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Hitchhiking Both Ways: Effect of Two Interfering Selective Sweeps on Linked Neutral Variation

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The neutral polymorphism pattern in the vicinity of a selective sweep can be altered by both stochastic and deterministic factors. Here, we focus on the impact of another selective sweep in the region of influence of a first one. We study the signature left on neutral polymorphism by positive selection at two closely linked loci, when both beneficial mutations reach fixation. We show that, depending on the timing of selective sweeps and on their selection coefficients, the two hitchhiking effects can interfere with each other, leading to less reduction in heterozygosity than a single selective sweep of the same magnitude and more importantly to an excess of intermediate-frequency variants relative to neutrality under some parameter values. This pattern can be sustained and potentially alter the detection of positive selection, including by provoking spurious detection of balancing selection. In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories. [PUBLICATION ABSTRACT]

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									Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.108.089706



                 Hitchhiking Both Ways: Effect of Two Interfering Selective
                            Sweeps on Linked Neutral Variation

                          Luis-Miguel Chevin,*,†,1 Sylvain Billiard‡ and Frederic Hospital§
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      *UMR de Genetique Vegetale, Ferme du Moulon, 91190 Gif sur Yvette, France, †Ecologie, Systematique et Evolution, UMR 8079,
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        Universite Paris-Sud, 91405 Orsay Cedex, France, §INRA, UMR1236 Genetique et Diversite Animales, 78352 Jouy-en-Josas,
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              France and ‡Genetique et Evolution des Populations Vegetales, Universite des Sciences et Technologies de Lille 1,
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