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					Iowa Drug Information Service (IDIS)
Iowa Drug Information Service (IDIS)

  Publisher
    University of Iowa College of Pharmacy
     Division of Drug Information
  Years Covered
    1966 to Present

  Scope
    Only includes articles about drugs in human
Iowa Drug Information Service (IDIS)
  Immediate access* to full-text articles from
   200+ English-language biomedical journals
   (includes several international journals)
    * = from 1988 to Present available as PDF
     Prior to 1988, full-text articles are on microfiche
Search Screen
Results Screen (with Details Hidden)
Results Screen (with Details Shown)
Controlled Vocabulary

  Similar to MeSH terms and Limits
    Drug

    Disease

    Descriptor
  Valid drug name is the United States Adopted Name

  Valid drug number is a 7- or 8-digit modified American
   Hospital Formulary Service (AHFS) number.
  Therapeutic categories are arranged in hierarchal order.

  Examples:
       24000000- Cardiovascular agents
       24040000 – Cardiac agents
       24040100 – Cardiac glycosides
       24040103 – Digitoxin
  Valid disease names and code numbers are from the International
    Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-
    CM) (a commonly used system of classifying diseases).

  Example:
     If you search for “varicose vein” in the Thesaurus, using the Look Up
      button next to the Disease field, or using the Disease Hierarchy, you will
      find several types of varicose veins and their associated codes:

          • VARICOSE VEIN NEC 456.
          • VARICOSE VEIN, SCROTAL 456.4
          • VARICOSE VEIN, VULVAL 456.6
        The periods in the codes subdivide the disease terms.
        The term NEC means “not elsewhere classified”
  There are more than 150 valid descriptor
   terms (with codes) which further limit
   information. Click the Look Up button next to
   the Descriptor field to see the entire list.
  Get to know the descriptors.
    Use the Descriptor Definitions link to search for
     the definition if you don’t understand what it
  Examples:
    Study Randomized Adult 135
    Side Ef Musculoskeletal 77
    Adm Parent Intraarticular 114
Descriptor Categories

  Article type (and population – adult, pediatric,
       Case report/series, reports, reviews, studies (case-
        controlled, cohort, randomized), government document,
        design/analysis (cross-over, meta-analysis, n-of-one
        trial, practice guideline, systematic review), and
        continuing education.

  Outcome
    Clinical results, economic outcomes, general outcomes,
     quality of life.
Descriptor Categories (continued)

  Pharmaceutic
    Drug analysis, drug manufacture, drug properties,
     pharmaceutic incompatibilities, pharmaceutics.

  Therapeutic
     Route of administration, clinical incompatibilities
      (contraindication, drug interaction, lab interaction,
      dietary interaction), clinical issues (dosage, mechanism
      of action, modification of effect, pharmacodynamics),
      drug use, side effects/adverse reactions, toxicology.
  Cross references all synonyms, trade names, or concepts
   to their valid drug/disease/descriptor terms/codes (valid
   terms appear in uppercase followed by their code

  Note that in the Thesaurus:
       (DR) = drug term
       (DI) = disease term
       (DE) = descriptor term

  Examples:
       thyroid dr – locates the word thyroid in the Drug field
       thyroid di – locates the word thyroid in the Disease field
       thyroid de – locates the word thyroid in the Descriptor field
Other Ways to Search
  Word(s) in the title and/or the abstract
  Author(s) (you can use the Look Up button next to
   this field)
       Example (enclose in quotation marks: last name,
        space, first initial, space, second initial):
         • “Smith J P” (you know the author’s last, first, and middle [if
           there is one] initials; IDIS even indexes the third initial if one is
           provided in the article)
         • “Smith J” (will give you all the Smiths whose first name begins
           with “J”)
         • “Smith” (will give you all the Smiths)
         • “Smith*” (will give you all the authors with Smith as the first 5
           letters of their last names – Smith, Smithard, Smithee,
           Smithells, etc.)
Other Ways to Search (continued)
  Journal (must use the correct IDIS journal
   abbreviation; use the Look Up button next to this
   field to locate the correct abbreviation)
  Volume, issue, starting page number (if known)

  Year
    Default is all years through current year.

    For 1 year, enter the same year into both the starting
     and ending year fields.
    For a range of years, enter the starting year and ending
Other Ways to Search (continued)
  Article number (if known)

  Sequence number (if known) – don’t worry about this too
   much. Each article is assigned 1 unique article number,
   but sometimes it will have 2 sequence numbers if all our
   indexing terms won’t fit in one record or if the article
   contains more than one primary concept.

  All fields – Caution: use of this field will result in MANY
   irrelevant citations (cross references of cross references of
   cross references, etc., in the Thesaurus are checked).
   This field is good to search for unique terms,
   abbreviations, or exact phrases that do not have a valid
   drug, disease, or descriptor term.

