris D, Evaluation of a novel uPAR partner fibulin-2. receptor and the function of their Institute SGH. Murrell G, Wang Y. interactions. Small interfering RNA (siRNA)-directed Orthopaedic Research Lin Z, Morris D, Wang Y. The aim of this proposal is to study whether the knockdown of tumour necrosis factor Institute SGH. TNF alpha can be inhibited by short interfering alpha (TNFa), a potential gene therapy RNAs (siRNA)-mediated gene silencing. approach for arthritis. Micro Indentation system. Orthopaedic Research Appleyard RC, Murrell GAC. Developing a micro-indentation device for Institute SGH. assessing the mechanical properties of fracture callus. New locking plate system for fixation of Orthopaedic Research Appleyard RC, Harris I. Comparing conventional and new locking plate osteoporotic bone: A biomechanical Institute SGH. systems in the fixation of normal and study. osteoporotic bone. Orthopaedic Research Institute shoulder Orthopaedic Research Appleyard RC, Sein ML, Developing a device for assessing the laxity of stability assessment device. Institute SGH. Walton JR, Murrell GAC. the shoulder. Effect of nitric oxide on bone fracture Orthopaedic Research Baldik Y, Diwan AD, Nitric oxide and fracture healing with the NO strength. Institute SGH. Appleyard RC, Janssen J, donor nitrosoalbumin. Murrell GAC. Can recombinant BMP-7 enhance Stryker Biotech, Diwan AD, Leong A. Fracture healing is impaired in osteoporotics. osteoporotic fracture healing? Orthopaedic Research We wonder whether RhBMP-7 used for new Institute SGH. bone formation, can enhance fracture healing in osteoporotics. Can autologous bone marrow-derived Orthopaedic Research Diwan AD, Ma D. Our work will evaluate the safety and efficacy of stem cells cure chronic back pain? Institute SGH, The using bone marrow-derived stem cells to repair Garvan Institute. intervertebral discs. Genetic basis of Klippel-Feil syndrome. Orthopaedic Research Diwan AD, Fang Z, Genetic basis of Klippel-Feil syndrome. Institute SGH. Clarke R, Murrell GAC. Oxidative stress and antioxidant Orthopaedic Research Wang M-X. Oxidative stress and antioxidant enzymes in enzymes in osteoarthritis. Institute SGH. osteoarthritis. Effects of NicOx compounds on Orthopaedic Research Wang M-X. Effects of NicOx compounds on chondrocyte chondrocyte function. Institute SGH. function. Telomerases in intervertebral disc Orthopaedic Research Chung S, Murrell GAC, Investigating the effect s of exogenous human degeneration. Institute SGH. Diwan AD. telomerase (hTERT) gene expression in cultured sheep annulus fibrosus and nucleus pulposus cells. Rotator cuff repair with bioabsorbable Orthopaedic Research Cummins C, Strickland S, In vivo evaluation of the clinical outcomes of screws. An in vivo and ex vivo Institute SGH. Appleyard R, Szomor Z, rotator cuff repairs with bioabsorbable screws investigation. Marshall J, Murrell G. compared with metal suture anchors, and comparing the ex vivo initial load to failure of rotator cuff repairs using three different bioabsorbable screws, suture anchors and transosseous sutures. Accuracy and reliability of arthroscopic Rheumatology and Oakley S, Portek I, The goal of the study was to determine the estimates of cartilage lesion size in Orthopaedic Surgery Szomor Z, Turnbull A, accuracy and reliability of arthroscopic percent aplastic simulation model. SGH, Dept of Murrell G, Kirkham B, estimates in a plastic knee simulation model. Rheumatology, Guys’ Lassere M. and Thomas’ Hospital, London. Mode of failure for rotator cuff repair with Lake Cook Orthopaedic Cummins C, Appleyard RC, Determining the primary mode of mechanical suture anchors. Associates, Barrington IL, Murrell G. failure for rotator cuffs repaired with suture Orthopaedic Research anchors at the time of revision rotator cuff Institute SGH. repair. A novel mutation in the non-helical linker Dermatology and Zhao YL, Kemp M, A novel mutation in the non-helical linker L1-2 L1-2 domain of keratin 14 in patients orthopaedic Surgery, Klingberg S, Welsey J, domain of keratin 14 in patients with Weber- with Weber-Cockayne epidermolysis SGH. Wang Y, Murrell GAC. Cockayne epidermolysis bullosa simplex. bullosa simplex. Expression of urokinase-type Orthopaedic Research Xia W, de Bock CE, Murrell Using a rat Achilles tendon model to study plasminogen activator and its receptor is Institute SGH. GAC, Wang Y. mRNA and protein expression of uPA and its upregulated during tendon healing. receptor (uPAR) during tendon healing, using immunohistochemical, Northern and Western blot analyses. Addition of