An Asymmetric Model of Heterozygote Advantage at Major Histocompatibility Complex Genes: Degenerate Pathogen Recognition and Intersection Advantage by ProQuest

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									Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.107.082131



                 An Asymmetric Model of Heterozygote Advantage at Major
                 Histocompatibility Complex Genes: Degenerate Pathogen
                         Recognition and Intersection Advantage

                                         Rick J. Stoffels*,†,1 and Hamish G. Spencer*
*Allan Wilson Centre for Molecular Ecology and Evolution, Department of Zoology, University of Otago, Dunedin 9054, New Zealand and
            †
             The Murray-Darling Freshwater Research Centre, CSIRO Land and Water, Wodonga, Victoria 3689, Australia
                                                   Manuscript received September 19, 2007
                                                 Accepted for publication November 29, 2007


                                                              ABSTRACT
                We characterize the function of MHC molecules by the sets of pathogens that they recognize, which we
             call their ‘‘recognition sets.’’ Two features of the MHC–pathogen interaction may be important to the
             theory of polymorphism construction at MHC loci: Fi
								
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