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2nd SGI INTERNATIONAL SUMMIT

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					     “Science in the Service of Women’s Health”




2nd SGI INTERNATIONAL SUMMIT
                 Reproductive Medicine
                           November 8-10, 2007
                               Valencia, Spain
                          Welcome Reception
                            November 7, 2007
                                                                              2nd International SGI Summit




                           “Science in the Service of Women’s Health”




Dear Colleagues:

I am pleased to welcome you to Valencia for the 2nd SGI International Summit on
“Reproductive Medicine”. Following the spirit of fostering scientific international participation,
the SGI continues with biannual Summits, with the goal of holding these topic-focussed
meetings primarily outside of North America.

We are pleased to host the second Summit in Valencia, a modern city with a history, which
dates back more than two thousand years. The city is easily accessible by road, rail, sea and
air. Valencia is world famous for its typical dish “la paella” and its fiesta “las fallas”. Its culture
and academic tradition along with its location on the Mediterranean shoreline and its pleasant
climate make the city the ideal setting for this meeting. The University of Valencia and Cátedra
Santiago Grisolía, Fundación Ciudad de las Artes y las Ciencias will offer its hospitality to this
SGI Summit, to be held in La Ciudad de las Artes y las Ciencias a complex for culture and
entertainment promoted by the Generalitat Valenciana Regional Authority and in its majority
designed by the Valencian architect Santiago Calatrava.

The topic of the second SGI Summit is in the field of Reproductive Medicine and is entitled
“From Embryo and Endometrium to Implantation: The Translational Research”. This is a
very important area of clinical and basic research with relevant translational impact. Twenty-
three plenary lectures will be presented along with ample time for poster presentations and
discussion. A conference report including summaries of plenary lectures and contributed
papers will be published.

I look forward to seeing you to Valencia in November 2007.


Professor Carlos Simón
Summit Chairman




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                                                                                      2nd International SGI Summit


SOCIETY FOR GYNECOLOGIC INVESTIGATION
EXECUTIVE COUNCIL 2006-2007
President                               President Elect                 Secretary –Treasurer
Linda C. Giudice, M.D., Ph.D.           Charles J. Lockwood, M.D.        David M. Olson, Ph.D.
San Francisco, CA USA                   New Haven, CT USA                Edmonton, AB Canada

Immediate Past President                President Nominee
Gerson Weiss, M.D.                      Felice Petraglia, M.D.
Newark, NJ USA                          Siena, Italy

COUNCIL MEMBERS

Ronald R. Magness, Ph.D. (2007)                       Joan S. Hunt, Ph.D. (2008)
Madison, WI USA                                       Kansas City, KS USA
M.Yusoff Dawood, M.D. (2007)                          Carole Mendelson, Ph.D. (2009)
Atlanta, GA USA                                       Dallas, TX USA
Patrick M. Catalano, M.D. (2008)                      Murray Mitchell, Dphil, S.Sc. (2009)
Cleveland, OH USA                                     Auckland, New Zealand


SCIENTIFIC COMMITTEE OF THE SUMMIT

Carlos Simón, M.D., Ph.D.                             Linda C. Giudice, M.D., Ph.D.
Valencia, Spain                                       San Francisco, CA USA
Antonio Pellicer,M.D., Ph.D.                          Charles J. Lockwood, M.D.
Valencia, Spain                                       New Haven, CT USA
Hilary O.D. Critchley, M.D.                           Asgerally T. Fazleabas, Ph.D.
Edinburgh, UK                                         Chicago, IL USA
                                                      Stephen Lye, PhD
                                                      Toronto, Canada

SECRETARIAT
Society for Gynecologic Investigation
409 12 th Street, SW
Washington DC 20024, USA
sgiava@aol.com
lgilders@acog.org
Tel: 1-202-863-2544
Fax: 1-202-863-0739

ORGANIZING SECRETARIAT
Cátedra Santiago Grisolía
Fundación Ciudad de las Artes y las Ciencias
Avda. Prolongación Paseo de la Alameda 42-B 1º 1ª
46023 Valencia (Spain)
catedrasg@cac.es
Tel: +34 96 197 46 70
Fax: +34 96 197 45 98

ACKNOWLEDGEMENTS
The SGI gratefully acknowledges Ferring Pharmaceuticals A/S (Denmark), Organon España, S.A. and Serono
España, S.A. for generous educational grants in support of the 2nd International SGI Summit.


