Submission id 0007 - DOC

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					                                   XXI ICMRBS
                           THE SCIENTIFIC PROGRAMME

                                   SUNDAY, January 16

4:00-6:30 pm        Sunday afternoon
                    INAUGURAL SESSION, Hall A
                    Chairpersons: Edwin D Becker & Girjesh Govil

Inaugural 4:15 pm   NMR and its Nobel Glory: Richard R. Ernst, Laboratorium für Physikalische
                    Chemie ETH Hönggerberg HCI 8093 Zürich, Switzerland

Inaugural 5:00 pm   The Evolution of the NMR View of Biological Macromolecules: Kurt
                    Wuthrich1 Dept. of Molecular Biology, The Scripps Research Institute (TSRI),
                    La Jolla, CA Institut fur Molekularbiologie and Biophysik, Eidgenossiche
                    Technische Hochschule (ETH) Zurich, CH-8093 Zurich, Switzerland

Inaugural 5.45 pm   Which aspects of brain function does fMRI measure?: Seiji Ogawa, Hamano
                    Life Science research Foundation, Ogawa Laboratories for Brain Function
                    Research, Shinjuku-ku, Tokyo, 160-0015, Japan

6:30-7:15 pm        CULTURAL PROGRAM, Hall A

7:30-9:00 pm        WELCOME DINNER, Mountain Heights, Shilpakala Vedika

                                  MONDAY, January 17

8:30-9:00 am        POSTER SET-UP, Halls D & E
                    Display your posters at the space mentioned in the program.

9:00-10:30 am       Monday morning
                    PLENARY SESSION, Hall A
                    Chairpersons: Ivano Bertini & Anil Kumar

Plenary 9:00 am     NMR Spectroscopy in Studies of Protein Folding and Misfolding: C. M.
                    Dobson, Department of Chemistry, University of Cambridge, Lensfield Road,
                    Cambridge CB2 1EW

Plenary 9:45 am     Understanding global systems biology via NMR spectroscopy and
                    metabonomics: Jeremy K. Nicholson, Biological Chemistry, Imperial College,
                    London University, London SW7 2AZ UK
10:30-11:00 am      BREAK (Tea), Shilpakala Vedika Lawns

11:00-01:00 am      Monday morning parallel session A
                    Proteomics, Hall A
                    Chairpersons: John Markley & P T Manoharan

MOA 11:00 am        Membrane Protein Structural Biology and Structural Genomics: T. A.
                    Cross1,2, F. P. Gao1,2, W. Brey1, P. GorÕkov1, E. Chekmenev1, K. Taylor2, R.K.
                    Nakamoto3, C. R. Sanders4 , F. Sonnichsen5, S. J. Opella6 et al, 1 National High
                    Magnetic Field Laboratory, Tallahassee, FL 32310, USA, 2 Florida State

                    University, Tallahassee, FL 32306, USA, 3University of Virginia,
                    Charlottesville, VA, USA, 4Vanderbilt University, Nashville, TN 37232-8725
                    USA, 5Case Western Reserve University, Cleveland, OH 41406-4970, USA,
                    6
                     University of California, San Diego, CA 92093-0307 USA


                                              1
MOA 11:30 am     The role of NMR in structural genomics: from gene to the biological
                 function of metalloproteins: Lucia Banci, Magnetic Resonance Center CERM
                 and Department of Chemistry, University of Florence, Via Luigi Sacconi 6,
                 50019, Sesto Fiorentino, Florence, Italy
MOA 12:00 pm     NMR-Based Structural Genomics at the Pacific Northwest National
                 Laboratory: Michael A. Kennedy, Pacific Northwest National Laboratory,
                 Biological Sciences Division, EMSL 2569, K8-98, Richland, WA 99352 USA
MOA 12:30 pm     Structural Proteomics of Eukaryotic Protein Domain Families: G. V. T.
                 Swapna, T. Acton, R. Shastry, Y. Chiang, J. Huang, H. Moseley, Gaetano
                 T,Montelione, Center for Advanced Biotechnology Medicine, Northeast
                 Structural Genomics Consortium, Rutgers University, Piscataway, NJ 08854
11:00-01:15 am   Monday morning parallel session B
                 SS NMR-I, Hall B
                 Chairpersons: H Akutsu & S Ganapaty

MOB 11:00 am     Double-Quantum Solid-State NMR of the Rhodopsin Chromophore: Wai
                 Cheu Lai1, Luminita Duma2, Marina Carravetta1, Ole G. Johannessen1, Michiel
                 A. Verhoeven3, Petra H. M. Bovee-Geurts4, Johan Lugtenburg3, Willem J.
                 deGrip4, Lyndon Emsley2, Steven P. Brown5, and Malcolm H. Levitt1, 1School
                 of Chemistry, University of Southampton, UK, 2Laboratoire de Chimie, ENS-
                 Lyon, France, 3Leiden Institute of Chemistry, Leiden University, The
                 Netherlands, 4Nijmegen Center for Molecular Life Sciences, University of
                 Nijmegen Medical School, The Netherlands, 5Department of Physics, University
                 of Warwick, UK

MOB 11:30 am     Structural Studies of Antimicrobial Peptides Using Solid-State NMR:
                 Ayyalusamy Ramamoorthy, S. Thennarasu, K. Yamamoto, T.
                 Narasimhaswamy, D. K. Lee, K. A. H. Henzler-Wildman, and K. J. Hallock,
                 Biophysics Research Division and Department of Chemistry, University of
                 Michigan, Ann Arbor, MI 48109-1055

MOB 12:00 pm     Structural Analysis of Membrane-Bound Peptide Mastoparan-X by Solid-
                 State NMR under Magic-Angle Spinning: Toshimichi Fujiwara and Hideo
                 Akutsu, Institute for Protein Research, Osaka University, Japan

MOB 12:30 pm     Investigation of uniformly 13C/15N labeled alpha-Synuclein Fibrils with
                 Multidimensional MAS Solid-State NMR: H. Heise,1 W. Hoyer,1 S. Becker,1
                 V. Subramaniam,1 T.M. Jovin,1 M. Baldus1, 1Max-Planck-Institut für
                 Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany

MOB 12:45 pm     Novel Solid-State NMR Approach to Structural Analysis of Proteins:
                 Application to Phoborhodopsin Transducer pHtrII in Lipid Membrane
                 Environment: Yoh Matsuki,1,4 Yuki Sudo,2 Chojiro Kojima,3 Toshimichi
                 Fujiwara,4 Naoki Kamo,2 Hideo Akutsu,4 1JST-BIRD,2Graduate School of
                 Pharmaceutical Science, Hokkaido University,3Graduate School of Biological
                 Science, Nara Institute for Science and Technology, 4Institute for Protein
                 Research, Osaka University

MOB 01:00 pm     Phase modulated Lee-Goldberg sequence and proton spectroscopy in solid-
                 state: P. K. Madhu, Elena Vinogradov, Leon Bosman, and Shimon Vega,
                 Department of Chemical Sciences, Tata Institute of Fundamental Research,
                 Colaba, Mumbai 400 005, India, Department of Chemical Physics, Weizmann
                 Institute of Science, Rehovot 76100, Israel




                                         2
11:00-01:00 pm   Monday morning parallel session C
                 Methods-I Hall C
                 Chairpersons: Pattrick Cozzone & N Jagannathan

MOC 11:00 am     High Resolution Brain MRI using a 4.7 T Magnet: Ordidge RJ, Thomas D,
                 Parkes H and Turner R, University College London
MOC 11:30 am     Determine peptide plane orientation using residual dipolar coupling: Joseph
                 D. Walsh1, John Kuszewski2 and Yun-Xing Wang1, 1Protein Nucleic Acid
                 Interaction Section, Structural Biophysics Laboratory,NCI-Frederick, NIH,
                 Frederick, MD 21702, 2Imaging Sciences Lab, Division of Computational
                 Biology, CIT, NIH, Bethesda, MD 20892

MOC 12:00 pm     Measurement of cerebral perfusion using bolus contrast MRI: Fernando
                 Calamante, Institute of Child Health,University College London, UK

MOC 12:30 pm     In-Cell NMR studies of various proteins expressed in E. coli: Masatoshi
                 Yoshimasu,1,2 Tsutomu Mikawa,2,3,4 Nobuhiro Hayashi,5 Takehiko Shibata,1,3,4
                 and Yutaka Ito2,3,4 1Cellular and Molecular Biology Laboratory and 3Research
                 Group of Bio-supramolecular Structure-Function, RIKEN, JAPAN;
                 2
                  CREST/JST; 4Graduate School of Integrated Science, Yokohama-City
                 University, JAPAN; 5Fujita Health University, JAPAN

MOC 12:45 pm     Novel Probes for Magnetic Resonance Imaging: A. Manivannan1 and S.
                 Sendhil Velan2, 1Physics Department, 2Center for Advanced imaging and
                 Radiology West Virginia University, Morgantown, WV 26506, USA

01:15-02:00 pm   LUNCH BREAK Sampradaya

02:00-04:00 pm   POSTER SESSION and EXHIBITS, Halls D & E (with tea and cookies)
                 Odd numbered posters are discussed during this time

04:00-06:15 pm   Monday afternoon parallel session A
                 Paramagnetic Proteins, Hall A
                 Chairpersons: Lucia Banci & B D N Rao


MOA 4:00 pm      Paramagnetic Labelling of Proteins for Biomolecular NMR:
                 Gottfried Otting1, Guido Pintacuda1,2, Thomas Huber3, Max A. Keniry1, Xun-
                 Cheng Su1, Ah Young Park1, Nicholas E. Dixon1, Ahmad Moshref2, Ainars
                 Leonchiks4, Anatoly Sharipo4, Andrei Kaikkonen2, 1 Australian National
                 University, Canberra, ACT 0200, Australia, 2 Karolinska Institute, S-17177
                 Stockholm, Sweden, 3 The University of Queensland, Department of athematics,
                 Brisbane QLD 4072, Australia, 4 University of Latvia, LV-1067 Riga, Latvia

MOA 4:30 pm      New Insights into STAT Tetramerization Derived from the Solution
                 Structure of the N-terminal Domain of STAT4: Vadim Gaponenko, Amanda
                 S. Altieri, Jess Li, Sergey Tarasov, R. Andrew Byrd, Structural Biophysics
                 Laboratory, National Cancer Institute, Frederick, MD 21702




                                          3
MOA 5:00 pm      Energetics and Mechanism of Ca2+ displacement by lanthanides in a
                 calcium binding protein: K.V.R. Chary, Department of Chemical Sciences,
                 Tata Institute of Fundamental Research, Mumbai 400 005

MOA 5.30 pm      NMR studies of copper (II) interacting with peptides derived from the
                 prion and the amyloid precursor proteins: Elena Gaggelli, Daniela Valensin
                 and Gianni Valensin, Department of Chemistry, University of Siena, Via Aldo
                 Moro, Siena 53100, Italy

MOA 5:45 pm      Roles of Noncoordinated Aromatic Residues in Redox Regulation of
                 Cytochrome c3 from Desulfovibrio vulgaris Miyazaki F: Yuki Takayama1,
                 Erisa Harada1,2, Rie Kobayashi3, Kiyoshi Ozawa3, and Hideo Akutsu1,1Institute
                 for Protein Research, Osaka University, Yamadaoka, Suita 565-0871, Japan,
                 Japan 2Biological Informatics Consortium, Chuo-ku, Tokyo 104-0032, Japan,
                 and Faculty of Engineering, 3Yokohama National University, Hodogaya-ku,
                 Yokohama 240-8501, Japan

MOA 6:00 pm      Structural basis for the observed magnetic anisotropic tensorial values in a
                 calcium binding protein: Sourajit M. Mustafi, Sulakshana Mukherjee and
                 Kandala V.R Chary, Department of Chemical Sciences, Tata Institute of
                 Fndamental Research, Mumbai 400005
04:00-06:15 pm   Monday afternoon parallel session B
                 MR Imaging-I Hall, B
                 Chairpersons: Zaver M Bhujwalla & R P Tripathi

MOB 4:00 pm      Ultra fast and parallel imaging: J. Hennig, University Hospital Freiburg,
                 Germany

MOB 4:30 pm      Direct and indirect detection of tissue protein and peptides in vivo using
                 exchangeable amide protons: Peter van Zijl and Jinyuan Zhou, Johns Hopkins
                 University Medical School, Dept. of Radiology, Div. of MRI Research,
                 Baltimore, MD 21205, F.M. Kirby Research Center for Functional Brain
                 Imaging, Kennedy Krieger Institute, Baltimore, MD 21205


MOB 5:00 pm      Potential of various in vivo MR methodologies in the evaluation of cancer:
                 Virendra Kumar, Uma Sharma, KA Danishad and N.R. Jagannathan,
                 Department of NMR, All India Institute of Medical Sciences, New Delhi, India
MOB 5:30 pm      Investigation of Muscle Metabolism by Multi-Dimensional Localized
                 Magnetic Resonance Spectroscopic Techniques at 3T: S. Sendhil Velan1,
                 Susan Lemieux1, Raymond R. Raylman1, M. Albert Thomas2,1Center for
                 Advanced Imaging and Department of Radiology, West Virginia
                 University2Department of Radiology, University of California, Los Angeles

MOB 5:45 pm      Activation of the Brain Center Associated with Visually Evoked Sexual
                 Arousal: Functional MR Imaging: Gwang Woo Jeong, Heoung Keun Kang,
                 Hyung Joong Kim, Hyeong Jung Kim, Jeong Jin Seo, Department of Radiology,
                 Chonnam National University Medical School, Gwangju 501-190, Korea


04:00-06:15 pm   Monday afternoon parallel session C
                 Nucleic Acid Structures-I, Hall C
                 Chairpersons: G Varani & R V Hosur




                                          4
MOC 4:00 pm       Molecular recognition during spliceosome assembly and RNA interference:
                  M. Sattler, EMBL Heidelberg, Germany

MOC 4:30 pm       No proton - No problem: Non-protonated Nuclei in NMR Studies of Nucleic
                  Acids: V. Sklenár, R. Fiala, and M. Munzarová ,Masaryk University Brno,
                  Czech Republic

MOC 5:00 pm       U6 RNA Structure and Function: Samuel Butcher, Department of
                  Biochemistry, University of Wisconsin, Madison, Madison, USA

MOC 5:30 pm       Unusual Primer-Template Structures for Low-Fidelity DNA Polymerases:
                  S. L. Lam and L. M. Chi, Department of Chemistry, The Chinese University of
                  Hong Kong, Hong Kong

MOC 6:00 pm       Structure of daunomycin complexed with d-TGATCA by nuclear
                  mangentic resonance spectroscopy and restrained molecular dynamics:
                  Monica,1 S.K.Barthwal,2 R. Barthwal,1, 1Department of Biotechnology and
                  2
                   Physics, Indian Institute of Technology Roorkee, 247667 India

MOC 6:15 pm       TRNOE analysis of the single-stranded DNA structure induced by binding
                  of the yeast mitochondrial DNA recombination protein Mhr1p: Tokiha
                  Masuda1,2, Tsutomu Mikawa1,2,3,4, Masatoshi Yoshimasu3,4, Feng Ling3,
                  Takehiko Shibata1,2,3 and Yutaka Ito1,2,3,41Molecular and Cellular Physiology
                  Laboratory, Graduate School of Integrated Science, Yokohama City University,
                  Japan; 2Research Group for Bio-supramolecular Structure-Function, RIKEN,
                  Japan; 3Cellular and Molecular Biology Laboratory, RIKEN, Japan;
                  4
                   CREST/JST

06:15-07:45 pm    CULTURAL PROGRAM Hall
A

08:00 onwards     DINNER AND FELICITATIONS TO THE HONORARY FELLOWS OF
                  NATIONAL MAGNETIC RESONANCE SOCIETY OF INDIA,
                  Rock Heights, Shilpakala Vedika

                               TUESDAY, January 18

9:00-10:30 am     Tuesday morning
                  PLENARY SESSION, Hall A
                  Chairpersons: H J Dyson & G Bodenhausen

Plenary 9:00 am   Mapping Equilibrium Protein Folding Pathways by NMR: R. V. Hosur,
                  Department of Chemical Sciences, Tata Institute of Fundamental Research,
                  Homi Bhabha Road, Mumbai 400 005

Plenary 9:45 am   Journey to Ultrahigh Magnetic Fields for MR imaging and spectroscopy:
                  an increasingly sensitive probe for brain function and chemistry: Kamil
                  Ugurbil, Center for Magnetic Resonance Research, Univ. of Minnesota Medical
                  School, Minneapolis, MN, USA

10:30-11:00 am    BREAK (Tea and cookies), Shilpakala Vedika
Lawns

11:00-01:00 pm    Tuesday morning parallel session A
                  Methods-II, Hall A




                                           5
                 Chairpersons: C Griesinger & Chandra Kumar

TOA 11:00 am     High pressure NMR extends protein structure and dynamics analyses to
                 higher energy conformers: Kazuyuki Akasaka, Department of
                 biotechnological Science, School of Biology-Oriented Science and Technology,
                 Kinki University, 930 Nishimitani, Uchita-cho, Wakayama 649-6493, Japan

TOA 11:30 am     Structural characterization proteins using RDCs and novel assignment
                 strategies: 1J.H. Prestegard, Lianmei Feng, T. Weldeghiorghis, Greg Wiley,
                 1
                  Complex Carbohydrate Research Center, University of GeorgiaAthens, GA,
                 30602, USA

TOA 12:00 pm     GFT NMR, Progress for Rapid NMR Data Collection: T. Szyperski, State
                 University of New York at Buffalo, Buffalo, NY 14260, USA

TOA 12:30 pm     Alignment tensor determination for a weakly-aligned protein based on
                 orientation-induced TROSY chemical shift changes: Shin-ichi Tate,1and
                 Hiroshi Moriuchi1, 1Biomolecular Engineering Research Institute (BERI),
                 Osaka, Japan

TOA 12:45 pm     Sample Patterning on the Surface of Planar NMR-Microcoils: K. Ehrmann1,
                 M. Gersbach1, P. Pascoal2, F. Vincent1, C. Massin1, D. Stamou2, P.-A. Besse1,
                 H. Vogel2 and R.S. Popovic1, 1Institute of Microsystems, 2Institute of Chemical
                 Sciences, EPFL – Swiss Federal Institute of Technology Lausanne, CH-1015
                 Lausanne, Switzerland
11:00-01:15 pm   Tuesday morning parallel session B
                 Molecular Recognition, Hall B
                 Chairpersons: Betty Gaffney & Javed Iqbal

TOB 11:00 am     Structure, Function and Heparin interaction of Human Hepatoma-Derived
                 Growth Factor-Related Proteins: Sue, S.C.1, Lee, W.T.1, Lin, Y.J.1, Chen,
                 J.Y.1, Lee, S.C.2 Wu, W.G.2 and Huang, T.H.*,1,3, 1Inst. Biomed. Sci., Academia
                 Sinica, Taipei; 2Inst. Bioinf. & Struct. Biol., Nat¡¦l Tsinghua U., Hsinchu;
                 3
                  Dept. Phys., Nat¡¦l Taiwan Normal U. , Taipei, Taiwan, R.O.C.

TOB 11:30 am     NMR investigation of protein-protein and protein-ligand interactions in
                 gene transcription and cellular signaling: Michael J. Plevin, Tapas Mal, Ivan
                 Bosanac, Jenny Chan, Le Zheng, and Mitsu Ikura, Division of Molecular and
                 Structural Biology, Ontario Cancer Institute and Department of Medical
                 Biophysics, University of Toronto, 610 University Ave., Toronto, Ontario, M5G
                 2M9, Canada

TOB 12:00 pm     Protein:Protein Interactions Studied with Paramagnetic NMR Tools: M.
                 Ubbink, M. Prudencio, A. N. Volkov, M. G. Finiguerra, M. D. Vlasie, Leiden
                 Institute of Chemistry, Leiden University, The Netherlands

TOB 12:30 pm     Solution structure of the UBA domain of budding yeast DSK2p in complex
                 with the ubiquitin: Ayako Ohno1,2, JunGoo Jee2,3, Kenichiro Fujiwara2,
                 Takeshi Tenno2,4, Natsuko Goda2, Hidehito Tochio2, Hideki Kobayashi5,
                 Hidekazu Hiroaki1,2 Masahiro Shirakawa2,3, 1Kihara Memorial Yokohama
                 Foundation for the advancement of Life Sciences, Kanagawa, Japan,
                 2
                  Yokohama City University, Kanagawa, Japan, 3RIKEN GSC, Kanagawa,
                 Japan, 4Ehime University, Ehime, Japan, 5Kyushu University, Fukuoka, Japan




                                          6
TOB 12:45 pm     Applications of NMR Spectroscopy and Structural Enzymology to Target-
                 based Discovery of Novel Antibacterials: Gunther Kern, Per-Olof Eriksson,
                 Tomas Lundqvist, Sushmita Lahiri, Elaina Zverina, Thomas A. Keating, Brian
                 Noonan and Gautam Sanyal*, Infection Discovery, AstraZeneca R&D Boston,
                 35 Gatehouse Drive, Waltham, MA 02451, USA and Structural Chemistry
                 Laboratory, AstraZeneca R&D Mölndal, Sweden

TOB 01:00 pm     Discovery of leads for the macrophage migration inhibitory factor using
                 fragment-based screening. A synergistic application of NMR, MS and X-
                 ray screening: C. Fernández, M.J.J. Blommers, F. Bitsch, A. Widmer, A.
                 Marzinzik, S. Lehmann, J.-M. Rondeau Novartis Institutes for Biomedical
                 Research, Basel, Switzerland
11:00-01:05 pm   Tuesday morning parallel session C
                 Informatics, Education and Capacity Building, Hall C
                 Chairpersons: K Akasaka & F Saparorich

TOC 11:00 am     Building capacity in magnetic resonance for the future: Ian C.P. Smith,
                 Institute for Biodiagnostics, National Research Council, Winnipeg, Canada

TOC 11:25 am     Automation in Protein Structure Determinations: John L. Markley1,2,3, Arash
                 Bahrami1,2,3, Claudia C. Cornilescu1,2,3, Gabriel Cornilescu1,3, Hamid
                 Eghbalnia1,3, Klaas Hallenga1,3, Masatsune Kainosho2,5, Min S. Lee2,3, Betsy L.
                 Lytle2,4, Carrie L. Newman2,3, Craig S. Newman1,2,3, Francis C. Peterson2,5,
                 Mark N. Shahan2,3, Shanteri Singh2,3, Jikui Song2,3, Marco Tonelli1,3, Ejan M.
                 Tyler2,3, Robert C. Tyler2,3, Eldon L. Ulrich1,2,3, Dmitriy A. Vinarov2,3, Brian F.
                 Volkman2,4, Liya Wang1,2,3, William M. Westler1,2,3, Qin Zhao2,3, and Zsolt
                 Zolnai1,2,3, 1National Magnetic Resonance Facility at Madison and 2Center for
                 Eukaryotic Structural Genomics, 3University of Wisconsin-Madison, Madison,
                 WI, USA, 4Medical College of Wisconsin, Milwaukee, WI, 5Tokyo Metropolitan
                 University, Tokyo, Japan

