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Comparative Analyses of Human Single- and Multilocus Tandem Repeats by ProQuest

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Using the compiled human genome sequence, we systematically cataloged all tandem repeats with periods between 20 and 2000 bp and defined two subsets whose consensus sequences were found at either single-locus tandem repeats (slTRs) or multilocus tandem repeats (mlTRs). Parameters compiled for these subsets provide insights into mechanisms underlying the creation and evolution of tandem repeats. Both subsets of tandem repeats are nonrandomly distributed in the genome, being found at higher frequency at many but not all chromosome ends and internal clusters of mlTRs were also observed. Despite the integral role of recombination in the biology of tandem repeats, recombination hotspots colocalized only with shorter microsatellites and not the longer repeats examined here. An increased frequency of slTRs was observed near imprinted genes, consistent with a functional role, while both slTRs and mlTRs were found more frequently near genes implicated in triplet expansion diseases, suggesting a general instability of these regions. Using our collated parameters, we identified 2230 slTRs as candidates for highly informative molecular markers. [PUBLICATION ABSTRACT]

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									Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.108.087882



  Comparative Analyses of Human Single- and Multilocus Tandem Repeats

              Darren Ames,1 Nick Murphy,1 Tim Helentjaris, Nina Sun and Vicki Chandler2
                        BIO5 Institute and Department of Plant Sciences, University of Arizona, Tucson, Arizona 85719
                                                       Manuscript received February 5, 2008
                                                      Accepted for publication April 28, 2008


                                                              ABSTRACT
                 Using the compiled human genome sequence, we systematically catal
								
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