In this article, the most striking differences between r1 and b1 paramutation are described and potential mechanisms are discussed relative to our current understanding of the role of RNA interference (RNAi) in mediating transcriptional silencing. The frequent association between paramutation and genes involved in pigmentation is likely to reflect ascertainment bias, because of the ease of scoring visible pigment phenotypes and the dispensable nature of anthocyanin for plant development.\n Second, at r1, the silencing might be stabilized through the more extensive DNA methylation that occurs.
Copyright Ó 2008 by the Genetics Society of America Perspectives Anecdotal, Historical and Critical Commentaries on Genetics Edited by James F. Crow and William F. Dove Paramutation: Epigenetic Instructions Passed Across Generations
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