TOC 11:50 am     Training of Young Biological NMR Scientists in Asia: Hideo Akutsu,
                 Institute for Protein Research, Osaka University, Suita 565-0871, Japan

TOC 12:15 pm     Activities of the Frankfurt Centre of Biomolecular MR for the Transfer of
                 MR Knowledge: H. Rueterjans1, 1Institute of Biophysical Chemistry,
                 J.W.Goethe University Frankfurt, Germany

TOC 12:40 pm     Education and Capacity Building in Biological NMR in Less Developed
                 Countries: Girjesh Govil, Tata Institute of Fundamental Research, Mumbai
                 400 005, India

01:15-02:00 pm   LUNCH BREAK, Sampradaya Vedika

02:00-04:00 pm   POSTER SESSION and EXHIBITS,
                 Halls D & E (with tea and cookies)

04:00-06:30 pm   Tuesday afternoon parallel session A
                 Proteins-I, Hall A
                 Chairpersons: G C K Roberts & S V Bhat

TOA 4:00 pm      Recent Multinuclear NMR Studies of Hemoglobin: New Insights into the
                 Structure-Function Relationship in Hemoglobin: Chien Ho1, Carnegie
                 Mellon University, Pennsylvania, USA




                                            7
TOA 4:30 pm      The structure and function of AHSP, a specific chaperone for alpha-
                 hemoglobin: David A. Gell1, Chris Lee1, Suiping Zhou2, Anne Rich3, Peter
                 Lay3, Andrew Gow2, Mitchell J. Weiss2 and Joel P. Mackay1, 1School of
                 Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
                 2
                  School of Chemistry, University of Sydney, NSW, Australia 3The Children's
                 Hospital of Philadelphia, Philadelphia, USA

TOA 5:00 pm      Structure determination of SAP-18: insight into the structural basis of
                 histone deacetylase specificity: Scott A. McCallum, JianPing Yin, and Wayne
                 J. Fairbrother, Genentech Inc., California, USA

TOA 5:30 pm      The Molecular Basis of Genetic Disease caused by Single Amino Acid
                 Residue Replacements: James A. Ferretti1, James M. Gruschus1, Kae-Jung
                 Hwang1, Hyun-Sook Lee1, Jin-Soo Maeng1, Jeong-Ho Ju1, James W. Mack1,
                 1
                   LBC, NHLBI, NIH, Bethesda, Maryland 20892 USA

TOA 6:00 pm      Alternative Conformations of the gp120 V3 Loop suggest a mechanism
                 for HIV-1 coreceptor selectivity and the Molecular Basis for Broad
                 Neutralization by antibody 447-52D: Osnat Rosen, Michal Sharon and Jacob
                 Anglister, Department of Structural Biology, The Weizmann Institute of Science,
                 Rehovot 76100, Israel

TOA 6:15 pm      Folding Mechanism of SUMO-1: Non Native Structural characteristics of
                 equilibrium intermediates: Ashutosh Kumar1, Sudha Srivastva1, Ram Kumar
                 Mishra2, Rohit Mittal2, Ramkrishna V. Hosur1,1Dept. of Chemical Sciences,
                 2
                  Dept. of Biological Sciences, Tata Institute of Fundamental Research, Homi
                 Bhabha Road, Colaba, Mumbai- 400005, India

04:00-06:30 pm   Tuesday afternoon parallel session B
                 MR in Human Health and Behavior, in vivo Spectroscopy and
                 Metabonomics, Hall B
                 Chairpersons: Ian Smith & Sudha Srivastava

TOB 4:00 pm      NMR in Disease Diagnosis and Treatment Monitoring: C.L. Khetrapal,
                 Center of Biomedical Magnetic Resonance, Sanjay Gandhi Post Graduate
                 Institute of Medical Sciences, Lucknow-226 014, India

TOB 4:30 pm      Spatially Resolved Two-dimensional MR Spectroscopy in vivo: M. Albert
                 Thomas, Department of Radiology, University of California-Los Angeles,
                 California, USA

TOB 5:00 pm      Glucose Utilization by Normal Erythrocytes is affected by Malarial Parasite
                 – P. falciparum infection: Haripalsingh M. Sonawat1*, Monika Mehta2#, Alfica
                 Sehgal2, Shobhona Sharma2, 1Department of Chemical Sciences and
                 2
                  Department of Biological Sciences, Tata Institute of Fundamental Research,
                 Homi Bhabha Road, Mumbai, India. #Present address: Section of Infectious
                 Diseases/Internal Medicine, School of Medicine, Yale University, New Haven
                 CT 06511, USA

TOB 5:30 pm      The Regulation of GABA Synthesis during Increased Brain Activity: Anant
                 B. Patel1, Robin A. de Graaf1, Kevin L. Behar2, Department of 1Diagnostic
                 Radiology and 2Psychiatry, Magnetic Resonance Research Center, Yale
                 University School of Medicine, New Haven, CT 06520, USA

TOB 5:45 pm      The hetero-nuclear NMR-based metabol(n)omics of plant and animal
                 systems: Jun Kikuchi1,2,3, Takashi Nishihara1, Kazuo Shinozaki2,4 & Takashi


                                          8
                Hirayama1,2,4, 1Grad. Sch. Integ. Sci., Yokohama City Univ; 2GSC, RIKEN
                Yokohama Inst.; 3CREST, JST & 4Plant Mol. Biol. Lab., RIKEN Tsukuba Inst.

TOB 6:00 pm     Restoration of hepatocyte function during decompression in human
                obstructive jaundice using 1H and 31P NMR spectroscopy of bile: Lakshmi
                Bala1, Pratima Tripathi1, G.A.Nagana Gowda1, C.L.Khetrapal1, Gunjan Shukla2
                and Gourdas Choudhuri2, 1Centre of Biomedical Magnetic resonance and
                2
                 Department of Gastroenterology Sanjay Gandhi Post Graduate Institute of
                Medical Sciences Raebareli Road, Lucknow- 226 014, India

4:00-6:30 pm    Tuesday afternoon parallel session C
                Nucleic Acid Structures-II, Hall C
                Chairpersons: S Butcher & B J Rao

TOC 4:00 pm     Protein and RNA dynamics play key roles in molecular recognition:
                Gabriele Varani, Zahra Shajani, Priti Deka and Gary Drobny,Department of
                Chemistry and Department of Biochemistry University of Washington, Seattle
                WA 98195-1700 USA

TOC 4:30 pm     Structure of hnRNP D Complexed with Telomere DNA, Unfolding of
                Quadruplex, and Discrimination of Intra- and Intermolecular Hydrogen
                Bonds: M. Katahira1, 1Yokohama National University, Yokohama, Japan

TOC 5:00 pm     Interaction of double-stranded RNA dependent protein kinase with HIV
                TAR RNA: Insil Kim, Corey Liu, and Joseph D. Puglisi, Stanford Magnetic
                Resonance Laboratory and Department of Structural Biology, Stanford
                University School of Medicine, Stanford, CA 94305-5126

TOC 5:30 pm     Solution Structures of DNA Duplexes Containing Oxidative Cytosine
                Lesions: Varatharasa Thiviyanathan, Anoma Somasunderam, David E. Volk,
                Tapas K. Hazra, Sankar Mitra and David G. Gorenstein, Department of HBCG,
                University of Texas Medical Branch, Galveston, TX 77555, USA

TOC 5:45 pm     Hix DNA site that is out of contact with Hin protein adds specificity to the
                Hin-hix recognition: Sung-Hun Bae,1 Dawei Sun,1 Jongchul Bang,1 Jae-Sun
                Shin,1 Byong-Seok Choi,1,1Dept. of Chemistry, Korea Advanced Institute of
                Science and Technology, Republic of Korea

TOC 6:00 pm     RNA thermometers: Saheli Chowdhury (1,2), Christophe Maris (2), Frederic
                Allain (2) and Franz Narberhaus (1,3), (1) Institute of Microbiology, ETH-
                Zentrum, CH-8092 Zuerich, Switzerland; (2) Institute for Molecular Biology
                and Biophysics, ETH-Hönggerberg, CH-8093 Zuerich, Switzerland; (3)
                Lehrstuhl fuer Biologie der Mikroorganismen, Ruhr-Universitaet Bochum, D
                              44780 Bochum, Germany

6:15-7:15 pm    VISIT TO CRAFT VILLAGE, SHILPARAMAM
7:15 pm         Transfer to Indian Institute of Chemical Technology, Hyderabad for
                Dinner

8:00 pm         DINNER at Indian Institute of Chemical Technology, Hyderabad

                           WEDNESDAY, January 19

9:00-10:30 am   Wednesday morning
                PLENARY SESSION, Hall A



                                         9
                  Chairperson: Gil Navon

Plenary 9:00 am   Protein-RNA Recognition Events in RNA Interference: Dinshaw J. Patel,
                  Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New
                  York, NY, 10021, USA

Plenary 9:45 am   The SAIL Method for Protein NMR Spectroscopy: Masatsune Kainosho,
                  CREST of JST and Graduate School of Science, Tokyo Metropolitan University
10:30-11:00 am    BREAK (Tea and cookies), Shilpakala Vedika Lawns

11:00-1:00 pm     Wednesday morning parallel session A
                  Protein Folding, Hall A
                  Chairpersons: C M Dobson & Jayant Udgaonkar

WOA 11:00 am      NMR Studies of the Protein Folding Landscape: H. Jane Dyson, Maria A.
                  Martinez-Yamout and Peter E. Wright, Department of Molecular Biology, The
                  Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA
                  92037.
WOA 11:30 am      Protein Folding Dynamics studied by Spin Relaxation: Mikael Akke1, Kaare
                  Teilum1, Patrik Lundstršm1, Frans A. A. Mulder1 and Flemming M. Poulsen2, 1
                  Department of Biophysical Chemistry, Lund University, Sweden, 2 Department
                  of Protein Chemistry, University of Copenhagen, Denmark
WOA 12:00 pm      NMR in isotropic and anisotropic phase to monitor the folding of a stable
                  native -hairpin via RDCs: Sebastian Meier and Stephan Grzesiek, Division of
                  Structural Biology, Biozentrum der UniversitŠt Basel, 4056 Basel,Switzerland

WOA 12:15 pm      Structural characterization of the partially collapsed apo-form of a EF-
                  hand calcium binding protein and its folding to holo state: Sulakshana
                  Mukherjee, Kavita Kuchroo, and Kandala V.R. Chary, Department of Chemical
                  Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai
                  400 005 India

WOA 12:30 pm      Residue-resolved structure, stability, folding and unfolding rates of kinetic
                  protein folding intermediates measured by NMR: Mallela M. G. Krishna,
                  Yan Lin, Leland Mayne & S. Walter Englander, Johnson Research Foundation,
                  University of Pennsylvania School of Medicine, Philadelphia, PA, USA 19104-
                  6059

WOA 12:45 pm      Residual structure and slow dynamics in α-synuclein: Carlos Bertoncini,
                  Claudio O. Fernandez, Wolfgang Hoyer, Christian Griesinger, Thomas M.
                  Jovin, Markus Zweckstetter,Max Planck Institute for Biophysical Chemistry, Am
                  Fassberg 11, D-37077 Göttingen, Germany

11:00-1:00 pm     Wednesday morning parallel session B
                  Membrane Proteins, Hall B
                  Chairpersons: R Norton & D Balasubramaniam

WOB 11:00 am      Solution NMR Studies of Polytopic Helical Membrane Proteins in Micelles
                  and Bicelles: Sebastien Poget, Douglas Kamen, Sean Cahill, and Mark Girvin,
                  Biochemistry Department, Albert Einstein College of Medicine, 1300 Morris
                  Park Ave, Bronx, NY 10461

WOB 11:30 am      Solution NMR Approaches for the Determination of High-Resolution
                  Structures of Integral Membrane Proteins: J. Bushweller1, T. Cierpicki1, Y.



                                          10
                Zhou1, B. Liang1, L. Tamm1, 1Molecular Physiology and Biological Physics,
                University of Virginia, Virginia, USA

WOB 12:00 pm    Membrane Protein in the remodelling shop: new properties for an old
                problem: Konstantin V. Pervushin, Laboratory of Physical Chemistry ETH
                Honggerberg, HCI F215 CH-8093 Zurich, Switzerland

WOB 12:30 pm    NMR Structural studies of nAChR M2 peptide: Yongae Kim1, Tae-Joon
                Park1, Mike Meslea2, and Stanley J. Opella2, 1: Dept. of Chemistry, HanKuk
                Univ. of Foreign Studies, YongIn, 449-791, KOREA, 2: Dept. of Chem. &
                Biochem., Univ. of Cal. San Diego, LaJolla, 92093-0307, USA

WOC 1:00 pm     Consequences of Acylation on Electrostatic Potential Distribution and
                Membrane Binding Properties of Dermaseptin Derivative K 4-S4(1-13) :
                Deborah E. Shalev1, Shahar Rotem2 and Amram Mor2, 1The Wolfson Centre for
                Applied Structural Biology, Silberman Institute of Life Sciences,
                 The Hebrew University of Jerusalem, Safra Campus, Givat Ram, 91904
                Jerusalem, Israel, 2Department of Biotechnology & Food Engineering,
                Technion - Israel Institute of Technology, 32000 Haifa, Israel

11:00-1:00 pm   Wednesday morning parallel session C
                Imaging-II, Hall C
                Chairpersons: R A Kamoroski & S K Sarkar

WOC 11:00 am    Functional Imaging of Cancer: Zaver M. Bhujwalla, JHU ICMIC Program,
                Department of Radiology, The Johns Hopkins University School of Medicine,
                Baltimore, MD 21205

WOC 11:30 am    Magnetic resonance in the developing brain: DG Gadian, Institute of Child
                Health, University College London, UK

WOC 12:00 pm    High resolution in vivo MRI and MRS of murine models of human
                neuropathologies: Patrick J. Cozzone and Angele Viola, Centre de Resonance
                Magnetique Biologique et Medicale (CRMBM) UMR CNRS 6612, Faculte de
                Medecine 27 Bd. Jean Moulin, 13005, Marseille (France)

WOC 12:30 pm    NEURAL MAPPING OF AUDITORY LEXICAL PROCESSING
                THROUGH FUNCTIONAL MRI: Y. Uma Sreekumar, S.S. Kumaran, S.
                Khushu and R.P. Tripathi, NMR Research Centre, Institute of Nuclear Medicine
                and Allied Sciences, Brig. S.K. Mazumdar Road, Delhi – 110 054, INDIA

WOC 12:45 pm    3D Proton MR Spectroscopic Imaging of Prostate in Men with raised PSA:
                Virendra Kumar*, R. Kumar#, S.C Das #, S Thulkar@, S. Duttagupta$, A.K
                Hemal#, N.P Gupta# and N.R Jagannathan*, Departments of NMR*, Urology# and
                Pathology$ All India Institute of Medical Sciences, New Delhi – 110029. INDIA

1:00-2:00 pm    LUNCH BREAK Sampradaya Vedika

2:00-4:00 pm    Wednesday afternoon parallel session
                Methods-III, Hall A
                Chairpersons: Ad Bax & V S S Sastry

WOA 2:00 pm     Studies of protein dynamics and a new method to study drug/target
                interactions: Carlos Bertoncini, Min-Kyu Cho, Claudio Fernandez, Henrike
                Heise, Marcel Reese, Fernando Rodriguez-Castaneda, Victor Sanchez, Marc
                Baldus, Teresa Carlomagno, Tom Jovin, Markus Zweckstetter, Christian


                                        11
               Griesinger, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11,
               37077 Gottingen

WOA 2:30 pm    Collagen as a Chiral Agent, Revealed for the First Time by NMR: Gil
               Navon, Uzi Eliav, School of Chemistry, Tel Aviv University, Tel Aviv 69978,
               Israel

WOA 3:00 pm    Assignment of Side Chain Resonances of Uniformly 13C-labeled Large
               Proteins: Daiwen Yang1; Yu Zheng1; Chien Ho2;Yingqi Xu1, 1Department of
               Biological Sciences and Department of Chemistry, National University of
               Singapore,14 Science Drive 4, Singapore 117543, 2Department of Biological
               Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA

WOA 3:30 pm    G-Matrix Fourier Transform NMR Spectroscopy for Complete Protein
               Resonance Assignments: Hanudatta S. Atreya and Thomas Szyperski,
               Department of Chemistry and Structural Biology, State University of New
               YorkNortheast Structural Genomics Consortium, Buffalo, NY 14260

WOA 3:45 pm    Probing Slow Backbone Dynamics in Proteins using TROSY-based
               Experiments to Detect Cross-correlated Time-modulation of Isotropic
               Chemical Shifts: Ranajeet Ghose*1,2 & Ananya Majumdar3, 1Department of
               Chemistry, City College of the City University of New York, New York, NY,
               2
                Graduate Programs in Chemistry and Biochemistry, Graduate Center of the
               City University of New York, New York, NY, 3Johns Hopkins University,
               Baltimore, MD

2:00-4:00 pm   Wednesday afternoon parallel session B
               ESR, Hall B
               Chairpersons: M C Krishna & B A Sastry

WOB 2:00 pm    Oxygen Physiology with In Vivo EPR Imaging: Howard J. Halpern,a,b ,Chad
               R. Haney,a,b Adrian Parasca,a,b Kazuhiro Ichikawa,a,b,e Eugene D. Barth,a,b
               Benjamin B. Williams, a,b Martyna Elas, a,b,c V.S. Subramanian,a,b Marta A.
               Zamora,d Jonathan N. River,d Gregory S. Karczmar,d Helena J. Mauceri,b Ralph
               R. Weichselbaum,b Colin Mailer,a,b Charles A. Pelizzari a,b , Gareth R. Eatonf,
               George A. Rinardf and Richard Quinef, aCenter for EPR Imaging In Vivo
               Physiology ,Departments ofb Radiation Oncology, University of Chicago,
               Chicago IL 60637 ,dRadiology, University of Chicago, Chicago IL 60637, e
               Biophysics, Kyushu University, Fukuoka, JP, c Molecular Biology, Jagiellonian
               University, Cracow, PO

WOB 2:30 pm    Applications of Hyperpolarized 13C and 15N: Klaes Golman
WOB 3:00 pm    EPR Spin Label Studies on Biological Cells and Membranes: Potential and
               Prospects for Radiobiological Research: K.P. Mishra., Bhabha Atomic
               Research Centre Radiation Biology and Health Sciences Division, Mumbai 400
               085
WOB 3:30 pm    The Large-Internal-Cavities of Fe and Mn Lipoxygenases: Betty J. Gaffney.
               Ann N. Imber. Fayi Wu. and Gurunathan Laxmikanthan. * Departments of
               Biological Sciences and *Chemistry and Biochemistry Florida State University.
               Tallahassee FL 32306

WOB 3:45 pm    ESR-Investigation of The System On The Base Of Microcrystalline
               Cellulose and Drug substances: S.A.Muratova,1N.D.Burkhanova,1
               G.V.Nikonovich1, S.Rashidova1, Institute of Polymer Chemistry and Physics,




                                        12
               Academy of Sciences, Republic of Uzbekistan, 7b, A.Kadyrii S tr.,700 128,
               Tashkent

2:00-4:00 pm   Wednesday afternoon parallel session C
               Oligosaccharides and Proteins, Hall C
               Chairpersons: G Valensin & K N Ganesh

WOC 2:00 pm    NMR Structure Determination of Bacterial Secondary Cell Wall Polymer
               Oligosaccharides: N. Müller,1 L. Trantirek,1 C. Steindl,1 C. Schäffer,2 P.
               Messner2, 1Johannes Kepler University, Linz, Austria, 2University of Natural
               Resources and Applied Life Sciences, Vienna, Austria

WOC 2:30 pm    Application of stable-isotope-labeling of glycopeptides to NMR analyses of
               sugar recognition by the intracellular lectins that determine the fates of
               glycoproteins in cells: Yoshiki Yamaguchi,1,2 Takeshi Hirao,1,2 Yukiko
               Kamiya,1,2 Noriko Takahashi,1,2 Koichi Kato1,2,3,4, 1Nagoya City University,
               Nagoya, Japan, 2CREST/JST, Saitama, Japan, 3RIKEN/GSC, Yokohama, Japan,
               4
                Institute for Molecular Science, Okazaki, Japan

WOC 2:45 pm    De Novo Design and Characterization of Glycosaminoglycan Binding
               Oligopeptides: G Jayaraman# and PC Lyu, Department of Life Sciences,
               National Tsing Hua University, Hsinchu, Taiwan

WOC 3:00 pm    Structural Investigation of the Human Hepatic Asialoglycoprotein Receptor
               and some D-Galactose Complexes: A.M. Bianucci^, F. Chiellini°, A.M. Piras°,
               K. H. Mayo*, L. J. Yao#, M. Spiess&, ^Department of Pharmaceutical Science –
               University of Pisa, Italy, °Department of Chemistry & Industrial Chemistry –
               University of Pisa, Italy, *Department of Biochemistry, Molecular Biology &
               Biophysic – University of Minnesota, Minneapolis, USA., #Department of
               Chemistry – University of Minnesota, Minneapolis, USA, &Department of
               Biochemistry Biozentrum – University of Basel, Basel (Switzerland)

WOC 3:15 pm    Towards Understanding the Conformation and Dynamics of Biologically
               Important Oligosaccharide Systems: C. Baby 1, M.S. Moni 1 and S.
               Subramanian 2, 1Sophisticated Analytical Instrumentation Facility, Indian
               Institute of Technology Madras, Chennai-600036, INDIA, 2Radiation Biology
               Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA

WOC 3:30 pm    Stathmin-Like Domain N-Terminal Peptides Impede Tubulin
               Polymerization: M.J. Clement,1 I. Jourdain,2 S. Lachkar,2 P. Savarin, 2 A.
               Sobel,2 P.A. Curmi,1 F. Toma,1, 1 Universite Evry-Val d Essonne; Laboratoire
               Structure et Reconnaissance des Biomolecules, EA3637, Evry, France, 2
               INSERM, U440, Institut du Fer a Moulin, Paris, France; UPMC, Paris, France

WOC 3 :45 pm   Helix insertion to eject a ligand: a global conformational transition in the
               pheromone-binding protein of Bombyx mori: Fred F. Damberger1, Erich
               Michel1, Reto Horst1, Donghan Lee1, Walter S. Leal2, Kurt Wüthrich1,, 1Institut
               für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule-
               Zürich, CH-8093 Zürich, Switzerland, 2Department of Entomology, University
               of California, Davis, CA 95616, USA

4:00-4:30 pm   BREAK (tea and cookies), Shilpakala Vedika Lawns

4:30-5:30 pm   Wednesday afternoon
               ICMRBS –Founder’s Medal Presentation & Winners Lecture, Hall A
               Chairperson: R Kaptein


                                        13
                  Model Free formalism for NMR relaxation analysis: How far can we go?:
                  S.-L. Chang1, A. Szabo2 & N. Tjandra1, 1Laboratory of Biophysical Chemistry,
                  NHLBI, 2Laboratory of Chemical Physics, NIDDK, National Institutes of
                  Health, Bethesda, MD 20892, U. S. A.

