How is eukaryotic gene expression different from prokaryotic gene expression?
Only _______% of eukaryotic DNA is translated, compared to ________% of prokaryotic DNA.
Controlling Eukaryotic Gene Expression
Transcription will not take place…
Once the transcription factors have assembled around the promoter,
Areas that regulate eukaryotic transcription:
a) The Enhancer Region: causes the chromosome to loop
Activator proteins bind to the enhancer regions and then to the
When the activator proteins bind to the transcription complex,
b) The Silencer Region:
Proteins that bind to the silencer sites prevent…
What is cancer?
What causes cancer?
The three deadliest human cancers:
Genes that cause cancer are called oncogenes.
The normal versions of these genes are called proto-oncogenes and they code for
How do proto-oncogenes become oncogenes?
c) Point mutations
Two genes that are significant: ras gene and the p53 gene.
The ras gene creates
The mutated ras protein is
The p53 gene becomes active when
Mutating the p53 gene can lead to
15% of the cancers worldwide are associated with
Certain viruses can insert ____________________ others may insert ____________ into proto-
oncogenes, turning them into ____________________.
1. Are Eukaryotic genomes under negative or positive control?
2. Since Eukaryotic genomes do not have operons what methods do they use to regulate gene
expression? Include a labeled diagram.
3. What is cancer? What causes it?
4. Explain the difference between oncogenes and proto-oncogenes. How are they significant to
5. What are the roles of the ras gene and the p53 gene in relation to cancer?