Translational Studies of Alcoholism: Bridging the Gap

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					                                Translational Studies 

                                   of Alcoholism

                                               Bridging the Gap
                                Natalie M. Zahr, Ph.D., and Edith V. Sullivan, Ph.D.

           Human studies are necessary to identify and classify the brain systems predisposing individuals to
           develop alcohol use disorders and those modified by alcohol, while animal models of alcoholism are
           essential for a mechanistic understanding of how chronic voluntary alcohol consumption becomes
           compulsive, how brain systems become damaged, and how damage resolves. Our current knowledge of
           the neuroscience of alcohol dependence has evolved from the interchange of information gathered from
           both human alcoholics and animal models of alcoholism. Together, studies in humans and animal
           models have provided support for the involvement of specific brain structures over the course of
           alcohol addiction, including the prefrontal cortex, basal ganglia, cerebellum, amygdala, hippocampus,
           and the hypothalamic–pituitary–adrenal axis. KEY WORDS: Alcohol dependence; alcoholism; chr
				
DOCUMENT INFO
Description: Human studies are necessary to identify and classify the brain systems predisposing individuals to develop alcohol use disorders and those modified by alcohol, while animal models of alcoholism are essential for a mechanistic understanding of how chronic voluntary alcohol consumption becomes compulsive, how brain systems become damaged, and how damage resolves. Our current knowledge of the neuroscience of alcohol dependence has evolved from the interchange of information gathered from both human alcoholics and animal models of alcoholism. Together, studies in humans and animal models have provided support for the involvement of specific brain structures over the course of alcohol addiction, including the prefrontal cortex, basal ganglia, cerebellum, amygdala, hippocampus, and the hypothalamic-pituitary-adrenal axis. [PUBLICATION ABSTRACT]
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