5:45 pm           EXCURSION TO GOLKONDA FORT; Light and Sound show; with
                  packed dinners

                               THURSDAY, January 20

9:00-10:30 am     Thursday morning
                  PLENARY SESSION, Hall A
                  Chairperson: H. Rueterjans

Plenary 9:00 am   Metalloproteins and advancements in NMR: Ivano Bertini, CERM, Via L.
                  Sacconi 6, Sesto Fiorentino 50019, ITALY

Plenary 9:45 am   Time-Domain Radiofrequency EPR for in Vivo Imaging Applications:
                  Murali C. Krishna, Nallathamy Devasahayam, Ramachandran Murugesan, Ken-
                  Ichiro Matsumoto, Sankaran Subramanian, James B.Mitchell, Radiation Biology
                  Branch, Center for Cancer Research, National Cancer Institute NIH, Bethesda,
                  Maryland, USA

10:30-11:00 am    BREAK (Tea and cookies), Shilpakala Vedika Lawns

11:00-01:15 pm    Thursday morning parallel session A
                  Methods-IV, Hall A
                  Chairpersons R A Byrd & S Roy

ThOA 11:00 am     NMR Approach for the Structural Determination of Protein Interfaces in
                  Complexes: Fabien Ferrage, Alex Shekhtman, Kaushik Dutta, Rong Xu, David
                  Cowburn, New York Structural Biology Center, New York, New York

ThOA 11:30 am     High level cell-free expression and specific labelling of integral membrane
                  proteins: F. Bernhard1, C. Klammt1, V. Dötsch1, 1Johann Wolfgang Goethe-
                  University, Frankfurt/Main, Germany

ThOA 12:00 pm     Enzyme Function by Solid State NMR: Cytochrome P450: Ann E
                  McDermott1, Tijana Jovanovic1, Micheal Harris1, 1Columbia University, New
                  York, NY USA.


ThOA 12:30 pm     High Expression with Corynebacterium glutamicum for NMR Sample
                  Preparation: M. Shinagawa,1 N. Shimba,1 T. Mizukoshi,1 N. Yamada,1 Y.
                  Kikuchi,1 and E. Suzuki.1, 1Ajinomoto Co., Japan
ThOA 12:45 pm     Cell free translation methods for NMR use: M Neerathilingam1,
                  L.H.Greene2, S.A.Colebrooke1, D Staunton1 and I.D. Campbell 1, 1Department
                  of Biochemistry, University of Oxford, Southparks Road,Oxford,OX1 3QU
                  2
                   University College London, Department of Biochemistry, Darwin Building,
                  Gower Street, London,WC1E 6BT
                                                                                                 13
ThOA 01:00 pm     The hetero-nuclear NMR-based metabolomics reveals incorporation of              C
                  and 15N-compounds into higher plants: Kenji Akamine1, Takashi
                  Hirayama1,2,3 Jun Kikuchi1,2,4, 1Grad. Sch. Integ. Sci., Yokohama City Univ,



                                           14
                 2
                 GSC, RIKEN Yokohama Inst, 3Plant Mol. Biol. Lab., RIKEN Tsukuba Inst,
                 4
                 CREST, JST

11:00-01:15 pm   Thursday morning parallel session B
                 Computational Methods, Hall B
                 Chairpersons: M Garland & Anil Saran

ThOB 11:00 am    Extraction of information from NMR spectra: M. Billeter,1 D. Malmodin,1 T.
                 Luan 2, 1 Biophysics Group, Department of Chemistry, Göteborg University,
                 Sweden, 2 Swedish NMR Centre, Göteborg University, Sweden

ThOB 11:30 am    Automated NMR Structure Calculation with Cyana: Peter Güntert, Tatsuo
                 Miyazawa Memorial Program, RIKEN Genomic Sciences Center, 1-7-22
                 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan

ThOB 12:00 pm    ISD, a probabilistic principle for structure determination by NMR: M.
                 Habeck,1 W. Rieping,1 M. Nilges,1, 1Structural Bioinformatics Unit, CNRS URA
                 2185, Pasteur Institute, 25-28 rue du docteur Roux, F-75015 Paris, France

ThOB 12:30 pm    Shedding Light on the Rhodopsin/Transducin Interface: L. Q. Anderson1,
                 M. A. Anderson1, N.Van Eps2, S. O. Smith3, W. L. Hubbell2, T. J. Baranski1, O.
                 G. Kisselev4, G. R. Marshall1, 1Washington University, Missouri; 2UCLA,
                 California; 2SUNY Stony Brook, New York; 4St. Louis University, Missouri, USA

ThOB 12:45 pm    Automated Structure Improvement and Verification of Proteins from NMR
                 and X-ray data: W. Gronwald, J. Trenner, K. Brunner, B. Ganslmeier, A.
                 Nassar, R. Kirchhöfer, K.-P. Neidig and H. R. Kalbitzer, Institute of Biophysics
                 and Physical Biochemistry, University of Regensburg, 93040 Regensburg,
                 Germany and Bruker Biospin, 76287Rheinstetten, Germany

ThOB 01:00 pm    Probing weakly structured conformational ensembles with residual dipolar
                 couplings: M. Louhivuori,1 K. Fredriksson,2 A. Annila,1,3, 1Department of
                 Physical Sciences, 2Program in Structural Biology and Biophysics Program,
                 Institute of Biotechnology, and 3Department of Biosciences, University of
                 Helsinki, Finland

11:00-01:00 pm   Thursday morning parallel session C
                 Membrane Proteins-II, Hall C
                 Chairpersons: A G Redfield & S R Kasturi

ThOC 11:00 am    Field-Cycling NMR in a Shared Commercial Spectrometer: Applications
                 to Nucleic Acids, Proteins, and especially Membranes (and lots more!): A.G.
                 Redfield, Brandeis, University, and Mary F. Roberts, Boston College.

ThOC 11:30 pm    Membrane Interactions of the Pore-forming Protein Equinatoxin II: 19F
                 NMR Studies: R.S. Norton,1 G. Anderluh,2 A. Razpotnik,2 Z. Podlesek,2 F.
                 Separovic3, 1 Walter and Eliza Hall Institute of Medical Research, Parkville
                 3050, Australia, 2 Department of Biology, Biotechnical Faculty, University of
                 Ljubljana, 1000 Ljubljana, Slovenia, 3 School of Chemistry, University of
                 Melbourne, 3010, Australia

ThOC 12:00 am    NMR Strategy for Membrane Proteins-ligands Interactions: Ichio
                 Shimada1,2, Graduate School of Pharmaceutical Sciences, the University of
                 Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan




                                          15
ThOC 12:30 pm   Solid-State Deuterium NMR Spectroscopy of Retinal Proteins in Aligned
                Membranes: Michael F. Brown,1,2 Gilmar F. J. Salgado,3 Andrey V. Struts,1
                Katsunori Tanaka,4 Naoko Fujioka,4 Sonja Krane,4 Koji Nakanishi4,
                Departments of 1Chemistry, 2Physics, and 3Biochemistry & Molecular
                Biophysics, University of Arizona, Tucson, Arizona 85721, USA, 4Department of
                Chemistry, Columbia University, New York, New York 10027, USA

1:00-2:00 pm    LUNCH BREAK Sampradaya Vedika

2:00-4:00 pm    POSTER SESSION and EXHIBITS, Halls D &E (with tea and cookies)
                Even numbered posters are discussed during this time.

4:00 pm         Transfer to hotels to refresh on their way to Ramoji Film city for Banquet
                Dinner

6:30 pm         Pick-up from hotels for Banquet Dinner

7:30 pm         DINNER Ramoji Film City, Hyderabad

                              FRIDAY, January 21

9:00-11:15 am   Friday morning parallel session A
                Proteins-II, Hall A
                Chairpersons D Cowburn & S Cowsik

FOA 9:00 am     Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins
                Revealed by the Closed Conformation of the Tandem PDZ Domains: Jia-Fu
                Long, Wei Feng, Ling-Nga Chan, Mingjie Zhang, Department of Biochemistry,
                Molecular Neuroscience Center, Hong Kong University of Science and
                Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China

FOA 9:30 am     Domain motion in cytochrome P450 reductase studied by domain-specific
                isotope labeling: Jackie Ellis1, Igor L. Barsukov1 and Gordon C.K. Roberts1,
                1
                 Biological NMR Centre, Department of Biochemistry, University of Leicester,
                PO Box 138, Leicester LE1 9HN, United Kingdom

FOA 10:00 am    NMR studies on structure and dynamics in transcription and translation:
                Rolf Boelens, Bijvoet Center for Biomolecular Research, Utrecht University,
                Padualaan 8, 3584 CH Utrecht, The Netherlands
FOA 10:30 am    How structure and stability influence the function of tea domain
                transcription factors: Asokan Anbanandam and Sudha Veeraraghavan,
                Department of Biochemistry and Molecular Biology and Structural Biology
                Research Center, UT-Houston Medical School, Houston, TX 77030
FOA 10:45 am    Structure and dynamics in solution of the complex of human dihydrofolate
                reductase with trimethoprim and NADPH: Nadezhda V. Kovalevskaya1,
                Vladimir I. Polshakov1,2, Berry Birdsall3, Alan F. Bradbury3, Thomas A.
                Frienkel4 and James Feeney3, 1 Center for Drug Chemistry, Moscow, Russia, 2
                Research Center for Magnetic Tomography & Resonance, M.V. Lomonosov
                Moscow State University, Moscow, Russia, 3 National Institute for Medical
                Research, London, United Kingdom, 4 MRC Biomedical NMR Center, London,
                United Kingdom

FOA 11:00 am    Folding Regulates Auto-processing of HIV-1 Protease Precursor: Amarnath
                Chatterjee1, Mridula P.1, Ram Kumar Mishra2, Rohit Mittal2, R. V. Hosur1,




                                        16
                1
                 Dept. of Chemical Sciences, 2Dept. of Biological Sciences, Tata Institute of
                Fundamental Research, Homi Bhabha Road, Colaba Mumbai- 400005, India

9:00-11:15 am   Friday morning parallel session B
                SS NMR-II, Hall B
                Chairpersons: T Fujiwara & K V Ramanathan

FOB 9:00 am     Structure Determination of Coat Proteins in Virus Particles: Stanley J.
                Opella, Department of Chemistry and Biochemistry, University of California,
                San Diego, La Jolla, California 92037-0307 USA

FOB 9:30 am     Structural studies of large membrane embedded proteins in natural
                membranes using solid state NMR: Anthony Watts, Department of
                Biochemistry, University of Oxford, Oxford, UK

FOB 10:00 am    High Frequency Dynamic Nuclear Polarization: R.G. Griffin,
                Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology,
                Cambridge, MA 02139

FOB 10:30 am    Structure studies of protein complexes with solid-state magic-angle
                spinning NMR: B.-J. van Rossum,1 L. Krabben,1 M. Hiller,1 F. Castellani,1 A.
                Diehl,1 K. Rehbein,1 C. Weise,2 F. Hucho,2 E. Bocharov,3 A. A. Shuga,3 A.
                Arseniev3, V. Kumar,4 W. Kühlbrandt4 and H. Oschkinat1, 1Forschungsinstitut
                für Molekulare Pharmakologie, Berlin, Germany, 2Institut für Biochemie, Freie
                Universität Berlin, Germany, 3Institute of Bioorganic Chemistry, Russian
                Academy of Sciences, Moscow, Russia, 4MPI of Biophysics, Frankfurt/Main,
                Germany

FOB 10:45 am    Dependence of protein solid state NMR spectra on the crystal environment:
                Hans Jürgen Sass & Stephan Grzesiek, Division of Structural Biology,
                Biozentrum der Universität Basel, Klingelbergstr. 70, CH-4056 Basel,
                Switzerland

FOB 11:00 am    Heteronuclear Scalar Correlation between Carbon and DQ Proton
                Chemical shifts in Solids: Vipin Agarwal (a), K.V.Ramanathan (a), Anne Lesage
                (b)
                    and Lyndon Emsley (b), (a) Sophisticated Instrument Facility, Indian Institute
                of Science, Bangalore, India, (b) Laboratoire de Chimie, UMR-5182
                CNRS/ENS, Ecole Normale Superieure de Lyon, France.

9:00-11:15 am   Friday morning parallel session C
                Drug Design, Hall C
                Chairpersons: M Ikura & S Pentyala

FOC 9:00 am     Structure-activity studies on circular proteins: David J Craik, Norelle L
                Daly, Fiona M Foley, Lillian Sando and Shane Simonsen, Institute for
                Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
.
FOC 9:30 am     NMR investigations of Kinases and Phosphatases: Harald Schwalbe, Center
                for Biomolecular Magnetic Resonance, Institute for Organic Chemistry and
                Chemical Biology, Marie-Curie-Str. 11, 60439 Frankfurt/Main, Germany

FOC 10:00 am    Development of small molecule inhibitors of S100B: David J. Weber and
                Joseph Markowitz, University of Maryland, School of Medicine




                                          17
FOC 10:30 am       Solution NMR structural studies of consus peptides from Indian marine
                   snails: Siddhartha P. Sarma1*, Sujit K. Sikdar1, K.S.Krishnan2 and P.Balaram1,
                   Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012,
                   India, Department of Biological Sciences, Tata Institute of Fundamental
                   Research, Mumbai 400 005, India
FOC 10:45 am       Conformational study of cyclic peptides containing exclusive cis Xaa-Pro
                   amide bond derived via ring closing metathesis: S. Kiran Kumar,a B. M.
                   Rajesh,b K. Vyas,b J. Moses Babu,b R. Vasudev,b Javed Iqbalb and A. C.
                   Kunwar.a, Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical
                   Technology, Hyderabad-500 007, India. (b) Discovery Research, Dr. Reddy’s
                   Research Foundation, Bollaram road, Miyapur, Hyderabad-500 050, India
FOC 11:00 am       Nucleation of -Hairpin Structures by a Three Residue Turn in a Designed
                   Synthetic Nonapeptide: S. Raghothama1, Rajkishor Rai 2and P. Balaram2,
                   1
                    Sophisticated Instruments Facility and 2Molecular Biophysics Unit, Indian
                   Institute of Science, Bangalore – 560 012. India

11:15-11:45 am     BREAK (Tea and cookies), Shilpakala Vedika Lawns

11:45-12:30 pm     Friday morning plenary session & concluding remarks Hall A
                   Chairpersons: S J Opella & C L Khetrapal


Plenary 11:45 am   Weak Alignment Provides Unique Opportunities in NMR Studies of
                   Biomolecules: David Bryce, Chris Jaroniec, Jerome Boisbouvier, Emeric
                   Miclet,Erin OÕNeil-Cabello, Tobias Ulmer, Justin Wu, Alex Grishaev, and Ad
                   Bax, Laboratory of Chemical Physics, NIDDK, NIH, Bethesda, MD 20892, USA

12:30-12:45 pm     CONCLUDING REMARKS by Mastasune Kainosho

12:45-02:00 pm     FAREWELL LUNCH, Sampradaya Vedika




                                            18
                                  ORAL + POSTER ABSTRACT

PO 1   In-Cell NMR studies of various proteins expressed in E. coli: Masatoshi Yoshimasu1,2,
       Tsutomu Mikawa2,3,4, Nobuhiro Hayashi5, Takehiko Shibata1,3,4, and Yutaka Ito2,3,4, 1Cellular and
       Molecular Biology Laboratory and 3Research Group of Bio-supramolecular Structure-Function,
       RIKEN, JAPAN; 2CREST/JST; 4Graduate School of Integrated Science, Yokohama-City
       University, JAPAN; 5Fujita Health University, JAPAN.

PO2    Novel Probes for Magnetic Resonance Imaging: A.Manivannan1 and S. Sendhil Velan2,
       1
         Physics Department, 2Center for Advanced imaging and Radiology, West Virginia
       University,Morgantown, WV 26506, USA

PO3    Alignment tensor determination for a weakly-aligned protein based on orientation-induced
       TROSY chemical shift changes: Shin-ichi Tate1, and Hiroshi Moriuchi1, 1Biomolecular
       Engineering Research Institute (BERI), Osaka, Japan


PO4    Sample Patterning on the Surface of Planar NMR-Microcoils: K. Ehrmann1, M. Gersbach1, P.
       Pascoal2, F. Vincent1, C. Massin1, D. Stamou2, P.-A. Besse1, H. Vogel2 and R.S. Popovic1,
       1
         Institute of Microsystems, 2Institute of Chemical Sciences, EPFL – Swiss Federal Institute of
       Technology Lausanne, CH-1015 Lausanne, Switzerland

PO5    G-Matrix Fourier Transform NMR Spectroscopy for Complete Protein Resonance
       Assignments: Hanudatta S. Atreya and Thomas Szyperski, Department of Chemistry and
       Structural Biology, State University of New York, and Northeast Structural Genomics Consortium,
       Buffalo, NY 14260

PO6    Probing Slow Backbone Dynamics in Proteins using TROSY-based Experiments to Detect
       Cross-correlated Time-modulation of Isotropic Chemical Shifts: Ranajeet Ghose*1,2 &
       Ananya Majumdar3, 1Department of Chemistry, City College of the City University of New York,
       New York, NY,2Graduate Programs in Chemistry and Biochemistry, Graduate Center of the City
       University of New York, New York, NY, 3Johns Hopkins University, Baltimore, MD

PO7    High Expression with Corynebacterium glutamicum for NMR Sample Preparation: M.
       Shinagawa,1 N. Shimba,1 T. Mizukoshi,1 N. Yamada,1 Y. Kikuchi,1 and E. Suzuki.1, 1Ajinomoto
       Co., Japan.

PO8    Cell free translation methods for NMR use: M Neerathilingam1, L.H.Greene2, S.A.Colebrooke1,
       D Staunton1 and I.D. Campbell1, 1Department of Biochemistry, University of Oxford, Southparks
       Road,Oxford,OX1 3QU. 2University College London, Department of Biochemistry, Darwin
       Building, Gower Street, London,WC1E 6BT

PO9    The hetero-nuclear NMR-based metabolomics reveals incorporation of 13C and 15N-
       compounds into higher plants: Kenji Akamine1, Takashi Hirayama1,2,3 ,Jun Kikuchi1,2,4, 1Grad.
       Sch. Integ. Sci., Yokohama City Univ; 2GSC, RIKEN Yokohama Inst.; 3Plant Mol. Biol. Lab.,
       RIKEN Tsukuba Inst. And 4CREST, JST

PO10   Investigation of uniformly 13C/15N labeled alpha-Synuclein Fibrils with Multidimensional
       MAS Solid-State NMR: H. Heise, W. Hoyer, S. Becker, V. Subramaniam, T.M. Jovin, M.
       Baldus, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen,
       Germany



                                                  19
PO11   Novel Solid-State NMR Approach to Structural Analysis of Proteins: Application to
       Phoborhodopsin Transducer pHtrII in Lipid Membrane Environment: Yoh Matsuki1,4, Yuki
       Sudo2, Chojiro Kojima3, Toshimichi Fujiwara4, Naoki Kamo2, Hideo Akutsu4,1JST-
       BIRD,2Graduate School of Pharmaceutical Science, Hokkaido University, 3Graduate School of
       Biological Science, Nara Institute for Science and Technology, 4Institute for Protein Research,
       Osaka University
PO12   Phase modulated Lee-Goldberg sequence and proton spectroscopy in solid-state: P. K.
       Madhu, Elena Vinogradov, Leon Bosman, and Shimon Vega, Department of Chemical Sciences,
       Tata Institute of Fundamental Research, Colaba, Mumbai 400 005, India, Department of
       Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
PO13   Structure studies of protein complexes with solid-state magic-angle spinning NMR: B.-J. van
       Rossum1, L. Krabben1, M. Hiller1, F. Castellani1, A. Diehl1, K. Rehbein1, C. Weise2, F. Hucho2,E.
       Bocharov3, A. A. Shuga3, A. Arseniev3, V. Kumar4, W. Kühlbrandt4 and H. Oschkinat1,
       1
         Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, 2Institut für Biochemie,
       Freie Universität Berlin, Germany, 3Institute of Bioorganic Chemistry, Russian Academy of
       Sciences, Moscow, Russia, 4MPI of Biophysics, Frankfurt/Main, Germany

PO14   Dependence of protein solid state NMR spectra on the crystal environment: Hans Jürgen Sass
       & Stephan Grzesiek, Division of Structural Biology, Biozentrum der Universität Basel,
       Klingelbergstr. 70, CH-4056 Basel, Switzerland

PO15   Heteronuclear Scalar Correlation between Carbon and DQ Proton Chemical shifts in
       Solids: Vipin Agarwal1, K.V.Ramanathan1, Anne Lesage2 and Lyndon Emsley2, 1Sophisticated
       Instrument Facility, Indian Institute of Science, Bangalore, India, 2Laboratoire de Chimie, UMR-
       5182 CNRS/ENS, Ecole Normale Superieure de Lyon, France

PO16   Structural Proteomics of Eukaryotic Protein Domain Families: G. V. T. Swapna, Gaetano T.
       Montelione and the Northeast Structural Genomics Consortium, Center for Advanced
       Biotechnology Medicine, Rutgers University, Piscataway, NJ 08854

PO17   Monitoring NMR Protein Structure Quality by Molecular Replacement: Michael A.
       Kennedy, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA,
       99354

PO18   How Structure and Stability influence the function of TEA domain Transcription Factors:
       Asokan Anbanandam and Sudha Veeraraghavan, Department of Biochemistry and Molecular
       Biology and Structural Biology Research Center, UT-Houston Medical School, Houston, TX
       77030

PO19   Structure and dynamics in solution of the complex of human dihydrofolate reductase with
       trimethoprim and NADPH: Nadezhda V. Kovalevskaya1, Vladimir I. Polshakov1,2, Berry
       Birdsall3, Alan F. Bradbury3, Thomas A. Frienkel4 and James Feeney3, 1 Center for Drug
       Chemistry, Moscow, Russia, 2 Research Center for Magnetic Tomography & Resonance, M.V.
       Lomonosov Moscow State University, Moscow, Russia, 3 National Institute for Medical Research,
       London, United Kingdom, 4 MRC Biomedical NMR Center, London, United Kingdom
PO20   Folding Regulates Auto-processing of HIV-1 Protease Precursor: Amarnath Chatterjee1,
       Mridula P.1, Ram Kumar Mishra2, Rohit Mittal2, R. V. Hosur1, 1Dept. of Chemical Sciences,
       2
         Dept. of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road,
       Colaba, Mumbai- 400005, India
PO21   Alternative Conformations of the gp120 V3 Loop suggest a mechanism for HIV-1 coreceptor
       selectivity and the Molecular Basis for Broad Neutralization by antibody 447-52D:
       Osnat Rosen, Michal Sharon and Jacob Anglister, Department of Structural Biology, The
       Weizmann Institute of Science, Rehovot 76100, Israel.



