Long-Term Dialysis Is a Renal Tx Risk by ProQuest


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      www.renalandurologynews.com                                                                                   DECEMBER 2008          Renal & Urology News 23

       Long-Term Dialysis Is a Renal Tx Risk
       Pretransplant hemodialysis over 10 years found to predict worse graft and patient survival
      PATIENTS ON hemodialysis (HD)                  89.2% and 95.8%, respectively, at one   and 93.1%, respectively. Eight patients   virus and cytomegalovirus infection,
      for more than 10 years prior to renal          year, 60.4% and 88.5% at five years,    in the long-term group (20.5%) experi-    were more frequent in the long-term
      transplantation have worse outcomes            and 33.4% and 80.4% at 10 years, the    enced acute rejection compared with       group. The researchers believe impaired
      after receiving their kidneys com-             authors reported in Transplantation     63 in the short-term group (15.7%).       intestinal absorption reduced uptake of
      pared with patients who received HD            Proceedings (2008;40:2297-2298). Pa-      Pretransplant complications, includ-    immunosuppressive agents, which led
      for shorter periods.                           tient survival rates were 93.2% and     ing diabetes mellitus, cardiovascular     to deficits in immunosuppression and
        This study of 436 patients who under-        98.6%, 79.3% and 95.4%, and 58.4%       disease, hypertension, and hepatitis C    subsequent acute rejection episodes. I
      went renal transplantation was led by
      Hidetaka Ushigome, MD, PhD, and
      his team at Kyoto Prefectural University
      Graduate School of Medical Science.
      Of this cohort, 39 patients had been
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