Identity-by-Descent Estimation and Mapping of Qualitative Traits in Large, Complex Pedigrees by ProQuest

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									Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.108.089912



        Identity-by-Descent Estimation and Mapping of Qualitative Traits in
                             Large, Complex Pedigrees

                                                                 Mark Abney1
                                  Department of Human Genetics, University of Chicago, Chicago, Illinois 60637
                                                       Manuscript received April 4, 2008
                                                      Accepted for publication May 2, 2008


                                                              ABSTRACT
                 Computing identity-by-descent sharing between individuals connected through a large, complex
              pedigree is a computationally demanding task that often cannot be done using exact methods. What I
              present here is a rapid computational method for estimating, in large complex pedigrees, the probability
              that pairs of alleles are IBD given the single-
								
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