                                                  20
PO22   Folding Mechanism of SUMO-1: Non Native Structural characteristics of equilibrium
       intermediates: Ashutosh Kumar1, Sudha Srivastva1, Ram Kumar Mishra2, Rohit Mittal2,
       Ramkrishna V. Hosur1, 1Dept. of Chemical Sciences, 2Dept. of Biological Sciences, Tata Institute
       of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai- 400005, India

PO23   NMR in isotropic and anisotropic phase to monitor the folding of a stable native -hairpin
       via RDCs: Sebastian Meier and Stephan Grzesiek, Division of Structural Biology, Biozentrum der
       Universit·t Basel, 4056 Basel, Switzerland

PO24   Structural characterization of the partially collapsed apo-form of a EF-hand calcium
       binding protein and its folding to holo state: Sulakshana Mukherjee, Kavita Kuchroo, and
       Kandala V.R. Chary, Department of Chemical Sciences, Tata Institute of Fundamental Research,
       Homi Bhabha Road, Mumbai 400 005 India

PO25   Residue-resolved structure, stability, folding and unfolding rates of kinetic protein folding
       intermediates measured by NMR: Mallela M. G. Krishna, Yan Lin, Leland Mayne & S. Walter
       Englander, Johnson Research Foundation, University of Pennsylvania School of Medicine,
       Philadelphia, PA, USA 19104-6059

PO26   Residual structure and slow dynamics in - synuclein: Carlos Bertoncini, Claudio O.
       Fernandez, Wolfgang Hoyer, Christian Griesinger, Thomas M. Jovin, Markus Zweckstetter, Max
       Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany

PO27   NMR studies of copper (II) interacting with peptides derived from the prion and the amyloid
       precursor proteins: Elena Gaggelli, Daniela Valensin and Gianni Valensin, Department of
       Chemistry, University of Siena, Via Aldo Moro, Siena 53100, Italy

PO28   Roles of Noncoordinated Aromatic Residues in Redox Regulation of Cytochrome c3 from
       Desulfovibrio vulgaris Miyazaki F: Yuki Takayama1, Erisa Harada12, Rie Kobayashi3, Kiyoshi
       Ozawa3, and Hideo Akutsu1, Institute for Protein Research, Osaka University, Yamadaoka, Suita
       565-0871, Japan, Japan 2Biological Informatics Consortium, Chuo-ku, Tokyo 104-0032, Japan,
       and Faculty of Engineering, 3Yokohama National University, Hodogaya-ku, Yokohama 240-8501,
       Japan
PO29   Structural basis for the observed magnetic anisotropic tensorial values in a calcium binding
       protein: Sourajit M. Mustafi, Sulakshana Mukherjee and Kandala V.R Chary, Department of
       Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India
PO30   NMR Structural studies of nAChR M2 peptide: Yongae Kim1, Tae-Joon Park1, Mike Meslea2,
       and Stanley J. Opella2, 1 Dept. of Chemistry, HanKuk Univ. of Foreign Studies, YongIn, 449-791,
       KOREA, 2Dept. of Chem. & Biochem., Univ. of Cal. San Diego, LaJolla, 92093-0307, USA

PO31   Consequences of Acylation on Electrostatic Potential Distribution and Membrane Binding
       Properties of Dermaseptin Derivative K4-S4(1-13): Deborah E. Shalev1, Shahar Rotem2 and
       Amram Mor2, 1The Wolfson Centre for Applied Structural Biology, Silberman Institute of Life
       Sciences, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, 91904 Jerusalem,
       Israel, 2Department of Biotechnology & Food Engineering, Technion - Israel Institute of
       Technology, 32000 Haifa, Israel

PO32   Unusual Primer-Template Structures for Low-Fidelity DNA Polymerases: S. L. Lam and L.
       M. Chi, Department of Chemistry, The Chinese University of Hong Kong, Hong Kong
PO33   Structure of daunomycin complexed with d-TGATCA by nuclear mangentic resonance
       spectroscopy and restrained molecular dynamics: Monica1, S.K.Barthwal2, R. Barthwal1,
       1
         Department of Biotechnology and 2Physics, Indian Institute of Technology Roorkee, 247667 India




                                                 21
PO34   TRNOE analysis of the single-stranded DNA structure induced by binding of the yeast
       mitochondrial DNA recombination protein Mhr1p: Tokiha Masuda12, Tsutomu Mikawa12,3,4,
       Masatoshi Yoshimasu3,4, Feng Ling3, Takehiko Shibata1,2,3 and Yutaka Ito1,2,3,4, 1Molecular and
       Cellular Physiology Laboratory, Graduate School of Integrated Science, Yokohama City
       University, Japan; 2Research Group for Bio-supramolecular Structure-Function, RIKEN, Japan;
       3
         Cellular and Molecular Biology Laboratory, RIKEN, Japan; 4CREST/JST
PO35   Solution Structures of DNA Duplexes Containing Oxidative Cytosine Lesions: Varatharasa
       Thiviyanathan, Anoma Somasunderam, David E. Volk, Tapas K. Hazra, Sankar Mitra and David
       G. Gorenstein, Department of HBCG, University of Texas Medical Branch, Galveston, TX 77555,
       USA
PO36   Hix DNA site that is out of contact with Hin protein adds specificity to the Hin-hix
       recognition: Sung-Hun Bae1, Dawei Sun1, Jongchul Bang1, Jae-Sun Shin1, Byong-Seok Choi1,
       1
         Dept. of Chemistry, Korea Advanced Institute of Science and Technology, Republic of Korea.

PO37   RNA thermometers: Saheli Chowdhury 1,2, Christophe Maris 2, Frederic Allain 2 and Franz
       Narberhaus 1,3, 1Institute of Microbiology, ETH-Zentrum, CH-8092 Zuerich, Switzerland; 2Institute
       for Molecular Biology and Biophysics, ETH-Hönggerberg, CH-8093 Zuerich, Switzerland; 3
       Lehrstuhl fuer Biologie der Mikroorganismen, Ruhr-Universitaet Bochum, D-44780 Bochum,
       Germany

PO38   Application of stable-isotope-labeling of glycopeptides to NMR analyses of sugar recognition
       by the intracellular lectins that determine the fates of glycoproteins in cells: Yoshiki
       Yamaguchi1,2, Takeshi Hirao1,2, Yukiko Kamiya1,2, Noriko Takahashi1,2, Koichi Kato1,2,3,4,
       1
         Nagoya City University, Nagoya, Japan, 2CREST/JST, Saitama, Japan, 3RIKEN/GSC, Yokohama,
       Japan, 4Institute for Molecular Science, Okazaki, Japan
PO39   De Novo Design and Characterization of Glycosaminoglycan Binding Oligopeptides: G
       Jayaraman# and PC Lyu, Department of Life Sciences, National Tsing Hua University, Hsinchu,
       Taiwan.
PO40   Structural Investigation of The Human Hepatic Asialoglycoprotein Receptor and some D-
       Galactose Complexes: A.M. Bianucci^, F. Chiellini°, A.M. Piras°, K. H. Mayo*, L. J. Yao#, M.
       Spiess&, ^Department of Pharmaceutical Science – University of Pisa, Italy, °Department of
       Chemistry & Industrial Chemistry – University of Pisa, Italy, *Department of Biochemistry,
       Molecular Biology & Biophysic – University of Minnesota, Minneapolis, USA, #Department of
       Chemistry – University of Minnesota, Minneapolis, USA, &Department of Biochemistry
       Biozentrum – University of Basel, Basel (Switzerland)

PO41   Towards Understanding the Conformation and Dynamics of Biologically Important
       Oligosaccharide Systems: C. Baby 1, M.S. Mon 1 and S. Subramaniam 2, 1 Sophisticated
       Analytical Instrumentation Facility, Indian Institute of Technology Madras, Chennai-600036,
       INDIA, 2Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

PO42   Stathmin-Like Domain N-Terminal Peptides Impede Tubulin Polymerization: M.J. Clement1,
       I. Jourdain2, S. Lachkar2, P. Savarin2, A. Sobel2, P.A. Curmi1, F. Toma1, 1 Universite Evry-Val d
       Essonne; Laboratoire Structure et Reconnaissance des Biomolecules, EA3637, Evry, France , 2
       INSERM, U440, Institut du Fer a Moulin, Paris, France; UPMC, Paris, France

PO43   Helix insertion to eject a ligand: a global conformational transition in the pheromone-
       binding protein of Bombyx mori: Fred F. Damberger1, Erich Michel1, Reto Horst1, Donghan
       Lee1, Walter S. Leal2, Kurt Wüthrich1, 1Institut für Molekularbiologie und Biophysik,
       Eidgenössische Technische Hochschule-Zürich, CH-8093 Zürich, Switzerland, 2Department of
       Entomology, University of California, Davis, CA 95616, USA

PO44   Solution structure of the UBA domain of budding yeast DSK2p in complex with the
       ubiquitin: Ayako Ohno1,2, JunGoo Jee2,3, Kenichiro Fujiwara2, Takeshi Tenno2,4, Natsuko Goda2,



                                                 22
       Hidehito Tochio2, Hideki Kobayashi5, Hidekazu Hiroaki1,2 Masahiro Shirakawa2,3, 1Kihara
       Memorial Yokohama Foundation for the advancement of Life Sciences, Kanagawa, Japan,
       2
         Yokohama City University, Kanagawa, Japan, 3RIKEN GSC, Kanagawa, Japan, 4Ehime
       University, Ehime, Japan, 5Kyushu University, Fukuoka, Japan

PO45   Applications of NMR Spectroscopy and Structural Enzymology to Target-based Discovery
       of Novel Antibacterials: Gunther Kern, Per-Olof Eriksson, Tomas Lundqvist, Sushmita Lahiri,
       Elaina Zverina, Thomas A. Keating, Brian Noonan and Gautam Sanyal*, Infection Discovery,
       AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA and Structural
       Chemistry Laboratory, AstraZeneca R&D Mölndal, Sweden

PO46   Discovery of leads for the macrophage migration inhibitory factor using fragment-based
       screening. A synergistic application of NMR, MS and X-ray screening: C. Fernández, M.J.J.
       Blommers, F. Bitsch, A. Widmer, A. Marzinzik, S. Lehmann, J.-M. Rondeau, Novartis Institutes
       for Biomedical Research, Basel, Switzeland

PO47   Solution NMR structural studies of conus peptides from Indian marine snails: Siddhartha P.
       Sarma1*, Sujit K. Sikdar1, K.S.Krishnan2 and P.Balaram1, 1Molecular Biophysics Unit, Indian
       Institute of Science, Bangalore 560 012, India, 2Department of Biological Sciences, Tata Institute
       of Fundamental Research, Mumbai 400 005, India

PO48   Conformational study of cyclic peptides containing exclusive cis Xaa-Pro amide bond
       derived via ring closing metathesis: S. Kiran Kumar1, B. M. Rajesh2, K. Vyas2, J. Moses Babu2,
       R. Vasudev2, Javed Iqbal2 and A. C. Kunwar1, 1Centre for Nuclear Magnetic Resonance, Indian
       Institute of Chemical Technology, Hyderabad-500 007, India, 2Discovery Research, Dr. Reddy’s
       Research Foundation, Bollaram road, Miyapur, Hyderabad-500 050, India

PO49   Nucleation of  -Hairpin Structures by a Three Residue Turn in a Designed Synthetic
       Nonapeptide: S. Raghothama1, Rajkishor Rai2 and P. Balaram2, 1Sophisticated Instruments
       Facility and 2Molecular Biophysics Unit, Indian Institute of Science, Bangalore – 560 012, India

PO50   3D Proton MR Spectroscopic Imaging of Prostate in Men with raised PSA: Virendra Kumar*,
       R. Kumar#, S.C Das #, S Thulkar@, S. Duttagupta$, A.K Hemal#, N.P Gupta# and N.R
       Jagannathan*, Departments of NMR*, Urology# and Pathology$ All India Institute of Medical
       Sciences, New Delhi – 110029. INDIA

PO51   NEURAL MAPPING OF AUDITORY LEXICAL PROCESSING THROUGH
       FUNCTIONAL MRI: Y. Uma Sreekumar, S.S. Kumaran, S. Khushu and R.P. Tripathi, NMR
       Research Centre, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road,
       Delhi – 110 054, INDIA

PO52   Investigation of Muscle Metabolism by Multi-Dimensional Localized Magnetic Resonance
       Spectroscopic Techniques at 3T: S. Sendhil Velan1, Susan Lemieux1, Raymond R. Raylman1, M.
       Albert Thomas2, 1Center for Advanced Imaging and Department of Radiology, West Virginia
       University, 2Department of Radiology, University of California, Los Angeles

PO53   Activation of the Brain Center Associated with Visually Evoked Sexual Arousal: Functional
       MR Imaging: Gwang Woo Jeong, Heoung Keun Kang, Hyung Joong Kim, Hyeong Jung Kim,
       Jeong Jin Seo, Department of Radiology, Chonnam National University Medical School, Gwangju
       501-190, Korea

PO54   The Regulation of GABA Synthesis during Increased Brain Activity: Anant B. Patel1, Robin
       A. de Graaf1, Kevin L. Behar2, Department of 1Diagnostic Radiology and 2Psychiatry, Magnetic
       Resonance Research Center, Yale University School of Medicine, New Haven, CT 06520, USA




                                                  23
PO55   The hetero-nuclear NMR-based metabol(n)omics of plant and animal systems: Jun
       Kikuchi1,2,3, Takashi Nishihara1, Kazuo Shinozaki2,4 & Takashi Hirayama1,2,4, 1Grad. Sch. Integ.
       Sci., Yokohama City Univ; 2GSC, RIKEN Yokohama Inst.; 3CREST, JST & 4Plant Mol. Biol. Lab.,
       RIKEN Tsukuba Inst.

PO56   Restoration of hepatocyte function during decompression in human obstructive jaundice
       using 1H and 31P NMR spectroscopy of bile: Lakshmi Bala1, PratimaTripathi1, G.A.Nagana
       Gowda1, C.L.Khetrapal1, Gunjan Shukla2 and Gourdas Choudhuri2, 1Centre of Biomedical
       Magnetic resonance and 2Department of Gastroenterology, Sanjay Gandhi Post Graduate
       Institute of Medical Sciences, Raebareli Road, Lucknow- 226 014, India

PO57   ESR-Investigation of The System On The Base Of Microcrystalline Cellulose and Drug
       substances: S.A.Muratova, N.D.Burkhanova, G.V.Nikonovich, S.Sh.Rashidova, Institute of
       Polymer Chemistry and Physics, Academy of Sciences, Republic of Uzbekistan, 7b, A.Kadyrii S
       tr.,700 128, Tashkent

PO58   Shedding Light on the Rhodopsin/Transducin Interface: L. Q. Anderson1, M. A. Anderson1,
       N.Van Eps2, S. O. Smith3, W. L. Hubbell2, T. J. Baranski1, O. G. Kisselev4, G. R. Marshall1,
       1
         Washington University, Missouri; 2UCLA, California; 2SUNY Stony Brook, New York; 4St. Louis
       University, Missouri, USA
PO59   Automated Structure Improvement and Verification of Proteins from NMR and X-ray data:
       W. Gronwald, J. Trenner, K. Brunner, B. Ganslmeier, A. Nassar, R. Kirchhöfer, K.-P. Neidig and
       H. R. Kalbitzer, Institute of Biophysics and Physical Biochemistry, University of Regensburg,
       93040 Regensburg, Germany and Bruker Biospin, 76287Rheinstetten, Germany
PO60   Probing weakly structured conformational ensembles with residual dipolar couplings: M.
       Louhivuori1, K. Fredriksson2, A. Annila1,3, 1Department of Physical Sciences, 2Program in
       Structural Biology and Biophysics Program, Institute of Biotechnology, and 3Department of
       Biosciences, University of Helsinki, Finland.


                                      POSTER ABSTRACTS

Methods

P1     Reducing Decoupler heating by an Order of Magnitude in Triple-resonance MAS NMR at
       750 MHz: F.David Doty1, Jatin Kulkarni1, George Entzminger1, Siddarth Shevgoor1, Kranti P.
       Shevgoor1, Tony Bielecki2,and Christopher Turner2 1Doty Scientific, 700 Clemson Rd., Columbia,
       SC, 29229, USA, 2Francis Bitter Magnet Lab, MIT, 170 Albany Street, Cambridge, MA, 02139,
       USA

P2     Side Chain Assignments of Methyl-Containing Residues in a Uniformly 13C-labeled
       Hemoglobin: Yu Zheng1 and Daiwen Yang1, 1Department of Biological Sciences and Department
       of Chemistry, National University of Singapore,14 Science Drive 4 Singapore 117543

P3     Sample Patterning on the Surface of Planar NMR-Microcoils: K. Ehrmann1, M. Gersbach1, P.
       Pascoal2, F. Vincent1, C. Massin1, D. Stamou2, P.-A. Besse1, H. Vogel2 and R.S. Popovic1,
       1
         Institute of Microsystems, 2Institute of Chemical Sciences, EPFL – Swiss Federal Institute of
       Technology Lausanne, CH-1015 Lausanne, Switzerland
P4     High b-value q-space analysis of bovine muscle ex vivo: loss of fiber orientation dependent
       diffusion: E. Gedat1, S. Mueller2, A. Stroh3, J. Wuerfel2, T. Tolxdorff1, 1Institute of Medical
       Informatics, 2Clinic and Polyclinic for Neurology, 3Institute of Radiology, 4Institute of
       Neuroimmunology, Charite University Medicine Berlin, Germany
P5     Determination of residual dipolar couplings of the alpha carbon site: P. Würtz, K. Fredriksson
       and P. Permi, NMR Laboratory, Institute of Biotechnology, University of Helsinki



                                                 24
P6    NMR Study of Stereo-Array Isotope-Labeled (SAILed) Proteins: Towards the high-
      throughput, high-precision structural determinations of larger proteins: Takuya Torizawa 1,
      Tsutomu Terauchi1, Yuki Iwashita2, Nozomi Sugimori2, Akira M. Ono1, Seiji Tsuchiya1, Mayuri
      Tai1, Peter Güntert3 and Masatsune Kainosho1, 2, 1CREST/JST, 2Graduate School of Science, Tokyo
      Metropolitan University, 3RIKEN GSC

P7    Implementation of parallel search algorithms using spatial encoding by nuclear magnetic
      resonance: Rangeet Bhattacharyya, Ranabir Das, K. V. Ramanathan, Anil Kumar, NMR
      Quantum Compuation and Quantum Information Group, Department of Physics and Sophisticated
      Instruments Facility, Indian Institute of Science, Bangalore, 560012, India

P8    Some Recent Methodological developments in NMR of oriented molecules: Raghav G.
      Mavinkurve1, Vinay Deepak1, Anu Joy2, N. Suryaprakash2 and K.V. Ramanathan2 , 1Department
      of physics and 2Sophisticated Instruments Facility, Indian Institute of Science, Bangalore 560 012
P9    Investigation of a dipolar coupled 8-qubit system for Quantum Information processing by
      NMR: Ranabir Das, Rangeet Bhattacharya and Anil Kumar , NMR Quantum Computation and
      Quantum Information Group, Department of Physics and Sophisticated Instruments Facility,
      Indian Institute of Science, Bangalore-560012, India

      13
P10    C R1ρ Relaxation Experiments Sampling μs Timescale Dynamics of Methyl Groups in
      Proteins: Ulrika Brath†, Mikael Akke†, Lewis E. Kay ‡, Frans A. A. Mulder†, †Department of
      Biophysical Chemistry, Lund University, Lund, Sweden, ‡Protein Engineering Networks of
      Excellence and Departments of Medical Genetics, iochemistry, and Chemistry, The University of
      Toronto, Toronto, Ontario M5S 1A8, Canada

P11   Residual dipolar oscillations in articular cartilage: Sarma V. S. Akella1,2, Ravinder R. Regatte2,
      Ravinder Reddy2, 1NMR Center, Indian Institute of Chemical Technology, Hyderabad, India,
      2
        MMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

P12   Measurements of Long-range Residual 1HN-13C Dipolar Couplings in Perdeuterated
      Proteins: P.R. Jensen1, S. Meier1, M. Blackledge2 and S. Grzesiek1, 1Department of Structural
      Biology, Biozentrum, University of Basel, Switzerland, 2Institut de Biologie Structurale, Grenoble,
      France

P13   HaCa dipole-dipole and Ha Curie spin relaxation cross-correlation effects in paramagnetic
      proteins - towards structural refinement: V. N. Sivanandama, Irena Mateckoa, Lukas Trantireka,
      Guido Pintacudab, Gottfried Ottingc and Norbert Müllera, aInstitute of Organic Chemistry,
      Johannes Kepler University, Linz, Austria, bDepartment of Medical Biochemistry and Biophysics,
      Karolinska Institute, Stockholm, Sweden; present address: Laboratoire de Chimie, Ecole
      Normale Superieure, Lyon, France, cResearch School of Chemistry, Australian National
      University, Canberra, Australia

P14   Mapping Protein-Protein Interactions by Solvent Exposed Amides Experiment: Kong Hung.
      Sze1, Donghai Lin2, Xuehui Liu3, Yinhua Yang1, Xiao Guan1 and Guang Zhu3, 1 Chemistry
      Department, Hong Kong University, Pokfulum Road, Hong Kong, 2 Shanghai Institute of Materia
      Medica, Shanghai 3 Biochemistry Department, HKUST, Hong Kong

P15   Combined Computational and Experimental Developments for Automated Determination of
      Protein Structures by NMR: Kong Hung Sze1, Yinhua Yang1, Xiao Guan1, Man Kit Tse1 and
      Igor Barsukov2, 1 Chemistry Department, Hong Kong University, Pokfulum Road, Hong Kong, 2
      Biological NMR Center, University of Leicester, United Kingdom
P16   Cross-correlated relaxation evidence for weak intramolecular hydrogen bonds in solution:
      Arunima and Narayanan Kurur*, Department of Chemistry, IIT Delhi, Hauz Khas, New Delhi
      110016




                                                 25
P17   Combined MRI and Optical Imaging of Vascular and Extravascular Transport Events in
      Solid Tumors: Arvind P. Pathak, Ph.D.1, Dmitri Artemov, Ph.D.1, David G. Jackson, Ph.D.2,
      Michal Neeman, Ph.D.3 and Zaver M. Bhujwalla, Ph.D.1, 1Department of Radiology, The Johns
      Hopkins University School of Medicine, Baltimore, MD, USA, 2MRC Human Immunology Unit,
      Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK, and
      3
        Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

P18   A Novel Filtering Technique Utilized for Aliased Peaks: Chojiro Kojima1, 1Nara Institute for
      Science and Technology, Nara, Japan

P19   Rotating frame experiments for NMR quantum computing: N. Ananth, V. Vimalan and N.
      Chandrakumar, Department of Chemistry, Indian Institute of Technology-Madras, Chennai – 600
      036

P20   Exchange spectroscopy: An approach involving modulated shaped RF pulses: V. Vimalan, S.
      Pal and N. Chandrakumar, Department of Chemistry, Indian Institute of Technology-Madras,
      Chennai – 600 036, Tamil Nadu, India

