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Application of Immunohistochemistry to Gynecologic Pathology by ProQuest

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CONTEXT: A large variety of tumors and lesions arise in the female genital tract. Although the majority of these can be correctly recognized on routine hematoxylin-eosin-stained slides, occasional cases present a diagnostic challenge. Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access. OBJECTIVE: To present our current knowledge of immunohistochemistry of the lesions of the female genital tract in a readily accessible form. DATA SOURCES: The review is based on previously published articles on this topic. CONCLUSIONS: Immunohistochemical stains help in reaching a conclusive diagnosis in a variety of problematic lesions seen in gynecologic pathology. As in any other system, immunohistochemical findings need to be interpreted in light of the clinical history and morphologic findings.

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									                    Application of Immunohistochemistry to
                             Gynecologic Pathology
                                Khush Mittal, MD; Robert Soslow, MD; W. G. McCluggage, FRCPath

● Context.—A large variety of tumors and lesions arise in              munohistochemistry of the lesions of the female genital
the female genital tract. Although the majority of these can           tract in a readily accessible form.
be correctly recognized on routine hematoxylin-eosin–                     Data Sources.—The review is based on previously pub-
stained slides, occasional cases present a diagnostic chal-            lished articles on this topic.
lenge. Immunohistochemical stains are extremely useful in                 Conclusions.—Immunohistochemical stains help in
resolving many of these problematic cases. As the knowl-               reaching a conclusive diagnosis in a variety of problematic
edge in this area is constantly expanding, it is useful to             lesions seen in gynecologic pathology. As in any other sys-
have this updated information in a review form for easy                tem, immunohistochemical findings need to be interpreted
access.                                                                in light of the clinical history and morphologic findings.
   Objective.—To present our current knowledge of im-                     (Arch Pathol Lab Med. 2008;132:402–423)


I  mmunohistochemical findings play a crucial role in the
    differential diagnosis of gynecologic lesions.1–3 Because
of the limitations of space, this article is almost exclusiv
								
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