Primary Pleural Neoplasia
Entities Other Than Diffuse Malignant Mesothelioma
Donald G. Guinee, MD; Timothy Craig Allen, MD, JD
● Context.—Overwhelmingly, the most common neoplasm rect diagnosis and optimal assessment of prognosis and
involving the pleura is metastatic carcinoma. In contrast, treatment.
diffuse malignant mesothelioma occurs relatively rarely; Data Sources.—Literature review and primary material
however, it is nonetheless the most common neoplasm pri- from the authors’ institutions.
mary to the pleura. Metastatic carcinoma and diffuse ma- Conclusions.—A nonexhaustive group of uncommon to
lignant mesothelioma each have their own prognostic and rare benign and malignant primary pleural neoplasms—
therapeutic characteristics. Other primary pleural neo- other than diffuse malignant mesothelioma—are present-
plasms occur uncommonly or rarely, with their own prog- ed, of which one must be aware in order to maintain an
nostic and therapeutic characteristics. appropriate index of suspicion to include them in the dif-
Objective.—To review primary pleural neoplasms other ferential diagnosis of a pleural tumor.