nitric oxide via Orthopaedic Research Yuan J, Murrell GAC, A study to determine if the addition of nitric nitroflurbiprofen enhances the material Institute SGH, Wei A-Q, Appleyard RC, oxide (NO) via nitroflurbiprofen would enhance properties of healing Achilles tendon. NicOx Foundation, del Soldato P, Wang M-X. rat Achilles tendon healing. France. Involvement of cytochrome c release Orthopaedic Research Yuan J, Murrell GAC, Investigating the effect of oxidative stress on and caspase-3 activation in the oxidative Institute SGH. Wei A-Q, Wang M-X. human tendon cell apoptosis and to explore stress induced apoptosis in human pathways by which tendon cell apoptosis was tendon fibroblasts. induced. Topographical analysis of the structural, Orthopaedic Research Appleyard RC, Studying the relationship between the biochemical and dynamic biomechanical Institute SGH, Division of Burkhardt D, Ghosh P topographical variations in the structural, properties of cartilage in an ovine model Veterinary and Read R, Cake M, Swain M biochemical and dynamic biomechanical of osteoarthritis. Biomedical Sciences Murrell GAC. properties of articular cartilage in order to Murdoch University, understand the role of mechanical factors on Department of the pathogenesis of osteoarthritis. Mechanical Engineering University of Sydney. The roles of growth factors in tendon and Orthopaedic Research Molloy T, Wang Y, The roles of growth factors in tendon and ligament healing. Institute SGH. Murrell GAC. ligament healing. Adenovirus mediated gene transfer for Orthopaedic Research Dai Q, Manfield L, Wang Y Investigating the transfection of Ad5CMVntLacZ tendon healing – enhanced efficiency Institute SGH. Murrell GAC. in primary cultured human rotator cuff tendon using a gelatin sponge. cells and in a rat Achilles tendon healing model in vivo as a potential method for enhancing tendon healing. Topical nitric oxide application in the Orthopaedic Surgery and Paoloni J, Appleyard R, Investigating topical nitric oxide donation in treatment of chronic extensor tendinosis Pharmacy SGH. Nelson J, Murrell GAC. treating chronic elbow tendinopathy. at the elbow: a randomized,double-blind, placebo controlled clinical trial. The rotator cuff: biological adaptations to Orthopaedic Research Malcarney H, Murrell GAC. A study of adaptive characteristics of the rotator its environment. Institute SGH. cuff and possible predisposition of the tendon complex to pathology. Cell death and tendinopathy. Orthopaedic Research Yuan J, Wang M-X, Cells of injured rotator cuff tendons have much Institute SGH. Murrell GAC. higher rates of apoptosis than cells of uninjured tendons. This study investigates why tendons exposed to excessive strain may become tendinopathic. Meshes in rotator cuff repair. A Orthopaedic Surgery Muller M, Appleyard RC, Aims to determine which meshes have the best biomechanical study. SGH. Osbahr D, Murrell GAC. mechanical properties for rotator cuff repair. Topical administration of the nitric oxide Veterinary and Cake M, Appleyard RC, Examines the effect of topical administration of donor glyceryl trinitrate modifies the Biomedical Sciences Read R, Ghosh P, glyceryl trinitrate (GTN) on the structural and structural and biomechanical properties Murdoch University, Swain M, Murrell GAC. biomechanical properties of uncalcified articular of ovine articular cartilage. Orthopaedic Surgery cartilage. SGH, Institute of Bone and Joint Research Royal North Shore Hospital, Faculty of Dentistry and Dept of Mechanical Engineering USYD. Meniscal and chondral loss in the Orthopaedic Research Jones HP, Appleyard RC, Investigating in vitro adaptive response of anterior cruciate ligament (ACL) injured Institute SGH. Mahajan S, Murrell GAC. secondary soft tissue restraints to chronic laxity knee. resulting from ACL transection. Shoulder stiffness: diagnosis. Orthopaedic Research Bhargav D, Murrell GAC. Examines the functional anatomy of the Institute SGH. shoulder joint, the pathology of the conditions that lead to shoulder stiffness and methods to differentiate them. Shoulder stiffness: management. Orthopaedic Research Bhargav D, Murrell GAC. Examines the methods available to treat the Institute SGH. various causes of stiff shoulders. An assessment of the inter-examiner Orthopaedic Research Tzannes A, Paxinos A, Estimating the reliability of commonly used reliability of tests for shoulder instability. Institute SGH. Callanan M, Murrell GAC. clinical tests for shoulder instability using an interexaminer agreement trial. The Orthopaedic Research Institute – Orthopaedic Research Paoloni J, Appleyard RC, Designing a testing system to record objective tennis elbow testing system: a modified Institute SGH. Murrell GAC. measurements of force generated with a chair pick-up test. Inter-rater and intra- resisted ankle plantarflexion test. rater reliability testing. Temporal outcomes of arthroscopic Orthopaedic Research Paxinos A, Walton JR, A prospective study aimed at documenting the stabilisation of superior labral (SLAP) Institute SGH. Rutten S, Muller M, pain and functional outcomes, over time, of tears with biodegradable tac. Murrell GAC. patients whose superior labral (SLAP) lesions had been repaired with bioabsorbable tacs. A randomised clinical trial investigating Orthopaedic Research Hayes K, Ginn K, Walton This study involved undertaking a randomised the efficacy of physiotherapy after rotator Institute SGH, Faculty of JR, Murrell GAC. clinical trial to compare outcomes for two forms cuff repair. Health Sciences USYD. of rehabilitation following rotator cuff repair. Identification of prognostic indicators for Orthopaedic Research Paoloni J, Appleyard RC, Identification of prognostic indicators for patient patient outcomes in extensor Institute SGH. Murrell GAC. outcomes in extensor tendinopathy at the tendinopathy at the elbow. elbow. Diagnostic values of tests for Orthopaedic Research Walton JR, Mahajan S, A prospective study to determine which clinical acromioclavicular joint pain. InstitutE SGH. Marshall J, Bryant C, and imaging tests were most helpful for Shnier R, Quinn R, diagnosing acromioclavicular joint pain. Murrell GAC. A randomised, double-blind, placebo Orthopaedic Research Paoloni J, Appleyard RC, A randomised, double-blind, placebo controlled controlled clinical trial investigating the Institute. Murrell GAC. clinical trial investigating the use of topical nitric use of topical nitric oxide application in oxide application in the treatment of achilles the treatment of Achilles tendonitis. tendonitis. Overexpression of anti-oxidant enzyme Orthopaedic Research Yuan J, Murrell GAC, An in vitro study investigating the protective role peroxiredoxin 5 protects human tendon Institute, Clinical Wei A-Q, Trickett A, played by PRDX5 in human tendon cells cells against apoptosis and loss of Haematology and SEALS Landtmeters M, Knoops B, against oxidative stress by reducing apoptosis cellular function during oxidative stress. Haematology SGH, Wang M-X. and maintaining collagen synthesis. Laboratory of Cell Biology, Univeriste Catholique de Louvain, France. Biomechanical, histologic and Orthopaedic Research Oakley S Biomechanical, histologic and macroscopic macroscopic assessment of articular Institute and Haen P-S, Portek I, assessment of articular cartilage in a sheep cartilage in a sheep model of Rheumatology, SGH. Szomor Z, Ghosh P, model of osteoarthritis. osteoarthritis. Kirkham B, Murrell GAC. The effects of thermal capsular Orthopaedic Research Chen S, Haen P-S, Walton A study to determine if patients with recurrent shrinkage on outcomes of arthroscopic Institute SGH, JR, Murrell GAC. anterior shoulder instability who have labral stabilization for primary anterior shoulder Department of Sports repair plus arthroscopic thermal capsulorrhaphy instability. Medicine Huashan have better outcomes than those with labral Hospital, Shanghai repair alone. China. Rotator cuff repair: an ex vivo analysis of Lake Cook Orthopaedic Cummins CA, Appleyard Determining the best combination of anchors suture anchor repair techniques on initial Associates, Orthopaedic RC, Strickland S, Haen P-S, and suture techniques for repairing torn rotator load to failure. Research Institute, Chen S, Murrell GAC. cuff tendons. Hospital for Special Surgery, New York. Clinical diagnosis of a superior glenoid Orthopaedic Research Muller M, Murrell GAC. Clinical diagnosis of a superior glenoid labrum labrum cyst with suprascapular nerve Institute SGH. cyst with suprascapular nerve entrapment entrapment (GLEN) lesion. (GLEN) lesion. An evaluation of the effects of the extent Orthopaedic Research Bhargav D, Murrell GAC. Evaluating effects of the extent of surgical of capsular release and of post-operative Institute SGH. release and of pos-operative physiotherapy on therapy on the temporal outcome of the outcomes of this procedure. adhesive capsulitits. A randomised, double-blind, placebo Orthopaedic Research Paoloni J, Appleyard RC, A randomised, double-blind, placebo controlled controlled clinical trial investigating the Institute SGH. Murrell GAC. clinical trial investigating the