MSDS Nitric Oxide and Nitrous Oxide Sulfer Dioxide and by jvz18720

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									MATERIAL SAFETY DATA SHEET

PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM),
SULFUR DIOXIDE (100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN
NITROGEN

1. Chemical Product and Company Identification

BOC Gases,                                                                 BOC Gases
Division of                                                                Division of
The BOC Group, Inc.                                                        BOC Canada Limited
575 Mountain Avenue                                                        5975 Falbourne Street, Unit 2
Murray Hill, NJ 07974                                                      Mississauga, Ontario L5R 3V8

TELEPHONE NUMBER: (908) 464-8100                                           TELEPHONE NUMBER: (905) 501-1700
24-HOUR EMERGENCY TELEPHONE                                                24-HOUR EMERGENCY TELEPHONE
NUMBER: CHEMTREC (800) 424-9300                                            NUMBER: (905) 501-0802
                                                                           EMERGENCY RESPONSE PLAN NO: 20101

PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE (100-
2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN
CHEMICAL NAME: Nitric oxide and Nitrous oxide (0.01-0.2%), Sulfur dioxide (0.01-0.2%), and Carbon
dioxide (1-18.5%) in Nitrogen
COMMON NAMES/SYNONYMS: N/A
TDG (Canada) CLASSIFICATION: A, D2B, D1A
WHMIS CLASSIFICATION: 2.2

PREPARED BY: Loss Control (908)464-8100/(905)273-7700
PREPARATION DATE: 9/10/97
REVIEW DATES: N/A

2. Composition, Information on Ingredients

             INGREDIENT                       % VOLUME               PEL-OSHA1               TLV-ACGIH2           LD50 or LC50
                                                                                                                 Route/Species
NITRIC OXIDE                                0.01-0.2             25 ppm                  25 ppm              LC50: 115 ppm/1 H
FORMULA: NO                                                                                                  inhalation/rat
CAS: 10102-43-9                                                                                              (CGA Pamphlet P-20,
RTECS #: QX0525000                                                                                           as NO2)
NITROUS OXIDE                               0.01-0.2             None Established        50 ppm TWA          TCLo: 24 mg/kg/2H
FORMULA: N2O                                                                                                 human/inhalation
CAS: 10024-97-2
RTECS #: QX1350000
SULFUR DIOXIDE                              0.01-0.2             5 ppm TWA               2 ppm TWA           LC50: 2520 ppm/1H
FORMULA: SO2                                                                             5 ppm STEL          inhalation/rat
CAS: 7446-09-5
RTECS #: WS4550000
CARBON DIOXIDE                              1-18.5               5000 ppm TWA            5000 ppm TWA        Not Available
FORMULA: CO2                                                                             30,000 ppm STEL
CAS: 124-38-9
RTECS #: FF6400000
NITROGEN                                    > 97.7               Simple Asphyxiant       Simple Asphyxiant   Not Available
FORMULA: N2
CAS: 7727-37-9
RTECS #: QW9700000
1
    As stated in 29 CFR 1910, Subpart Z (revised July 1, 1993)
2
    As stated in the ACGIH 1996-97 Threshold Limit Values for Chemical Substances and Physical Agents


MSDS: G-221
Revised: 9/10/97                                                                                                Page 1 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

3. Hazards Identification

                                         EMERGENCY OVERVIEW
Harmful if inhaled. Sulfur dioxide may cause eye, skin, and respiratory irritation, pulmonary edema
and chemical pneumonitis. Nitric oxide can greatly decrease the ability of the blood to carry oxygen
causing cyanosis and methemoglobinemia. Carbon dioxide exposure can cause nausea and
respiratory problems. Nitrous oxide acts as a general anesthetic. In air, nitric oxide is rapidly
converted to nitrogen dioxide which can cause respiratory distress and pulmonary edema at
relatively low concentrations. If irritation occurs, exposure is likely to have already occurred. Sulfur
dioxide reacts with water to produce sulfurous acid. Non-flammable. Contents under pressure. Use
and store below 120 °F.

