China Liver Transplant Registry Living Donor Liver Transplantation by rub18840

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									China Liver Transplant Registry
 Living Donor Liver Transplantation
              4 Nov 2007
Number of liver transplantation from 1993–2007
3000                                                                                     2778
                 Total: 10729
2500                                                                                            2379

                                                                                  2009
2000


1500
                                                                           1039
1000                                                                                                   839
                                                                    563
500                                                          271
          3      1      3      5      2   15 70 154
   0
     93

            94

                   95

                          96

                                 97

                                        98

                                               99

                                                      00

                                                             01

                                                                    02

                                                                           03

                                                                                  04

                                                                                         05

                                                                                              Ju 06

                                                                                                      07
   19

          19

                 19

                        19

                               19

                                      19

                                             19

                                                    20

                                                           20

                                                                  20

                                                                         20

                                                                                20

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                                                                                                   20

                                                                                                   20
                                                                                                ly
             Number of LDLT
              Jan – Nov 2007
Total: 391
                            Number of LDLT
                             1995 – Nov 2007                           238
250
             Total: 391

200



150



100
                                                                74


50                                                       31
                             19     16     11
       1       1      2                            3
 0
      1995    1997   2000    2001   2002   2003   2004   2005   2006   2007
  Age of LDLT Recipients

Recipients
– Range: 3 months to 74.7 years
– Average: 36.5 years
Donors
– 19 to 65 years
– Average: 35.9 years
Distribution of age for LDLT recipients

              Frequency           %
 <18              92              23.5
18-34             60              15.3
35-49            145              37.1
50-64             90              23.0
 65 +             4               1.0
Total            391              100
       Distribution of age among LDLT
               2001 – Nov 2007
         <18   18-34     35-49   50-64    >65
100%
 90%
 80%
 70%
 60%
 50%
 40%
 30%
 20%
 10%
  0%
        2001 2002 2003   2004 2005 2006   Nov
                                          2007
 Distribution of LDLT donor age

           Frequency         %
<18            0             0
18-34         154           45.6
35-49         150           44.4
50-64          33           9.8
65 +           1            0.3
Total         338           100
              Donor BMI

               Frequency   %
Underweight       14       5.2
  Normal          199      74.3
Overweight        50       18.7
  Obese            5       1.9
   Total          268      100
              Body weight comparison
                Donor vs. Recipient

                     Frequency         %


Donor < Recipient       101            36.6


Donor = Recipient        9             3.3


Donor > Recipient       166            60.1


      Total             276            100
                        LDLT graft

                                          Frequency    %
Right lobe (without MHV)                    102       57.3
Right lobe (with MHV)                        47       26.4
Left lobe (without MHV)                      16       9.0
Left lobe (with MHV)                         9        5.1
Left lateral segment                         2        1.1
Extended left lateral segment                1        0.6
Left lobe (with MHV) + caudate lobe          1        0.6
                                  Total     178       100
             GRBW

             Frequency   %


 < 0.8 %        36       18.1


0.8 % - 1%      75       37.7


  >1%           88       44.2


  Total         199      100
              Diagnosis

 Primary diagnosis of pediatric LDLT
 recipients (23.5%):
1. Wilson’s disease 37%
2. Biliary atresia 12.0 %
 Primary diagnosis of adult LDLT recipients
 (76.5%):
1. Malignant disease 40.1%
2. Acute hepatic necrosis 13.6 %
                    Overall cumulative survival rates of LDLT recipients
                                     1995 – Nov 2007
                           88.9 %
Cumulative survival (%)



                                    74.5 %
                                              72.2 %
                                                             65.0 %




                             Median follow-up:2.5 months




                                             Time (months)
          Hospital mortality of LDLT

                   Frequency           %


Discharged            263              90.5


Deceased              25               9.5


  Total               288              100
  Recipient Complications

                             LDLT

 Bile duct complications     6.8 %

Blood vessel complications   9.5 %
        Donor outcome

Donor Mortality ?
Donor complications ?
              Center   Frequency   %
                1         114      29.2
                2         61       15.6
                3         47       12.0
                4         36       9.2
                5         31       7.9
                6         22       5.6
                7         20       5.1
                8          9       2.3
                9          8       2.0
LDLT number
  by center     10         7       1.8
                11         6       1.5
                12         6       1.5
                13         4       1.0
                14         4       1.0
                15         3       0.8
                16         2       0.5
                17         2       0.5
                18         1       0.3
                19         1       0.3
              Total       391      100
Thank You
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