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                                                                                    2nd International SGI Summit

Meeting at a Glance
  Wednesday                 Thursday                             Friday                         Saturday
 November 7th              November 8th                       November 9th                    November 10th

Welcome Reception            Morning                              Morning                         Morning
                             Session I                           Session III                     Session VI
   20:00 – 21:00     “The Preimplantation Embryo”              “Endometriosis”             “Translational Research”
                                Chair:                             Chair:                            Chair:
                    Andre C. Van Steirteghem, M.D.       Antonio Pellicer, M.D., Ph.D.    Hilary O.D. Critchley, M.D.

                            08:15 – 13:00                       08:20 – 11:00                    09:00 – 12:40



                       Afternoon Session                        Late Morning
                           Session II                            Session IV
                         “The Endometrium”                “Embryonic Implantation”
                                                                    Chair:
                      “Endometrial Regulation”            Carlos Simón, M.D., Ph.D.
                               Chair:
                     Charles J. Lockwood, M.D.                   11:20 – 13:20

                           14:30 – 16:30                         Afternoon
                                                                 Session V
                     “Endometrial Remodelling”
                                                             Meet the Presenters
                               Chair:
                    Linda C. Giudice, M.D., Ph.D.              Poster Session
                                                               15:00 – 16:00
                           16:50 – 18:50
                                                                Oral Session
                                                                16:00 – 17:00




                    2nd SGI INTERNATIONAL SUMMIT
                         Reproductive Medicine
                          November 8-10, 2007
                               Valencia, Spain




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                                                                     2nd International SGI Summit


Wednesday, November 7, 2007
           20:00 – 21:00 Welcome Reception

Thursday, November 8, 2007
                      Session I – The Preimplantation Embryo
          Morning
          08:15 – 08:30 Introduction
          Chair: Andre C. Van Steirteghem, M.D. (Belgium)
          08:30 Assessment of Human Embryo Viability
                  David K. Gardner, Ph.D. (USA)
          09:10 The Human Embryo Genome
                   Dagan Wells, Ph.D. (USA)
          09:50 The Human Embryo Proteome
                  Francisco Domínguez (Spain)
          10:30 Coffee Break
          11:00 Epigenetic Alterations: Implications for ART
                  Lorraine E. Young, Ph.D. (UK)
          11:40 Single Embryo Transfer: An Evidence Based Approach
                  Siladitya Bhattacharya, M.D., MRCOG (UK)
          12:20 Round Table: Can We Select The Embryo?
          13:00 Working Lunch

                           Session II – The Endometrium
          Afternoon
          Endometrial Regulation
          Chair: Charles J. Lockwood, M.D. (USA)
          14:30 Hormone Receptor Dynamics in the Receptive Endometrium
                  Hilary O.D. Critchley, M.D. (UK)
          15:10 Genomics of Human Endometrial Receptivity
                  Linda C. Giudice, M.D., Ph.D. (USA)
          15:50 Are UNK Cells Pivotal in Decision Bleed or Decidualise?
                  Ashley Moffet, M.D. (UK)
          16:30 Coffee break

          Endometrial Remodelling
          Chair: Linda C. Giudice, M.D., Ph.D. (USA)
          16:50 Endometrial Angiogenesis
                  Peter A.W. Rogers, Ph.D. (AUS)
          17:30 Hemostatic Mechanisms on the Endometrium
                  Charles J. Lockwood, M.D. (USA)
          18:10 Adult Progenitor Stem Cell Population in the Human and Mice
                  Endometrium
                  Carlos Simón, M.D., Ph.D. (Spain)
          18:50 Conclusions

                  Evening on your own




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                                                                          2nd International SGI Summit




Friday, November 9, 2007
                             Session III - Endometriosis
          Morning
          Chair: Antonio Pellicer, M.D., Ph.D. (Spain)
          08:20 Advances in Human Endometriosis
                 Aydin Arici, M.D. (USA)
          09:00 Aberrant Gene Expression in Endometriosis
                 Hugh S. Taylor, M.D., Ph.D. (USA)
          09:40 Implications of Angiogenesis in Endometriosis
                 Robert N. Taylor, M.D., Ph.D. (USA)
          10:20 Insights into the Pathophysiology of Endometriosis: Lessons
                 from a Baboon Model
                 Asgerally T. Fazleabas, Ph.D. (USA)
          11:00 Coffee break

