Laboratory accidents occur with dismaying regularity. Nearly 10,000 accidents were reported in research laboratories in 2005, injuring nearly 2 out of every 100 researchers. Accident prevention is critical for any proactive safety and health program, particularly in laboratories and research settings. With proper training, engineering controls and administrative precautions, these risks can be effectively managed. However, accidents can and do happen, so in appropriate response methodology is needed to mitigate the situation and prevent recurrences. The methodology should include the following: 1. site investigation, 2. facility information, 3. witness interviews, 4. root-cause analysis, and 5. communication of findings. An implementation plan for corrective measures based on the root causes identified should be developed shortly after acceptance of the investigation findings. Corrective measures need to be monitored to ensure that they are being implemented and are delivering the intended effect. Metrics should be integrated into existing systems to streamline the performance improvement process and increase the likelihood of acceptance.