ROTAVIRUS ACUTE DIARRHEA AFTER INTRODUCTION OF A G1P8 VACCINE: A COHORT STUDY
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R.Q. GURGEL , S.C.F. VIEIRA , P.B. FONTES , V.F. BARROS , M.R. FERREIRA , L.D. DE SOUZA , O.C. OLIVEIRA , L.
Federal University of Sergipe, Aracaju, Brazil, University of Liverpool, Liverpool, UK
Background: Rotavirus acute diarrhea is an important cause of morbimortality all over the world. Brazil was one of the pioneers
countries in the implantation of the rotavirus vaccine at the National Expanded Program for Immunization in march 2006.
Methods: Two vaccinated and not vaccinated children cohorts were studied at the Santa Maria district in Aracaju, a brazilian
northeastern city, from November 2006 to November 2008. 250 children were allocated in each group, with age varying from 2 to 25
months. They were visited at home two times per month to verify the occurrence of acute diarrhea and, in case of diarrhea, stool
samples were collected to be analized by ELISA, RT-PCR and eletropherotyping.
Results: There were 583 episodes of acute diarrhea, 47,2% (275) in not vaccinated and 52,8% (308) in vacci nated children. 512
samples were collected and 250 were already analized. Twelve were positive at ELISA, 8 from the vaccinated group and 4 from t he
not vaccinated group. Nine samples were genotyped: among vaccinated 3 were GNTPNT and 2 G2P4; among not vaccinated, 2
classified as GNTPNT, 1 G2PNT e 1 G2P4.
Conclusions: After the implantation of the rotavirus vaccine, we verified a change in the profile of acute diarrhea and of the
circulating rotavirus strains.