ROUTE OF ENTRY:
  Skin Contact             Skin Absorption            Eye Contact             Inhalation              Ingestion
      Yes                        No                       Yes                    Yes                     No

HEALTH EFFECTS:
         Exposure Limits                              Irritant                               Sensitization
                Yes                                     Yes                                      No
             Teratogen                          Reproductive Hazard                            Mutagen
                Yes                                     Yes                                      Yes
Synergistic Effects
None known

Carcinogenicity: -- NTP: No      IARC: No      OSHA: No

EYE EFFECTS:
Over-exposure to sulfur dioxide may cause severe eye irritation and possible damage. Over-exposure to nitric
oxide may cause severe irritation.

SKIN EFFECTS:
Sulfur dioxide and nitric oxide are severely irritating to the skin and all living tissue.

INGESTION EFFECTS:
Unlikely; product is a gas.

INHALATION EFFECTS:
Sulfur dioxide is irritating to the upper and lower respiratory tract and all mucosal tissue. Chemical
pneumonitis and pulmonary edema may result from exposure to the lower respiratory tract and deep lung.
Nitric oxide reacts with blood hemoglobin to form nitrosylhemoglobin (NOHb), a compound which cannot
transport oxygen to body tissues. In air, nitric oxide is rapidly converted to nitrogen dioxide which can cause
delayed chemical pneumonitis and pulmonary edema. Exposure can result in unconsciousness and death.
Carbon dioxide is a powerful cerebral vasodilator. Inhalation of large concentrations can cause circulatory
insufficiency leading to coma and death. Nitrous oxide may have an anesthetic effect with decreased pulse rate
without a decrease in blood pressure or body temperature.




MSDS: G-221
Revised: 9/10/97                                                                                    Page 2 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

SIGNS AND SYMPTOMS:
Initial symptoms of exposure to sulfur dioxide include nose and throat irritation, becoming steadily worse,
suffocating and painful. The irritation extends to the chest causing a cough reflex which may be violent and
painful and may include the discharge of blood or vomiting with eventual collapse. Other symptoms may
include headache, general discomfort and anxiety.

Some nitrogen dioxide is invariably present when nitric oxide is in air. Initially, following inhalation of
nitrogen oxides, irritation to the throat, tightness of the chest, headache, nausea and gradual loss of strength
are seen. Severe symptoms may be delayed (possibly for several hours) and include cyanosis, increased
difficulty in breathing, irregular respiration, lassitude and possible eventual death due to pulmonary edema in
untreated cases.

CHRONIC EFFECTS:
Repeated exposure to nitric oxide may cause a permanent decrease in pulmonary function, chronic irritation of
the respiratory tract, and tooth corrosion. Repeated or prolonged low level exposure to sulfur dioxide may
cause corrosion of the teeth.

TARGET ORGANS:
Eyes, skin, respiratory system, blood, central nervous system (CNS)

MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE:
May aggravate pre-existing respiratory conditions. Persons with anemia, cardiovascular disease, or chronic
conjunctivitis and smokers may be at increased risk from exposure.

NFPA HAZARD CODES                      HMIS HAZARD CODES                        RATINGS SYSTEM

Health:       2                        Health:       2                          0 = No Hazard
Flammability: 0                        Flammability: 0                          1 = Slight Hazard
Reactivity:   0                        Reactivity:   0                          2 = Moderate Hazard
                                                                                3 = Serious Hazard
                                                                                4 = Severe Hazard
4. First Aid Measures

EYE:
PERSONS WITH POTENTIAL EXPOSURE SHOULD NOT WEAR CONTACT LENSES. Flush
contaminated eyes with copious quantities of water for 15 minutes parting eyelids ensure complete flushing.
Seek immediate medical attention.

SKIN:
Remove contaminated clothing and flush affected area with large amounts of water. If irritation occurs, seek
medical attention.

INGESTION:
Unlikely; product is a gas.




