Current Funded Cancer Research Projects by bfk20410

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									         Current Funded Cancer Research Projects                                     SIU School of Medicine                                            8/05

Name                      Department/Division                                 Project Title                   Agency                Period        Total
Blaine Bartholomew, Ph.D., Biochemistry & Molecular Biology, SIUC             Chromatin remodeling &          National Institutes
Associate Professor        http://www.siu.edu/departments/biochem/            transcription repression        of Health
                                                                                                                                    2004 - 2009 $1,251,250

                                                                              Transcriptional activation by   National Institutes
                                                                              reorganizing chromatin          of Health           2002 - 2005      $870,617

Sukesh R. Bhaumik, Ph.D., Biochemistry & Molecular Biology, SIUC              Mechanisms of Eukaryotic        Translational
Assistant Professor       http://www.siu.edu/departments/biochem/             Transcription-coupled           Research Grant
                                                                              Ubiquitination and DNA Repair   SIU Cancer            2004 - 2005     $25,000
                                                                              in Vivo                         Institute

                                                                              Mechanisms of Eukaryotic        Central Research
                                                                              Gene Regualtion by the          Committee
                                                                              Proteasome Complex In Vivo      Awards           2005 - 2006          $20,000


Gregory Brewer, Ph.D.,    Medical Microbiology, Immunology and Cell Biology   3-D neural networks             National Institutes
Professor                 http://www.siumed.edu/mmi/                                                          of Health
                                                                                                              subcontract         2003 - 2007      $631,130


                                                                              Treatment of Rat Glioblastoma Translational
                                                                              with Neuropreservation        Research Grant
                                                                                                            SIU Cancer              2004 - 2005     $35,000
                                                                                                            Institute

Deliang Cao, M.D., Ph.D., Medical Microbiology, Immunology and Cell Biology   Mechanisms affecting            American Cancer
Assistant Professor        & SIU Cancer Institute                             fluoropyrimidine activity and   Society
                          http://www.siumed.edu/mmi/                          tumor selectivity                                     2005 - 2007    $600,000


Subhas Chakrabarty,        Molecular Pathology, M.D. Anderson Cancer Center   Transforming growth factor      National Institutes
Ph.D., Associate Professor                                                    action in colon cancer          of Health
                                                                                                                                    1988 - 2005 $1,537,329
Michael W. Collard, Ph.D., Physiology & SIU Cancer Institute             The Role of DNA Repair          Translational
Associate Professor        http://www.siumed.edu/physiology/             Enzymes in Prostate Cancer      Research Grant
                                                                                                                            2004 - 2005   $25,000
                                                                                                         SIU Cancer
                                                                                                         Institute
                                                                         Internal Co-Investigator(s): Jodi Huggenvik, Ph.D.


Randolph C. Elble, Ph.D., Cancer Biology Program, Cornell University     Tumor suppression by a         Philip Morris
Senior Research Associate                                                stress-inducible chloride      External
                                                                         channel                        Research           2004 - 2007    $900,000
                                                                                                        Program

Peter Hardwicke, Ph.D     Biochemistry & Molecular Biology, Carbondale   Control of Na+ -Ca2+           Central Research
                                                                         Exchanger Activity by cAMP     Committee, SIU
                                                                                                        School of        2005-2006        $20,000
                                                                                                        Medicine

Yuqing Hou, Ph.D.,        Chemistry & SIU Cancer Institute               Synthesis and Anticancer        Translational
Research Assistant                                                       Activity Study of a Stable      Research Grant
Professor                                                                                                                 2004 - 2005     $25,000
                                                                         Ginsenoside Rh² Analog          SIU Cancer
                                                                                                         Institute
                                                                         Internal Co-Investigator(s): Laura Murphy, Ph.D.

Jodi Huggenvik, Ph.D.,    Physiology & SIU Cancer Institute              NUDR: A Potential Tumor        National Cancer
Associate Professor       http://www.siumed.edu/physiology/              Suppressor of Childhood        Institute
                                                                         Cancers                                           2001 - 2006 $1,170,000


                                                                         Tumor Suppressor Activities of National Cancer
                                                                         NUDR and PTEN in Prostate Institute
                                                                                                                           2003 - 2006    $219,266

                                                                         Internal Co-Investigator(s): Kounosuke Watabe, Ph.D.

James P. Malone, M.D.,    Department of Surgery, Div of Otolaryngology   Intramural INGN 201 in         Introgen, Inc.
Assistant Professor       http://www.siumed.edu/surgery/otol/            patients with squamous cell
                                                                         carcinoma                                         2004 - 2005    $133,200


                                                                         Markers of Lymph Node          Central Research
                                                                         Metastasis in Squamous Cell    Committee
                                                                         Carcinoma of the Head and                         2005-2006      $20,000
                                                                         Neck
Mary McAsey, Ph.D.,    Department of Obstetrics & Gynecology   Effect of estrogen on neurite    IL Department of
Assistant Professor    http://www.siumed.edu/ob/index.html     growth and synaptic density      Public Health
                                                                                                                 2004 - 2005      $30,000
                                                                                                53280006

