As one of 39 National Cancer Institute-designated Comprehensive Cancer Centers and one of the largest in the world, leadership at The University of Texas M. D. Anderson Cancer Center recognized the importance of a thorough informed consent process to patient safety. In 2007, M. D. Anderson implemented an advanced automated solution, which had been embedded directly into its electronic medical record system to maximize effectiveness. In order to address the shortcomings inherent to their paper-based informed consent process, they began to explore automated informed consent applications (AICAs) and found they offered a range of benefits. After integration of the AICA within ClinicStation, they adopted a phased approach to implementing the AICA in order to maximize success and drive adoption by demonstrating incremental benefits to various user groups. They began to identify the benefits of an AICA almost immediately after implementation.