                       Session IV – Embryonic Implantation
          Late-Morning
          Chair: Carlos Simón, M.D., Ph.D. (Spain)
          11:20 Endocannabinoid Signalling is Critical to Periimplantation Events
                 Sudhansu K. Dey, Ph.D. (USA)
          12:00 The Adhesion Phase: The Role of L-Selectin and its Ligands
                 Olga Genbacev-Krtolica, Ph.D. (USA)
          12:40 The Invasion Phase
                  Paul Bischof, Ph.D. (Switzerland)
          13:20 Working Lunch

                         Session V – Poster & Oral Sessions
          15:00–16:30 Poster Session
          16:30-17:00 Oral Session

          20:00        Attendee Dinner:
                       A Spanish Evening at Devesa Gardens with Entertainment
                      (This is a ticketed event. See registration form)




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Saturday, November 10, 2007
                               Session VI – Translational Research
                Morning
                Chair: Hilary O.D. Critchley, M.D. (UK)
                09:00 Early Pregnancy Loss: Embryo or Endometrial Failure?
                        Lesley Regan, M.D., FRCOG (UK)
                09:40 Trophoblast Function in Preeclampsia and Preterm Delivery
                        Susan J. Fisher, Ph.D. (USA)
                10:20 The Endometrium as a Contraceptive Target
                         Kristina Gemzell-Danielson, M.D., Ph.D. (Sweden)
                11:00 Coffee break
                11:20 The Nude Mice Model for Translational Research on Endometriosis
                        Antonio Pellicer, M.D., Ph.D. (Spain)
                12:00 The Primate Model for Translational Research in Endometriosis
                         Thomas D’Hooghe, M.D., Ph.D. (Belgium)
                12:40    Conclusions



ABSTRACT SUBMISSION

Abstract submission for oral presentations and poster session deadline is August 1st, 2007. The instructions for
completing the Abstract Form can be found on the SGI Web Site http://www.sgionline.org.

Instructions for Completing the Abstract Form

This form is for online submission of your completed abstract. Unlike the online submissions program for the SGI
annual meeting, this form cannot be edited or retracted. Once you have entered information into this form, you
must submit the form. Please be sure that the information that you type into this form is in its final version before
submitting it.

1. Your abstract should contain (a) a sentence stating the study’s specific objectives, unless this is given by the
title, (b) a brief statement of the methods, if pertinent, (c) a summary of the results (d) a statement of the
conclusions.

2. Add codes for any special formatting. Verify that your abstract is correct.

3. Submit abstract, but only when you are sure that your abstract is complete and in final form. Please verify that
your abstract is correct before submitting.

4. The abstract must not exceed one A-4 page in length including title, author and coauthors, address and text.

5. You will receive a confirmation number via e-mail indicating that your abstract was received. Reference this
number in any written correspondence or telephone conversations regarding your abstract submission.

SGI 2nd International Summit Abstracts c/o
Cátedra Santiago Grisolía
Fundación Ciudad de las Artes y las Ciencias
Prolongación Pº de la Alameda 42-B, 1º-1ª
46023 Valencia
Spain
                                                                                         2nd International SGI Summit

Phone: +34 96 197 46 70
Fax: +34 96 197 45 98
E-mail: catedrasg@cac.es

Deadline: All abstracts must be submitted before August 1st, 2007, 14:00 PM, Eastern Standard Time.

If not submitted by this date and time, your abstract will not be accepted.




