mAb for RIT and Imaging in Pancreatic Cancer by ProQuest


The research, in nude mice bearing caPanl human pancreatic cancer xenografts, included biodistribution studies and nuclear imaging of the radiolabeled TFlO and/or a TF10-pretargeted hapten-peptide (IMP-288). ^sup 125^I-labeled TFlO was found to clear rapidly from the blood, with levels decreasing to 1% injected dose per gram (%ID/g) by 16 h, at which time tumor uptake was 3.47 0.66 %ID/g, with no accumulation in normal tissue. ^sup 111^In-labeled IMP-288 was administered 16 h after the TF10.

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