CARBONYL CONDENSATIONREACTIONSCARBONYL CONDENSATION REACTIONS•Aldol Reaction•Dehydrationof Aldol Products•Intramolecular Aldol Reaction•Claisen Condensation Reaction•Intramolecular Claisen Condensation•Michael Reaction•Stork Enamine Reaction•Robinson Annulation ReactionGeneral Mechanism of Carbonyl CondensationOne carbonyl partner with an alpha hydrogen atom is converted by base into its enolate ion.OCRCHOHCOCCOR:....RCOCOH2CO:::ElectrophilicAcceptorNucleophilicDonorThis enolate ion acts as a nucleophilic donor and adds to the electrophilic carbonyl group of the acceptor partnerProtonation of the tetrahedral alkoxide ion intermediate gives the neutral condensation product.OH2RCCCOH-OHO+New C-C BondALDOL REACTION•occurs between two aldehyde or ketone molecules with a catalytic base•reaction can occur between two components that have alpha hydrogens•reversible condensation reaction•two highlights: enolate formation and nucleophilic attack at a carbonyl carbon•Aldol products are: alpha-ß-unsaturated aldehydes/ketones and ß-hydroxy aldehydes/ketonesMechanism of the Aldol ReactionHO:HCHHCOHBase removes anacidic alpha hydrogenfrom one aldehydemolecule, yieldinga resonance-stabilized eno-late ion.COCH3H::OH+2CHHCHO..CH3CHOCHHHOCH::-..The enolate ion attacks a second aldehydemolecule in a nucleophilic addition reaction to give a tetrahedral alkoxide ion intermediate.HO2COCHCCHHHHOHHO3+-:Protonation of the alkoxide ion intermediate yields neutral aldol product and regenerates the base catalyst.Dehydration of Aldol Products: Synthesis of Enones•ß-hydroxy aldehydes and ß-hydroxy ketones formed in aldol reactions can be easily dehydrated to yield conjugated enones•Dehydration is catalyzed by both acid and base•Reaction conditions for dehydration are only slightly more severe than for condensation•Conjugated enones are more stable than nonconjugated enonesCOCHCOHOHBase-catalyzedCOCCOH::-..Enolate ionCOCCOH-+Dehydration of Aldol ProductsCCCOOHHH+Acid-catalyzedCCCOHOH2+EnolCOCCHO+3+Mixed Aldol Reaction•If two similar aldehydes/ketones react under aldol conditions, 4 products may be formed•A single product can be formed from two different components :If one carbonyl component has no alpha-hydrogens or if one carbonyl compound is much more acidic than the other.Intramolecular Aldol Reaction:•Treatment of certain dicarbonyl compounds with base can lead to cyclic products•A mixture of cyclic products may result , but the more strain-free ring is usually formedIntramolecular Aldol Reaction of 2, 5-hexanedione yields 3-methyl-2-cyclopentenoneaCHHHHCOHHOCCCC332,5-HexanedionebCHHHCOHHCCCCHHO 3--OHPath ACHHHCOHHCCCCHHOH3CCCCCCHHHHHHOHHO HO3-:....CHOHO32+3-Methyl-2-cyclopentenoneNaOH, H2OPath bNaOH, H2OCHHHHCOHHOCCCC33HO-CHHHCOHCCCCHHOH3-CHHHCOHCCCCHHHO3-OHH....CHHCHOHH OO33-:....(2-Methylcyclopropenyl)ethanone(NOT formed)CHOCHHO33+2Claisen Condensation Reaction• Carbonyl condesation that occurs between two ester components and gives a ß-keto ester product• Reaction is reversible and has a mechanism similar to aldol reaction• Major difference from aldol condensation is the expulsion of an alkoxide ion from the tetrahedral intermediate of the initial Claisen adduct• 1 equivalent of base is neededto drive the reaction to completion because the product is often acidicMechanism of Claisen Condensation:• involves nucleophilic acyl substitution of an ester enolate ion on the carbonyl group of a second ester molecule• tetrahedral intermediate expels an alkoxide leaving group to yield an acyl substitution productMechanism of the Claisen Condensation ReactionCH3COEtO-OEtEthoxide base abstracts an acidic alpha hydrogen atom from an ester molecule, yielding an ester enolate ion:CH2COEtOEtOHCH3C:O:OEt+Nucleophilic donorElectrophilic acceptorIn a nucleophilic addition,this ion adds to a secondester molecule, giving a tetrahedral intermediate.CH3C:O: -OEtCH2COEtO..The tetrahedral intermediateis not stable. It expels ethoxideion to yield the new carbonyl compound, ethyl acetoacetate.But