MSDS: G-221
Revised: 9/10/97                                                                                 Page 3 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

INHALATION:
PROMPT MEDICAL ATTENTION IS MANDATORY IN ALL CASES OF OVER-EXPOSURE. RESCUE
PERSONNEL SHOULD BE EQUIPPED WITH SELF-CONTAINED BREATHING APPARATUS.
Conscious persons should be CARRIED (not assisted) to an uncontaminated area and inhale fresh air with
supplemental oxygen. Quick removal from the contamination area is most important. Keep the patient warm,
quiet and under competent medical observation until the danger of delayed pulmonary edema has passed (at
least 72 hours). Any physical exertion during this period should be discouraged as it may increase the severity
of the pulmonary edema or chemical pneumonitis. Bed rest is indicated.

Unconscious persons should be moved to an uncontaminated area, and if breathing has stopped, administer
artificial resuscitation and supplemental oxygen. Once respiration has been restored, they should be treated as
above.
5. Fire Fighting Measures

Conditions of Flammability: Not flammable
Flash point:                        Method:                             Autoignition
None                                Not Applicable                      Temperature: None
LEL(%): None                                          UEL(%): None
Hazardous combustion products: None
Sensitivity to mechanical shock: None
Sensitivity to static discharge: None

FIRE AND EXPLOSION HAZARDS:
Non-flammable. Cylinder may rupture or explode from pressure when involved in a fire situation.

EXTINGUISHING MEDIA:
Any. Use media appropriate for surrounding fire. Sulfur dioxide forms sulfurous acid solutions with water.

FIRE FIGHTING INSTRUCTIONS:
Firefighters should wear a NIOSH/MSHA approved full-facepiece self-contained breathing apparatus (SCBA)
operated in positive pressure mode and full turnout or bunker gear.


6. Accidental Release Measures

Evacuate all personnel from affected area. Ventilate enclosed spaces. Deny entry to persons not wearing
appropriate protective equipment. If leak is in user's equipment, be certain to purge piping with inert gas prior
to attempting repairs. If leak is in container or container valve, contact the appropriate emergency telephone
number listed in Section 1 or call your closest BOC location. Do not re-enter hazard area until product has
dispersed.

7. Handling and Storage

Electrical classification: Non-hazardous.

Most metals corrode when in contact with wet sulfur dioxide.




MSDS: G-221
Revised: 9/10/97                                                                                 Page 4 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

Use only in well-ventilated areas. Valve protection caps must remain in place unless container is secured with
valve protection outlet piped to use point. Do not drag, slide or roll cylinders. Use a suitable hand truck for
cylinder movement. Use a pressure-reducing regulator when connecting cylinder to lower pressure (< 3000
psig) piping or systems. Do not heat cylinder by any means to increase the discharge rate of product from the
cylinder. Use a check valve or trap in the discharge line to prevent hazardous back flow into the cylinder.

Protect cylinders from physical damage. Store in cool, dry, well-ventilated area of non-combustible
construction away from heavily trafficked areas and emergency exits. Do not allow the temperature where
cylinders are stored to exceed 120º F (49º C). Cylinders should be stored upright and firmly secured to prevent
falling or being knocked over. Use a “first-in first-out” inventory system to prevent full cylinders being stored
for excessive periods of time. Stationary customer site vessels should operate in accordance with the
manufacturer's and BOC’s instruction. Do not attempt to repair, adjust or in any other way modify the
operation of these vessels. If there is a malfunction or other type of operations problem with the vessel, contact
the closest BOC location immediately.

For additional recommendations, consult Compressed Gas Association Pamphlets G-3, SB-6, and P-11.

Never carry a compressed gas cylinder or a container of a gas in cryogenic liquid form in an enclosed space
such as a car trunk, van or station wagon. A leak can result in a fire, explosion, asphyxiation or a toxic
exposure.