GENERAL INFORMATION
Symposium Venue
Auditorio Santiago Grisolía
Museo de las Ciencias Príncipe Felipe
Avda. Autovía del Saler, nº 7
46013 Valencia (Spain)
The Museo de las Ciencias Principe Felipe is in the dry bed river Turia. From the centre of the city it can be easily
reached by taxi in 10 minutes. Buses number 19 and 35 from the City Hall square takes about 15 minutes.
Registration/Hospitality/Information Desk
These services will be provided at the symposium venue as follows:
   - Wednesday, November 7th, from 18:00 p.m. – 21:00 p.m.
   - Thursday, November 8th, from 7:30 a.m. – 19:00 p.m.
   - Friday, November 9th, from 7:30 a.m. – 17:30 p.m.
   - Saturday, November 10th, from 8:30 a.m. – 12:30 p.m.
Each registrant will receive a bag containing a program, abstract book, name badge and other symposium
material.
SGI will award six €500 (Euro) travel grants for the six outstanding abstracts submitted.
Language
The official language of the meeting will be English
Exhibition
The exhibition will be situated in the hall of the auditorium. Exhibits will be opened throughout the meeting.
Poster
Posters of 70 cm/ 27" width and 100 cm / 39" height should be prepared in advance and should be brought in
person by the participant. Do not mail your poster. Ideally a poster should be self-explanatory, clear and specific,
and should present the material logically and legibly.
VISA
Spain is part of the European Union. Citizens of member states of the European Union only need an ID or
passport and do not need visas. Congress delegates who require a visa can obtain one from the Spanish
Embassy in their home country. An official letter of invitation to attend the congress can be forwarded to any
participant upon request for obtaining a visa. However, this invitation implies no obligation, financially or
otherwise.
Currency, Bank, and Post Office
The official currency is Euro. Banks are generally open from 9:00 a.m. to 2:30 p.m. Monday to Friday. Post
Offices are open from 9:00 a.m. to 7:00 p.m. Most hotels and shops accept major credit cards.
Internet Room
An Internet point will be located in a room next to the Auditorium. It will be operational from Thursday November
8th to Friday November 9th from 9:00 a.m. – 5:00 p.m. on Saturday November 10th from
9:00 a.m. – 12:00 p.m. E-mail service will be available in the Internet room.

Attendance Certificates
A certificate of attendance will be given to all registered participants.
Smoking Policy
Participants will be kindly requested to refrain from smoking inside of the Science Museum and in the lecture hall.



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                                                                                           2nd International SGI Summit


Weather
Valencia enjoys a mild temperate Mediterranean climate. The average annual temperature is 17ºC (62.6ºF) with
warm summers and very mild winters, rarely below 10ºC (50ºF) . There is only light rainfall mainly in autumn and
the beginning of spring.
Transportation
A city bus service from the symposium site to the centre of Valencia is available at:
http://www.emtvalencia.es/b1024.htm.

Buses number 19, 35 and 40 from the City Hall square takes about 15 minutes. Bus number 95 goes along the
dry bed river. The ticket bus costs 1,10€..
Registration & Session Fees
Member & Non-Member: €280 (Euro)
In-Training: €130 (Euro)
Friday Night Attendee Dinner: €30 (Euro)
*The In-Training category is for: Residents and Ph.D. Students. If you register as In-Training, you must send a
sponsor letter from your University with your registration form and payment.
The registration packet includes: Badge, Bag, Abstract Book, Coffee Breaks, Welcome Reception and Lunches.
Travel Agency Information
The travel agency Viajes Iberia has booked rooms in several hotels within walking distance of the venue.
Information can be obtained from:
Ms. Matilde García-Conde
Tel: +34 96 353 61 65
Fax: +34 96 394 06 06
E-mail: valencia.hernancortes23@viajesberia.com
How to Reach Valencia
By Air
Manises Airport is situated eight km. west of the city. There is a frequent bus-service from the terminal to the city
centre and taxi-service. Information: +34 961 59 85 00.

Aero-Bus: Direct bus service Airport/Valencia/Airport. Everyday, from 6:00 a.m. to 22:00 p.m. (every 20
minutes). Approximate price: 2,50 €. Stops: Airport (Departures Terminal) - Av. del Cid with Burgos Street (Local
Police Headquarters) - Bailén (G.V.Ramón y Cajal tunnel) - Ángel Guimerá with Juan Llorens Street - Av. del Cid
(in front of Local Police Headquarters) - Airport. http://www.aena.es

By Train
Valencia North Station is situated in the city centre. Trains arrive and depart for all national and international
destinations. It also caters for local destinations within the Valencian Province. http://www.renfe.es
By Sea
Although Valencia is principally an industrial port it also operates a frequent ferry service to the Balearic Islands
and is the starting point for many Mediterranean Cruises. It is well connected to the city centre by a number of
frequent bus routes: http://www.emtvalencia.es/b1024.htm.
By Road
The AP-7 Motorway runs down the East Coast of Spain connecting Valencia to the main European Motorway
network and to A-23 Sagunto-Somport and the A-3 Madrid-Valencia dual Carriageway. Most coach services
arrive and depart from Valencia Central Bus Station: Tel: +34 963 466 266




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