ANTIMICROBIAL RESISTANCE TRENDS IN SHIGELLA SPECIES AMONG PATIENTS WITH ACUTE DIARRHEA IN
CHILDREN HOSPITAL OF TABRIZ , IRAN
S. HOSSEINPOUR SAKHA , M.E. RAHBANI NOBAR
Infectious Disease, Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran
Background & objectives: The study was carried out to determine the pattern of antimicrobial resistance of shigella species
among patients with acute diarrehea in children hospital of Tabriz.
Materials & methods: The study included all of acute diarrhea patients who visited in the children hospital of Tabriz, Iran during
2002-2004 . All children whose fecal cultures yielded shigella species and antibiotic sensitivity testing was done were included in the
Results: A total of 45 isolated of shigella, 39 of which were shigella flexneri and 4 shigella sonnei. The rate of resistence in shigl la
flexneri to ampicilin and trimetoprim - sulfametoxazol were 89.6% , 89.1% respectively. Multidrug resistance were in 65.7% cases.
Almost all isolated shigella sonnei were resistant to ampicilin and 75% were resistant to trimethoprim sulfamethoxazol All of shigella
species were found to be sensitive to third generation cephalosporins and nalidixic acid.
Conclusion: These results suggest the shigella flexneri is the important spp in this region with high rate of resistance to commonly
prescribed antibiotic and the need to reassess the use of antibiotic agent in treatment of shigllosis.
Keywords: Shigella species, Shigllosis, Antibiotic sensitivity.