                                                               Mechanisms of action of          Excellence in
                                                               estrogen in the olfactory bulb   Academic
                                                                                                Medicine/State of 2004 - 2005     $35,000
                                                                                                Illinois

                                                               Apolipoprotein E genotype with Excellence in
                                                               aventricular hemorrhage        Academic
                                                                                              Medicine/State of        2005        $9,827
                                                                                              Illinois

Yin-Yuan Mo, Ph.D.,    Medical Microbiology, Immunology and    Ubc9 as a novel target for       National Cancer
Assistant Professor    Cell Biology & SIU Cancer Institute     cancer therapy                   Institute           2004 - 2007   $854,125
                       http://www.siumed.edu/mmi/
                                                               Modulation of ER mediated        Excellence in
                                                               gene expression by               Academic
                                                               sumoylation                      Medicine/State of      2005       $49,952
                                                                                                Illinois

                                                               Dysregulation of RNA          Department of
                                                               Interference in Breast Cancer Defense BCRP
                                                                                                                    2005 - 2006   $107,250
                                                                                             Concept Award

Laura Murphy, Ph.D.,   Department of Physiology, SIUC          Adjuvant Ginseng Use During National Center
Associate Professor    http://www.siumed.edu/physiology/       Breast Cancer Drug Therapy for
                                                                                           Complementary
                                                                                           and Alternative          2003-2006     $393,250
                                                                                           Medicine
Dao-tai Nie, Ph.D.,        Medical Microbiology, Immunology and                 Lipoxygenase, angiogenicity,     Department of
Assistant Professor        Cell Biology & SIU Cancer Institute                  and prostate cancer              Defense New
                           http://www.siumed.edu/mmi/                           radioresistance                  Investigator        2004 - 2006   $321,750
                                                                                                                 Award

                                                                                A Tissue Engineering             Department of
                                                                                Approach to Study the            Defense BCRP
                                                                                Progression of Breast Cancer     New Concept         2004 - 2005   $107,250
                                                                                Metastasis in Bone               Award

                                                                                An Autonomous Signaling       IL Department of
                                                                                Loop for Cell Motility in     Public Health
                                                                                Prostate Cancer: Novel Target
                                                                                for Anti-Metastasis Therapy                    2005 - 2006         $95,480



Elizabeth Peralta, M.D.,   Department of Surgery, Division of General Surgery   Interaction of Vitamin E and     The Breast
Assistant Professor        http://www.siumed.edu/surgery/                       Tamoxifen in the Adjuvant        Center at SIU,
                                                                                Treatment of Breast Cancer       Denim and           2004 - 2005   $50,000
                                                                                                                 Diamonds Fund

                                                                                Vitamin E Analogue in Breast Excellence in
                                                                                Cancer Treatment             Academic
                                                                                                             Medicine/State of          2005       $25,000
                                                                                                             Illinois

                                                                                Vitamin E Analogues in Breast Translational
                                                                                Cancer Treatment                Research Grant
                                                                                                                                  2004 - 2005     $20,000
                                                                                                                SIU Cancer
                                                                                                                Institute
                                                                                Internal Co-Investigator(s): Yuqing Hou, Ph.D.; Sophia Ran, Ph.D.

Vickram Ramkumar, Ph.D., Department of Pharmacology                             Nuclear factor Kappa B and       Excellence in
Associate Professor      http://www.siumed.edu/pharm/home.html                  renal adenosine receptor         Academic
                                                                                                                 Medicine/State of      2005       $44,137
                                                                                                                 Illinois

                                                                                Mechanism of nerve growth        Central Research
                                                                                factor regulation of vanilloid   Committee
                                                                                receptor-1 expression                                2004 - 2005   $14,250
Sophia Ran, Ph.D.,          Medical Microbiology, Immunology and Cell Biology &   Evaluation of anti-metastatic   American Cancer
Assistant Professor         SIU Cancer Institute                                  potential of novel antibodies   Society, IL
                            http://www.siumed.edu/mmi/                            targeting tumor vessels         Division
                                                                                                                                     2004 - 2005     $87,478




                                                                                  Pre-clinical evaluation of      Translational
                                                                                  Paclitaxel nanoparticles        Research Grant
                                                                                  combined with anti-angionic     SIU Cancer
                                                                                  antibody 3G4 for treatment of   Institute          2004 - 2005     $25,000
                                                                                  breast cancer


                                                                                  Internal Co-Investigator(s): Elizabeth Peralta, M.D.; Krishna Rao, M.D., Ph.D.