use of topical nitric use of topical nitric oxide application in oxide application in the treatment of chronic the treatment of chronic supraspinatus supraspinatus tendonosis. tendonosis. The role of ultrasound in diagnosing Orthopaedic Research Murrell GAC, Ryder S, The role of ultrasound in diagnosing rotator cuff rotator cuff pathology. Institute SGH. Bowman N. pathology. Ovariectomy alters the structural and School of Veterinary and Cake M, Appleyard RC, This study examines the effect of oestrogen biomechanical properties of ovine Biomedical Sciences Read R, Smith M, Murrell depletion on the structural and chemical femoro-tibial articular cartilage and Murdoch University, GAC, Ghosh P. properties of articular cartilage and the upregulates cartilage iNOS. Orthopaedic Research production of nitric oxide synthase and Institute SGH, Institute of nitrotyrosine by these tissues. Bone and Joint Research, Royal North Shore Hospital. A novel mutation in the non-helical linker Dermatology and Kemp M, Zhao YL, A novel mutation in the non-helical linker L1-2 L1-2 domain of keratin 14 resulting in a Orthopaedic Research Klingberg S, Wesley J, domain of keratin 14 resulting in a different different phenotype of epidemolysis Institute SGH. Wang Y, Lloyd L, Murrell phenotype of epidermolysis bullosa simplex. bullosa simplex. GAC, Murrell DF. Arthroscopy – a potential “gold standard Orthopaedic Research Oakley S, Portek I, Szomor Arthroscopy – a potential “gold standard for the for the diagnosis of the early Institute and Z, Appleyard RC, Ghosh P, diagnosis of the early chondropathy of early chondropathy of early osteoarthritis. Rheumatology SGH. Kirkham B, Murrell GAC. osteoarthritis. Effect of tissue strain on cell metabolism. Orthopaedic Research Suenaga N, Little C, Load various tendons and cell seeded Institute SGH, Raymond Appleyard RC. constructs to investigate the effect of cyclic Purves Laboratories loading on cellular response. Royal North Shore Hospital. Effect of age on articular cartilage. Orthopaedic research Ho R, Appleyard RC. Correlating the change in the indentation Institute SGH, properties of sheep cartilage with increasing Department of age. Mechanical Engineering, USYD. Optical strain measurement system. Orthopaedic Research Errington B, Khanna S, Developing a system to measure the in-vitro Institute and Cancer Care Appleyard RC. strain profile in tendon while under load. Research Institute SGH, Department of Mechanical Engineering, USYD. Effect of age on spine stability. Orthopaedic Research Clarke e, Appleyard RC, Investigating the alteration in the biomechanical Institute SGH, Institute of L Bilston. properties of spinal motion segments with age Biomedical Research, in sheep. Prince of Wales Hospital. Sexual Health Unit Switching from Sildenafil citrate (Viagra) E-Lily. Carmody C. Study completed approx 30 recruited and only to Tadalafil (Cialis) in treatment of about 20 completed the study due to: didn’t erectile dysfuntion: multinational meet with inclusion criteria, protocol violations. assessment of treatment practice. A double-blind, randomised, active Norvartis. Carmody C. Nil recruitments therefore have withdrawn from controlled, multi-center study to assess the study. the efficacy and safety of self-initiated short course (2day) oral famiciclovir therapy in immunocompetent patients with active recurrent genital herpes. Speech Therapy Clinical signs of dysphagia and Speech Pathology SGH. Relf W. To reduce stroke related complications, aspiration after stroke: Lesion analysis effective ways to screen and accurately identify by CT and MRI. patients at risk of swallowing difficulties (dysphagia) and aspiration after stroke are needed. To date, neither a core of clinical predictors, nor lesion site, has provided a valid and reliable screening tool. To further previous studies this research aims to evaluate a possible relationship between lesion location and 6 previously identified clinical predictors of risks of aspiration in acute stroke patients. Division of Women and Children’s Health Postnatal Outcomes Project (POP). 1 West Postnatal SGH, in Schmeid V (UTS), Research, conducted on the postnatal ward at partnership with Centre Gutwein R, Steinlein E, SGH, aimed to improve hospital based for Family Health and Cooke M (UTS), postnatal care. The study described the Midwifery UTS. Wong P (UTS). postpartum midwifery care required by women, midwives’ perception of what constitutes quality postnatal care and the strategies designed to improve the quality of hospital based postnatal care.