8. Exposure Controls, Personal Protection

EXPOSURE LIMITS1:
            INGREDIENT                       % VOLUME                 PEL-OSHA1                  TLV-ACGIH2                 LD50 or LC50
                                                                                                                           Route/Species
NITRIC OXIDE                                  0.01-0.2              25 ppm                       25 ppm                LC50: 115 ppm/1 H
FORMULA: NO                                                                                                            inhalation/rat
CAS: 10102-43-9                                                                                                        (CGA Pamphlet P-20,
RTECS #: QX0525000                                                                                                     as NO2)
NITROUS OXIDE                                 0.01-0.2              None Established             50 ppm TWA            TCLo: 24 mg/kg/2H
FORMULA: N2O                                                                                                           human/inhalation
CAS: 10024-97-2
RTECS #: QX1350000
SULFUR DIOXIDE                                0.01-0.2              5 ppm TWA                    2 ppm TWA                   LC50: 2520 ppm/1H
FORMULA: SO2                                                                                     5 ppm STEL                  inhalation/rat
CAS: 7446-09-5
RTECS #: WS4550000
CARBON DIOXIDE                                1-18.5                5000 ppm TWA                 5000 ppm TWA                Not Available
FORMULA: CO2                                                                                     30,000 ppm STEL
CAS: 124-38-9
RTECS #: FF6400000
NITROGEN                                      > 97.7                Simple Asphyxiant            Simple Asphyxiant           Not Available
FORMULA: N2
CAS: 7727-37-9
RTECS #: QW9700000
1
  Refer to individual state of provincial regulations, as applicable, for limits which may be more stringent than those listed here.
2
  As stated in 29 CFR 1910, Subpart Z (revised July 1, 1993)
3
  As stated in the ACGIH 1996-1997 Threshold Limit Values for Chemical Substances and Physical Agents.

IDLH: 100 ppm SO2; 100 ppm NO

ENGINEERING CONTROLS:
Hood with forced ventilation and local exhaust to control sulfur dioxide and nitric oxide concentrations to
below acceptable exposure guidelines.



MSDS: G-221
Revised: 9/10/97                                                                                                           Page 5 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

EYE/FACE PROTECTION:
Gas-tight goggles or full-facepiece respirator

SKIN PROTECTION:
Protective gloves of suitable material.

RESPIRATORY PROTECTION:
Respiratory protection is dependent upon the magnitude of exposure. A positive pressure air line with full-face
mask and escape bottle or full-facepiece self-contained breathing apparatus should be available for emergency
use. Select respiratory protection in accordance with 29 CFR 1910.134.

OTHER PROTECTION:
Safety shoes, safety shower, emergency eyewash station
9. Physical and Chemical Properties

PARAMETER                                                 VALUE                        UNITS
Physical state (gas, liquid, solid)                       : Gas
Vapor pressure                                            : Not Available
Vapor density (Air = 1)                                   : Not Available
Evaporation point                                         : Not Available
                                                                                       o
Boiling point                                             : Not Available                F
                                                                                       o
                                                          : Not Available                C
                                                                                       o
Freezing point                                            : Not Available                F
                                                                                       o
                                                          : Not Available                C
pH                                                        : Not Available
Specific gravity                                          : Not Available
Oil/water partition coefficient                           : Not Available
Solubility (H20)                                          : Very slight
Odor threshold                                            : Not Applicable
Odor and appearance                                       : Colorless, odorless gas.

10. Stability and Reactivity

STABILITY:
Stable.

INCOMPATIBLE MATERIALS:
Nitric oxide reacts with oxidizing agents, halides, hydrocarbons, oxygen, and vigorously with fluorine, fluorine
oxides and chlorine in the presence of moisture. Sulfur dioxide forms sulfurous acid solutions with water and
reacts with powdered alkali metals, brass, copper, water, ammonia, zinc, and aluminum.

HAZARDOUS DECOMPOSITION PRODUCTS:
Nitric oxide oxidizes in air to form nitrogen dioxide, which is extremely reactive and a strong oxidizer. Nitric
oxide reacts with moisture and oxygen to form nitrous and nitric acids.

HAZARDOUS POLYMERIZATION:
Will not occur.




MSDS: G-221
Revised: 9/10/97                                                                                Page 6 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN

11. Toxicological Information

INHALATION:
Mice which inhaled a total of 320 ppm nitric oxide exhibited convulsions as well as cyanosis. The affinity of
nitric oxide for ferrous hemoglobin is 1400 times that of carbon monoxide.