  Search for case reports in which
  rasburicase was used to treat acute
  lymphoblastic leukemia in children.
Example: Using the Lookup Buttons

  Drug
    Valid term/number: "RASBURICASE
  Disease
    Valid term/number: "LEUKEMIA, LYMPHOID,
     ACUTE 204.0"
  Descriptor
    Valid term/number: "CASE REPORT
Example: Using the Thesaurus
  rasburicase dr
      • Locates rasburicase in the Drug field (RASBURICASE
  acute lymphoblastic leukemia di
      • Locates acute lymphoblastic leukemia in the Disease field
  case report de
      • Locates case report in the Descriptor field – there are 3 types;
        select the one that applies to children (CASE REPORT
        PEDIATRIC 1)
      • In this example, you will have to use “common sense” or the
        thesaurus of a dictionary to determine that pediatric = children.
        Use the Descriptor Definitions link to find that a pediatric
        patient is a newborn to 12 years of age.
Example: Results
  This search yields 2 results (articles 559551 and 505702)

  To see all the terms that were used to index the article,
   change the “Output/Display Format” to Full Results and
   click Adjust. This is similar to looking at the full citation in
   PubMed to get an idea of other terms you might want to
   search for.
       Note about Full Results: You can work backwards if you find a
        relevant citation in another database; locate the article in IDIS
        using the other fields or general terms, look at the “Full Results” of
        what you get to see the valid terms, plug them in, and redo the
        search to locate more articles on the subject.

  Click on the article number to read the article.
IDIS Search Tips
General Search Tips

  The key to successful searching in the IDIS
   database is being able to use and apply the
   Drug, Disease, and Descriptor fields.
  Before executing the search, make sure
   your operators make sense. If not, correct
   them. There are different defaults (“and”
   vs. “or”) in different fields.
Truncating Words

  Use the asterisk (*) to truncate words. This
   will allow you to find the term if it isn’t
   indexed exactly the way you think it is. For
   example, “kidney ston*” would find kidney
   stone, kidney stones, kidney stonage,
   kidney stoning (all of these terms aren’t in
   IDIS or even real terms, but this is just to
   give you an example). Think about
   appropriate places to truncate terms.
Words/Terms Not in Controlled Vocabulary

  Not all words/terms will have an appropriate
   controlled vocabulary term. If you try your
   absolute best and cannot find an
   appropriate term, try searching for the word
   or term in the Title, Abstract, or All Fields
Sources of Help Within IDIS

  Help link
  Links on the left side of the screen
  Information button (i) next to each field

  The Thesaurus is the official “dictionary” of
   controlled vocabulary terms.
  Don’t forget to add DR, DI, or DE,
   depending on what you are looking for so
   that you won’t have to scroll through
   irrelevant terms.
Exploding Drug Classes
  Explode drug classes by locating the class in the
   Thesaurus, and truncating the drug code at the
   appropriate place.

  For example, if you search 24040100 (cardiac glycosides
   – a class of drugs), your search will only retrieve articles
   that talk about that class in general. It will not locate
   articles about the individual drugs in the class. If you
   wanted information about all cardiac glycosides, you
   should search 240401*. This will pick up 24040101
   (deslanoside), 24040102 (digitalis), 24040103 (digoxin),
Population Tags

  IDIS uses “population tags” in the Disease field:
     Neonate, pediatric, puberty and adolescence, and
      geriatric are all “population tags” that can be used in
      the Disease field (search the Thesaurus for them).
     If you are looking for any type of article related to one of
      these age groups, use the appropriate population tag in
      the Disease field (instead of searching for the age
      group using an article type in the Descriptor field).
Article Classifications Without Descriptors

   Search Author field for:
     “Editorial” - editorial

     “Letter to ed” – letter to the editor

   Search Disease field for:
     “Corrigendum” – erratum, addendum,
      retraction (type will be indicated in Title
Specific Types of Questions:
Side/Effect Adverse Reaction Caused by a Drug
   Locate articles about a side effect/adverse
    reaction that a drug causes:
       Drug:
         • Enter the drug that is causing the side effect/adverse reaction.
       Disease:
         • In general, you won’t need a disease term because the drug
           will likely cause the side effect/adverse reaction in all diseases,
           so disease isn’t important in these cases (unless the question
           specifies a specific disease).
       Descriptor:
         • Use the appropriate side effect/adverse effect descriptor.
           Searching the Thesaurus for “drug induced” and the side
           effect/adverse reaction that you are looking for will usually
           provide the correct descriptor.
Specific Types of Questions:
Drug Used to Treat Side Effect/Adverse Reaction
   Locate articles about a drug that is used to treat
    a side effect/adverse reaction of a drug:
       Drug:
         • Enter the drug that is being used to treat the side effect, NOT
           the drug that caused it .
       Disease:
         • Enter the term “ TX/AE-Drug/Chemical E999.” plus the disease
           term/code for the disease that the drug caused.
       Descriptor:
         • Generally will not use a side effect/adverse reaction descriptor
           unless it has to do with the drug that is in the Drug field. Other
           types of descriptors may apply if the question calls for it.
Specific Types of Questions:
Drug Interactions
   Locate articles about two or more drugs
   that interact:
     Drug:
      • Enter all drugs that interact (use AND operator).
     Disease:
      • Generally won’t use
     Descriptor:
      • “Drug interaction 50” and “Drug combination 16”
         – Alternatively, you can enter:
      • 50 and 16
Specific Types of Questions:
Drug Used to Prevent a Disease
  Find articles about a drug(s) that are used
   to prevent a disease:
     Drug:
      • Enter the drug(s) that is/are being use to prevent the
     Disease:
      • Enter the term “Prophylaxis NEC V07.” plus the
        disease term/code that the drug is preventing.
     Descriptor:
      • As indicated.
Specific Types of Questions:
   Find information about a drug that someone has
    overdosed or been overdosed on, has tried to
    commit suicide with, has been poisoned with, or
    is showing signs of toxicity from:
       Drug:
         • Enter the drug(s) of interest.
       Disease:
         • Enter the term/code “Suicide/Overdose/Poisoning E950.”
       Descriptor:
         • As indicated.

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