Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants

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Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants Powered By Docstoc
					Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.108.089052




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     Incorporation of Y9-Ty1 cDNA Destabilizes Telomeres in Saccharomyces
                    cerevisiae T
				
DOCUMENT INFO
Description: Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements. [PUBLICATION ABSTRACT]
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