ethoxide ion is basic enoughto convert the beta-keto esterproduct into its enolate, thus shifitng the equilibrium and drivingthe reaction to completion.CH3COCH2COEtOEtO-+CH3COCHCOEtO_..EtOH+CH3COCH2COEtOOH2+Protonation by addition of acidin a separate step yields the finalproduct.H3O+Mixed Claisen Condesation•occurs only when one of the two ester components has no alpha-hydrogens, and thus can’t form enolate ion•can also be carried out between esters and ketones resulting a synthesis of ß-diketonesExample of Mixed Claisen Condensation1. NaH/THF+2. H30COCHOCH2OEtEtOEthyl benzoylacetateCOOEtEthyl Benzoate(Acceptor)+CHOCOEt3Ethyl Acetate(Donor)Intramolecular Claisen Condensation: Dieckmann Cyclization• can be carried out with diesters• works best on 1, 6-diesters and 1,7-diesters• 5-membered cyclic ß-ketoesters result from Dieckmann cyclization of 1,6-diesters• 6-membered cyclic ß-keto esters result from cyclization of 1,7-diestersExamples of Intramolecular Claisen CondensationOOOCOHOEtOEtDiethyl hexanedioate (a 1,6 -Diester)1. Na+ -OEt, ethanol2. H3O+OEtEtOEthyl 2-oxocyclopentanecarboxylate (82%)OOOCOOEtOEtDiethyl heptanediote (a 1,7-Diester)1. Na+ -OEt, ethanol2. H3O+OEt+Ethyl-2-oxocyclohexane carboxylateIntramolecular Claisen Condensation MechanismHOHOEtCOOEt+OEtNa-Base abstracts an acidic alpha-proton from the carbon atom next to one of the ester groups, yielding an enolote ion.Intramolecular nucleophilic addition of the ester enolate ion to the carbonyl group of the second ester group at the other end of the chain then gives a cyclic tetrahedral intermediate.OHHtEOCOOEt+EtO:..-HOCOOEttEO::..-Loss of alkoxide ion from the tetrahedral intermediate forms a cyclic beta-keto ester.OHO.HCOOEt+tEO:....-COOEt-EtO+Deprotonation of the acidic beta-keto ester gives an enolate ion…OHHO+H3OCOOEt+2…which is protonated by addition of aqueous acid at the endoth the reaction to generate the neutral beta-keto ester product.Michael Reaction•Conjugate addition of a carbon nucleophile to an alpha, ß-unsaturated acceptorBest Michael Reactions:• Between unusually acidic donors (ß-ketoesters or ß-diketones)• Unhindered alpha,ß-unsaturated acceptors• Stable enolates are Michael donors, and alpha,ß-unsaturated compounds are Michael acceptorsThe Michael ReactionEtOOCCCOCH3HHNa+-OEtThe base catalyst removes an acidic alpha proton from the startingbeta-keto ester to generate a stabilized enolate ion nucleophile.The nucleophile adds to thealpha,beta-keto unsaturated ketone electrophile in a Michael reaction to generate a new enolate as product.EtOCOCCOCH3H-EtOHCHCCH3CHOCH3CCCHHCHHCO2EtCCH3OO..+..OEtOHH3CCCCHHCCOCH3HHCO2EtHEtO-+The enolate product abstracts an acidic proton, either from solvent or from starting keto ester, to yield the final addition product.Some Michael Acceptors and Michael DonorsH2CCHCHOH2CCHCO2EtH2CCHCNH2CCHCOCH3H2CCHNO2H2CCHCONH2PropenolEthyl PropanoatePropenenitrile3-Buten-2-oneNitroethylenePropenamideRCOCH2COR'RCOCH2CO2EtEtO2CCH2CO2EtRCOCH2CNRCH2NO2Beta-DiketoneBeta-Keto EsterMalonic EsterBeta-Keto nitrileNitro compoundMichaelAcceptorsMichael DonorsStork Enamine Reaction• enamine adds to an alpha,ß-unsaturated carbonyl acceptor in a Michael-type process• Overall reaction is a three-step sequence:Step 1: Enamine formation from a ketoneStep 2: Michael-type addition to an alpha, ß-unsaturated carbonyl compoundStep 3: Enamine Hydrolysis back to ketone• net effect of Stork Enamine reaction sequence is the Michael addition of a ketone to an alpha,ß-unsaturated carbonyl compoundExample of Stork Enamine ReactionONH-H2ONH2CCHCCH3O..CyclohexanoneAn enamineNCH2CHCCH3-..ONCH2CH2CCH3O+OH2OCH2CH2CCH3ONH+A 1,5-diketoneRobinson Annulation Reaction: Carbonyl Condensation Reaction in Synthesis• leads to the formation of substituted cyclohexenones• 2 step process:Michael reactionIntramolecular Aldol reaction• Treatment of a ß-diketone or ß-keto ester with an alpha, ß-unsaturated ketone leads first to a Michael addition, which is followed by intramolecular aldol cyclization