P21   NMR-Based Structural Genomics at the Pacific Northwest National Laboratory: Michael A.
      Kennedy, Pacific Northwest National Laboratory, Biological Sciences Division, EMSL 2569, K8-
      98, Richland, WA 99352 USA

P22   FT-NMR STUDY OF WATER SOLUBLE FULLERENE DERIVATIVES: RACHANA
      SINGH+, SANJAY KANOJIA++, AJIT SRIVASTAVA++, T.H. GOSWAMI+, D.N. TRIPATHI++,
      +
        ELECTRONIC & SMART MATERIALS / ++CENTRAL ANALYTICAL FACILITY DIVISION,
      DEFENCE MATERIALS & STORES RESEAECH & DEVELOPMENT ESTABLISHMENT,
      DMSRDE P.O., G.T. ROAD, KANPUR – 208013

P23   Measurement of 1J(Ni, Ci), 1J(Ni, C’i-1), 2J(Ni, Ci-1), 2J(HNi, C’i-1) and 2J(HNi, Ci) values in
      13
         C/15N labeled proteins: Sulakshana Mukherjee, Sourajit M. Mustafi, H.S Atreya, and K.V.R
      Chary, Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400
      005, India

P24   Localization Of Nanoscale Magnetic Domains By Magnetic Force Microscopy: Mayur Savla,
      Denis V. Pelekhov, Camelia Selcu, Petra Schmalbrook, Chris Hammel, Michael Knopp and
      Gunjan Agarwal, Ohio State University, Columbus, OH, USA
SOLID-STATE NMR
P25   Structure Analysis of Chlorosomal Bacteriochlorophyll c Assembly and Chlorosomes
      by Solid-state NMR: Ayako Egawa 1 , Kengo Akiba 1, Yoshinori Kakitani 2, Yasusyi
      Koyama 2 , Toshimichi Fujiwara 1 and Hideo Akutsu 1 , 1 Institute for Protein Research, Osaka
      University, 2 Faculty of Science and Technology, Kwansei Gakuin University

P26   Proton-Carbon Correlation Studies of Enantiomers Oriented in Chiral Nematics: H.S.Vinay
      Deepak1 and K.V.Ramanathan2, 1 Physics Department, Indian Institute of Science, Bangalore,
      India, 2 Sophisticated Instruments Facilty, Indian Institute of Science, Bangalore, India

P27   Homonuclear Correlation Experiments for Half-integer Spin Quadrupolar Nuclei: T.G.
      Ajithkumar 1, T. Anupõld 2 , A.Samoson 2, E.R.H. van Eck 3 and A.P.M. Kentgens 3, 1 Central
      NMR Facility, National Chemical Laboratory, Pune 411 008, India, 2 National Institute for
      Chemical Physics and Biophysics, Academia Tee 23, Tallinn, Estonia, 3 Department of
      Physical Chemistry / Solid-State NMR, Institute for Molecules and Materials, Radboud
      University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

P28   Deuterium Correlation Studies in Solids: Jayanthi.S$, Bibhuti Das$, and K.V.Ramanathan*,
      $
        Department of Physics.,Indian Institute of Science,Bangalore 560012, India, *Sophiticated
      Instruments Facility,Indian Intitute of Science,Bangalore 560012, India



                                                 26
P29   Heteronuclear Dipolar Decoupling Effects in Multiple-Quantum and Satellite-Transition
      Magic-Angle Spinning: S. Ganapathya, J. -P. Amoureuxb, L. Delevoyeb, and P. K. Madhuc, aSolid
      State NMR Group, National Chemical Laboratory, Pune 411 008, India, bCNRS-8012, ENSCL-
      USTL, 59652 Villeneuve d’Ascq, France, cDept. of Chemical Sciences, TIFR, Colaba, Mumai 400
      005, India
PROTEIN EXPRESSION AND ISOTOPE LABELLING
P30   Expressed Protein Ligation to Study the Rhodopsin/G-Protein Interface: Insights from
      High-Resolution Solution NMR: L.L. Anderson1, S.O. Smith2, T.J. Baranski1, G.R. Marshall1,
      1
        Washington University, Missouri; 2SUNY Stony Brook, New York, USA

P31   Application of the wheat germ cell-free protein synthesis system to the structural and
      functional analysis of proteins with multidimensional NMR spectroscopy: M. Shimizu1, T.
      Ogasawara1, Y. Endo1, R. Tanaka2, T. Kohno2, E.H. Morita1, 1Ehime University, Ehime, Japan,
      2
        Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
STRUCTURAL & FUNCTIONAL PROTEOMICS
P32   NMR Structure of the N-terminal Domain of SUMO Ligase PIAS1 and Its Interactions with
      regulatory Factors and DNA: S. Okubo1, F. Hara1, Y. Tsuchida1, S. Shimotakahara1,2, S.
      Suzuki2, H. Hatanaka3, S. Yokoyama2,4, H. Tanaka1, H. Yasuda1 and H. Shindo1,2, 1Tokyo
      University of Pharmacy & Life Science, Hachioji, Tokyo 192-0392, Japan, 2RIKEN GSC,
      Tsurumi-ku, Yokohama 230-0045, 3Kyushu University, Hakozaki, Fukuoka 812-8581, and 4the
      University of Tokyo, Bunkyo-ku, Tokyo 110-0033
P33   Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional
      Genomics: Adelinda Yee , Bin Wu, and Cheryl H. Arrowsmith, Ontario Cancer Institute and
      Department of Medical Biophysics, and Department of Medical Genetics, University of Toronto,
      200 Elizabeth Street, Toronto, ON, Canada M5G 2C4


P34   Molecular mechanism responsible for control of the redox potential of P. Aeruginosa
      cytochrome c551 revealed by paramagnetic 1H NMR and electrochemical studies: Shin-ichi J.
      Takayama,1 Shin-ichi Mikami,1 Norifumi Terui,1 Hajime Mita,1 Jun Hasegawa,2 Yoshihiro
      Sambongi,3 and Yasuhiko Yamamoto1, 1 Graduate school of pure and applied sciences, University
      of Tsukuba, Tsukuba 305-8571, Japan, 2 Daiichi Pharmaceutical Co., Ltd., Edogawa-ku, Tokyo
      134-8630, Japan, 3 Graduate School of Biosphere Science, Hiroshima University, Higashi-
      Hiroshima 739-8528, Japan

P35   Solution Structure Calculation Of Two Hypothetical Proteins From Pseudomonas
      Aeruginosa Genome: Sampath Srisailam and Cheryl Arrowsmith, Clinical Genomic Center,
      University Health Network, Toronto, Ontario, Canada
P36   Structural studies on the C-terminal peptides of glycosomal Phosphoglycerate Kinase from
      Leishmania mexicana: Vidya Raghunathan, Sangita Aggarwal, National Institute of Immunology,
      Aruna Asaf Ali Marg, N.Delhi – 110067, INDIA

P37   GYF domain proteomics: Michael Kofler1 and Christian Freund1, 1Protein Engineering Group,
      Forschungsinstitut für Molekulare Pharmakologie und Freie Universität Berlin, Robert-Rössle-
      Str. 10, 13125 Berlin,Germany

P38   Structure-Functional Relation of a Novel Calcium Binding Protein from Entamoeba
      histolytica: Ritu Bansal-Mutalik1, Sourajit M. Mustafi1, Paramita Chakrabarty2, Alok
      Bhattacharya2 and Kandala V.R. Chary1 , 1Department of Chemical Sciences, Tata Institute of
      Fundamental Research, Mumbai, India, 2School of Environmental Sciences and School of Life
      Sciences, Jawaharlal Nehru University, New Delhi, India
P39   p53 Dimerization Mutants Lack DNA Binding by Missing Cooperativity: A. Dehner,1 C.
      Klein,2 S. Hansen,2 M. Schwaiger,2 H. Kessler,1 1Department Chemie, Technische



                                              27
      Universität München, 85747 Garching, Germany, 2Pharma Research, Roche Diagnostics GmbH,
      82372 Penzberg, Germany

P40   NMR structural studies on a hypothetical protein, YKR049C derived from Saccharomyces
      cerevisiae: Jinwon Jung1, Cheol-Jin Lee1, Adelinda Yee2, Cheryl H. Arrowsmith2 and Weontae
         1 1
      Lee , Department of Biochemistry, Yonsei University, Seoul, Korea, 2Ontario Cancer Institute,
      University of Toronto, Toronto, Canada
P41   Distributed Computing and NMR Constraint-Based Protein Structure         Determination:
      Applied for Endothelin-1 and Holo-neocarzinostatin: H. Takashima,1 T. Yoshida,2 T. Ishino,2
      K. Hasuda,3 N. Mimura,1 Y. Nishi,2 T. Ohkubo,2 Y. Kobayashi,2 1Novartis Institutes for
      BioMedical Research, Tsukuba, 2Osaka University, Osaka, 3POLA Chemical   Industries Inc.,
      Japan

PROTEIN STRUCTURE, INTERACTION & DYNAMICS

P42   Structural survey of the La autoantigen: insights into RNA recognition:D. Sanfelice1, C.
      Alfano1, J. Babon2, G. Kelly3, S. Curry4 and Maria R Conte1, 1Biophysics Laboratories, IBBS,
      University of Portsmouth, Portsmouth PO1 2DT, UK, 2Department of Molecular structure, Walter
      and Eliza Hall Institute, Vic 3052, Australia, 3Biomedical NMR Centre, National Institute for
      Medical Research, London NW7 1AA, UK, 4Department of Biological Sciences, Imperial
      College London, SW7 2AZ, UK

P43   NMR Structure of a Type IVb Pilin from Salmonella typhi and Its Assembly into Pilus:
      Xing-Fu Xu,1 Yih-Wan Tan,1 Lam Lam,2 Jim Hackett,2 Mingjie Zhang,2 and Yu-Keung Mok,1
      1
        Department of Biological Sciences, National University of Singapore, Singapore 117543,
      2
        Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water
      Bay, Hong Kong

P44   Water in hydrophobic cavities in proteins: a computational study: Chandra Verma,
      Computational Biology, Bioinformatics Institute, Biopolis, Singapore-138671

P45   Determination of the Binding Specificity of the 12S and 5S Subunits of the Transcarboxylase
      by Saturation Transfer Difference NMR: Rakesh Bhat, Claudia Peikert, Karsten Seeger and
      Stefan Berger, Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, D-04103
      Leipzig, Germany

P46   The tetrameric L27 domain complex as an organization platform for supramolecular
      assemblies: Wei Feng1, Jia-Fu Long1, Jing-Song Fan1, Tetsuya Suetake1, and Mingjie Zhang1,
      1
        Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water
      Bay, Kowloon, Hong Kong, China

P47   Molecular architecture of the insulin-like growth factor binding proteins (IGFBPs): Sudipta
      Majumdar, Madhumita Ghosh, Igor Siwanowicz, Loyola D’Silva, and Tad A. Holak, Max Planck
      Institute for Biochemistry, D‑ 82152 Martinsried, Germany

P48   Molecular determinants for complex formation between the retinoblastoma protein and the
      LXCXE sequence containing proteins: Mahavir Singh, Marcin Krajewski, and Tad A. Holak,
      Max Planck Institute for Biochemistry, D-82152 Martinsried, Germany

P49   NMR Structural Studies on DdCAD-1: a Ca2+-dependent Cell-Cell Adhesion Molecule: Zhi
      Lin1, Eric Huang2, Chi-Hung Siu2, Daiwen Yang1, 1 Dept of Bio Sci, National University of
      Singapore, Singapore, 2Banting and Best Department of Medical Research and Department of
      Biochemistry University of Toronto,Toronto, Ontario M5G 1L6, Canada




                                               28
P50   Lipid bilayer triggers the release of chromophore from neocarzinostatin: Hariharan
      Parameswarana,b, Shan-Ho Choub, Der-Hang China*, aDepartment of Chemistry, National Chung
      Hsing University, Taichung, Taiwan, ROC.; bInstitute of Biochemistry, National Chung Hsing
      University, Taichung, Taiwan, ROC

P51   Nickel binding to histone H4: Maria Antonietta Zoroddua, Massimiliano Peanaa, Serenella
      Medicia, Max Costab, aDepartment of Chemistry & Faculty of Pharmacy, University of Sassari,
      Italy, bDepartment of Environmental Medicine, N.Y . University, School of Medicine, USA

P52   Nickel binding in the C-terminal domain of Cap43 protein: Maria Antonietta Zoroddua,
      Massimiliano Peanaa, Serenella Medicia, Teresa Kowalik-Jankowskab, Henryk Kozlowskib, Max
      Costac, aDepartment of Chemistry, University of Sassari, Sassari, Italy, bFaculty of Chemistry,
      University of Wroclaw, Po; cDepartment of Environmental Medicine, New York University, USA

P53   NMR and biophysical studies on the periplasmic domain of Escherichia coli sensor histidine
      kinase EnvZ: Ahmad Khorchid1, Masayori Inouye2, and Mitsuhiko Ikura1, 1Division of Molecular
      and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics,
      University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada, 2Department
      of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA

P54   Tracking NMR-defined exchange motions across the folding-unfolding equilibrium of horse
      ferricytchorme c: D. Krishna Rao,* S. Satyanarayana and Abani K. Bhuyan, University of
      Hyderbad, School of Chemistry, Hyderbad 500 046

P55   Structure and Interactions of the Malarial Surface Antigen AMA1: R.S. Norton,1 Z.P. Feng,1
      R.A. Evans-Stevenson,1 D.W. Keizer,1 S. Yao,1 A. Coley,2,3,4 M. Foley,2,3 R.F. Anders2,4, 1 Walter
      and Eliza Hall Institute of Medical Research, Parkville 3050, Australia, 2 Department of
      Biochemistry, La Trobe University, Bundoora 3083, Australia, 3 CRC for Diagnostics and 4 CRC
      for Vaccine Technology, Bundoora 3083, Australia

P56   C-Terminal Domain of Insulin-Like Growth Factor (IGF) Binding Protein-6. Implications
      for Regulation of IGF Action: R.S. Norton,1 S.J. Headey,1,2 D.W. Keizer,1 S. Yao,1 L.A. Bach2,
      1
        Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia, 2 Department of
      Medicine, University of Melbourne, Austin Hospital, Heidelberg 3084, Australia

P57   NMR snap shots of a fluctuating ubiquitin structure at 30 bar-3kbar: Ryo Kitahara1,
      Shigeyuki Yokoyama12,3,4, Kazuyuki Akasaka1,5, 1Structural and Molecular Biology Lab.,
      2
        Structurome Research Group, RIKEN Harima, 3RIKEN Genomic Science Center, 4Department of
      Biophisics and Biotechnology, University of Tokyo, 5Department of Biotechnological Science,
      Kinki University

P58   Solution structural studies on E.coli pantothenate synthetase using NMR methods: Kalyan
      Sundar Chakrabarti and Siddhartha P. Sarma, Molecular Biophysics Unit, Indian Institute of
      Science, Bagalore-560012

P59   Rational Design of Akt Specific Inhibitors: Christian Roumestand, Daniel Auguin, Virginie
      Ropars, and Masayuki Noguchi, Centre de Biochimie Structurale, Faculte de Pharmacie,
      Montpellier France, Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido
      University, Japan

P60   TROSY-NMR and Saturation Transfer Studies of Calmodulin Complexed with Intact
      Human Lactoferrin: H. Ishida1 and H. J. Vogel1, 1University of Calgary, Alberta, Canada

P61   Biophysical characterization of a molten globular affibody: C. Lendel,1 V. Dincbas-Renqvist,1
      A. Flores,2 E. Wahlberg,1 J. Dogan,1 T. Härd3, 1 Royal Institute of Technology (KTH), Stockholm,
      Sweden, 2 Umeå University, Umeå, Sweden, 3 Göteborg University, Göteborg, Sweden


                                                 29
P62   Conformations of Nucleotides Bound to Wild Type and Y78F Mutant Yeast Guanylate
      Kinase: Proton Two Dimensional Transferred NOESY Measurements: Bruce D. Ray1, Gotam
      K. Jarori2, Honggao Yan3, Vidya Raghunathan4, and B.D. Nageswara Rao1, 1Department of
      Physics, Indiana University - Purdue University at Indianapolis (IUPUI), Indiana, USA, 2Tata
      Institute of Fundamental Research, Mumbai, India, 3Department of Biochemistry Michigan State
      University, East Lansing, MI, USA, 4National Institute of Immunology, New Delhi, India

P63   Structural Basis of Myosin Phosphatase Inhibitory Protein, CPI-17: S.Ohki1, F.Matsuzawa2,
      K.Yokota1, and M.Eto3, 1Japan Advanced Institute of Science and Technology (JAIST), 2Celester
      Lexico-Sciences, 3Univ. of Virginia

P64   NMR studies on the 56kDa Escherichia coli nickel-binding protein NikA: Sundaresan
      Rajesh1,2,3,4, Kaori Kurashima1,2,5 , Daniel Nietlispach6, Masahiro Shirakawa7, Jonathan Heddle3,
      Jeremy Tame3 and Yutaka Ito1,2,5, 1Research Group for Bio-supramolecular Structure-Function,
      RIKEN, JAPAN; 2Molecular and Cellular Physiology, 3Protein Design, and 7Molecular
      Biophysics Laboratories, Graduate School of Integrated Science, Yokohama City University,
      JAPAN; 4Division of Cancer Studies, School of Medicine, University of Birmingham, UK;
      5
        CREST, JST, JAPAN; 6Department of Biochemistry, University of Cambridge, UK

P65   Structural features of Neurokinin-2 Receptor Selective Peptide Agonists and their role in
      receptor selectivity: Indu R.Chandrashekar1, M. Anil Kumar1, Anjali Dike1, Sudha
      M.Cowsik1 and Gita Subha Rao2, 1School Of Life Sciences, Jawaharlal Nehru University, New
      Delhi, India-110067, 2Department of Biophysics, All India Institute of Medical Sciences, New
      Delhi, India

P66   Structural characterization of Scyliorhinin I: A dual NK1/NK2 receptor agonist: Anjali Dike,
      Indu Chandrashekar, Anil Mantha and Sudha M Cowsik, Jawaharlal Nehru University, New
      Delhi-67, INDIA

P67   Investigation of the protein with the help of multidimensional NMR spectroscopy: M. D.
      Mukrasch1, M. Zweckstetter1, C. Griesinger1, M. von Bergen2, J. Biernat2, E.-M. Mandelkow2, E.
      Mandelkow2, 1Max-Planck-Institute for biophysical chemistry, Göttingen, 2Max-Planck-
      Arbeitsgruppen für strukturelle Molekularbiologie Hamburg

P68   Conformational analysis of HIV Rev protein in solution at acidic pH: Daniel Padró and
      Francisco Blanco, Structural and Computational Biology Programme, Centro Nacional de
      Investigaciones Oncológicas Melchor Fernández Almagro 3, 28029 Madrid, Spain

P69   NMR Structural Studies of the Interferon α Signaling Complex: Sabine R. Quadt1, Jordan H.
      Chill1, Rina Levy1, Jacob Piehler2, Jacob Anglister1, 1Department of Structural Biology, Weizmann
      Institute of Science, Rehovot, Israel; 2Institute of Biochemistry, Johann Wolfgang Goethe
      University Frankfurt am Main, Germany

P70   Residual Dipolar Couplings and some specific Models for Motional Averaging: M.
      Deschamps,1 I.D. Campbell,1 J. Boyd1, 1Oxford University, United Kingdom

P71   Probing Protein-Peptide Binding Surfaces Using Charged Stable Free Radicals and
      Transverse Paramagnetic Relaxation Enhancement (PRE):M. Deschamps,1 E.S. Pilka,1 J.R.
      Potts,1 I.D. Campbell,1 J. Boyd1, 1Oxford University, United Kingdom

P72   Sorting out a sortase: characterizing the substrate binding site of sortase A from
      Staphyloccocus aureus: C.K. Liew1, N. Suree1, B.T. Smith1, M.T. Naik1, R. Pilpa1, U.
      Ilangovan1, M.E. Jung1, R.T Clubb1, 1Department of Chemistry and Biochemistry, University of
      California, Los Angeles




                                                30
P73   NMR Structure Studies of an Anion Binding Channel-Forming Heptapeptide: Gabriel A.
      Cooka, Mahalaxmi Aburib, Paul E. Smithb, John M. Tomicha, Robert Pajewskic, Paul H.
      Schlesingerc, George W. Gokelc, aDepartment of Biochemistry Kansas State University,
      Manhattan, KS 66506, bDepartment of Chemistry Kansas State University, Manhattan, KS 66506,
      c
        Department of Molecular Biology & Pharmacology, Washington University School of Medicine,
      St. Louis, MO 63110

P74   Towards the solution structure of a 34 kDa ternary complex involved in bacteriophage
      Lambda recombination: M.D. Sam1, E.A. Fadeev1, C.V. Papagiannis2, R.C. Johnson2 and R.T.
      Clubb1, 1Department of Chemistry and Biochemistry, University of California, Los Angeles, USA,
      2
        Department of Biological Chemistry, UCLA School of Medicine, USA

P75   Solution structure of the DNA binding domain A of Saccarimyces cerevisiae RPA and its
      interaction with single stranded DNA: Chin-Ju Park1, Joon-Hwa Lee2, Mi-Kyung Lee1, Sung
      Jae Cho1 and Byong-Seok Choi1, 1Department of Chemistry and National Creative Research
      Initiative Center, Korea Advanced Institute of Science and Technology, Korea, 2Department of
      Chemistry and Biochemistry, University of Colorado at Boulder, USA

P76   Solution Structural Studies of Regulatory Subunit of Acetohydroxy Acid Synthase: Ashima
      Mitra1 and Siddhartha.P.Sarma1, 1Molecular Biophysics Unit, Indian Institute of Science,
      Bangalore

P77   Mapping the Binding Interface of XPF-ERCC1 complex by Cross-saturation Experiment:
      Yun-Jeong Choi, Mi-Kyung Yoon, Seikh Imtiaz Ali and Byong-Seok Choi, Department of
      Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-
      gu, Daejon, 305-701, Korea

P78   3D Structure Of Elderberry Lectin and its Unexpected EL:N,N',N''-Triacetylchitotriose 2:1
      Binding Ratio: C. Mihai15, L. Buts2, L. Wyns2, W. J. Peumans3, E. J. M. Van Damme4, J. C.
      Martins1 and R. Willem5, 1Eenheid NMR en Structuuranalyse, Universiteit Gent, Belgium, 2Dienst
      Ultrastructuur, VIB, Vrije Universiteit Brussel, Belgium, 3Laboratory for Phytopathology and
      Plant Protection, Katholieke Universiteit Leuven, Belgium, 4Vakgroep Moleculaire
      Biotechnologie, Universiteit Gent, Belgium, 5HNMR Centre and POSC, Vrije Universiteit Brussel,
      Belgium

P79   Danger, Homo-dimer : M. Coles, S. Djuranovic, M. Hulko, A.N. Lupas, Max-Planck-Institute
      for Developmental Biology, TŸbingen, German

