1 Which of the following is NOT an important characteristic of either Neisseria gonorrhoeae or Neisseria meningitidis? A Polysaccharide capsule B IgA protease C M protein D Pili 2 Several pathogens are transmitted either during gestation or birth. Which one of the following is LEAST likely to be transmitted at these times?
A Haemophilus influenzae B Treponema pallidum C Neisseria gonorrhoeae D Chlamydia trachomatis 3 Each of the following statements concerning gonorrhoea is correct EXCEPT A infection in men is more frequently symptomatic than in women B A presumptive diagnosis can be made by finding gram negative kidney –bean shaped
Diplococci within neutrophils in a urethral discharge C the definitive diagnosis can be made by detecting atleast a 4 fold rise in antibody titre to N gonorrhoeae. D gonococcal conjunctivitis of the new born rarely occurs in the United States because silver nitrate or erythromycin is commonly used as prophylaxis
4 Each of the following statements concerning neisseriae is correct EXCEPT A they are gram negative diplococci B they produce IgA protease as a virulence factor C they are oxidase positive D they grow best under anaerobic conditions
A 24 Yr old man reports a painful urethral discharge. Direct gram stain reveals the presence of intracellular gram negative diplococci . He tells his physician that he has had gonorrhoea 3 times. What is the most likely explanation for his lack of protective immunity from these previous infections? A Antigenic and phase variation have altered surface proteins
B pilin and opa proteins are poor immunogens C the patient has an immunodeficiency disorder D protective immunity is best achived through vaccination. Further tets indicated that this patient was also infected with chlamydia. The treatment strategy would most likely include A Penicillin alone B A third generation cephalosporine such as
C A fluoroquinolone such as Ciprofloxacin alone D A combination of a third generation cephalosporin with doxycycline Regarding Gonorrhea which is incorrect? A caused by a bacterium B can be treated only with Penicillin C if untreated, can occassionally lead to infertility D is frequently asymptomatic in women
• N gonorrhoeae is a fastidious pathogen and found in sites often contaminated with normal flora. Which of the following is the best medium for isolation? • A Sheep blood agar • B Loeffler’s serum slope • C Thayer Martin medium • D TCBS Medium • E Lowenstein jensen medium