                                                                                                               Central Research
                                                                                  A Regulatory Role of VEGF-A
                                                                                                               Committee, SIU
                                                                                  in the Formation of Tumor
                                                                                                               School of        2004 - 2006          $14,250
                                                                                  Lymphatic Vessels and Breast
                                                                                                               Medicine
                                                                                  Cancer Metastasis

                                                                                  Improving Therapeutic Gains in Department of
                                                                                  Patients with Breast Cancer     Defense BCRP
                                                                                  after Treatment with Paclitaxel Concept Award      2005-2006      $107,250


                                                                                  Optimizing response of breast IL Department of
                                                                                  tumors to chemotherapy        Public Health
                                                                                                                                     2005-2006       $70,000

Krishna Rao, M.D., Ph.D.,   Internal Medicine & SIU Cancer Institute              Molecular studies of mammary Central
Assistant Professor         http://www.siumed.edu/medicine/DGIM/                  spindle cell carcinoma       Research
                                                                                                               Committee, SIU
                                                                                                                                    2004 - 2005     $13,015
                                                                                                               School of
                                                                                                               Medicine

                                                                                  Role of Rab 25 in Breast        American
                                                                                  Cancer Pathogenesis             Cancer Society,
                                                                                                                  Institutional      2005-2006      $20,000
                                                                                                                  Research Grant
Laura Rogers, M.D.,         Department of Internal Medicine                          Evaluation of novel agents     Excellence in
Assistant Professor         http://www.siumed.edu/medicine/DGIM/                     which target neovasculature of Academic
                                                                                     breast tumors                  Medicine/State     2004 - 2005     $46,640
                                                                                                                    of Illinois

                                                                                     Exercise and breast cancer      Central
                                                                                     survivors                       Research
                                                                                                                     Committee, SIU
                                                                                                                                       2004 - 2005     $13,930
                                                                                                                     School of
                                                                                                                     Medicine

                                                                                     Exercise and rural breast       American
                                                                                     cancer survivors                Cancer Society,
                                                                                                                                       2005-2007      $230,772
                                                                                                                     IL Division

Leonard P. Rybak, M.D.,     Department of Surgery, Div of Otolaryngology             Restoration of cochlear          American
Ph.D., Professor            http://www.siumed.edu/surgery/otol/                      function by cell transplantation Otological
                                                                                                                      Society          2004 - 2005     $40,000

                                                                                     Endogenous modulation of        National Institute
                                                                                     cochlea injury                  of Health          1994 - 2009   $975,975

                                                                                     Internal Co-Investigator(s): Vickram Ramkumar, Ph.D.

                                                                                     Peripheral and central         National Institues
                                                                                     mechanisms of tinnitus         of Health
                                                                                     generation                                        2002 - 2007    $1,042,561
                                                                                     Co-Investigator with Carol Bau er, M.D.

Thomas Tarter, M.D., Ph.D., Department of Surgery, Division of Urology, Section of   Study of efficacy & safety of   GlaxoSmithKline
Assistant Professor,        Urologic Oncology                                        Dutasteride to reduce risk of   Co.
Section Head                http://www.siumed.edu/surgery/urology/                   biopsy-detectable prostate
                                                                                                                                       2004 - 2008    $192,200
                                                                                     cancer


                                                                                     Significance of PGE2            Central
                                                                                     Production in Human Renal       Research
                                                                                     Cell Carcinoma                  Committee, SIU
                                                                                                                                       2005-2006       $20,000
                                                                                                                     School of
                                                                                                                     Medicine

Rita Trammell, Ph.D.        Department of Surgery                                    Role of Ubc9 in drug            Wm. E. McElroy
Assistant Research          Division of Orthopaedics and Rehabilitation              resistance                      Charitable
                                                                                                                     Foundation     2004 - 2005        $25,000
Instructor
Kounosuke Watabe, Ph.D., Medical Microbiology, Immunology and Cell Biology & SIU   The role of tumor metastases US Army Dept
Professor                Cancer Institute                                          suppressor gene, Drg1, in    Of Defense
                                                                                                                                    2005 - 2008   $425,887
                         http://www.siumed.edu/mmi/                                breast cancer

                                                                                   Anti-tumor peptide for the     Amer. Lung
                                                                                   treatment of lung cancer       Assn, Illinois    2004 - 2005    $28,000

                                                                                   Mechanism of tumor             US Army Dept of
                                                                                   metastasis suppression by      Defense
                                                                                   KAI1 gene                      PC031038        2003 - 2006     $534,437

                                                                                   Internal Co-Investigator(s): Vickram Ramkumar, Ph.D.

                                                                                   Tumor suppressor activities on National Cancer
                                                                                   NUDR and PTEN in Prostate Institute
                                                                                   Cancer                                         2003 - 2005     $109,633

                                                                                   Internal Co-Investigator(s): Thomas Tarter, M.D., Ph.D.

                                                                                   Tumor metastatis suppressor National Cancer
                                                                                   gene on human chromosome Institute
                                                                                   16 in prostate cancer                       2001 - 2005        $141,000


                                                                                   Fatty acid synthase as         Excellence in
                                                                                   molecular target for cancer    Academic
                                                                                   therapy                        Medicine/State        2005       $56,192
                                                                                                                  of Illinois

                                                                                   Institutional Research Grant to American
                                                                                   fund small grants program in Cancer Society,
                                                                                   oncology                        National         2005 - 2007   $127,500


                                                                                   Fatty Acid Synthase as a        William E.
                                                                                   Therapeutic Target for Prostate McElroy
                                                                                   Cancer                          Charitable        2005-2007     $50,000
                                                                                                                   Foundation
                                                                                                                                                  $14,036,783

								
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