P80   Solution NMR Studies of Holo form of Plasmodium falciparum Acyl Carrier Protein: Alok
      Kumar Sharma1, Shailendra Kumar Sharma1, Rahul Modak2, Namita Surolia2, Avadhesha Surolia1
      and Siddhartha P. Sarma1, 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore
      560012, 2Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific
      Research, Jakkur,Bangalore 560064

P81   Kinetics and Mechanism of Microsecond Conformational Changes in Plastocyanin Induced
      by Histidine Protonations: A 15N Relaxation Study: Mathias A. S. Hass1, Marianne H.
      Thuesen2, Hans E. M. Christensen2,Jens J. Led1, 1 Department of Chemistry, University of
      Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark, 2 Department of Chemistry,
      The Technical University of Denmark, Building 207, DK-2800 Lyngby, Denmark

P82   Solution Structure of Sterile Alpha Motif (SAM) Domain of Deleted in Liver Cancer-1
      (DLC-1): Shuai Yang, Jingfeng Zhang, Boon Chuan Low, Daiwen Yang, Department of
      Biological Sciences and Department of Chemistry, National University of Singapore, 14 Science
      Drive 4 Singapore 117543




                                               31
P83   Eukaryotic Translation Termination Factor GSPT/eRF3 Recognizes PABP with Chemical
      Exchange Using Two Overlapping Motifs: M. Osawa1, T. Nakanishi1, S. Hoshino1, T. Katada1,
      and I. Shimada1,2, 1Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, Tokyo, Japan; 2BIRC, Tokyo,
      Japan

P84   The solution structure of the DNA binding domain of NikA: H. Yoshida1, N. Furuya1, Y.J.
      Lin2, T. Komano1, P. Güntert2, M. Kainosho1, 1CREST/JST and Tokyo Metropolitan University,
      Tokyo, Japan, 2RIKEN Genomic Sciences Center, Yokohama, Japan

P85   NMR studies on the sensory domain of the two component Histidine kinases , DcuS and
      CitA: Vinesh Vijayan1 , Michael Bott2, Gottfried Unden3, Markus Zweckstetter1, and Christian
      Griesinger1, 1Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077
      Göttingen, Germany,2 Institut für Biotechnologie 1, Forchungszentrum Jülich, D-52425 Jülich,
      Germany,3Institut für Microbiologie und Weinforschung, Universität Mainz, Becherweg 15, D-
      55099 Mainz, Germany

P86   Solution Structure of the Replication Initiator Protein Nuclease Domain from a Nanovirus:
      Ramón Campos-Olivas and Susana Vega, CNIO (Spanish National Cancer Center), Madrid,
      Spain

P87   NMR structure determination of mouse Apolipoprotein AI/prebHDL Particles: Arun
      Sivashanmugam1, Xuefeng Ren1, Leslie Korando1, Lei Zhao1, Qianqian Li1, Daniel Sparks2 &
      Jianjun Wang1, 1 Department of Biochemistry and Molecular Biology and Department of
      Anatomy, Southern Illinois University, Carbondale, Illinois, USA, 62901- 4413, 2 Heart Institute,
      University of Ottawa, Ottawa, Ontario, CANADA

P88   Structural Basis for the cyclic AMP Signal Translation in PKA by NMR: Rahul Das2,
      Veronica Esposito2, Bart Kalata2, S. Brown1, T. Sjoberg1, D. J. Vigil1, S. S. Taylor1, G. Melacini2*,
      1
        University of California, San Diego, USA, 2 McMaster University, Hamilton, Ontario, Canada

P89   Protein Dynamics Play a Key Role in Determining the Specific Recognition of GU-rich
      polyadenylation regulatory elements by human Cstf-64 protein: Pritilekha Deka, P. K. Rajan,
      Jose’ Manuel Perez-Canadillas1 and Gabriele Varani*, Department of Biochemistry and
      Department of Chemistry, University of Washington, Seattle Washington 98195-1700, USA,
      1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH England

P90   NMR analysis of human mitochondrial ABC transporter, ABCB6: Kaori Kurashima1,2,3
      Hiroshi Sembongi3,4, Takehiko Shibata1,2,3 and Yutaka Ito1,2,3, 1Research Group for Bio-
      supramolecular Structure-Function, RIKEN, JAPAN; 2CREST, JST, JAPAN;, 3Molecular
      Biophysics Laboratories, Graduate School of Integrated Science, Yokohama City University,
      JAPAN; 4Mitochondrial Diseases Group, MRC Dunn Human Nutrition Unit, UK

P91   Structural and functional analyses of Thermus thermophilus RecO: Jin Inoue1,2, Masayoshi
      Honda1,2,3, Takehiko Shibata1,2,4, Yutaka Ito1,2,3, and Tsutomu Mikawa1,2,3,4, 1Graduate School of
      Integrated Science, Yokohama City University,Japan; 2Research Group for Bio-supermolecular
      Structure Function and 4Structurome Research Group, RIKEN, Japan; 3CREST/JST

P92   Molecular mechanism of RecR-DNA interactions: Masayoshi Honda1,2,3, Jin Inoue1,2, Yosimasu
      Masatoshi1,3, Tsutomu Mikawa1,2,3,4, Takehiko Shibata1,2, and Yutaka Ito1,2,3, 1Research Group for
      Bio-supramolecular Structure-Function RIKEN, JAPAN; 2Molecular and Cellular Physiology
      Laboratory, Graduate School of Integrated Science, Yokohama City University, JAPAN;
      3
        CREST/JST; 4Structurome Res. Group, RIKEN, JAPAN

P93   The Solution Structure of the FATC Domain of the Protein Kinase TOR Suggests a Redox-
      Dependent Regulatory Mechanism: Sonja A. Dames1, Jose M. Mulet2, Klara Rathgeb-Szabo1,




                                                  32
       Michael N. Hall2, & Stephan Grzesiek1, 1Department of Structural Biology, 2Department of
       Biochemistry, Biozentrum, University of Basel, Switzerland

P94    Structure and Dynamics Characterization of Protein Domains in the Transacylase
       Component of Human Mitochondrial Branched-Chain Ketoacid Dehydrogenase: Chi-Fon
       Chang1, Yi-Jan Lin2, Hui-Ting Chou3, Shin-Jye Lee3, David T. Chuang4, Tai-Huang Huang1,3,
       1
         Gemomics Research Center, Academia Sinica, Nan-Kang, Taipei 11529, Taiwan, 2RIKEN
       Genomic Sciences Center, Yokohama 230-0045, Japan, 3Institute of Biomedical Sciences
       Academia Sinica, Nan-Kang, Taipei 11529, Taiwan, 4Dept of Biochemistry, U. of Texas
       Southwestern Medical Center, Dallas, Texas

P95    Physical Properties of Spider Dragline Silk Investigated by Solid-State NMR Spectroscopy:
       Isabelle Marcotte1, Fritz Vollrath2 and Beat H. Meier1, 1Department of Physical Chemistry, ETH-
       Hönggerberg, CH-8093, Zürich, Switzerland, 2Department of Zoology, Oxford University, OX1
       3PS Oxford, United Kingdom

P96    Cryptic vinculin binding sites in the talin rod : Ian Fillingham, Alexandre R. Gingras, Bipin
       Patel, Jonas Emsley, David R. Critchley, Gordon C.K. Roberts and Igor L. Barsukov,
       Biological NMR Centre, University of Leicester, University Road, Leicester, LE1 7RH, UK

P97    Role of Neurokinin B and Ab-protein fragment 25-35 on aging rat brain synaptosomes: Anil
       K Mantha, Indu R. Chandrashekar, Anjali Dike, K. Moorthy, Najma Z. Baquer and Sudha M.
       Cowsik, School of Life Sciences, Jawaharlal Nehru University, New Delhi – 110 067, INDIA

P98    GTPase Effector Domain of Dynamin: structure function relationships: Jeetender Chugh1,
       Amarnath Chatterjee1, Ashutosh Kumar1, Ram Kumar Mishra2, Rohit Mittal2, and Ramakrishan V.
       Hosur1, 1Departments of Chemical and 2Biological Sciences, Tata Institute of Fundamental
       Research, Homi Bhabha Road, Mumabi 400005, India

P99    Conformation and Dynamics of Protein L12 in Solution and on the Ribosome: Frans A. A.
       Mulder, Lamine Bouakaz, Anna Lundell, Musturi Venkataramana, Anders Liljas, Suparna Sanyal
       and Mikael Akke, Departments of Biophysical Chemistry & Molecular Biophysics, Lund
       University, Sweden, & Department of Cell and Molecular Biology, BMC, Uppsala University,
       Sweden

P100   Structural Characterization of Filamin Repeat 21 And its Interaction With Migfilin: S. S.
       Ithychanda1, X. Wang1, Y. Xu1, C. Wu2, J, Qin1, 1Cleveland Clinic Foundation, Cleveland, USA,
       2
         University of Pittsburgh, Pittsburgh, USA

P101   Protein Structure from Residual Dipolar Couplings and Minimal NOE Information using
       Molecular Fragment Replacement: Georg Kontaxis1, Zhengrong Wu2, Frank Delaglio3 and Ad
       Bax3, 1Department of Structural Biology, Vienna University, Austria, 2Department of
       Biochemistry, Ohio State University, OH, USA, 3NIDDK, NIH, Bethesda, MD, USA

P102   Heteronuclear NMR Investigations of Dynamic Regions of Intact E. coli Ribosomes: John
       Christodoulou*, Göran Larsson*,, Paola Fucini†, Kresten Lindorff-Larsen*, Michele
       Vendruscolo*, Christina Redfield‡, Jürgen Schleucher¶       and Christopher M. Dobson*,
       *Department of Chemistry, University of Cambridge, Cambridge, UK, † Max-Planck-Institute für
       Molekulare Genetik, Berlin, Germany, ‡ Oxford Centre for Molecular Sciences, University of
       Oxford, Oxford, UK, ¶ Department of Medical Biochemistry and Biophysics, Umeå University,
       Umeå, Sweden

P103   Solution Structure of a Vanadium-binding Protein, Vanabin2 from the Vanadium-rich
       Ascidian, Ascidia sydneiensis samea:  Toshiyuki Hamada1,2, Miwako Asanuma1, Tatsuya
           3                   1
       Ueki , Fumiaki Hayashi , Naohiro Kobayashi1, Shigeyuki Yokoyama1, Hitoshi Michibata3,




                                                33
       Hiroshi Hirota1,2 , 1 RIKEN Genomic Sciences Center, Yokohama, JAPAN,           2
                                                                                           Yokohama City
       University, Yokohama, JAPAN, 3 Hiroshima University, Hiroshima, JAPAN

P104   Characterization of magnesium-binding site in the calcium-binding photoprotein aequorin
       by NMR analysis: Wakana Ohashi1, Satoshi Inouye2, Toshio Yamazaki1, Yukiko Doi-
       Katayama1,      higeyuki Yokoyama1, Hiroshi Hirota1, RIKEN Genomic Sciences Center,
       Yokohama, JAPAN,        Yokohama Research Center, Chisso Corporation, Yokohama, JAPAN

P105   MR Studies of Activating Domain of Transcription Factor Hex with GST: A. Sakurai1, D. A.
       remu1, J. Kurita2, T. Noguchi3, S. Meshitsuka1, 1Tottori Univ., Tottori, 2Varian Inc., 3Nagoya
       niv., Nagoya, Japan

P106   Structural characterisation by NMR of bioengineered cyclic peptides for the treatment of
       multiple sclerosis: Masa Cemazar1, Claude Bernard2 and David Craik1, 1Institute for Molecular
       Bioscience, University of Queensland, Brisbane, Australia, 2Neuroimmunology Laboratory, La
       Trobe University, Melbourne, Australia

P107   Histidine residues are essential for optimal metal binding to bacterial metallothionein:
       Claudia A. Blindauer1,2, M. Tahir Razi1,3, Dominic J. Campopiano1 and Peter J. Sadler, 1University
       of Edinburgh, UK; 2University of Warwick, UK; 3Bahauddin Zakariya University, Multan,
       Pakistan

P108   NMR Evidence for Enzyme-Induced Strain in the Michaelis Complex of Serine Protease
       from SGNH-hydrolase Family with Paraoxon: Mechanism of Initial Noncovalent Binding:
       Sergiy I. Tyukhtenko1, Ching-Yu Chou1, Chi-Fon Chang2, Tai-Huang Huang1,2, 1Institute of
       Biomedical Sciences, Academia Sinica, Nan-Kang, Taipei 11529, Taiwan, 2Genomics Research
       Center, Academia Sinica, Nan-Kang, Taipei 11529, Taiwan

P109   NMR Solution Structure Investigation of the Mitochondrial Protein Import Receptor Tom20
       from Arabidopsis thaliana: Henrik Biverståhl, Anna-Karin Berglund, Elzbieta Glaser and Lena
       Mäler, Stockholm University, Sweden

P110   Combined MD and NMR Analysis of Short Peptides: J. Graf1*, P. Nguyen2*, Y. Mu2, G.
       Stock2, H. Schwalbe1, 1 Institute of Organic Chemistry and Chemical Biology, 2 Institute of
       Physical and Theoretical Chemistry, J. W. Goethe-University Frankfurt a. M., Germany

P111   Analysis of DNA and ATP binding sites in the central domain of RecA using
       multidimensional NMR spectroscopy: Tsutomu Mikawa1, 2, Takehiko Shibata1 and      Yutaka
       Ito1, 2, 1Research Group for Bio-supramolecular Structure-Function, RIKEN, JAPAN, 2CREST,
       JST
       1
P112    H, 13C and 31P NMR of inositol 1,4,5-trisphosphate (IP3) in complex with IP3 receptor:
       Tapas K. Mal1, Ivan Bosanac1, Jenny Chan1, Akira Ono,2 Masatsune Kainosho2, Ad Bax3,
       Mitsuhiko Ikura1, 1Division of Molecular and Structural Biology, Ontario Cancer Institute and
       Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto,
       Ontario, M5G 2M9, Canada, 2Department of Chemistry Faculty of Science, Tokyo Metropolitan
       University, 1-1 Minami-oshawa, Hachioji, Tokyo, 192-0397, Japan, 3Laboratory of Chemical
       Physics, NIDDK, National Institutes of Health, Bethesda, MD 20892-0520, USA

P113   Structural Investigations of the Pre-mRNA Processing Protein Prp24 from S. cerevisiae: N.J.
       Reiter1, S. Kwan2, M. Tonelli3, A. Bahrami3, H. Eghbalnia3, D.A. Brow2, S.E. Butcher1,3,
       1
         University of Wisconsin-Madison, Department of 1Biochemistry, 2Biomolecular Chemistry, and
       the 3National Magnetic Resonance Facility at Madison (NMRFAM), Wisconsin, USA




                                                  34
P114   Characterization of Correlated Chemical Exchange in a C-terminal Calmodulin Mutant
       using Multiple Quantum Spin Relaxation: Patrik Lundström, Frans A.A. Mulder and Mikael
       Akke, Department of Biophysical Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden

P115   Structure and function of the C-terminal domain of Abl kinase: Cameron Mackereth1, Oliver
       Hantschel1, Silke Wiesner1, Thomas Guettler2, Michael Sattler1, Giulio Superti-Furga1, 1European
       Molecular Biology Laboratory, Heidelberg, Germany, 2Ruprecht-Karls-Universitaet, Heidelberg,
       Germany

P116   Structure and functional analysis of the MYND domain: Roberta Spadaccini1, Matthew
       Bottomley2, Stephane Ansieu3 & Michael Sattler1, 1EMBL Heidelberg Germany, 2IRBM- Pomezia
       (Rome) Italy, 3INSERM,ENS-Lyon,France

P117   Investigating a large protein by NMR Spectroscopy: E. coli Citrate Synthase: K. Choudhary,
       J. O’Neil and H.W. Duckworth, University of Manitoba, Winnipeg, Manitoba, Canada

P118   NMR Study of the Interaction of the beta-Amyloid Peptide of Alzheimer's Disease with
       Potential Aggregation-Inhibitors: D. Benaki1, K. Stathopoulou2, M. Pelecanou1, E. Mikros2,
       1
         Institute of Biology, NCSR “Demokritos” 15310 Athens, Greece, 2Division of Pharmaceutical
       Chemistry, University of Athens, Panepistimiopolis, Zografou 157 71, Greece

P119   NMR studies on the biomolecules: Structural analysis of proteins and peptides: Woo-Sung
       Son1 Yong-Jin Kim1, Won-Je Kim1, Su-Jin Kang1, Min-duk Seo1, Sung-Jean Park1, Sung-Jean
       Park1, Bong-Jin Lee1, 1National Research Laboratory for Membrane Protein Structure, College of
       Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul, Republic of
       Korea

P120   Backbone Dynamics of Sortase A and Sortase B in Staphylococcus aureus: 15N Relaxation
       Study: Pilpa R., Naik M., Liew C, Suree N. and Clubb R*

P121   Structure-function studies on binding of Forkhead-Associated domain FHA1 of the DNA
       damage checkpoint protein Rad53 with the biological and synthetic partners: Anjali
       Mahajan1, Chunhua Yuan2,3 and Ming-Daw Tsai1,2,3,4,5, 1Biophysics Program, The Ohio State
       University, 2Campus Chemical Instrument Center, The Ohio State University, 3Department of
       Chemistry, The Ohio State University, 4Department of Biochemistry, The Ohio State University,
       5
         Genomics Research Center, Academia Sinica, Taiwan

P122   Structure of the pyrin domain from the zebrafish caspase, Caspy: K. Johan Rosengren and
       Justine M. Hill, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD
       4072, Australia

P123   Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by
       NMR spectroscopy ¨C structural basis of thermostability and enzymatic activities: Kong
       Hung Sze1, Yinhua Yang1, Xiao Guan1, Man Kit Tse1, K.K. Cheung2 and KamBo Wong2, 1
       Chemistry Department, Hong Kong University, Pokfulum Road, Hong Kong, 2 Biochemistry
       Department, the Chinese University of Hong Kong, Hong Kong

P124   Studies of Peptide Hormone/Receptor Interactions by NMR Spectroscopy: N. Tidten1, N.
       Link1, T. Lauber1, D. Schuster1, K. Vitzithum1, P. Rösch1, U. C. Marx1,2, 1Lehrstuhl für
       Biopolymere, Universität Bayreuth, 95440 Bayreuth, Germany, 2Institute for Molecular
       Bioscience, University of Queensland, Brisbane QLD 4072, Australia

P125   Methyl dynamics for understanding hydrophobic core packing of dynamically different
       motifs of dsRBD of PKR: Ravi P. Barnwal, Tista R. Chaudhuri, S. Nanduri and Qin J §,
       Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road,
       Colaba, Mumbai-400005 and §Cleveland Clinic Foundation, Cleveland OH, USA


                                                 35
P126   lternative splicing factor ZNF265 and its interaction with RNA: Fionna Loughlina and Joel
       Mackaya, University of Sydney, NSW, Australia

P127   Solution structures of plant telomere binding proteins: S.G. Ko1,3, H.Y. Park1,3, J. Shin1,3, E. Y.
       Yu2,3, M.G. Hwang3, S.W. Yang3, I. K. Chung2,3, W.T. Kim3, M.H. Cho3 and W. Lee1,3,
       1
         Department of Biochemistry, 2Department of Biology, College of Science, and 3Protein Network
       Research Center, Yonsei University, Seoul 120-749, Korea

P128   Structure and DNA Binding Mode of C-terminal Domain of Response Regulatory Protein
       from Helicobacter pylori: Byoung young Jeon1, Eunmi Hong1, Jin-Hwan Kim2 ,Young-Ho Jeon2
       and Weontae Lee1, 1Department of Biochemistry and Biomolecular NMR Laboratory, Yonsei
       University, Seoul 120-749, Korea; 2Crystalgenomics, Inc. Daeduk, Taejon 305-390 Korea

P129   Solution structure of a two-component response regulatory protein derived from
       Helicobacter pylori: Eunmi Hong, Byoung-young Jeon, Joon Shin and Weontae Lee*,
       Department of Biochemistry and Biomolecular NMR Labortory, Yonsei University, Seoul 120-749,
       Korea

P130   Denaturant Induced Protein Stabilization: A PMRD Study: M. Trivikaram Rao1, A.K.
       Bhuyan2, K. Venu1 and V.S.S. Sastry1, School of Physics1 and School of Chemistry2, University
       of Hyderabad, Hyderabad, 500 046, India

P131   Structural analysis of scavenger receptor LOX-1 and its interaction with oxidized LDL: I.
       Ohki, T. Ishigaki, T. Oyama, K. Morikawa, S. Tate, Biomolecular Engineering Research Institute
       (BERI), Osaka, JAPAN

P132   New tools to study protein-ligand interaction by nuclear magnetic resonance spectroscopy:
       Sridhar Sreeramulu, Thomas Langer, Martin Vogtherr, Ulrich Schieborr and Harald Schwalbe,
       Institute of Organic Chemistry and Chemical Biology, J. W. Goethe-University Frankfurt a. M.,
       Germany

P133   Solution structure of ribosomal protein L16 from Thermus thermophilus HB8: Mitsuhiro
       Nishimura1, Takuya Yoshida1, Mikako Shirouzu2,3, Takaho Terada2,3, Seiki Kuramitsu3,4 ,
       Shigeyuki Yokoyama2,3,5, Tadayasu Ohkubo1 and Yuji Kobayashi1, 1Graduate School of
       Pharmaceutical Sciences, Osaka University, Osaka Japan, 2RIKEN Genomic Sciences Center,
       Yokoyama Japan. 3RIKEN Harima Institute at SPring-8, Hyogo Japan, 4Department of Biology,
       Graduate School of Science, Osaka University, Osaka Japan, 5Department of Biophysics and
       Biochemistry, Graduate School of Science, the University of Tokyo, Tokyo, Japan

P134   A receptor that directly interacts with small GTPases. NMR structure of the Rac1 binding
       domain of human plexin-B1 and surface mapping: Yufeng Tong and Matthias Buck,
       Department of Physiology and Biophysics, Case Medical School, Cleveland, Ohio, USA, 44106

P135   Structure and function of the subdomains of MAP-LC3: T. Kouno1, M. Mizuguchi1, I.
       Tanida2, T. Ueno2, E. Kominami2, K. Kawano3, 1Toyama Med. Pharm. Univ., Fac. Pharm. Sci.,
       Toyama, Japan, 2Juntendo Univ., Sch. Med., Tokyo, Japan, 3Hokkaido Univ., Grad. Sch. Sci.,
       Sapporo, Japan

P136   Solution structure of rice phytochrome B nuclear localize signal domain: Toshitatsu
       Kobayashi1, Ryo Tabata1, Masaki Mishima1, Kayo Akagi2, Nobuya Sakai2, Etsuko Katoh2,
       Makoto Takano2, Toshimasa Yamazaki2 and Chojiro Kojima1, 1 Graduate School of Biological
       Science, Nara Institute of Science and Technology, and 2National Institute of Agrobiological
       Sciences (NIAS)




                                                  36
P137   Toward a More Perfect Order: Molecular Geometry of a Membrane-Associating Protein
       and Its Ligands: Anita I. Kishore, Ronald D. Seidel, and James H. Prestegard, Complex
       Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia,
       USA 30602