A minimum lethal human exposure of 400 ppm for 1 minute has been reported for sulfur dioxide. Inhalation
of 1000 ppm from 10 minutes to several hours can cause death from respiratory depression.

Patient intoxication was reported from inhalation of an anesthetic of 75% nitrous oxide in oxygen that was
contaminated with more than 1.5% nitric oxide. Both patients suffered from cyanosis and methemoglobinemia
as well as respiratory distress and pulmonary edema attributed to NO2.

Deaths from silogas containing upwards of 140 ppm nitric oxide (“silo-fillers’ disease”) have been reported.


EYES: Contact with high concentrations of sulfur dioxide can cause burns and lesions which may result in
loss of vision.

SKIN: Dermal tissues exposed to toxic levels of sulfur dioxide exhibited acid-like burns and skin lesions
resulting in early necrosis and scarring.

SUBCHRONIC:
Rat inhalation of nitric oxide (50 mg/m3/6H/7W-I) produced changes in liver and lung weights as well as
overall weight loss or decreased weight gain.

CHRONIC:
Chronic or repeated exposures may cause permanent decrements in pulmonary function.

OTHER: Sulfur dioxide has induced genetic changes in mammalian, insect, bacterial, and yeast cell assay
systems. Reproductive toxicity and developmental changes in newborns have been observed in experimental
animals exposed to sulfur dioxide. Functional changes in the respiratory systems of exposed dogs, and red
blood cells of rats were observed following sulfur dioxide exposure.


12. Ecological Information

A series of atmospheric chemical reactions in which nitric oxide is involved lead to the formation of
photochemical smog.


13. Disposal Considerations

Do not attempt to dispose of residual waste or unused quantities. Return in the shipping container
PROPERLY LABELED, WITH ANY VALVE OUTLET PLUGS OR CAPS SECURED AND VALVE
PROTECTION CAP IN PLACE to BOC Gases or authorized distributor for proper disposal.




MSDS: G-221
Revised: 9/10/97                                                                                Page 7 of 8
PRODUCT NAME: NITRIC OXIDE AND NITROUS OXIDE (100-2000 PPM), SULFUR DIOXIDE
(100-2000 PPM), AND CARBON DIOXIDE (1-18.5%) IN NITROGEN


14. Transport Information

      PARAMETER                           United States DOT                              Canada TDG
PROPER SHIPPING NAME:                       Compressed gas n.o.s.                      Compressed gas n.o.s.
                                   (Nitric oxide, Sulfur dioxide in Nitrogen)
HAZARD CLASS:                                          2.2                                      2.2
IDENTIFICATION NUMBER:                             UN 1956                                   UN 1956
SHIPPING LABEL:                           NONFLAMMABLE GAS                            NONFLAMMABLE GAS


15. Regulatory Information

SARA TITLE III NOTIFICATIONS AND INFORMATION

SARA TITLE III - HAZARD CLASSES:
Acute Health Hazard
Sudden Release of Pressure Hazard

Nitric oxide and sulfur dioxide are listed as extremely hazardous substances (EHSs) subject to state and local
reporting under Section 304 of SARA Title III (EPCRA) with Threshold Planning Quantities (TPQs) of 500
and 100 pounds respectively and reportable quantities of 1 pound.

SARA TITLE III - SECTION 313 SUPPLIER NOTIFICATION:
None


16. Other Information

Compressed gas cylinders shall not be refilled without the express written permission of the owner. Shipment
of a compressed gas cylinder which has not been filled by the owner or with his/her (written) consent is a
violation of transportation regulations.

DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES:
Although reasonable care has been taken in the preparation of this document, we extend no warranties and
make no representations as to the accuracy or completeness of the information contained herein, and assume
no responsibility regarding the suitability of this information for the user's intended purposes or for the
consequences of its use. Each individual should make a determination as to the suitability of the information
for their particular purpose(s).




MSDS: G-221
Revised: 9/10/97                                                                                Page 8 of 8

								
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