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[...] hyperphosphatemia decreases the activity of the enzyme responsible for converting inactive Vitamin D to active Vitamin D. This, in turn, will impair the absorption of calcium from the gastrointestinal tract and reduce mobilization of calcium and phosphorus from the bone (Figure One). [...] control of serum phosphate plays an important role in prevention of secondary hyperparathyroidism, metabolic bone disease, and soft tissue and vascular calcification. Two other phosphate binding agents have been tried: (1) Calcium carbonate has been found to be much less effective in binding phosphate than aluminum, and (2) Sucralfate (the basic aluminum salt of sucrose octasulfate) is also less effective than aluminum hydroxide or aluminum hydroxide sucrose in reducing serum phosphate levels.
Hyperphosphatemia and its treatment By MaryBeth Blokker, Pharmacist,Victoria Hospital, Londo
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