P138   Backbone Resonance Assignments of Human Normal Adult Hemoglobin in the Deoxy Form:
       Sahu, S.C., Simplaceanu, V., Ho, N. T., Giovannelli, J. L. and Ho, C., Department of Biological
       Sciences, Carnegie Mellon University, Pittsburgh, PA, USA

P139   The solution conformation of the type I hydrophobin EAS: J.P. Mackay1, A.H. Kwan1, J.M.
       Matthews1, R. Winefield2,3 and M. Templeton, 1University of Sydney, Sydney, Australia, 2Massey
       University, Palmerston North, New Zealand, 3Mt Albert Research Centre, Auckland, New Zealand

P140   Structural Determination of a High Potency Channel-Forming Peptides: Gabriel A. Cook1,
       Om Prakash1, Takeo Iwamoto1, Dejian Ma2, Bruce D. Schultz3, Yan Xu2, John M. Tomich1,
       1
         Biochemistry, Kansas State University, Manhattan, KS, USA, 2Anesthesia, University of
       Pittsburgh Medical School, Pittsburgh, PA, USA, 3Anatomy and Physiology, Kansas State
       University, Manhattan, KS, USA

P141   NMR studies of Cre recombinase: C. Amero, M. Foster, Biophysics Program, Ohio State
       University, Ohio, USA

P142   Structure and recognition of ubiquitination signals: Masahiro Shirakawa1,2, Kenichiro
       Fujiwara1, Ayako Ohno1,3, Takeshi Tenno1, JunGoo Jee1,2, Hidehito      Tochio1,    Hidekazu
               1,3 1                                             2
       Hiroaki , Yokohama City University, Kanagawa, Japan, RIKEN GSC, Kanagawa, Japan,
       3
         Kihara Memorial Yokohama Foundation for the advancement of Life Sciences, Kanagawa, Japan

P143   BIOPHYSICAL CHARECTERIZATION OF PROTEASE INDUCED ENZYMATIC
       DEGRADATION OF POLY-3-HYDROXY BUTRYIC ACID: Sumana Chatterjee,
       Department of Chemistry, Basanti Devi College, 147B, Rashbehari Avenue , Kolkata 700029,
       India

P144   NMR Investigations on Structure, Stability and pH Driven Monomer-Dimer transition in
       DLC8a: P. M. Krishna Mohan1, Amarnath Chatterjee1, Anindya Ghosh2, and Ramakrishna V.
       Hosur1, 1Department of Chemical Sciences, and 2Department of Biological Sciences, Tata Institute
       of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India

P145   Functional dynamics at small and large time/size scales:Erik R.P. Zuiderweg. M. Revington,
       Y. Zhang, T.Wang, S.Cai, Biophysics, Biochemistry and Chemistry, The University of Michigan.
       930 N. University Ave, Ann Arbor, MI 48109, USA

P146   Structural Plasticity of the Apoptosis Protein BAD: Rebecca S. Lipsitz, Richard J. Youle, and
       Nico Tjandra, Laboratory of Biophysical Chemistry, NHLIB,NIH

P147   Insights into the Formation of the Arsenate Reductase - Thioredoxin Complex: P.
       Vanhaesebrouck1, J. Messens2, K. Van Belle2, K. Wahni2, L. Wyns2, J. C. Martins1, 1NMR and
       Structure Analysis Unit, Universiteit Gent, Belgium, 2Department for Ultrastructure, Vrije
       Universiteit Brussel, Belgium

P148   Structure, Function and Stability of the HeadPiece C-terminal Domain: W. Vermeulen1, D.
       Bourry1, P. Vanhaesebrouck1, F. A. M. Borremans1, M. Van Troys2, C. Ampe2, J. C. Martins1,
       1
         NMR and Structure Analysis Unit and 2Department of Biochemistry, Universiteit Gent, Belgium

P149   Structure and recognition of ubiquitination signals: Masahiro Shirakawa1,2, Kenichiro
       Fujiwara1, Ayako Ohno1,3, Takeshi Tenno1, JunGoo Jee1,2, Hidehito Tochio1, Hidekazu Hiroaki1,3,




                                                 37
       1
       Yokohama City University, Kanagawa, Japan, 2RIKEN GSC, Kanagawa, Japan, 3Kihara
       Memorial Yokohama Foundation for the advancement of Life Sciences, Kanagawa, Japan

P150   Slow motion studies of a c-terminal complexed centrine by using cross correlated dynamics
       involving modulations of isotropic chemical shifts: Fatiha Kateb*, Luisa Poggi,* Daniel
       Abergel*, Gil Craescu $ and Geoffrey Bodenhausen*, *Ecole Normale Superieure, Paris;
       $Institut Curie, Orsay

PROTEIN FOLDING
P151   Implications of Molten Globule State(s) Involved in the Drug Delivery Process in
       Neocarzinostatin: S. Aranganathan1, 2, T. K. S. Kumar2, 3, Chin Yu2, 3 and Der-Hang Chin*1,
       1
         Departmnet of Chemistry, National Chung Hsing University, Taiwan, ROC, 2Department of
       Chemistry, National Tsing Hua University, Taiwan, ROC, 3Department of Chemistry and
       Biochemistry, University of Arkansas, USA

P152   NMR Investigation of Trp-Rich Helices: Mahalakshmi#, S. Raghothama* and P. Balaram#,
       Molecular Biophysics Unit# and Sophisticated Instruments Facility*,Indian Institute of Science,
       Bangalore 560012, India

P153   Expanding the Turn Segment of Designed -Hairpin Peptides: NMR Analysis: K. Muruga
       Poopathi Raja and P. Balaram, Molecular Biophysics Unit, Indian Institute of Science,
       Bangalore-560012

P154   NMR Analysis of Designed -Hairpin Peptides with Modified -turn: K.Muruga             Poopathi
       Raja and P.Balaram, Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012

P155   Residual Dipolar Couplings from Denatured Proteins in Multiple Alignment Media: Erika
       Gebel1 and David Shortle, Department of Biological Chemistry, 1Program in Computational and
       Molecular Biophysics, The Johns Hopkins University School of Medicine, Maryland, USA

P156   Studies on the folding of proteins in solution as well as in membranes: Blake Hill, Guru
       Thuduppathy

P157   Probing the folding energy landscape of an EF-hand calcium binding protein through
       hydrogen exchange: Sulakshana Mukherjee, Kavita Kuchroo, Kandala V.R. Chary and Girjesh
       Govil, Department of Chemical Sciences, Tata Institute of Fundamental Research ,Homi Bhabha
       Road, Mumbai 400 005 India
P158   Protein Folding Kinetics by Relaxation Dispersion Measurements: Kaare Teilum1,
       Flemming M. Poulsen2 and Mikael Akke1, 1Department of Biophysical Chemistry, Lund
       University, Sweden, 2Department of Protein Chemistry, University of Copenhagen,
       Denmark
P159   Order amid disorder - Nascent structural motifs examined by residual dipolar
       couplings: K. Fredriksson,1 M. Louhivuori,2 A. Annila,2,3 1Program in Structural      Biology
       and Biophysics Program, Institute of Biotechnology, 2Department of Physical Sciences, and
       3
         Department of Biosciences, University of Helsinki, Finland
P160   Interaction of DnaK Substrate Binding Domain with Apomyoglobin Polypetides:
       Implications for Protein Folding and Misfolding: Senapathy Rajagopalan, Nese Kurt, Carolina
       Vega, and Silvia Cavagnero*, Department of Chemistry, University of Wisconsin-Madison, 1101
       University Ave., Madison, WI 53706, U.S.A.

P161   Protein Folding Studies of Marginally Stable Proteins by NMR Relaxation Methods :
       M. Tollinger,1 L.E. Kay,2 J.D. Forman-Kay,2 R. Konrat,11University of Vienna, Austria,
       2
         University of Toronto, Canada




                                                38
P162   Studies of Residual Structure of Human Prion Protein hPrP (121-230): Jitendra Kumar,
       Christian Richter, Susanne Grimme and Harald Schwalbe, Johann Wolfgang Goethe-Universität,
       Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic
       Resonance, Marie Curie Strasse 11, D-60439, Frankfurt am Main, Germany
P163   NMR studies of Aromatic Interactions in Designed Peptides: R. Mahalakshmi#, S.
       Raghothama* and P. Balaram#, Molecular Biophysics Unit# and Sophisticated Instruments
       Facility*, Indian Institute of Science, Bangalore 560012, Indi

PARAMAGNETIC PROTEINS

P164   Correlation Between Hydrogen Bond Lengths and Reduction Potentials: Mutagenesis
       Studies on Residues 44 and 8 of Clostridium pasteurianum Rubredoxin : I-Jin Lin,1 Erika B.
       Gebel, 1,2 Timothy E. Machonkin, 1,3 William M. Westler, 1 and John L. Markley 1, 1 University of
       Wisconsin-Madison, Wisconsin, USA 2 Johns Hopkins University, Maryland, USA 3 University of
       Rochester, New York, USA

MEMBRANE PROTEINS
P165   Conformational study of the membrane-spanning fusogenic peptides using solid-state
       NMR : Prashant Agrawal1, Frans Hulsbergen1, Mathias Hofmann2, Dieter Langosch2, Nico
       Meeuwenoord3, Hermen Overkleeft3 and Huub de Groot1, 1 Biophysical Organic Chemistry,
       Leiden Institute of Chemistry, Leiden University P.O. box 9502, 2300 RA, Leiden, The
       Netherlands, 2 Lehrstuhl Chemie der Biopolymere, TU München, Weihenstephaner Berg 3, 85354
       Freising-Weihenstephan, Germany , 3 Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden
       University P.O. box 9502, 2300 RA, Leiden, The Netherlands

P166   Solution NMR structural studies of MBP: M.M.Monette2, D.S. Libich1, V.J. Roberston1,
       G.Harauz1, 1University of Guelph, Guelph, Ontario, Canada; 2Bruker BioSpin, Milton, Ontario,
       Canada

P167   Measurement of residual dipolar couplings for integral membrane proteins and structure
       refinement of OmpA in DPC micelles: Tomasz Cierpicki, Binyong Liang, Lukas Tamm and
       John H. Bushweller, Department of Molecular Physiology and Biological Physics, University of
       Virginia

P168   Solution structure of TF1Fo ATP synthase subunit c : T. Nakano 1, T. Ikegami 1, T. Suzuki 2, 3,
       M. Yoshida 2, 3, H. Akutsu 1, 1Osaka University, Osaka, Japan, 2Tokyo Institute of Technology,
       Kanagawa, Japan, 3Japan Science and Technology Corporation, Kanagawa, Japan

P169   Solid-State NMR Studies of the Membrane Interactions of A42 from Alzheimer's Disease:
       Crystal T.L. Lau1, Kevin J. Barnham2, Colin L. Masters2 and F. Separovic1, 1School of
       Chemistry and 2Department of Pathology, The University of Melbourne and 2The Mental Health
       and Research Institute, VIC 3010, Australia

P170   Is membrane interaction domain a necessity for localization: Phospholipase C delta1 as an
       example of shuttling protein?   Srinivas N. Pentyala, Departments of Anesthesiology,
       Urology, Physiology & Biophysics, School of Medicine, State University of New York, Stony
       Brook, NY, USA
P171   Proton-decoupled 15N solid-state NMR investigation of synthetic ion-channel peptide
       reconstituted in oriented lipid bilayers: Sudheendra U.S and Burkhard Bechinger, FRE 2446,
       University Louis Pasteur, 4, rue Blaise Pascal, 67000 Strasbourg, FRANCE


P172   Structural Changes associated with Mycobacterium tuberculosis H37Rv ESAT-6:CFP-10
       omplex Formation: Akshaya Kumar Meher*, Naresh Chandra Bal*, Kandala V. R. Chary,$ and
       Ashish Arora*, *Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226



                                                 39
       001, India, and $Department of Chemical Science, Tata Institute of Fundamental Research,
       Mumbai 400 004, India

NUCLEIC ACIDS STRUCTURE
P173   Structure-Function Analysis of Picornaviral Internal Cis-acting RNA Replication
       Elements:Varatharasa Thiviyanathan, Yan Yang, Rene Rijnbrand, Kumar Kaluarachchi, Stanley
       M. Lemon, and David G. Gorenstein, Sealy Center for Structural Biology, University of Texas
       Medical Branch, Galveston, Texas 77555, USA

P174   Structural Roles of CTG Repeats in DNA Trinucleotide Repeat Expansion: L.M. Chi and
       S.L. Lam, Department of Chemistry, The Chinese University of Hong Kong, Hong Kong
P175   Unusual Dynamics of A·A Mismatch with 5’-Purine and 3’-Pyrimidine Flanking Bases: C.
       W. Kwok and S. L. Lam, Department of Chemistry, The Chinese University of Hong Kong, Hong
       Kong
P176   Structural and thermodynamic investigation of the HIV-1 frameshift inducing element:
       David W. Staple and Samuel E. Butcher, Department of Biochemistry, University of
       Wisconsin-Madison
P177   Structure of stem-loop d from a key picornaviral replication site: H. Huang,*2 S.J. Headey,*1
       J.K. Claridge,1 G.A. Soares,1 K. Dutta,3 D. Yang,4 Pascal, S.M.1, 1Institute of Fundamental
       Sciences, Massey University, Palmerston North, New Zealand, 2Department of Biochemistry &
       Biophysics, University of Rochester Medical Center (present address: Vaccinex Incorporated,
       Rochester NY), 3New York Structural Biology Center, New York, NY, 4Department of Biological
       Sciences & Department of Chemistry, National University of Singapore

OLIGOSACCHARIDES AND PROTEINS
P178   NMR Studies of C-linked Carbo--amino acids Containing Variety of Sugar Moieties, K.
       Narsimulu, K. V. S. Ramakrishna, A. Ravisankar, K. Ravinder Reddy, V. Subhash, P. Nagender,
       B. Srinivas, P. Jayaprakash, Palakodety Radha Krishna, B. Jagannadh, G. V. M. Sharma and A. C.
       Kunwar, Indian Institute of Chemical Technology, Hyderabad, India-500 007
MOLECULAR RECOGNITION
P179   Identification of Ligand Fragments and their Binding Orientation Using WaterLOGSY and
       1D Selective Inter-ligand QUIET-NOEs: B. J. Stockman, D. T. A. Hadden, P. V. Sahasrabudhe,
       J. T. Herberg, J. C. Hagadorn, J. P. Martin Jr., D. C. Rohrer, Pfizer, Inc., Pfizer Global Research
       & Development, Groton, Connecticut, USA

P180   Dissection study and inhibitor design targeting SARS 3C-like protease: Jiahai Shi and
       Jianxing Song , Department of Biological Sciences, National University of Singapore, 10 Kent
       Ridge Crescent, Singapore 119260
P181   Identification of novel inhibitors of the ZipA/FtsZ complex by NMR: Désirée H. H. Tsaoa,
       Yuanhong Lia, Thomas S. Rush IIIa, Lidia Mosyaka, Mark Stahl, Karl Malakian, Lee D.
       Jenningsb, Alan G. Sutherlandb, Alexey Ruzind and Juan Alvareza, Wyeth Research, 87
       Cambridge Park Drive, Cambridge, MA 02140, Chemical and Screening Sciences, Structural
       Biology and Computational Chemistrya, Medicinal Chemistryb and Infectious diseasesc
P182   Tracking Apo-Necocarzinostain Conformational Changes that may Corresponds to
       Chromophore Release Using NMR Analysis at Residue Level : Christopher G. Sudhahar1,
       Der-Hang Chin1*, 1Department of Chemistry, National Chung Hsing University, Taichung,
       Taiwan, ROC

P183   NMR Based Investigations of Drug Induced Phospholipidosis From Early Prediction to
       Marker Assessment: Kris A. Borzilleri1, Jinghai J. Xu1, Margaret C. Dunn1, Markus Boehm1,
       Lora Robosky2, Michael Reily2, David Baker2, Anne Tilloy-Ellul3, Marie-Therese Masson3,
       Bishop Wlodecki1, Keith C. Jendza1, Michael A. Brodney1, Linda A. Chatman1, Susan D.Anway1



                                                  40
       and Jane M. Withka1, Pfizer Global Research and Development –   1
                                                                           Groton, CT 06340;   2
                                                                                                   Ann
       Arbor, MI, 3 Amboise, France
P184   Study     on    the    complexation       between    DNA   and   porphyrin   derivatives:
       Takako Ohyama1,Hajime Mita1 and Yasuhiko Yamamoto1,        1
                                                                  Graduate school of pure and
       applied sciences, University of Tsukuba, Tsukuba, JAPAN
P185   Can structural features explain differences in potency between the Ga and Y Complexes of
       DOTATOC? M. V. Deshmukh 1, G. Voll 1, A. Kühlewein 1, H. Mäcke 2, J. Schmitt 2, H. Kessler
       1
         , Gerd Gemmecker 1,    1
                                  Chemistry Department, TU Munich, Garching, Germany, 2 Institute
       of Nuclear Medicine, University Hospital, Basel, Switzerland

P186   Structure Assisted Alteration of AT-Recognition Profile: A Study of Drug-DNA Complex:
       Prateek Pandya and Surat Kumar, Applied Sciences, Faculty of Engineering, Dayalbagh
       Educational Institute, Dayalbagh, Agra-282 005
P187   Solution conformation of Substance P antagonists, [D-Arg1, D-Trp7,9, Leu11]-SP, [D-
       Arg1, D- Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD
       Simulations: Arati Prabhua, Alpeshkumar Maldea, Sudha Srivastavab and Evans Coutinhoa*,
       a
         Department of Pharmaceutical Chemistry, Bombay College of       Pharmacy,      Kalina,
       Mumbai 400 098, India, bTata Institute of Fundamental Research, Homi Bhabha Road,
       Navy Nagar, Colaba, Mumbai 400 005, India

P188   Probing the effect of N- and C- terminal length on the conserved G-P-G-    R segment
       in       the V3 loop of HIV-1: *Sudha Srivastava, #Meena Kanyalkar, *Mamata
       Joshi, @Evans     Coutinho and @$Anil Saran, *National Facility    for High Field NMR,
       Tata Institute of Fundamental Research, Homi        Bhabha Road, Mumbai -400005, India,
       #                                                                          $
         P.K.M.K. College of     Pharmacy,        Worli, Mumbai –400018, India,     CSIR
                          @
       Emeritus Scientist, Department of Pharmaceutical Chemistry, Bombay College of
       Pharmacy, Kalina,         Santacruz, Mumbai -400098
P189   Correlation between binding cooperativity and protein conformational flexibility as studied
       by hydrogen-to-deuterium amide NH exchange: Vladimir I. Polshakov1,2, Berry Birdsall3,
       Thomas A. Frenkiel4 and James Feeney3, 1 Center for Drug Chemistry, Moscow, Russia, 2
       Research Center for Magnetic Tomography & Spectroscopy, M.V. Lomonosov Moscow State
       University, Moscow,     Russia, 3 National Institute for Medical Research (NIMR), London,
                        4
       United Kingdom, MRC Biomedical NMR Centre, NIMR, London, United Kingdom
       13
P190    C NMR Relaxation Studies Reveal a Complex Pattern of Motion in the Binding Site for
       Human U1A Protein: Z.Shajani1 and G.Varani1,2, Department of Chemistry1 and Department of
       Biochemistry2

P191   Design, Synthesis and Characterization of a Novel Cyclic Curcumin-cystine Bioconjugate
       with their antifungal and antioxidant properties: Neha kapoor & Krishna misra*, Centre for
       Biotechnology, University of Allahabad, Allahabad - (211002)

P192   The Binding Site of Acetylcholine Receptor From Synthetic Peptides to Mimitope Structure:
       T. Scherf,1 R. Kasher2, M. Balass,2 M. Fridkin, 3 S. Fuchs,4 and E. Katchalski-Katzir2 ,
       Departments of 1Chemical Research Support, 2Biological Chemistry, 3Organic Chemistry and
       4
         Immunology, Weizmann Institute of Science, Rehovot 76100, Israel

P193   Phage Library for Molecular Recognition Analysis by NMR: H. Takahashi1, Y. Mizukoshi2,
       M. Nagasu2, and I. Shimada1, 3, 1BIRC, AIST, Tokyo, Japan, 2JBIRC, JBIC, Tokyo, Japan, 3The
       University of Tokyo, Tokyo, Japan
P194   NMR study of homo and hetero oligomers of furanoid based sugar amino acid: S. Kiran
       Kumar, Saumya Roy, T. K. Chakraborty and A. C. Kunwar, Indian Institute of Chemical
       Technology, Hyderabad, India 500 007




                                               41
P195   Application of DOSY in Identification of Peptide Conformers in Solution: B.
       Kumaran1, Rajkishor Rai2, S. Raghothama1, 1Sophisticated Instruments Facility, 2Molecular
       Biophysics Unit, Indian Institute of Science, Bangalore – 560 012
MR IMAGING
P196   Laccase Catalyzed Cross-linking of Peptides and Proteins: M.-L.        Mattinen,1  C.     L.
                  2         1          1         1              2          1 1
       Steffensen, K. Kruus, R. Lantto, K. Autio, J. H. Nielsen, J. Buchert , VTT Biotechnology,
       Espoo, Finland, 2DIAS Research Centre Foulum, Tjele, Denmark

P197   Structure of adriamycin complexed with d-TGATCA by Proton and Phosphorus-31 Nuclear
       Magnetic Resonance Spectroscopy : P. Agrawal,1 S. K. Barthwal,2 and R. Barthwal1,
       Department of Biotechnology1 and Physics2, Indian Institute of Technology Roorkee, 247667,
       India
       1
P198    H and 31P NMR studies on binding of anticancer drug mitoxantrone with d-CGATCG: M.
       Kaur1, P. Awasthi1, Monica1, S.K. Barthwal2 and R. Barthwal1, Department of Biotechnology1 and
       Physics2, Indian Institute of Technology Roorkee, 247667, India

P199   Determination of 13C CSA tensor parameters: Extension of the model-independent approach
       to an RNA kissing complex undergoing anisotropic rotational diffusion in solution: Sapna
       Ravindranathan1, Chul-Hyun Kim2, Geoffrey Bodenhausen3, 1National Chemical Laboratory,
       Pune, India, 2California State University, Hayward CA, USA, 3Ecole Normale Supérieure,
       Paris, France and Ecole Polytechnique Fédérale, Lausanne, Switzerland
P200   EPR IMAGES OF CHROMIUM (V) IN PADDY (Oryza Sativa) ROOTS: K.
       VICTOR BABU and T. RAMASAMI, Chemical Physics Department, Central Leather Research
       Institute- Council of Scientific and Industrial Research, Adyar, Chennai – 600 020, India
P201   Structure of antitumor agent mitoxantrone wth DNA hexamer d-(ATCGAT)2 by 1H and 31P
       NMR: R. Durairaj1, Prashansa Agrawal1, S. K. Barthwal 2, Ritu Barthwa11, Department of
       Biotechnology1 and Physics2, Indian Institute of Technology Roorkee, Roorkee 247 667, India

P202   NMR based solution structure of antitumor drugs, Berberine and Palmatine: Lata Chauhan1,
       Kushuma Bisht1, Sudhir Kumar Barthwal2 And Ritu Barthwal1, Dept. Biotechnology1 And
       Physics2, Indian Institute Of Technology Roorkee, 247667, India

P203   NMR based solution structure of anticancer drugs, Sanguinarine and Luteolin: Santosh
       Kumari1, Amit Kumar1, S.K. Barthwal2 and Ritu Barthwal1, Dept. Biotechnology1 and
       Physics2, Indian Institute of Technology, Roorkee, 247 667, India
MR IN HUMAN HEALTH & BEHAVIOUR, IN VIVO SPECTROOSCOPY, METABONOMICS

P204   Phosphorus MR spectroscopic changes mediated by choline kinase knock-down in a human
       breast tumor model: K. Glunde1, N. Mori1, V. Raman1, and Z. M. Bhujwalla1, 1Johns Hopkins
       University School of Medicine, Baltimore, Maryland, United States
P205   Determination of cholesterol in human serum and bile using Proton Nuclear Magnetic
       Resonance spectroscopy: Y. Jadegoud1, Madhulika Srivastava1, G. A. Nagana Gowda1, V.
       Ramesh2, Pratul Sinha3, Ajay Sharma4, V. K. Kapoor4 and C. L. Khetrapal1, 1Centre of Biomedical
       Magnetic Resonance, Departments of 2Pathology, 3Transfusion Medicine and 4Surgical
       Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road,
       Lucknow 226 014, INDIA

P206   Quantification of glycine and taurine conjugated bile acids in human bile using 1H NMR
       spectroscopy: Omkar Ijare1, B. S. Somashekar1, G. A. Nagana Gowda1, V. K. Kapoor2 and C. L.
       Khetrapal1, 1Centre of Biomedical Magnetic Resonance and 2Department of Surgical
       Gastroenterology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Raebareli Road,
       Lucknow-226 014, INDIA




                                                42
P207   Prediction of therapeutic outcome in patients with Fulminant Hepatic Failure using 1H
       Nuclear Magnetic Resonance spectroscopy: Varsha Saxena1, Ashish Gupta1, G.A. Nagana
       Gowda1, Rajan Saxena2, S. K. Yachha3 and C. L. Khetrapal1, 1Centre of Biomedical Magnetic
       Resonance, Departments of 2Surgical Gastroenterology and 3Gastroenterology, Sanjay Gandhi
       Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, INDIA
       1
P208     H NMR spectroscopy for the diagnosis of urinary tract infection with special reference to
       Pseudomonas aeruginosa and Klebsiella pneumonia: Ashish Gupta1, Mayank Dwivedi2, G. A.
       Nagana Gowda1, Archana, Ayyagari2, A. A. Mahdi3, M. Bhandari4 and C. L.   Khetrapal1,
       1                                                                       2
         Centre of Biomedical Magnetic Resonance and Departments of Microbiology and
       4
         Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 3Department of
       Biochemistry, KGMU Lucknow
       1
P209    H NMR study of Malabsorption Syndrome: Lakshmi Bala1, Uday C. Ghoshal2, Ujjala
       Ghoshal3, G. A. Nagana Gowda1 and C. L. Khetrapal1, 1Centre of Biomedical Magnetic Resonance
       and Departments of 2Gastroenterology and 3Microbiology Sanjay Gandhi Post Graduate Institute
       of Medical Sciences, Raebareli Road, Lucknow- 226 014, India

P210   Age Related Differences in the BOLD Post-Stimulus Undershoot: K. Gopinath1, C.
       Wierenga2,3, T. Conway2,3, B. Crosson2,3, R. Briggs1, 1Department of Radiology, University of
       Texas Southwestern Medical Center, Dallas, TX, USA, 2Department of Clinical Psychology,
       University of Florida and 3VA Brain Rehabilitation R & D Center, Gainesville, FL, U.S.A.
P211   Web Accessible MR decision support system for brain tumour diagnosis and prognosis,
        incorporating in vivo and ex vivo genomic and metabolomic data (FP6-2002-
        LIFESCIHEALTH 503094); Acronym: eTUMOUR, Bernardo Celda
P212   Lexical processing in trilingual subjects: cortical mapping using fMRI: S.S. Kumaran,Y. Uma
       Sreekumar, S. Khushu and R.P. Tripathi, NMR Research Centre, Institute of Nuclear Medicine
       and Allied Sciences, Brig. S.K. Mazumdar Road, Delhi – 110 054, INDIA

P213   Role of Diffusion weighted imaging and MR spectroscopy in Radiation necrosis: Ashok
       Kumar, Shilpi Modi, S.S. Kumaran, S. Khushu, Prabhjot Kaur and R.P. Tripathi, NMR
       Research Centre, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar
       Road, Delhi – 110 054, INDIA
P214   Volumetric MRI analysis of the Hippocampus with aging: S Khushu, S Sharma, S S Kumaran,
       R P Tripathi, NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Lucknow
       Road, Delhi 110054, India
P215   In-vivo Measurement of Apparent diffusion coefficient in normal and malignant prostate
       tissue: Virendra Kumar*, R. Kumar#, S. Thulkar@, S. Duttagupta$, A.K. Hemal#, N.P. Gupta# and
       N.R. Jagannathan* , Departments of NMR*, Urology# , Radiodiagnosis@ and Pathology$, All India
       Institute of Medical Sciences, New Delhi – 110029. INDIA

P216   Differentiation of Abdominal Body Fluids by In Vitro 1-H MR Spectroscopy for Clinical
       Applications: Sang Soo Shin, Heoung Keun Kang, Gwang Woo Jeong, Department of Radiology,
       Chonnam National University Medical School, Kwangju 501-757, Korea

P217   NMR Analysis of Biological Fluids in Epilepsy Associated with anti-GAD Antibodies: U. C.
       Marx1, G. D. Jackson2,3, D. J. Craik1, L. Kinton2, S. F. Berkovic2,3, R. M. Wellard2 , 1Institute for
       Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia, 2Brain Research
       Institute, Melbourne, VIC 3081, Australia, 3Department of Medicine, University of Melbourne,
       VIC 3081, Australia

P218   Determination of brain metabolite concentrations by in vivo localized proton spectroscopy
       with correction of relaxation effect: Nashiely PINEDA ALONSO *, Serge AKOKA **, Evelyne
       BAGUET **, Frederique TOULGOAT *, Hubert DESAL *, * Service de Neuroradiologie
       Diagnostique et Interventionnelle. Hospital G&R Laennec. CHU de Nantes, France, **



                                                   43
       Laboratoire d'Analyse Isotopique et Electrochimique de Metabolisme. UMR CNRS 6006,
       University of Nantes. France

P219   Quantitative identification of the protonation state of histidines in vitro and in vivo:
       N. Shimba,1,2 Z. Serber,1 C.S. Craik,1 V. Dötsch1, 1University of California San Francisco, USA,
       2
         Ajinomoto Co., Japan

P220   The Origin of T2 in Articular Cartilage MRI as a Function of its Maturation: Hadassah
       Shinar, Keren Keinan-Adamsky, Gil Navon, School of Chemistry, Tel Aviv University, Tel Aviv
       69978, Israel

P221   A Technique for the Measurement of Renal ATP in a Large Animal Model of Septic Shock :
       R. M. Wellard1, G. Pell1, J. Williams2, C. May2, L. Wan2, G. D. Jackson1,3, R. Bellomo4 , 1Brain
       Research Institute, Melbourne, Australia, 2University of Melbourne, Howard Florey Institute,
       3
         Department of Medicine, University of Melbourne, 4Intensive Care, Austin Health, Melbourne,
       Australia
P222   Cerebral Pyruvate Carboxylase Flux is Unaltered during Intense Activation: Anant B. Patel1,
       Golam M.I. Chowdhury2, Robin A. de Graaf1, Douglas L. Rothman1, Robert G. Shulman1, Kevin
       L. Behar2, Department of 1Diagnostic Radiology and 2Psychiatry, Magnetic Resonance Research
       Center, Yale University School of Medicine, New Haven, CT 06520, USA

P223   In-vivo Proton MRS of Brain in Chronic Obstructive Pulmonary Disease Patients: Virendra
       Kumar*, S. Sinha@, R. Guleria@, U. Sharma* and N. R. Jagannathan*, Departments of NMR* and
       Medicine@, All India Institute of Medical Sciences, New Delhi – 110 029, India
P224   Application of Spectral Deconvolution Method for Evaluation of Brain Tumors: in vivo 1-H
       MR Spectroscopy: HK Kang, GW Jeong, JJ Seo, HJ Kim, Department of Radiology, Chonnam
       National University Medical School, Gwangju 501-190, Korea
P225   Potential of various in vivo MR methodologies in the evaluation of cancer: Virendra Kumar,
       Uma Sharma, KA Danishad and NR Jagannathan, Department of NMR, All India Institute of
       Medical Sciences, New Delhi. India
P226   Utility of Proton Magnetic Resonance Spectroscopic Imaging (MRSI) in Breast            Cancer:
       Danishad KA*, Kumar V*, Sharma U*, Seenu V#, Jagannathan NR*, Departments of           NMR*
       and Surgery#, All India Institute of Medical Sciences, New Delhi -110029, INDIA
P227   Proton MR CSF Analysis and New Software as Predictors for the Differentiation of
       Meningitis in Children, a Subramanian A., b Gupta A., b Saxena S., c Gupta A., d Kumar R., e
       Nigam A., e Kumar R., f Mandal S.K. and a Roy R, a NMR Laboratory, Division of SAIF, Central
       Drug Research Institute, Lucknow, India, (rajaroy_cdri@yahoo.com) b Babu Banarasi Das
       National Institute of Technology and Management, Lucknow, India, c Center for Biomedical
       Magnetic Resonance and d Department of Pediatric Neurosurgery, Sanjay Gandhi Post-Graduate
       Institute          of            Medical            Sciences,            Lucknow,      India,
       e
         Department of Paediatrics, King George’s Medical University, Lucknow, India,
       f
         Division of Biometry and Statistics, Central Drug Research Institute, Lucknow, India
P228   Proton NMR Analysis and Identification of Predictive Metabolite-Descriptors for the
       Differentiation of Unresponsive and Responsive Strains in Leishmania donovani:
       a,‡
           Subramanian A., b Srivastava M., c Roy U., c Rastogi A.K., b Mandal S.K. and a Roy R, a NMR
       Laboratory, Division of SAIF, Central Drug Research Institute, Lucknow, India,
       (rajaroy_cdri@yahoo.com) b Division of Biometry and Statistics, Central Drug Research Institute,
       Lucknow, Indi,. cDivision of Biochemistry, Central Drug Research Institute, Lucknow, India,
       ‡
         Practice School Division, Birla Institute of Technology & Science, Pilani, Rajasthan, India

P229   Cholesterol Esters and Ceramide in Human Intracranial Tuberculomas: a Subramanian A.,
       b
         Joshi B.S. and a Roy R, a NMR Laboratory, Division of SAIF, Central Drug Research Institute,
       Lucknow, India, (rajaroy_cdri@yahoo.com), b Bruker India Scientific Pvt. Ltd., Lucknow, India



                                                 44
P230   NMR Spectroscopic Evaluation of Axillary Nodes in Breast Cancer:U. Sharma*, M.N. Pavan
       Kumar@, V. Seenu@ and N. R. Jagannathan*, Departments of NMR*and Surgery@, All India
       Institute of Medical Sciences, New Delhi – 110029, India

P231   Detailed molecular differentiation among gliomas by HR-MAS. A precise classification of
       GBM.: MC.Martínez-Bisbal, D. Monleón, V. Esteve, MB. Martínez-Granados and B. Celda,
       Depto. Química Física, Universitat de Valencia, c/Dr. Moliner, 50, 46100-Burjassot (Valencia)
       Spain

P232   Anti-inflammatory Treatment Reduced Breast Cancer Cell Invasion and Caused
       Metabolic   Changes Characteristic of a Less Malignant Phenotype:, B. Gimi, D.
       Artemov, Z.M. Bhujwalla, Radiology - MR Research, Johns Hopkins University, Baltimore, MD,
       USA

P233   VEGF Overexpression Increased Invasion and Altered Metabolism in a Human Prostate
       Cancer Cell Line Co-cultured with Endothelial Cells under Hypoxia: F.   Wildes,      V.
       Raman, D. Artemov, and Z.M. Bhujwalla, Radiology, JHU ICMIC Program, Johns      Hopkins
       University, Baltimore, MD, USA

P234   Development of uniformly 13C, 15N-labeling methods in animal system for a hetero-nuclear
       NMR-based metabolomics: Michitaka Suto1, Takashi Nishihara1 & Jun Kikuchi1,2,3, 1Grad. Sch.
       Integ. Sci., Yokohama City Univ; 2GSC, RIKEN Yokohama Inst. & 3CREST, JST

P235   The hetero-nuclear NMR-based metabolomics reveals incorporation of 13C, 15N-compounds
       into higher plants: Kenji Akamine1, Takashi Hirayama1,2,3 and Jun Kikuchi1,2,4, 1Grad. Sch.
       Integ. Sci., Yokohama City Univ; 2GSC, RIKEN Yokohama Inst.; 3Plant Mol. Biol. Lab., RIKEN
       Tsukuba Inst. and 4CREST, JST

P236   Effect of oxygen level on metabolic fluxes and metabolite levels of yeast studied by NMR
       spectroscopy: Paula Jouhten, Minna Perälä, Eija Rintala, Laura Ruohonen, Merja Penttilä and
       Hannu Maaheimo, VTT Technical Research Centre of Finland, Helsinki, Finland
P237   Induction of in vitro metabolism and motility in asthenospermic human spermatozoa by L-
       arginine and nitric oxide synthesis: associated with active sperm anion transport system:
       Sudha Srivastava, #Anita Agarwal, Rahul Jaiswal and Girjesh Govil, National Facility for High
       Field NMR, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai –400005,
       India #Department of Physiology, Seth G. S. Medical College,Parel, Mumbai-400006, India

ESR
P238   Measurement of oxygen and superoxide in the perfused heart by EPR spectroscopy: Vijay
       Kumar Kutala, Mark G Angelos, Carlos A Torres, Jason D Stoner, Marwan Mohammad,
       Periannan Kuppusamy, Davis Heart Lung Research Institute, Ohio State University, Columbus,
       OH,USA

P239   MRI Study of Root Hair Dynamics and Micro Scale Water Uptake Patterns: T. Kushnir1, E.
       Segal2, Y. Itzchak1 and U. Shani2, 1Department of Diagnostic Imaging, MRI Unit, The Chaim
       Sheba Medical Center, Tel Hashomer, Israel, 2Department of Soil & Water Sciences, Faculty of
       Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem,
       Rehovot, Israel
P240   MRI shows intravenous and intra amygdala Kainic Acid increase rat CBF: M. T. Acosta, J.
       P. Munasinghe, M. Banerjee, A.Yamaguchi, M. A. Rogawski, M. Angstadt, T. Wilson, A. Silva,
       W. Theodore, A. Koretsky, National Institute of Neurological Disease and Stroke, National
       Institute of Health, Bethesda, Maryland, United States

COMPUTATIONAL METHODS




                                               45
P241   Early Prediction of White Matter Changes in Tumor Cases due to Radiotherapy using
       Magnetic Resonance Images: S.B.MEHTA ,1 S.CHAUDHURY,2 A. BHATTACHARYYA ,3
       A. JENA4, 1S. B. Mehta, Delhi College of Engineering Bawana road, Delhi – 110 042. 2(Prof. )
       Dr. S. CHAUDHURY Indian Institute of Technology Hauz khas, Delhi – 110 016. 3(Prof.)
       Dr. A. BHATTACHARYYA, Delhi College of Engineering Bawana road, Delhi – 110 042,
       4
         Dr. A. Jena Chief MRI, MRI Center, Rajiv Gandhi Cancer Hospital, Rohini, Delhi 110085

P242   Simulations of chemical exchange in NMR using QSim: Magnus Helgstrand, Dept. of
       Biophysical Chemistry, Lund University, SE-221 00 Lund, Sweden

P243   Experimental demonstration of Complementarity of Entanglement and Interference
       by Nuclear Magnetic Resonance:Arindam Ghosh and Anil Kumar , NMR Quantum Computation
       and Quantum Information Group Department of Physics and Sophisticated Instruments Facility,
       Indian Institute of Science, Bangalore-560012, India

P244   Nuclear Magnetic Resonance implementation of adiabatic Deutsch-Jozsa algorithm: Avik
       Mitra, Arindam Ghosh, Ranabir Das and Anil Kumar, NMR Quantum Computation and Quantum
       Information Group Department of Physics and Sophisticated Instruments Facility, Indian Institute
       of Science, Bangalore-560012, India

P245   Programmable quantum state discriminator by Nuclear Magnetic Resonance: T. Gopinath,
       Ranabir Das, and Anil Kumar, NMR Quantum Computing and Quantum Information Group,
       Department of Physics and Sophisticated Instruments Facility, Indian Institute of Science,
       Bangalore-560012, India

P246   Automated Structure Determination of Proteins from NMR data: W. Gronwald, J. Trenner,
       K. Brunner, B. Ganslmeier, A. Nassar, R. Kirchhöfer, K.-P. Neidig and H. R. Kalbitzer, Institute
       of Biophysics and Physical Biochemistry, University of Regensburg, 93040 Regensburg, Germany
       and Bruker Biospin, Rheinstetten, Germany

P247   The use of unassigned signals in NMR structure determination: Eiso AB1, David Pugh,2 Rob
       Kaptein,1 Rolf Boelens,1 and Alexandre Bonvin1, 1University of Utrecht, The Netherlands.
       2
         University of the Western Cape, South Africa

P248   SolARIA: automated cross-peak assignment for MAS solid-state NMRIn the last years,
       solid- state NMR developed towards a technique suitable for solving       structures   of
       immobilised    proteins          at atomic resolution.: Fossi Michele, Department of NMR-
       Supported      Structural Biology,       Forschungsinstitut für   Molekulare
       Pharmakologie (FMP), Robert- Rössle-Str. 10, 13125 Berlin, Germany

P249   Calculations of Chemical Shielding and Electric Field Gradient Tensors in Molecular Sieves:
       Gurpreet Singha, S. Ganapathya , J. P. Amoureuxb ,J. F. Paulc and S. Cristolc, aNMR Facility,
       National Chemical Laboratory, Pune, India, bLCPS, University of Sciences and Technologies,
       Lille, cLaboratoire Catalyse, University of Sciences and Technologies, Lille

P250   THEORETICAL MODEL OF ACTIN,                       AORTIC       SMOOTH        MUSCLE -1LVT:
       R.Sagajkar, Accelrys Software Solution

INFORMATICS, EDUCATION AND CAPACITY BUILDING

P251   The New York Structural Biology Center, NMR Facility: Michael Goger, Jean-
       Christophe Hus, Boris Itin, Kaushik Dutta & David Cowburn, NMR Facility, NYSBC, 89 Convent
       Avenue, New York, New York, 10027-7556, USA
P252   NMR FEATURES IN THE NEW RCSB PROTEIN DATA BANK QUERY ENGINE: Gary
       L. Gilliland1 and who from SDSC2Ken Addess2, Nita Desphande2 and Helen Berman1, RCSB



                                                 46
       Protein Data Bank: 1Rutgers, the State University of New Jersey, Department of Chemistry,
       Piscataway, NJ 08854, 2San Diego Supercomputer Center at the University of California, San
       Diego, 9500 Gilman Drive, La Jolla, CA 92093
P253   A new approach for determining the orientation of a weakly bound ligand in the receptor
       binding pocket. The epothilone-A / Tubulin complex: V.M. Sánchez,1 M. Reese,1 J. Meiler,2
       M.J. Blommers,3 C. Griesinger,1 T. Carlomagno1, 1 Max Planck Institute for Biophysical
       Chemistry, Goettingen, Germany, 2 University of Washington, Seattle, USA, 3 Core Technologies,
       Novartis Pharma AG, Basel, Switzerland.
P254   Solution structure of RNA containing GU bulge: NMR study of r (CUGGGCGG). r
       (CCGCCUGG): R. P. Ojha, Biophysics Unit, Department of Physics, DDU Gorakhpur
       University, Gorakhpur – 273 009, India
P255   Solution conformation two peptides derived from bovine seminalplasmin (SPLN) protein by
       1
         H NMR and restrained molecular dynamics:P. N. Sunil Kumar1, C. Sadasivan1, K. S. Devaky2
       and M. Haridas1*, 1Department of Life Sciences, Kannur University, Palayadu, Kerala-670 661,
       India, 2School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala-686 560, India.
P256   Helical Formation and Conformational Stability in Homo and Hetero Oligomoers of
       Furanoid cis--Sugar-Amino Acid: B. Jagadeesh, A. Prabhakar, S. Chandrasekhar, M.S. Reddy
       and B. Jagannadh, Indian Institute of Chemical Technology, Tarnaka, Hyderabad- 500 007, India.
NATIONAL MAGNETIC RESONANCE ABSTRACTS

P257   Chemical shift evolution based separation of the integrals of partially resolved doublets
       using non-selective RF pulses G. A. Nagana Gowda, Centre of Biomedical Magnetic Resonance,
       Sanjay Gandhi Post graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014,
       INDIA
P258   A new class of thermotropic-lyotropic liquid crystals: An NMR study: S. Somashekar1, G.A.
       Nagana Gowda1, Hui Chen2 and David Abdallah2, R.G. Weiss2 and C.L. Khetrapal1, 1Centre of
       Biomedical Magnetic Resonance, Sanjay Gandhi Post Graduate Institute of Medical Sciences,
       Lucknow, India, 2 Department of Chemistry, Georgetown University, Washington D.C., USA
P259   A Novel Intramolecular Rearrangement Investigated by NMR Leading to the Synthesis of
       Biheterocyclic Indole-Benzoimidazole derivatives on Solid Phase: aRoy A.D., b Kundu B. and a
       Roy R. a NMR Laboratory, Division of SAIF, Central Drug Research Institute, Lucknow, India.
       (rajaroy_cdri@yahoo.com)
       b
         Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
P260   Studies on Catalytic Behavior of FCC Catalysts by 29Si and 27 Al MAS NMR Techniques:
       Babita Behera, Siddharth Ray, I.D.Singh, Indian Institute of Petroleum, Dehradun-248005
P261   Aminoquinazolines to Imidazoquinazolines: Mechanism of Cyclisation via Structure
       Elucidation Leading to Transamidation in Solid Phase: a,¶ Grover R.K., a Sharma S., b Kundu
       B. and a Roy R., a NMR Laboratory, Division of SAIF, Central Drug Research Institute, Lucknow,
       India. (rajaroy_cdri@yahoo.com)
       b
         Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
       ¶
         Present Address: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey
       Pines Road, La Jolla, California 92037, USA.
P262   Preparation and relaxation studies of Fe2O3 conjugated with biologically compatible
       polymers: Rashi Mathur, Rakesh Kumar Sharma, Anil Kumar Mishra*, Institute of Nuclear
       Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi-110054,
       India, akmishra@inmas.org




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